{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:17:37Z","timestamp":1766135857297},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.yexmp.2007.05.004","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T12:26:58Z","timestamp":1181824018000},"page":"419-427","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of gene expression related to hepatic cell maturation and differentiation in a chemically induced mouse hepatoblastoma cell line"],"prefix":"10.1016","volume":"83","author":[{"given":"Tetsuya","family":"Sakairi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoko","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Utsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Kohge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2007.05.004_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/excr.1996.0340","article-title":"Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies","volume":"229","author":"Abe","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexmp.2007.05.004_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0046-8177(87)80219-8","article-title":"Hepatoblastoma: an immunohistochemical and ultrastructural study","volume":"18","author":"Abenoza","year":"1987","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/jhep.2001.26751","article-title":"A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver","volume":"34","author":"Akhurst","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/intimm\/3.2.175","article-title":"The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts","volume":"3","author":"Brown","year":"1991","journal-title":"Int. Immunol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3835(95)03884-Y","article-title":"Lack of p53 point mutations in chemically induced mouse hepatoblastomas: an end-stage, highly malignant hepatocellular tumor","volume":"95","author":"Calvert","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2007.05.004_bib50","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1182\/blood.V94.5.1495","article-title":"Functional and molecular analysis of hematopoietic progenitors derived from the aorta-gonad-mesonephros region of the mouse embryo","volume":"94","author":"Delassus","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2007.05.004_bib7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/carcin\/10.7.1345","article-title":"Promotion of malignant \u2018embryonal\u2019 liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA\/2\u00d7C57BL\/6)F1 mice initiated with N-nitrosodiethylamine","volume":"10","author":"Diwan","year":"1989","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2007.05.004_bib8","series-title":"The Role of Cell Types in Hepatocarcinogenesis","first-page":"71","article-title":"Origin and pathology of hepatoblastoma in mice","author":"Diwan","year":"1992"},{"key":"10.1016\/j.yexmp.2007.05.004_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3835(95)90154-X","article-title":"Further evidence for promoter-dependent development of hepatoblastoma in the mouse","volume":"89","author":"Diwan","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2007.05.004_bib9","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/carcin\/8.11.1737","article-title":"A precursor\u2013product relationship exists between oval cells and hepatocytes in rat liver","volume":"8","author":"Evarts","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2007.05.004_bib10","first-page":"1541","article-title":"In vivo differentiation of rat liver oval cells into hepatocytes","volume":"49","author":"Evarts","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2007.05.004_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0940-2993(11)80399-4","article-title":"Oval cells\u2013hepatocytes relationships in Dipin-induced hepatocarcinogenesis in mice","volume":"45","author":"Factor","year":"1993","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib12","first-page":"409","article-title":"Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse","volume":"145","author":"Factor","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib13","series-title":"Pathology of Tumors in Laboratory Animals","first-page":"223","article-title":"Tumours of the liver","volume":"vol. II","author":"Frith","year":"1994"},{"key":"10.1016\/j.yexmp.2007.05.004_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/excr.1996.0134","article-title":"Coexpression of stem cell factor and c-kit in embryonic and adult liver","volume":"224","author":"Fujio","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexmp.2007.05.004_bib15","first-page":"368","article-title":"Promotion of growth and differentiation of rat ductular oval cells in primary culture","volume":"48","author":"Germain","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2007.05.004_bib16","first-page":"1243","article-title":"Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver","volume":"22","author":"Golding","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(01)02423-1","article-title":"Hepatic maturation in differentiating embryonic stem cells in vitro","volume":"497","author":"Hamazaki","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yexmp.2007.05.004_bib18","series-title":"Pathology of the Mouse","article-title":"Liver and gallbladder","author":"Harada","year":"1999"},{"key":"10.1016\/j.yexmp.2007.05.004_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1182\/blood.V96.3.925","article-title":"Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor","volume":"96","author":"Heinrich","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2007.05.004_bib20","first-page":"2291","article-title":"Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer","volume":"6","author":"Hibi","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/j.yexmp.2007.05.004_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1126\/science.279.5350.577","article-title":"Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors","volume":"279","author":"Hirota","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.yexmp.2007.05.004_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(00)00387-6","article-title":"Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma","volume":"154","author":"Jeng","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2007.05.004_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1292\/jvms.62.263","article-title":"Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma","volume":"62","author":"Kobayashi","year":"2000","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.yexmp.2007.05.004_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1293\/tox.16.247","article-title":"Non-cloning synthesis of cRNA probe and its application to in situ hybridization