{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:30:01Z","timestamp":1771457401631,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AAU01021898-02"],"award-info":[{"award-number":["AAU01021898-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.yexmp.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T16:23:32Z","timestamp":1412526212000},"page":"477-483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mallory\u2013Denk Body (MDB) formation modulates ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH)"],"prefix":"10.1016","volume":"97","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Tillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel W.","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2014.10.001_bb0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.yexmp.2007.12.004","article-title":"Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice","volume":"84","author":"Bardag-Gorce","year":"2008","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.yexmp.2010.03.001","article-title":"SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model","volume":"88","author":"Bardag-Gorce","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0015","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3748\/wjg.v17.i17.2172","article-title":"Mallory\u2013Denk Bodies in chronic hepatitis","volume":"17","author":"Basaranoglu","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0020","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1101\/sqb.2005.70.010","article-title":"Aberrant gene silencing in tumor progression: implications for control of cancer","volume":"70","author":"Baylin","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0025","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jhep.2010.04.031","article-title":"Hepatocellular ballooning in NASH","volume":"53","author":"Caldwell","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0030","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/cells3020627","article-title":"The ufm1 cascade","volume":"3","author":"Daniel","year":"2014","journal-title":"Cells"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0035","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3892\/ol.2014.2301","article-title":"Aberrant DNA methylation in hepatocellular carcinoma tumor suppression (review)","volume":"8","author":"Dong","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/978-1-59745-416-2_23","article-title":"Epigenetic targets in cancer epidemiology","volume":"471","author":"Dumitrescu","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0045","first-page":"3225","article-title":"A gene hypermethylation profile of human cancer","volume":"61","author":"Esteller","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0050","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/onc.2011.411","article-title":"MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma","volume":"31","author":"Fan","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/449148a","article-title":"Epigenetics: perceptive enzymes","volume":"449","author":"Ferguson-Smith","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4254\/wjh.v2.i8.295","article-title":"Mallory\u2013Denk body pathogenesis revisited","volume":"2","author":"French","year":"2010","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/scbi.1999.0138","article-title":"Hypermethylation of tumor suppressor genes in cancer","volume":"9","author":"Herman","year":"1999","journal-title":"Semin. Cancer Biol."},{"issue":"33 Suppl.","key":"10.1016\/j.yexmp.2014.10.001_bb0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0075","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4132\/KoreanJPathol.2012.46.1.1","article-title":"CpG island hypermethylation in gastric carcinoma and its premalignant lesions","volume":"46","author":"Kang","year":"2012","journal-title":"Korean J. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0085","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1074\/jbc.M610590200","article-title":"Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2","volume":"282","author":"Kang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0090","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00018-008-8432-4","article-title":"Epigenetic mechanisms in mammals","volume":"66","author":"Kim","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0095","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.4161\/cc.25451","article-title":"Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation","volume":"12","author":"Kim","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0100","doi-asserted-by":"crossref","first-page":"12232","DOI":"10.1074\/jbc.M109.065920","article-title":"A novel LZAP-binding protein, NLBP, inhibits cell invasion","volume":"285","author":"Kwon","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0105","doi-asserted-by":"crossref","first-page":"e18517","DOI":"10.1371\/journal.pone.0018517","article-title":"Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis","volume":"6","author":"Lemaire","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0110","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","volume":"18","author":"Li","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0115","doi-asserted-by":"crossref","first-page":"19489","DOI":"10.1074\/jbc.M513249200","article-title":"The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0120","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/hep.22029","article-title":"S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory","volume":"47","author":"Li","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0125","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.yexmp.2011.05.009","article-title":"Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1month using the rat intragastric tube feeding model","volume":"91","author":"Li","year":"2011","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0130","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/ijc.23979","article-title":"Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: implications of the gender disparity in liver cancer susceptibility","volume":"124","author":"Liao","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0135","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3892\/ol_00000143","article-title":"Array-based profiling of the differential methylation status of CpG islands in hepatocellular carcinoma cell lines","volume":"1","author":"Liu","year":"2010","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0140","first-page":"2349","article-title":"Epigenetics of hepatocellular carcinoma: a new horizon","volume":"125","author":"Liu","year":"2012","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yexmp.2014.05.010","article-title":"Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory\u2013Denk bodies (MDBs) form","volume":"97","author":"Liu","year":"2014","journal-title":"Exp. Mol. Pathol."},{"issue":"Spec No 1","key":"10.1016\/j.yexmp.2014.10.001_bb0150","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1093\/hmg\/ddm021","article-title":"Cancer genetics of epigenetic genes","volume":"16","author":"Miremadi","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yexmp.2005.11.001","article-title":"Mallory body forming cells express the preneoplastic hepatocyte phenotype","volume":"80","author":"Nan","year":"2006","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0160","first-page":"65","article-title":"DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation","volume":"20","author":"Oh","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yexmp.2007.12.003","article-title":"Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis","volume":"84","author":"Oliva","year":"2008","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yexmp.2008.11.002","article-title":"Betaine prevents Mallory\u2013Denk body formation in drug-primed mice by epigenetic mechanisms","volume":"86","author":"Oliva","year":"2009","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexmp.2010.04.001","article-title":"The role of cytokines in UbD promoter regulation and Mallory\u2013Denk body-like aggresomes","volume":"89","author":"Oliva","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0180","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/ajcn\/86.1.14","article-title":"Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium","volume":"86","author":"Purohit","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0185","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1073\/pnas.94.2.684","article-title":"Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide","volume":"94","author":"Ramchandani","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0190","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.cellsig.2011.02.003","article-title":"DNA hypermethylation as a chemotherapy target","volume":"23","author":"Ren","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0195","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/nar\/27.11.2291","article-title":"The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors","volume":"27","author":"Robertson","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0200","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1038\/sj.onc.1204339","article-title":"DNA methylation, chromatin inheritance, and cancer","volume":"20","author":"Rountree","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0205","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1038\/emboj.2010.116","article-title":"Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity","volume":"29","author":"Shiwaku","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fonc.2014.00080","article-title":"DNA methyltransferases: a novel target for prevention and therapy","volume":"4","author":"Subramaniam","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0215","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1128\/MCB.16.8.4555","article-title":"De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase","volume":"16","author":"Vertino","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexmp.2014.10.001_bb0220","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/46214","article-title":"Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene","volume":"402","author":"Xu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2014.10.001_bb0225","doi-asserted-by":"crossref","first-page":"e48587","DOI":"10.1371\/journal.pone.0048587","article-title":"Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480014001610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480014001610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T17:40:55Z","timestamp":1565890855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480014001610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0014480014001610"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2014.10.001","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mallory\u2013Denk Body (MDB) formation modulates ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH)","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}