{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:49:57Z","timestamp":1791301797739,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.yexmp.2011.10.001","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T23:48:56Z","timestamp":1318895336000},"page":"126-130","source":"Crossref","is-referenced-by-count":11,"title":["The effect of SAMe and betaine on Hepa 1\u20136, C34 and E47 liver cell survival in vitro"],"prefix":"10.1016","volume":"92","author":[{"given":"Joan","family":"Oliva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgil S.","family":"Buslon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2011.10.001_bb0005","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/jhep.2002.30419","article-title":"S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells","volume":"35","author":"Ansorena","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0010","first-page":"689","article-title":"Acetylcholine synthesis and neuron differentiation","volume":"44","author":"Biagioni","year":"2000","journal-title":"International Journal of Developmental Biology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0015","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1053\/j.gastro.2009.08.010","article-title":"The addition of choline to parenteral nutrition","volume":"137","author":"Buchman","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0020","first-page":"1444","article-title":"Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells","volume":"58","author":"Cai","year":"1998","journal-title":"Cancer Research"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0025","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1124\/mol.53.4.638","article-title":"Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells","volume":"53","author":"Chen","year":"1998","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/bdrc.20163","article-title":"DNA methylation of cancer genome","volume":"87","author":"Cheung","year":"2009","journal-title":"Birth Defects Research. Part C, Embryo Today"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0035","first-page":"1059","article-title":"The occurrence of neoplasms in the liver, lungs, and other tissues of rats as a result of prolonged choline deficiency","volume":"22","author":"Copeland","year":"1946","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0040","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1053\/jhep.2002.35536","article-title":"Prevention of bile acid-induced apoptosis by betaine in rat liver","volume":"36","author":"Graf","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-4613-1151-5_11","article-title":"The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets","volume":"399","author":"Henning","year":"1996","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1440-1746.2005.04043.x","article-title":"Review of genetic and epigenetic alterations in hepatocarcinogenesis","volume":"21","author":"Herath","year":"2006","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0055","first-page":"G14","article-title":"Changes in methionine adenosyltransferase during liver regeneration in the rat","volume":"275","author":"Huang","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0180","series-title":"Dietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Panthothenic Acid, Biotin, and Choline","first-page":"390","author":"Institute of Medicine","year":"1998"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0168-9525(97)01013-5","article-title":"Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products","volume":"13","author":"Kotb","year":"1997","journal-title":"Trends in Genetics"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0075","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.108.2.229","article-title":"The scanning model for translation: an update","volume":"108","author":"Kozak","year":"1989","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0080","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.2353\/ajpath.2010.090810","article-title":"Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice","volume":"176","author":"Li","year":"2010","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1124\/mol.108.054411","article-title":"S-adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells","volume":"76","author":"Li","year":"2009","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0090","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1073\/pnas.091016398","article-title":"Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation","volume":"98","author":"Lu","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.alcohol.2005.03.011","article-title":"Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer","volume":"35","author":"Lu","year":"2005","journal-title":"Alcohol"},{"issue":"Suppl 1","key":"10.1016\/j.yexmp.2011.10.001_bb0100","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1440-1746.2007.05289.x","article-title":"S-adenosylmethionine in cell growth, apoptosis and liver cancer","volume":"23","author":"Lu","year":"2008","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0105","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/hep.22990","article-title":"S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model","volume":"50","author":"Lu","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0163-7258(96)00197-0","article-title":"S-adenosylmethionine synthesis: molecular mechanisms and clinical implications","volume":"73","author":"Mato","year":"1997","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1096\/fj.01-0401rev","article-title":"S-adenosylmethionine: a control switch that regulates liver function","volume":"16","author":"Mato","year":"2002","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0120","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/hep.21650","article-title":"Role of S-adenosyl-l-methionine in liver health and injury","volume":"45","author":"Mato","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0125","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/153537020623100503","article-title":"Choline transport for phospholipid synthesis","volume":"231","author":"Michel","year":"2006","journal-title":"Experimental Biology and Medicine (Maywood)"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0130","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/carcin\/4.12.1619","article-title":"Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets","volume":"4","author":"Mikol","year":"1983","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0135","first-page":"223","article-title":"Lipotropic factors and oncogenesis","volume":"206","author":"Newberne","year":"1986","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0140","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yexmp.2007.12.003","article-title":"Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis","volume":"84","author":"Oliva","year":"2008","journal-title":"Experimental and Molecular Pathology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0145","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00018-009-0015-5","article-title":"DNA hypomethylation in the origin and pathogenesis of human diseases","volume":"66","author":"Pogribny","year":"2009","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mrfmmm.2009.05.003","article-title":"Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet","volume":"669","author":"Pogribny","year":"2009","journal-title":"Mutation Research"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0155","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1749-6632.1954.tb36443.x","article-title":"Liver carcinoma and related lesions in chronic choline deficiency","volume":"57","author":"Salmon","year":"1954","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0160","first-page":"213","article-title":"Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets","volume":"77","author":"Shivapurkar","year":"1986","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0165","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1515\/CCLM.2005.187","article-title":"Betaine: a key modulator of one-carbon metabolism and homocysteine status","volume":"43","author":"Ueland","year":"2005","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0170","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/hep.20274","article-title":"S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: role of protein phosphatase 1 and Bcl-x(S)","volume":"40","author":"Yang","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.10.001_bb0175","doi-asserted-by":"crossref","first-page":"1488S","DOI":"10.3945\/ajcn.2009.27113B","article-title":"Epigenetic mechanisms for nutrition determinants of later health outcomes","volume":"89","author":"Zeisel","year":"2009","journal-title":"American Journal of Clinical Nutrition"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480011001626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480011001626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:57:42Z","timestamp":1560790662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480011001626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0014480011001626"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2011.10.001","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}