{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:32:25Z","timestamp":1751481145858},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.yexmp.2005.08.001","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T16:40:03Z","timestamp":1126888803000},"page":"249-258","source":"Crossref","is-referenced-by-count":21,"title":["Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor"],"prefix":"10.1016","volume":"79","author":[{"given":"Asile","family":"El-Darahali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie S.","family":"Mader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Hoskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2005.08.001_bib1","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1182\/blood.V95.12.3859","article-title":"A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency","volume":"95","author":"Apasov","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2005.08.001_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1172\/JCI200110360","article-title":"Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling","volume":"108","author":"Apasov","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2005.08.001_bib3","first-page":"1887","article-title":"Adenosine-mediated killing of cultured epithelial cancer cells","volume":"60","author":"Barry","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2005.08.001_bib4","first-page":"2349","article-title":"Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification","volume":"53","author":"Barry","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2005.08.001_bib5","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1073\/pnas.92.18.8373","article-title":"p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency","volume":"92","author":"Benveniste","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2005.08.001_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(04)86001-2","article-title":"Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation","volume":"86","author":"Blackburn","year":"2005","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib7","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1074\/jbc.273.9.5093","article-title":"Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency","volume":"273","author":"Blackburn","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2005.08.001_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0090-1229(79)90109-0","article-title":"Thymic morphology in immunodeficiency diseases: results of thymic biopsies","volume":"12","author":"Borzy","year":"1979","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1158\/0008-5472.CAN-03-3060","article-title":"Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells","volume":"64","author":"Br\u00f6ker","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2005.08.001_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-3476(97)70199-9","article-title":"Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants","volume":"130","author":"Buckley","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.yexmp.2005.08.001_bib11","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jcb.10562","article-title":"Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways","volume":"89","author":"Butler","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexmp.2005.08.001_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0300-9084(02)01376-7","article-title":"The Apaf-1 apoptosome: a large caspase-activating complex","volume":"84","author":"Cain","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.yexmp.2005.08.001_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(00)00399-X","article-title":"SCH 58261 and ZM 241385 differentially prevent the motor effects of CGS 21680 in mice: evidence for a functional \u2018atypical\u2019 adenosine A2A receptor","volume":"401","author":"El Yacoubi","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0006-291X(02)02910-8","article-title":"Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase","volume":"300","author":"Ezeamuzie","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2005.08.001_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1081-1206(10)63176-6","article-title":"Apoptosis","volume":"78","author":"Fleisher","year":"1997","journal-title":"Ann. Allergy, Asthma, Immunol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib16","first-page":"143","article-title":"Nomenclature and classification of purinoreceptors","volume":"46","author":"Fredholm","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yexmp.2005.08.001_bib17","first-page":"527","article-title":"International union of pharmacology: XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yexmp.2005.08.001_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-4157(96)00008-1","article-title":"Nucleoside and nucleobase transport systems of mammalian cells","volume":"1286","author":"Griffith","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexmp.2005.08.001_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/eji.200425738","article-title":"New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing immunodeficiency associated with adenosine deaminase deficiency","volume":"35","author":"Hershfield","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.yexmp.2005.08.001_bib20","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1203\/00006450-199333011-00008","article-title":"Overview of biochemical abnormalities and molecular genetics of adenosine deaminase deficiency","volume":"33","author":"Hirschhorn","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.yexmp.2005.08.001_bib21","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1016\/S0021-9258(19)34118-3","article-title":"Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage","volume":"265","author":"Kizaki","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2005.08.001_bib22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1006\/bbrc.1996.0331","article-title":"Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A3 receptor agonists","volume":"219","author":"Kohno","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2005.08.001_bib23","first-page":"205","article-title":"Reactive oxygen species and the mitochondrial signaling pathway of cell death","volume":"20","author":"Le Bras","year":"2005","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib24","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.freeradbiomed.2004.03.020","article-title":"Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor","volume":"36","author":"Lemarie","year":"2004","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.yexmp.2005.08.001_bib25","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1073\/pnas.95.16.9567","article-title":"Induction of an apoptotic program in cell-free extracts by 2-chloro-2\u2032-deoxyadenosine 5\u2032-triphosphate and cytochrome c","volume":"95","author":"Leoni","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2005.08.001_bib26","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/18.21.6027","article-title":"p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2005.08.001_bib27","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1073\/pnas.74.12.5482","article-title":"Two distinct adenosine-sensitive sites on adenylate cyclase","volume":"74","author":"Londos","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2005.08.001_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-3083.1989.tb01193.x","article-title":"Plasticity of T-cell function: II. Transient induction of CD8 (Ly-2) expression in cloned EL-4 lymphoma cells depending on cell density","volume":"30","author":"Melchers","year":"1989","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.yexmp.2005.08.001_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2004.10.009","article-title":"Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA","volume":"224","author":"Park","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2005.08.001_bib31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cyto.990120713","article-title":"Simultaneous flow cytometric method to measure phagocytosis and oxidative products by neutrophils","volume":"12","author":"Perticarari","year":"1991","journal-title":"Cytometry"},{"key":"10.1016\/j.yexmp.2005.08.001_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.RES.86.1.76","article-title":"Extracellular adenosine induces apoptosis of human arterial smooth muscle cells via A2b-purinoreceptor","volume":"86","author":"Peyot","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yexmp.2005.08.001_bib33","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/intimm\/8.7.1139","article-title":"S-adenosylhomocysteine as a physiological mediator of Apo-1-mediated apoptosis","volume":"8","author":"Ratter","year":"1996","journal-title":"Int. Immunol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib34","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1074\/jbc.272.15.9677","article-title":"Substrate specificities of caspase family proteases","volume":"272","author":"Talanian","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2005.08.001_bib35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1083\/jcb.141.6.1423","article-title":"The regulation of reactive oxygen species production during programmed cell death","volume":"141","author":"Tan","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yexmp.2005.08.001_bib36","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1172\/JCI9944","article-title":"Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures","volume":"106","author":"Thompson","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2005.08.001_bib37","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0021-9258(19)70056-8","article-title":"A biochemical genetic study of the role of specific nucleoside kinases in deoxyadenosine phosphorylation by cultured human cells","volume":"256","author":"Ullman","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2005.08.001_bib38","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/bbrc.1998.9333","article-title":"dATP causes specific release of cytochrome c from mitochondria","volume":"250","author":"Yang","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2005.08.001_bib39","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.181.5.1661","article-title":"Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo","volume":"181","author":"Zamzami","year":"1995","journal-title":"J. Exp. Med."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480005000924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480005000924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T18:14:16Z","timestamp":1626545656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480005000924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0014480005000924"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2005.08.001","relation":{},"ISSN":["0014-4800"],"issn-type":[{"type":"print","value":"0014-4800"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}