{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:03:47Z","timestamp":1773803027088,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.yexmp.2012.04.011","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T09:54:43Z","timestamp":1334829283000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling"],"prefix":"10.1016","volume":"93","author":[{"given":"Osamu","family":"Narumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohide","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuho","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2012.04.011_bb0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0010","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Molecular Pharmaceutics"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4049\/jimmunol.1100500","article-title":"Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice","volume":"187","author":"Ather","year":"2011","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0020","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/eji.200324569","article-title":"Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways","volume":"34","author":"Bachar","year":"2004","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0025","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0030","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1165\/ajrcmb.12.3.7873190","article-title":"Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice","volume":"12","author":"Brusselle","year":"1995","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0035","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.intimp.2006.11.006","article-title":"Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis","volume":"7","author":"Camacho-Barquero","year":"2007","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0040","first-page":"176","article-title":"Effect of glucocorticoid in mice of asthma induced by ovalbumin sensitisation and RSV infection","volume":"29","author":"Chi","year":"2011","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0045","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO Journal"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1465-9921-10-100","article-title":"TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids","volume":"10","author":"Doerner","year":"2009","journal-title":"Respiratory Research"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2217\/imt.11.88","article-title":"Therapeutic potential of targeting TNF\/TNFR family members in asthma","volume":"3","author":"Doherty","year":"2011","journal-title":"Immunotherapy"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0065","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0091-6749(95)70128-1","article-title":"Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation","volume":"95","author":"Fahy","year":"1995","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0070","doi-asserted-by":"crossref","first-page":"25284","DOI":"10.1074\/jbc.M414645200","article-title":"Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity","volume":"280","author":"Fang","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0075","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/rccm.200502-198OC","article-title":"House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation","volume":"172","author":"Fattouh","year":"2005","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1523-1755.2004.00713.x","article-title":"Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells","volume":"66","author":"Gaedeke","year":"2004","journal-title":"Kidney International"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0085","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1165\/ajrcmb.16.6.9191468","article-title":"Myofibroblast involvement in the allergen-induced late response in mild atopic asthma","volume":"16","author":"Gizycki","year":"1997","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0090","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1046\/j.1365-2222.2003.01716.x","article-title":"Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model","volume":"33","author":"Gough","year":"2003","journal-title":"Clinical and Experimental Allergy"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0100","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.4049\/jimmunol.176.3.1733","article-title":"Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells","volume":"176","author":"Groskreutz","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrneph.2009.15","article-title":"The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases","volume":"5","author":"Ha","year":"2009","journal-title":"Nature Reviews Nephrology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1164\/rccm.200811-1730OC","article-title":"Induction of epithelial\u2013mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1","volume":"180","author":"Hackett","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0115","first-page":"439","article-title":"A look at the pathogenesis of asthma: the need for a change in direction","volume":"9","author":"Holgate","year":"2010","journal-title":"Discovery Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0091-6749(00)90066-6","article-title":"Epithelial\u2013mesenchymal interactions in the pathogenesis of asthma","volume":"105","author":"Holgate","year":"2000","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0125","doi-asserted-by":"crossref","first-page":"F1287","DOI":"10.1152\/ajprenal.00017.2008","article-title":"Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells","volume":"294","author":"Huang","year":"2008","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1574-695X.2007.00293.x","article-title":"Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells","volume":"51","author":"Jang","year":"2007","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0135","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/j.1365-2222.2007.02812.x","article-title":"Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma","volume":"37","author":"Kim","year":"2007","journal-title":"Clinical and Experimental Allergy"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0140","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/ndt\/gfn756","article-title":"Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells","volume":"24","author":"Kimura","year":"2009","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2478\/v10042-008-0029-0","article-title":"Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients","volume":"46","author":"Kowal","year":"2008","journal-title":"Folia Histochemica et Cytobiologica"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2003.10.011","article-title":"The plasmin system in airway remodeling","volume":"112","author":"Kucharewicz","year":"2003","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0155","doi-asserted-by":"crossref","first-page":"L337","DOI":"10.1152\/ajplung.90434.2008","article-title":"Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model","volume":"296","author":"Kuramoto","year":"2009","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0160","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MCP.0b013e32832c975a","article-title":"Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer","volume":"15","author":"Lee","year":"2009","journal-title":"Current Opinion in Pulmonary Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0165","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1471-4159.2008.05236.x","article-title":"A broadly neuroprotective derivative of curcumin","volume":"105","author":"Liu","year":"2008","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0170","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.neurobiolaging.2008.05.020","article-title":"A pyrazole derivative of curcumin enhances