{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:02:38Z","timestamp":1765666958989},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.yexmp.2011.11.005","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T09:03:06Z","timestamp":1322730186000},"page":"222-228","source":"Crossref","is-referenced-by-count":21,"title":["Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro"],"prefix":"10.1016","volume":"92","author":[{"given":"Michael","family":"Saugspier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang E.","family":"Thasler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Gehrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Hellerbrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2011.11.005_bb0005","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1530-0277.1999.tb04208.x","article-title":"Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease","volume":"23","author":"Arthur","year":"1999","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0010","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.biocel.2009.03.001","article-title":"Hepatic stellate cell: a star cell in the liver","volume":"41","author":"Atzori","year":"2009","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-2001-17558","article-title":"Hepatic stellate cells as a target for the treatment of liver fibrosis","volume":"21","author":"Bataller","year":"2001","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0025","doi-asserted-by":"crossref","first-page":"15225","DOI":"10.1074\/jbc.M212639200","article-title":"Specific expression and regulation of the new melanoma inhibitory activity-related gene Mia2 in hepatocytes","volume":"278","author":"Bosserhoff","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0030","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510290347","article-title":"Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease","volume":"29","author":"Caldwell","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00011-008-8162-y","article-title":"Meta060 inhibits multiple kinases in the Nf-Kappab pathway and suppresses LPS-mediated inflammation in vitro and ex vivo","volume":"58","author":"Desai","year":"2009","journal-title":"Inflammation Research"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.200900314","article-title":"Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis","author":"Dorn","year":"2010","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10495-005-1055-4","article-title":"The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis","volume":"10","author":"Elsharkawy","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0050","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1378\/chest.18.1.10","article-title":"Tolerance and effects of lupulon in man","volume":"18","author":"Farber","year":"1950","journal-title":"Diseases of the Chest"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0055","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1021\/jf8038132","article-title":"Comparative study of hop-containing products on human cytochrome P450-mediated metabolism","volume":"57","author":"Foster","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0060","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0065","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/hep.510270514","article-title":"Inhibition of Nfkappab in activated rat hepatic stellate cells by proteasome inhibitors and an Ikappab super-repressor","volume":"27","author":"Hellerbrand","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0070","first-page":"G269","article-title":"Cytokines induce Nf-Kappab in activated but not in quiescent rat hepatic stellate cells","volume":"275","author":"Hellerbrand","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0075","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2036.2007.03586.x","article-title":"Adipokines and cytokines in non-alcoholic fatty liver disease","volume":"27","author":"Jarrar","year":"2008","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0080","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0003-2697(63)90040-X","article-title":"Detection of bile acids in thin-layer chromatography","volume":"5","author":"Kritchevsky","year":"1963","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0085","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/carcin\/bgm080","article-title":"Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic Sw620 cells and in a rat model of colon carcinogenesis","volume":"28","author":"Lamy","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0168-8278(00)80159-2","article-title":"Nuclear factor Kappab in proliferation, activation, and apoptosis in rat hepatic stellate cells","volume":"33","author":"Lang","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0100","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1172\/JCI118304","article-title":"Activation of hepatic stellate cells by Tgf alpha and collagen type I is mediated by oxidative stress through C-Myb expression","volume":"96","author":"Lee","year":"1995","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0095","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/carcin\/bgm054","article-title":"Humulone inhibits phorbol ester-induced Cox-2 expression in mouse skin by blocking activation of Nf-Kappab and Ap-1: Ikappab kinase and C-Jun-N-terminal kinase as respective potential upstream targets","volume":"28","author":"Lee","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.addr.2009.03.011","article-title":"Transcriptional regulation of hepatic stellate cells","volume":"61","author":"Mann","year":"2009","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and Mecp2: implications for wound healing and fibrogenesis","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1079\/BJN20041384","article-title":"Dietary isohumulones, the bitter components of beer, raise plasma hdl-cholesterol levels and reduce liver cholesterol and triacylglycerol contents similar to PPARalpha activations in C57bl\/6 mice","volume":"93","author":"Miura","year":"2005","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0125","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0016-5085(03)01213-7","article-title":"A novel Mcp-1 gene polymorphism is associated with hepatic Mcp-1 expression and severity of Hcv-related liver disease","volume":"125","author":"Muhlbauer","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0120","doi-asserted-by":"crossref","first-page":"G1000","DOI":"10.1152\/ajpgi.00338.2003","article-title":"Differential effects of deoxycholic acid and taurodeoxycholic acid on Nf-Kappa B signal transduction and Il-8 gene expression in colonic epithelial cells","volume":"286","author":"Muhlbauer","year":"2004","journal-title":"American Journal of Physiology \u2014 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0130","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/hep.1840110114","article-title":"The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21years","volume":"11","author":"Powell","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0135","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/bbrc.2001.5934","article-title":"Inhibition of angiogenesis by humulone, a bitter acid from beer hop","volume":"289","author":"Shimamura","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0140","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0002-9440(10)63383-4","article-title":"Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease","volume":"165","author":"Steiling","year":"2004","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1026392429112","article-title":"Charitable state-controlled foundation human tissue and cell research: ethic and legal aspects in the supply of surgically removed human tissue for research in the academic and commercial sector in Germany","volume":"4","author":"Thasler","year":"2003","journal-title":"Cell and Tissue Banking"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0150","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1271\/bbb.61.1027","article-title":"Apoptosis to Hl-60 by humulone","volume":"61","author":"Tobe","year":"1997","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0155","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1021\/np800740m","article-title":"Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds","volume":"72","author":"Van","year":"2009","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0190","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mnfr.200800493","article-title":"Hop bitter acids efficiently block inflammation independent of gralpha, PPARalpha, or PPARgamma","volume":"53","author":"Van","year":"2009","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0195","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.22363","article-title":"Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis","volume":"48","author":"Wouters","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0170","doi-asserted-by":"crossref","first-page":"33456","DOI":"10.1074\/jbc.M403456200","article-title":"Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance","volume":"279","author":"Yajima","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.yexmp.2011.11.005_bb0175","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.ijo.0802965","article-title":"Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents","volume":"29","author":"Yajima","year":"2005","journal-title":"International Journal of Obesity"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480011001882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480011001882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T07:00:09Z","timestamp":1543388409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480011001882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0014480011001882"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2011.11.005","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}