{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:27:51Z","timestamp":1794547671001,"version":"4.9.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016334","name":"Jiangsu Provincial Medical Center","doi-asserted-by":"publisher","award":["CXZX202227"],"award-info":[{"award-number":["CXZX202227"]}],"id":[{"id":"10.13039\/501100016334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270943"],"award-info":[{"award-number":["82270943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.yexcr.2026.115195","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:51:17Z","timestamp":1791906677000},"page":"115195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["OPTN-TRIP6-mediated F-actin mechanical support regulates phagophore closure to govern craniofacial skeletal development"],"prefix":"10.1016","volume":"463","author":[{"given":"Zhenyi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9698-2994","authenticated-orcid":false,"given":"Wanshu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2026.115195_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.ctdb.2018.12.013","article-title":"Regulatory mechanisms of jaw bone and tooth development","volume":"133","author":"Yuan","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2020.11.037","article-title":"Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis","volume":"184","author":"Yu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115195_bib3","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.7150\/thno.58052","article-title":"GATA4-driven miR-206-3p signatures control orofacial bone development by regulating osteogenic and osteoclastic activity","volume":"11","author":"Guo","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.yexcr.2026.115195_bib4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2026.115195_bib5","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3390\/ijms22031315","article-title":"The special developmental biology of craniofacial tissues enables the understanding of oral and maxillofacial physiology and diseases","volume":"22","author":"Weber","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2026.115195_bib6","doi-asserted-by":"crossref","first-page":"54e","DOI":"10.1097\/PRS.0000000000007451","article-title":"Craniofacial and long bone development in the context of distraction osteogenesis","volume":"147","author":"Shah","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.yexcr.2026.115195_bib7","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1093\/hmg\/ddw171","article-title":"Modeling craniofacial and skeletal congenital birth defects to advance therapies","volume":"25","author":"Neben","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexcr.2026.115195_bib8","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.yexcr.2026.115195_bib9","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib10","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexcr.2026.115195_bib11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2015.09.071","article-title":"Optineurin negatively regulates osteoclast differentiation by modulating NF-\u03baB and interferon signaling: implications for Paget's disease","volume":"13","author":"Obaid","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.yexcr.2026.115195_bib12","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1080\/15548627.2020.1839286","article-title":"Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2026.115195_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/15548627.2026.2624745","article-title":"Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization","volume":"22","author":"Liu","year":"2026","journal-title":"Autophagy"},{"key":"10.1016\/j.yexcr.2026.115195_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae082","article-title":"Research progresses on mitochondrial-targeted biomaterials for bone defect repair","volume":"11","author":"Wang","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.yexcr.2026.115195_bib15","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.14336\/AD.2023.0201","article-title":"Mitochondrial dynamics: working with the cytoskeleton and intracellular organelles to mediate mechanotransduction","volume":"14","author":"Huang","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.yexcr.2026.115195_bib16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.devcel.2018.01.007","article-title":"Myosin VI-dependent actin cages encapsulate Parkin-positive damaged mitochondria","volume":"44","author":"Kruppa","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2026.115195_bib17","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.cellsig.2011.06.004","article-title":"TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity","volume":"23","author":"Lin","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.yexcr.2026.115195_bib18","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s11008-005-0095-8","article-title":"Downregulation of TRIP6 gene expression induces actin cytoskeleton rearrangements in human carcinoma cell lines","volume":"39","author":"Guryanova","year":"2005","journal-title":"Mol. Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib19","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3390\/ijms20071694","article-title":"Regulation of proliferation, differentiation and functions of osteoblasts by Runx2","volume":"20","author":"Komori","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2026.115195_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.devcel.2016.04.002","article-title":"Sp7\/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification","volume":"37","author":"Hojo","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yexcr.2026.115195_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2015.05.046","article-title":"New insights into the biology of osteocalcin","volume":"82","author":"Zoch","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2026.115195_bib22","doi-asserted-by":"crossref","first-page":"C111","DOI":"10.1152\/ajpcell.00120.2019","article-title":"Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport","volume":"318","author":"Schlesinger","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yexcr.2026.115195_bib23","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.3390\/ijms22115445","article-title":"Regulation and role of transcription factors in osteogenesis","volume":"22","author":"Chan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexcr.2026.115195_bib24","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.3390\/cells9122630","article-title":"Deciphering the relevance of bone ECM signaling","volume":"9","author":"Alcorta-Sevillano","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.yexcr.2026.115195_bib25","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3389\/fimmu.2018.01017","article-title":"Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma","volume":"9","author":"Toth","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexcr.2026.115195_bib26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fimmu.2018.01024","article-title":"Optineurin: a coordinator of membrane-associated cargo trafficking and autophagy","volume":"9","author":"Ryan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexcr.2026.115195_bib27","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.it.2016.07.002","article-title":"Cellular functions of optineurin in health and disease","volume":"37","author":"Slowicka","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.yexcr.2026.115195_bib28","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.yexcr.2026.115195_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.yexcr.2026.115195_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.824812","article-title":"Recent advances in enhancement strategies for osteogenic differentiation of mesenchymal stem cells in bone tissue engineering","volume":"10","author":"Zha","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib31","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1038\/s41467-018-06570-x","article-title":"Transformation of amorphous calcium phosphate to bone-like apatite","volume":"9","author":"Lotsari","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2026.115195_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/stem.2248","article-title":"Murine mesenchymal stem cell commitment to differentiation is regulated by mitochondrial dynamics","volume":"34","author":"Forni","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.yexcr.2026.115195_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/scd.2015.0193","article-title":"Energy metabolism in mesenchymal stem cells during osteogenic differentiation","volume":"25","author":"Shum","year":"2016","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.yexcr.2026.115195_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2026.115195_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jmb.2019.07.016","article-title":"Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors","volume":"432","author":"Johansen","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41580-020-0241-0","article-title":"Mechanisms governing autophagosome biogenesis","volume":"21","author":"Nakatogawa","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib37","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.cell.2012.11.001","article-title":"The hairpin-type tail-anchored SNARE Syntaxin 17 targets to autophagosomes for fusion with endosomes\/lysosomes","volume":"151","author":"Itakura","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115195_bib38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201607039","article-title":"Atg8 family LC3\/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1\/Parkin mitophagy and starvation","volume":"215","author":"Nguyen","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib39","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41467-018-05254-w","article-title":"An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexcr.2026.115195_bib40","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.yexcr.2026.115195_bib41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41586-021-03795-7","article-title":"Aged skeletal stem cells generate an inflammatory degenerative niche","volume":"597","author":"Ambrosi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2026.115195_bib42","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ng.562","article-title":"Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone","volume":"42","author":"Albagha","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexcr.2026.115195_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.932065","article-title":"Update on the pathogenesis and genetics of Paget's disease of bone","volume":"10","author":"Gennari","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2026.115195_bib44","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.239822","article-title":"OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion","volume":"133","author":"O'Loughlin","year":"2020","journal-title":"J. Cell Sci."}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:07:18Z","timestamp":1794546438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726003125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0014482726003125"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115195","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OPTN-TRIP6-mediated F-actin mechanical support regulates phagophore closure to govern craniofacial skeletal development","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115195"}}