{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:04:05Z","timestamp":1784664245662,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.yexmp.2010.06.002","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T10:11:46Z","timestamp":1277547106000},"page":"190-196","source":"Crossref","is-referenced-by-count":42,"title":["The role of macrophages and mast cells in lymphangiogenesis and angiogenesis in cervical carcinogenesis"],"prefix":"10.1016","volume":"89","author":[{"given":"Dolores","family":"Utrera-Barillas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Castro-Manrreza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Guti\u00e9rrez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Arciniega-Ru\u00edz de Esparza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garc\u00eda-Cebada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Velazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Flores-Res\u00e9ndiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ben\u00edtez-Bribiesca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2010.06.002_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-065X.2008.00607.x","article-title":"The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance","volume":"222","author":"Allavena","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.yexmp.2010.06.002_bib2","first-page":"3111","article-title":"Molecular mechanisms regulating the angiogenic phenotype in tumors: clinical impact in the future","volume":"27","author":"Aubry","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.yexmp.2010.06.002_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1177\/002215540104900816","article-title":"The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix","volume":"49","author":"Ben\u00edtez-Bribiesca","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.yexmp.2010.06.002_bib4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/sj.bjc.6605219","article-title":"Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer","volume":"101","author":"Boneberg","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.1525-1438.2002.01082.x","article-title":"Characterization of mast cells according to their content of tryptase and chymase in normal and neoplastic human uterine cervix","volume":"12","author":"Cabanillas-S\u00e1ez","year":"2002","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","article-title":"Macrophages: obligate partners for tumor cell migration, invasion, and metastasis","volume":"124","author":"Condeelis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2010.06.002_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1080\/j.1600-0412.1999.780312.x","article-title":"Macrophage infiltration and angiogenesis in cervical squamous cell carcinoma-clinicopathologic correlation","volume":"78","author":"Davidson","year":"1999","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.yexmp.2010.06.002_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s004180050303","article-title":"Multiple epitope labeling by the exclusive use of alkaline phosphatase conjugates in immunohistochemistry","volume":"110","author":"Deininger","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10585-007-9123-5","article-title":"Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms","volume":"24","author":"Eccles","year":"2007","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.yexmp.2010.06.002_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-2008-1026330","article-title":"Local immune reactions in carcinoma in situ and cervix cancer\u2014a histologic and immunohistochemical study","volume":"51","author":"Falk","year":"1991","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.yexmp.2010.06.002_bib11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1590\/S1516-31802007000400008","article-title":"Intensity of cervical inflammatory reaction as a risk factor for recurrence of carcinoma of the uterine cervix in stages IB and IIA","volume":"125","author":"Fregnani","year":"2007","journal-title":"S\u00e3o Paulo Med. J."},{"key":"10.1016\/j.yexmp.2010.06.002_bib12","first-page":"2632","article-title":"Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers","volume":"60","author":"Fujimoto","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2010.06.002_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.humpath.2006.01.025","article-title":"Lymphatic vessel density as a prognostic indicator for patients with stage I cervical carcinoma","volume":"37","author":"Gao","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.1874010","article-title":"IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion","volume":"24","author":"Gocheva","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexmp.2010.06.002_bib15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2010.06.002_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ygyno.2006.11.023","article-title":"Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression-clinicopathological correlation","volume":"105","author":"Hammes","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ygyno.2008.04.038","article-title":"Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease","volume":"110","author":"Hammes","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1525-1438.2003.13035.x","article-title":"Presence and quantification of macrophages in squamous cell carcinoma of the cervix","volume":"13","author":"Heller","year":"2003","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2741\/e101","article-title":"Expression of VEGF, VEGF-C and VEGFR-2 in in situ and invasive SCC of cervix","volume":"2","author":"Jach","year":"2010","journal-title":"Front. Biosci."