{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:09:02Z","timestamp":1792656542622,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.yexmp.2009.06.003","type":"journal-article","created":{"date-parts":[[2009,7,4]],"date-time":"2009-07-04T08:12:19Z","timestamp":1246695139000},"page":"99-104","source":"Crossref","is-referenced-by-count":113,"title":["Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis"],"prefix":"10.1016","volume":"87","author":[{"given":"Sandra J.","family":"Saouaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Furuuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2009.06.003_bib1","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1182\/blood-2008-01-133769","article-title":"Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines","volume":"112","author":"Buglio","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2009.06.003_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2005.02.022","article-title":"Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis","volume":"164","author":"Camelo","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.yexmp.2009.06.003_bib3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1525-0016(03)00235-1","article-title":"A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis","volume":"8","author":"Chung","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.yexmp.2009.06.003_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexmp.2009.06.003_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexmp.2009.06.003_bib6","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1186\/ar1484","article-title":"The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells","volume":"7","author":"Frey","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.yexmp.2009.06.003_bib7","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/pr050188r","article-title":"Resetting the epigenetic histone code in the MRL-lpr\/lpr mouse model of lupus by histone deacetylase inhibition","volume":"4","author":"Garcia","year":"2005","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.yexmp.2009.06.003_bib8","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/NRL.0b013e31815bb3b7","article-title":"Antiepileptic drugs: from scientific evidence to clinical practice","volume":"13","author":"Garcia-Morales","year":"2007","journal-title":"Neurologist"},{"key":"10.1016\/j.yexmp.2009.06.003_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/epi.1.2.2678","article-title":"Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis","volume":"1","author":"Gray","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.yexmp.2009.06.003_bib10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2009.06.003_bib11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yexmp.2009.06.003_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11926-999-0011-7","article-title":"Animal models of rheumatoid arthritis and related inflammation","volume":"1","author":"Joe","year":"1999","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.yexmp.2009.06.003_bib13","first-page":"293","article-title":"The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo","volume":"22","author":"Jones","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yexmp.2009.06.003_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pathophys.2005.07.011","article-title":"Animal models of rheumatoid arthritis and their relevance to human disease","volume":"12","author":"Kannan","year":"2005","journal-title":"Pathophysiology"},{"key":"10.1016\/j.yexmp.2009.06.003_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexmp.2009.06.003_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/art.10198","article-title":"Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance","volume":"46","author":"Kim","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexmp.2009.06.003_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.0105-2896.2006.00405.x","article-title":"FOXP3 ensembles in T-cell regulation","volume":"212","author":"Li","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.yexmp.2009.06.003_bib18","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1073\/pnas.0700298104","article-title":"FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression","volume":"104","author":"Li","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2009.06.003_bib19","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/sj.bjp.0707165","article-title":"Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents","volume":"150","author":"Lin","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2009.06.003_bib20","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1073\/pnas.051507098","article-title":"Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells","volume":"98","author":"Mishra","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2009.06.003_bib21","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/art.11063","article-title":"CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis","volume":"48","author":"Morgan","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexmp.2009.06.003_bib22","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1002\/art.21195","article-title":"Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells","volume":"52","author":"Morgan","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexmp.2009.06.003_bib23","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.0504301102","article-title":"Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107","volume":"102","author":"Murali","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2009.06.003_bib24","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1074\/jbc.M610443200","article-title":"An essential role of human Ada3 in p53 acetylation","volume":"282","author":"Nag","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2009.06.003_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/rheumatology\/ken003","article-title":"Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells","volume":"47","author":"Nakamura","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.yexmp.2009.06.003_bib26","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1002\/art.20709","article-title":"Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1\/Cip1) expression","volume":"50","author":"Nishida","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yexmp.2009.06.003_bib27","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.4049\/jimmunol.173.6.4171","article-title":"Modulation of renal disease in MRL\/lpr mice by suberoylanilide hydroxamic acid","volume":"173","author":"Reilly","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2009.06.003_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaut.2008.04.020","article-title":"The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB\/W F1 mice","volume":"31","author":"Reilly","year":"2008","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.yexmp.2009.06.003_bib29","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s00018-007-7079-x","article-title":"The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?","volume":"64","author":"Rosenberg","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.yexmp.2009.06.003_bib30","doi-asserted-by":"crossref","first-page":"14023","DOI":"10.1073\/pnas.0806726105","article-title":"TGF-{beta} and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3","volume":"105","author":"Samanta","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2009.06.003_bib31","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells","volume":"13","author":"Tao","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2009.06.003_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood-2005-11-4567","article-title":"TNF downmodulates the function of human CD4+CD25hi T-regulatory cells","volume":"108","author":"Valencia","year":"2006","journal-title":"Blood"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480009000847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480009000847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T15:55:45Z","timestamp":1545148545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480009000847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0014480009000847"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2009.06.003","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}