analysis of formalin-fixed paraffin embedded tissue","volume":"16","author":"Kobayashi","year":"2003","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1293\/tox.6.21S","article-title":"Histopathological studies of mouse hepatoblastoma induced by DEN","volume":"6","author":"Kojima","year":"1993","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1182\/blood.V84.3.691.691","article-title":"Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells","volume":"84","author":"Krause","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2007.05.004_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0002-9440(10)65250-9","article-title":"Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas","volume":"154","author":"Lasota","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.canlet.2005.02.046","article-title":"Induction of gastric GIST in rat and establishment of GIST cell line","volume":"231","author":"Mukaisho","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2007.05.004_bib30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/030098588602300511","article-title":"Hepatoblastoma with squamous differentiation in a B6C3F1 mouse","volume":"23","author":"Nonoyama","year":"1986","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/030098588802500407","article-title":"Mouse hepatoblastomas: a histologic, ultrastructural, and immunohistochemical study","volume":"25","author":"Nonoyama","year":"1988","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib31","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/hep.510250512","article-title":"Expression of alpha-fetoprotein and stem cell factor\/c-kit system in bile duct ligated young rats","volume":"25","author":"Omori","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510260325","article-title":"Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in the adult rat","volume":"26","author":"Omori","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/abbi.1998.0849","article-title":"Ontogeny of the murine glucose-6-phosphatase system","volume":"358","author":"Pan","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yexmp.2007.05.004_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1477-3163-4-19","article-title":"The role of c-kit and imatinib mesylate in uveal melanoma","volume":"4","author":"Pereira","year":"2005","journal-title":"J. Carcinog."},{"key":"10.1016\/j.yexmp.2007.05.004_bib35","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1053\/jhep.2003.50104","article-title":"Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers","volume":"37","author":"Petersen","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1097-0215(19980119)75:2<171::AID-IJC1>3.0.CO;2-R","article-title":"Expression of the c-Kit receptor and its ligand SCF in non-small-cell lung carcinomas","volume":"75","author":"Pietsch","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2007.05.004_bib37","first-page":"591","article-title":"Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro","volume":"150","author":"Rogler","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib38","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","author":"Rozen","year":"2000"},{"key":"10.1016\/j.yexmp.2007.05.004_bib39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mpo.10175","article-title":"Stem-like cells in hepatoblastoma","volume":"39","author":"Ruck","year":"2002","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2559.1995.tb00253.x","article-title":"Immunoreactivity of sinusoids in hepatoblastoma: an immunohistochemical study using lectin UEA-1 and antibodies against endothelium-associated antigens, including CD34","volume":"26","author":"Ruck","year":"1995","journal-title":"Histopathology"},{"key":"10.1016\/j.yexmp.2007.05.004_bib41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/01926230152499962","article-title":"Greater expression of transforming growth factor alpha and proliferating cell nuclear antigen staining in mouse hepatoblastomas than hepatocellular carcinomas induced by a diethylnitrosamine-sodium phenobarbital regimen","volume":"29","author":"Sakairi","year":"2001","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yexmp.2007.05.004_bib42","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1292\/jvms.63.1121","article-title":"Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital","volume":"63","author":"Sakairi","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.yexmp.2007.05.004_bib43","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/cncr.11585","article-title":"Where do we stand with hepatoblastoma? A review","volume":"98","author":"Schnater","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.yexmp.2007.05.004_bib44","first-page":"2416","article-title":"Preferential expression of c-kit protooncogene transcripts in small cell lung cancer","volume":"51","author":"Sekido","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2007.05.004_bib45","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/jcs.00388","article-title":"Isolation of hepatoblasts based on the expression of Dlk\/Pref-1","volume":"116","author":"Tanimizu","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yexmp.2007.05.004_bib46","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1093\/jnci\/51.5.1689","article-title":"Malignant mouse-liver tumors resembling human hepatoblastomas","volume":"51","author":"Turusov","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.yexmp.2007.05.004_bib47","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0046-8177(90)90231-S","article-title":"A cytokeratin-immunohistochemical study of hepatoblastoma","volume":"21","author":"Van Eyken","year":"1990","journal-title":"Hum. Pathol."},{"issue":"Suppl 1","key":"10.1016\/j.yexmp.2007.05.004_bib48","doi-asserted-by":"crossref","first-page":"11881","DOI":"10.1073\/pnas.1734199100","article-title":"The origin and liver repopulating capacity of murine oval cells","volume":"100","author":"Wang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2007.05.004_bib49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1476-4598-5-46","article-title":"The stem cell factor\/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells","volume":"5","author":"Yasuda","year":"2006","journal-title":"Mol. Cancer"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480007000810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480007000810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T03:04:17Z","timestamp":1587611057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480007000810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0014480007000810"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2007.05.004","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}