{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:38:52Z","timestamp":1792741132796,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Cell Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.yexcr.2026.115197","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:03:09Z","timestamp":1792738989000},"page":"115197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-Cell Resolution Mapping Reveals Cell Death-Associated Stress Programs and Osteogenic-Chondrogenic Differentiation Imbalance in Subchondral Bone Mesenchymal Stem Cells of Knee Osteoarthritis"],"prefix":"10.1016","author":[{"given":"Zilong","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexcr.2026.115197_bib1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2026.115197_bib2","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.yexcr.2026.115197_bib3","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.yexcr.2026.115197_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.rehab.2016.07.004","article-title":"An update on the pathophysiology of osteoarthritis","volume":"59","author":"Mobasheri","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"10.1016\/j.yexcr.2026.115197_bib5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","article-title":"Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk","volume":"12","author":"Goldring","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.yexcr.2026.115197_bib6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.yexcr.2026.115197_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar4405","article-title":"Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes","volume":"15","author":"Li","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.yexcr.2026.115197_bib8","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.joca.2013.06.003","article-title":"A commentary on modelling osteoarthritis pain in small animals","volume":"21","author":"Malfait","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.yexcr.2026.115197_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.yexcr.2026.115197_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.yexcr.2026.115197_bib11","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.yexcr.2026.115197_bib12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/art.10118","article-title":"Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis","volume":"46","author":"Murphy","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.yexcr.2026.115197_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.biomaterials.2018.11.036","article-title":"Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt\/\u03b2-catenin pathway","volume":"192","author":"Deng","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexcr.2026.115197_bib14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2026.115197_bib15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell","volume":"6","author":"Tang","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yexcr.2026.115197_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/annrheumdis-2017-212863","article-title":"Single-cell RNA-seq analysis reveals the progression of human osteoarthritis","volume":"78","author":"Ji","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.yexcr.2026.115197_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexcr.2026.115197_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.yexcr.2026.115197_bib19","first-page":"575","article-title":"Gene co-expression analysis for functional classification and gene-disease predictions","volume":"19","author":"van Dam","year":"2018","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.yexcr.2026.115197_bib20","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.yexcr.2026.115197_bib21","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/dev.091777","article-title":"Stem cell metabolism in tissue development and aging","volume":"140","author":"Shyh-Chang","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.yexcr.2026.115197_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2014.09.017","article-title":"Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration","volume":"70","author":"Stegen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2026.115197_bib23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrrheum.2012.135","article-title":"Metabolic syndrome meets osteoarthritis","volume":"8","author":"Zhuo","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.yexcr.2026.115197_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bone.2014.10.014","article-title":"Characterization of bone marrow-derived mesenchymal stem cells in aging","volume":"70","author":"Baker","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.yexcr.2026.115197_bib25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.yexcr.2026.115197_bib26","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexcr.2026.115197_bib27","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yexcr.2026.115197_bib28","first-page":"273","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism","volume":"171","author":"Stockwell","year":"2017","journal-title":"redox biology, and disease, Cell"},{"key":"10.1016\/j.yexcr.2026.115197_bib29","article-title":"Ferroptosis in osteosarcoma: a promising future","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexcr.2026.115197_bib30","article-title":"Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications","volume":"11","author":"Zhang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yexcr.2026.115197_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: an injury drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexcr.2026.115197_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexcr.2026.115197_bib33","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.joca.2015.02.009","article-title":"Inflammatory biomarkers in osteoarthritis","volume":"23","author":"Daghestani","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.yexcr.2026.115197_bib34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7326\/M14-1231","article-title":"Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis","volume":"162","author":"Bannuru","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.yexcr.2026.115197_bib35","doi-asserted-by":"crossref","first-page":"847","DOI":"10.5966\/sctm.2015-0245","article-title":"Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial","volume":"5","author":"Pers","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.yexcr.2026.115197_bib36","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1097\/TP.0000000000000678","article-title":"Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial","volume":"99","author":"Vega","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.yexcr.2026.115197_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70637","article-title":"Machine learning-assisted analysis of the oral cancer immune microenvironment: from single-cell level to prognostic model construction","volume":"29","author":"Yang","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yexcr.2026.115197_bib38","doi-asserted-by":"crossref","DOI":"10.2196\/49051","article-title":"Evaluation of mobile health technology interventions for the postdischarge management of patients with head and neck cancer: scoping review","volume":"11","author":"Li","year":"2023","journal-title":"JMIR Mhealth Uhealth"}],"container-title":["Experimental Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014482726003149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:03:14Z","timestamp":1792738994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014482726003149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S0014482726003149"],"URL":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115197","relation":{},"ISSN":["0014-4827"],"issn-type":[{"value":"0014-4827","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-Cell Resolution Mapping Reveals Cell Death-Associated Stress Programs and Osteogenic-Chondrogenic Differentiation Imbalance in Subchondral Bone Mesenchymal Stem Cells of Knee Osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Experimental Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexcr.2026.115197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115197"}}