{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:10:39Z","timestamp":1792131039180,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP120100861"],"award-info":[{"award-number":["DP120100861"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.yexmp.2012.11.001","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T17:34:15Z","timestamp":1353346455000},"page":"350-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Autoimmune hepatitis: What must be said"],"prefix":"10.1016","volume":"93","author":[{"given":"Ian R.","family":"Mackay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2012.11.001_bb0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-010611-134701","article-title":"Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex","volume":"52","author":"Bharadwaj","year":"2012","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0010","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.3748\/wjg.14.3374","article-title":"Autoimmune liver serology: current diagnostic and clinical challenges","volume":"14","author":"Bogdanos","year":"2008","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0015","first-page":"67","article-title":"A modification of Jerne's theory of antibody production using the concept of clonal selection","volume":"20","author":"Burnet","year":"1957","journal-title":"The Australian Journal of Science"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0020","series-title":"The Clonal Selection Theory of Acquired Immunity","author":"Burnet","year":"1959"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0025","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1182\/blood-2007-05-091074","article-title":"Absence of regulatory T-cell control of TH1 and TH17 T cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease","volume":"110","author":"Chen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0030","doi-asserted-by":"crossref","first-page":"919","DOI":"10.4049\/jimmunol.153.3.919","article-title":"David W. Talmage and the advent of the cell selection theory of antibody synthesis","volume":"153","author":"Cruse","year":"1994","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0035","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/iub.1046","article-title":"BAFF\/BLyS inhibitors: a new prospect for treatment of systemic lupus erythematosus","volume":"64","author":"Fairfax","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0090-1229(75)90087-2","article-title":"Hypothesis. Autoantibodies and immunological theories: an analytic review","volume":"4","author":"Grabar","year":"1975","journal-title":"Clinical Immunology and Immunopathology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0045","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.1840180435","article-title":"Meeting report: International Autoimmune Hepatitis Group","volume":"18","author":"Johnson","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0050","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22736","article-title":"Apoptosis and the biliary specificity of primary biliary cirrhosis","volume":"49","author":"Lleo","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0055","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.4049\/jimmunol.176.7.4484","article-title":"Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis","volume":"176","author":"Longhi","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1055\/s-2005-916330","article-title":"The etiopathogenesis of autoimmunity","volume":"25","author":"Mackay","year":"2005","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0075","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3748\/wjg.14.3292","article-title":"Historical reflections on autoimmune hepatitis","volume":"14","author":"Mackay","year":"2008","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0085","doi-asserted-by":"crossref","first-page":"A251","DOI":"10.1016\/j.autrev.2009.10.007","article-title":"Travels and travails of autoimmunity: an historical journey from discovery to rediscovery","volume":"9","author":"Mackay","year":"2010","journal-title":"Autoimmunity Reviews"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0095","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1309\/LM7EUBRRUPLF9V6R","article-title":"Autoimmune hepatitis: from the clinic to the diagnostics laboratory","volume":"42","author":"Mackay","year":"2011","journal-title":"Laboratory Medicine"},{"issue":"Supplement 1","key":"10.1016\/j.yexmp.2012.11.001_bb0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00535-010-0325-2","article-title":"A 50-year experience with autoimmune hepatitis: and where are we now","volume":"46","author":"Mackay","year":"2011","journal-title":"Journal of Gastroenterology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0060","series-title":"Autoimmune Disease: Pathogenesis, Chemistry and Therapy","author":"Mackay","year":"1963"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0065","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1749-6632.1965.tb19000.x","article-title":"Autoimmune hepatitis","volume":"124","author":"Mackay","year":"1965","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0080","series-title":"Actin, Actin-binding Proteins and Disease","first-page":"50","article-title":"Autoantigenicity of actin","author":"Mackay","year":"2008"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jhep.2012.04.005","article-title":"Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment?","volume":"57","author":"Oo","year":"2012","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0105","first-page":"288","article-title":"Plasma cell hepatitis with special attention to steroid therapy","volume":"99","author":"Page","year":"1960","journal-title":"Journal of Diseases of Children"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5694\/mja11.10821","article-title":"A seminal monograph: Mackay and Burnet's Autoimmune Diseases","volume":"196","author":"Roberts-Thomson","year":"2012","journal-title":"The Medical Journal of Australia"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0115","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.21.120601.141122","article-title":"Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses","volume":"22","author":"Sakaguchi","year":"2004","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1440-1746.1987.tb00152.x","article-title":"The significance of cell death by apoptosis in hepatobiliary disease","volume":"2","author":"Searle","year":"1987","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0120","series-title":"The Autoimmune Diseases","first-page":"3","article-title":"Autoimmunity: a history of the early struggle for recognition","author":"Silverstein","year":"2006"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0130","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/hep.22149","article-title":"Identification of plasma membrane autoantigens in autoimmune hepatitis type 1 using a proteomics tool","volume":"47","author":"Tahiri","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0135","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.3748\/wjg.14.3306","article-title":"Aetiopathogenesis of autoimmune hepatitis","volume":"14","author":"Vergani","year":"2008","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0140","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20120822","article-title":"Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo","volume":"209","author":"Yadav","year":"2012","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.yexmp.2012.11.001_bb0145","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2012.03.009","article-title":"The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments","volume":"36","author":"Zhang","year":"2012","journal-title":"Immunity"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480012001669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480012001669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:48:05Z","timestamp":1757990885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480012001669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0014480012001669"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.11.001","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoimmune hepatitis: What must be said","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2012.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}