{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:38:25Z","timestamp":1793381905800,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.yexcr.2026.115192","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:51Z","timestamp":1791959871000},"page":"115192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recombinant human follicle-stimulating hormone injection versus Gonal-f\u00ae in controlled ovarian stimulation for assisted reproductive technology: A multicenter, randomized, assessor-blind, active-controlled phase III trial"],"prefix":"10.1016","volume":"463","author":[{"given":"Haiyan","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyun","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2026.115192_bib1","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.jacr.2020.01.018","article-title":"ACR appropriateness criteria\u00ae female infertility","volume":"17","author":"Wall","year":"2020","journal-title":"J. Am. Coll. Radiol."},{"key":"10.1016\/j.yexcr.2026.115192_bib2","article-title":"Global, regional, and national burden of female infertility and trends from 1990 to 2021 with projections to 2050 based on the GBD 2021 analysis","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115192_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13112711","article-title":"Integrative approaches to ovulation induction in polycystic ovary syndrome: a narrative review of conventional and complementary therapies","volume":"13","author":"Song","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.yexcr.2026.115192_bib4","volume":"vol. 3","author":"Alizadeh Hooshyar","year":"2025"},{"key":"10.1016\/j.yexcr.2026.115192_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ph13070136","article-title":"Human recombinant FSH and its biosimilars: clinical efficacy, safety, and cost-effectiveness in controlled ovarian stimulation for in vitro fertilization","volume":"13","author":"Bergandi","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.yexcr.2026.115192_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/jhrs.jhrs_37_23","article-title":"Clinical outcomes in patients receiving originator follitropin alfa and follitropin alfa biosimilars in real-world clinical practice: a retrospective study","volume":"16","author":"Patel","year":"2023","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.yexcr.2026.115192_bib7","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1007\/s12325-020-01512-w","article-title":"The frequency of ovarian hyperstimulation syndrome and thromboembolism with originator recombinant human follitropin alfa (GONAL-f) for medically assisted reproduction: a systematic review","volume":"37","author":"Velthuis","year":"2020","journal-title":"Adv. Ther."},{"key":"10.1016\/j.yexcr.2026.115192_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107224","article-title":"Biosimilars and interchangeability: regulatory, scientific, and global perspectives","volume":"213","author":"Iskit","year":"2025","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.yexcr.2026.115192_bib9","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2147\/RMHP.S456277","article-title":"Recombinant human follicle-stimulating hormone in controlled ovarian hyperstimulation with assisted reproductive technology in China: a cost-effectiveness analysis","volume":"17","author":"Li","year":"2024","journal-title":"Risk Manag. Healthc. Policy"},{"key":"10.1016\/j.yexcr.2026.115192_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaf097.925","article-title":"P-619 comparison of ART outcome in conventional daily dosing vs alternate day dosing of follicle stimulating hormone (FSH) in IVF\/ICSI cycles","volume":"40","author":"Sharma","year":"2025","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.yexcr.2026.115192_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.rbmo.2015.01.005","article-title":"A multi-centre phase 3 study comparing efficacy and safety of Bemfola(\u00ae) versus Gonal-f(\u00ae) in women undergoing ovarian stimulation for IVF","volume":"30","author":"Rettenbacher","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.yexcr.2026.115192_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.rbmo.2022.10.006","article-title":"Comparison of recombinant human FSH biosimilar QL1012 with Gonal-f\u00ae for ovarian stimulation: a phase-three trial","volume":"46","author":"Hu","year":"2023","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.yexcr.2026.115192_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-015-0135-8","article-title":"Randomized, active-controlled, comparative phase 3 efficacy and safety equivalence trial of ovaleap\u00ae (recombinant human follicle-stimulating hormone) in infertile women using assisted reproduction technology (ART)","volume":"14","author":"Strowitzki","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.yexcr.2026.115192_bib14","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1038\/s41598-025-86962-4","article-title":"The first multiple center prospective study of rhFSH CTP in patients undergoing assisted reproductive technology in China","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115192_bib15","volume":"vol. 15","author":"Cruz","year":"2024"},{"key":"10.1016\/j.yexcr.2026.115192_bib16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.fertnstert.2008.01.064","article-title":"Clinical efficacy of highly purified urinary FSH versus recombinant FSH in volunteers undergoing controlled ovarian stimulation for in vitro fertilization: a randomized, multicenter, investigator-blind trial","volume":"91","author":"Baker","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.yexcr.2026.115192_bib17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0015-0282(01)03246-0","article-title":"Updated meta-analysis of recombinant follicle-stimulating hormone (FSH) versus urinary FSH for ovarian stimulation in assisted reproduction","volume":"77","author":"Daya","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.yexcr.2026.115192_bib18","article-title":"Recombinant versus urinary gonadotrophin for ovarian stimulation in assisted reproductive technology cycles","volume":"2011","author":"van Wely","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.yexcr.2026.115192_bib19","volume":"vol. 12","author":"Kaplan","year":"2021"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:15:08Z","timestamp":1793380508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726003095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0014482726003095"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115192","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant human follicle-stimulating hormone injection versus Gonal-f\u00ae in controlled ovarian stimulation for assisted reproductive technology: A multicenter, randomized, assessor-blind, active-controlled phase III trial","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115192"}}