},{"key":"10.1016\/j.yexmp.2010.06.002_bib20","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1158\/0008-5472.CAN-07-2572","article-title":"Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer","volume":"68","author":"Jeon","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2010.06.002_bib21","doi-asserted-by":"crossref","first-page":"33671","DOI":"10.1074\/jbc.M702889200","article-title":"Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1","volume":"282","author":"Johnson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2010.06.002_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc2618","article-title":"Microenvironmental regulation of metastasis","volume":"9","author":"Joyce","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1134\/S0006297908070031","article-title":"Mechanisms of angiogenesis","volume":"73","author":"Karamysheva","year":"2008","journal-title":"Biochemistry (Mosc)."},{"key":"10.1016\/j.yexmp.2010.06.002_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.pathmechdis.3.121806.151515","article-title":"Molecular biology and pathology of lymphangiogenesis","volume":"3","author":"Karpanen","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/mi.2008.33","article-title":"Evolving immunosuppressive microenvironment during human cervical carcinogenesis","volume":"1","author":"Kobayashi","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib26","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","article-title":"Macrophages regulate the angiogenic switch in a mouse model of breast cancer","volume":"66","author":"Lin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2010.06.002_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ygyno.2007.05.029","article-title":"Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix","volume":"107","author":"Longatto-Filho","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygyno.2007.08.095","article-title":"Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis","volume":"108","author":"Mazibrada","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2010.06.002_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00022744-200103000-00002","article-title":"Standardization in immunohistochemistry","volume":"9","author":"O'Leary","year":"2001","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00004347-199304000-00018","article-title":"Natural history of cervical intraepithelial neoplasia: a critical review","volume":"12","author":"Ost\u00f6r","year":"1993","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib32","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1447-0756.2007.00666.x","article-title":"Correlation of angiogenesis and recurrence-free survival of early stage cervical cancer patients undergoing radical hysterectomy with pelvic lymph node dissection","volume":"33","author":"Phoophitphong","year":"2007","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.yexmp.2010.06.002_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2010.06.002_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2613.2009.00689.x","article-title":"A comparative study of the spatial distribution of mast cells and microvessels in the foetal, adult human thymus and thymoma","volume":"91","author":"Raica","year":"2010","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ygyno.2008.11.013","article-title":"Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study","volume":"112","author":"Randall","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1937-6448(09)75004-X","article-title":"The controversial role of mast cells in tumor growth","volume":"275","author":"Ribatti","year":"2009","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.critrevonc.2007.01.006","article-title":"Vascular endothelial growth factor (VEGF) signaling in tumor progression","volume":"62","author":"Roskoski","year":"2007","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib38","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"Schoppmann","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib39","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","article-title":"Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation","volume":"86","author":"Solinas","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1525-1438.2003.13197.x","article-title":"A prognostic insight on in vivo expression of interleukin-6 in uterine cervical cancer","volume":"13","author":"Srivani","year":"2003","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib41","first-page":"1063","article-title":"Local immune responses in uterine cervical carcinogenesis","volume":"48","author":"Takehara","year":"1996","journal-title":"Nippon Sanka Fujinka Gakkai Zasshi"},{"key":"10.1016\/j.yexmp.2010.06.002_bib42","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/path.1467","article-title":"Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis","volume":"201","author":"Van Trappen","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib43","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/emboj\/20.6.1223","article-title":"Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice","volume":"20","author":"Veikkola","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2010.06.002_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2407-9-64","article-title":"Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study","volume":"9","author":"Zhang","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.yexmp.2010.06.002_bib45","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ygyno.2007.01.046","article-title":"Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells","volume":"105","author":"Zhu","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2010.06.002_bib46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00432-008-0442-y","article-title":"Serum vascular endothelial growth factor: a prognostic factor in cervical cancer","volume":"135","author":"Zusterzeel","year":"2009","journal-title":"J. Cancer Res. Clin. Oncol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480010000869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480010000869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T05:22:05Z","timestamp":1544419325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480010000869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0014480010000869"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2010.06.002","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}