memory","volume":"31","author":"Maher","year":"2010","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cellimm.2009.07.004","article-title":"Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model","volume":"260","author":"Matsuo","year":"2009","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0180","doi-asserted-by":"crossref","first-page":"L908","DOI":"10.1152\/ajplung.00115.2011","article-title":"Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice","volume":"301","author":"Miyamoto","year":"2011","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0185","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/thx.2010.136523","article-title":"Sputum IL-6 concentrations in severe asthma and its relationship with FEV1","volume":"66","author":"Morjaria","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0190","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jep.2010.07.026","article-title":"Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-kappaB inhibition","volume":"136","author":"Oh","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0195","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1164\/rccm.200806-974OC","article-title":"Toll\/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses","volume":"179","author":"Phipps","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0200","first-page":"49","article-title":"Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin","volume":"22","author":"Ray","year":"2003","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0205","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/thx.2008.108290","article-title":"Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD","volume":"64","author":"Saha","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0210","doi-asserted-by":"crossref","first-page":"e3508","DOI":"10.1371\/journal.pone.0003508","article-title":"Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity","volume":"3","author":"Santel","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0215","doi-asserted-by":"crossref","first-page":"L967","DOI":"10.1152\/ajplung.90349.2008","article-title":"The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability","volume":"295","author":"Shetty","year":"2008","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0220","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1182\/blood-2008-12-196212","article-title":"Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration","volume":"114","author":"Sisson","year":"2009","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.yexmp.2012.04.011_bb0225","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1752-699X.2010.00193.x","article-title":"Remodeling in asthma and COPD\u2014differences and similarities","volume":"4","author":"Skold","year":"2010","journal-title":"The Clinical Respiratory Journal"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0230","doi-asserted-by":"crossref","first-page":"e12969","DOI":"10.1371\/journal.pone.0012969","article-title":"Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-kappaB activation","volume":"5","author":"Song","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0235","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/gast.2002.37050","article-title":"Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice","volume":"123","author":"Sugimoto","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0240","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1074\/jbc.M109.056523","article-title":"Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial\u2013mesenchymal transition by promoting hyaluronan\u2013CD44\u2013moesin interaction","volume":"285","author":"Takahashi","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0245","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2567.2011.03473.x","article-title":"Synthetic double-stranded RNA enhances airway inflammation and remodelling in a rat model of asthma","volume":"134","author":"Takayama","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0250","first-page":"L346","article-title":"Interleukin 6-receptor expression on human bronchial epithelial cells: regulation by IL-1 and IL-6","volume":"270","author":"Takizawa","year":"1996","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0255","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0260","doi-asserted-by":"crossref","first-page":"31900","DOI":"10.1074\/jbc.M703729200","article-title":"Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells","volume":"282","author":"Venugopal","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0265","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1164\/rccm.201011-1762OC","article-title":"Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation","volume":"184","author":"Vieira","year":"2011","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0270","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/09031936.02.00226302","article-title":"Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma","volume":"19","author":"Wark","year":"2002","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0275","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1016\/j.bmc.2005.03.035","article-title":"Anti-oxidant activities of curcumin and related enones","volume":"13","author":"Weber","year":"2005","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"Suppl. 1","key":"10.1016\/j.yexmp.2012.04.011_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1752-699X.2010.00190.x","article-title":"Pathological airway remodelling in inflammation","volume":"4","author":"Westergren-Thorsson","year":"2010","journal-title":"The Clinical Respiratory Journal"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0285","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-5926-6-5","article-title":"Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes","volume":"6","author":"Wickert","year":"2007","journal-title":"Comparative Hepatology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0290","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1513\/pats.200601-004TK","article-title":"Epithelial origin of myofibroblasts during fibrosis in the lung","volume":"3","author":"Willis","year":"2006","journal-title":"Proceedings of the American Thoracic Society"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0295","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0300","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/CS20080502","article-title":"Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential","volume":"116","author":"Wong","year":"2009","journal-title":"Clinical Science (London, England)"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0305","first-page":"2851","article-title":"Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin","volume":"30","author":"Wong","year":"2010","journal-title":"Anticancer Research"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0310","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cbi.2011.02.014","article-title":"Aldose reductase inhibition suppresses airway inflammation","volume":"191","author":"Yadav","year":"2011","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0315","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000081724","article-title":"Dexamethasone increased plasminogen activator inhibitor-1 expression on human umbilical vein endothelial cells: an additive effect to tumor necrosis factor-alpha","volume":"71","author":"Yamamoto","year":"2004","journal-title":"Pathobiology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0320","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jaci.2006.01.009","article-title":"Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model","volume":"117","author":"Yamashita","year":"2006","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.yexmp.2012.04.011_bb0325","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","article-title":"TGF-beta and epithelial-to-mesenchymal transitions","volume":"24","author":"Zavadil","year":"2005","journal-title":"Oncogene"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480012000561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480012000561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:58:43Z","timestamp":1762145923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480012000561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0014480012000561"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.04.011","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}