{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:04:08Z","timestamp":1790939048896,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.yexmp.2012.03.003","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T10:09:36Z","timestamp":1331114976000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: Involvement of matrix metalloproteinases"],"prefix":"10.1016","volume":"92","author":[{"given":"H.H.","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Narasaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Phoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Seet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2012.03.003_bb0005","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1164\/rccm.200907-1128OC","article-title":"Neutrophil alpha-defensins cause lung injury by disrupting the capillary\u2013epithelial barrier","volume":"181","author":"Bdeir","year":"2010","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0010","doi-asserted-by":"crossref","first-page":"H45","DOI":"10.1152\/ajpheart.00273.2009","article-title":"Inhibition of matrix metalloproteinase activity in vivo protects against vascular hyporeactivity in endotoxemia","volume":"298","author":"Cena","year":"2010","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1189\/jlb.0605353","article-title":"Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release","volume":"79","author":"Chakrabarti","year":"2006","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0020","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1590\/S0100-879X2000000700004","article-title":"Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury","volume":"33","author":"Corbel","year":"2000","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0741-5214(00)90163-0","article-title":"Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms","volume":"31","author":"Curci","year":"2000","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0030","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000167961","article-title":"Gene expression profiles in murine influenza pneumonia","volume":"1","author":"Dessing","year":"2009","journal-title":"Journal of Innate Immunity"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thx.2005.051979","article-title":"Matrix metalloproteinases in destructive pulmonary pathology","volume":"61","author":"Elkington","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2174\/138161207779313551","article-title":"Matrix metalloproteinases as valid clinical targets","volume":"13","author":"Fingleton","year":"2007","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0045","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.humpath.2005.11.023","article-title":"Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury","volume":"37","author":"Fligiel","year":"2006","journal-title":"Human Pathology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0050","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1749-6632.1999.tb07752.x","article-title":"Attenuation of oxidant-induced lung injury by the synthetic matrix metalloproteinase inhibitor BB-3103","volume":"878","author":"Foda","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0055","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/AAC.50.2.739-743.2006","article-title":"Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice","volume":"50","author":"Fujita","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0060","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.pupt.2006.08.006","article-title":"Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function","volume":"20","author":"Fujita","year":"2007","journal-title":"Pulmonary Pharmacology & Therapeutics"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0065","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1165\/ajrcmb.20.6.3482","article-title":"Role of matrix metalloproteinases in models of macrophage-dependant acute lung injury: evidence for alveolar macrophage as source of proteinases","volume":"20","author":"Gibbs","year":"1999","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-9-53","article-title":"Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice","volume":"9","author":"Gualano","year":"2008","journal-title":"Respiratory Research"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajh.2830470102","article-title":"Thrombomodulin: a marker for endothelial damage during orthotopic liver transplantation","volume":"47","author":"Himmelreich","year":"1994","journal-title":"American Journal of Hematology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10142-011-0247-y","article-title":"Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines","volume":"12","author":"Ivan","year":"2012","journal-title":"Functional and Integrative Genomics"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0085","first-page":"902","article-title":"Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthma","volume":"113","author":"Lee","year":"2004","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.micinf.2004.11.004","article-title":"Microarray and real-time RT-PCR analyses of differential human gene expression patterns induced by severe acute respiratory syndrome (SARS) coronavirus infection of Vero cells","volume":"7","author":"Leong","year":"2005","journal-title":"Microbes and Infection"},{"issue":"Suppl. B","key":"10.1016\/j.yexmp.2012.03.003_bb0095","doi-asserted-by":"crossref","first-page":"25B","DOI":"10.1016\/S0828-282X(06)70983-7","article-title":"Matrix metalloproteinases in cardiovascular disease","volume":"22","author":"Liu","year":"2006","journal-title":"Canadian Journal of Cardiology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0100","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2741\/1915","article-title":"Matrix metalloproteinases (MMPs) in health and disease: an overview","volume":"11","author":"Malemud","year":"2006","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0105","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1432-1033.1991.tb16027.x","article-title":"Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8","volume":"198","author":"Masure","year":"1991","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0110","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1183\/09031936.04.00096003","article-title":"The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair","volume":"24","author":"McElroy","year":"2004","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0115","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1165\/rcmb.2008-0423OC","article-title":"MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis","volume":"42","author":"Narasaraju","year":"2010","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.micinf.2008.09.013","article-title":"Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis","volume":"11","author":"Narasaraju","year":"2009","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0130","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/thx.49.6.602","article-title":"Matrix metalloproteases and lung disease","volume":"49","author":"O'Connor","year":"1994","journal-title":"Thorax"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0135","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrc884","article-title":"Strategies for MMP inhibition in cancer: innovations for the post-trial era","volume":"2","author":"Overall","year":"2002","journal-title":"Nature Reviews. Cancer"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0140","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0741-5214(96)70279-3","article-title":"Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase","volume":"23","author":"Petrinec","year":"1996","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00134-009-1727-6","article-title":"H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment","volume":"36","author":"Quispe-Laime","year":"2010","journal-title":"Intensive Care Medicine"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0150","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1164\/ajrccm.154.2.8756805","article-title":"Matrix metalloproteinases and TIMP in acute respiratory distress syndrome","volume":"154","author":"Ricou","year":"1996","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0155","first-page":"551","article-title":"Matrix metalloproteinases, angiogenesis, and cancer","volume":"9","author":"Rundhaug","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0160","first-page":"A3257","article-title":"Modulation of influenza-induced morbidity and mortality in mice by doxycycline","volume":"179","author":"Ryan","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2144\/05381RV01","article-title":"Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors","volume":"38","author":"Snoek-van Beurden","year":"2005","journal-title":"Biotechniques"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/1568010033484133","article-title":"Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies","volume":"2","author":"St-Pierre","year":"2003","journal-title":"Current Drug Targets. Inflammation and Allergy"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1164\/ajrccm.155.1.9001287","article-title":"Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome","volume":"155","author":"Torii","year":"1997","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0180","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/cc8893","article-title":"Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications","volume":"14","author":"van der Sluijs","year":"2010","journal-title":"Critical Care"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0185","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1182\/blood-2008-01-132860","article-title":"Toll-like receptor-mediated activation of neutrophils by influenza A virus","volume":"112","author":"Wang","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2152\/jmi.57.26","article-title":"Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection","volume":"57","author":"Wang","year":"2010","journal-title":"The Journal of Medical Investigation"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0195","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s007050050592","article-title":"Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells","volume":"144","author":"Yeo","year":"1999","journal-title":"Archives of Virology"},{"key":"10.1016\/j.yexmp.2012.03.003_bb0200","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2169\/internalmedicine.49.3022","article-title":"Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus","volume":"49","author":"Yokoyama","year":"2010","journal-title":"Internal Medicine"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448001200024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448001200024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:58:33Z","timestamp":1762145913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448001200024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S001448001200024X"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.03.003","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: Involvement of matrix metalloproteinases","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}