{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:23:26Z","timestamp":1767914606581,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (C)","award":["16590328"],"award-info":[{"award-number":["16590328"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.yexmp.2015.06.007","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T12:39:06Z","timestamp":1434631146000},"page":"116-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Receptor-selective IL-4 mutein modulates inflammatory vascular cell phenotypes and attenuates atherogenesis in apolipoprotein E-knockout mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Yanhui","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2015.06.007_bb0005","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/eji.1830270725","article-title":"Mouse macrophage development in the absence of the common gamma chain: defining receptor complexes responsible for IL-4 and IL-13 signaling","volume":"27","author":"Andersson","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clim.2009.07.002","article-title":"Adaptive immunity and atherosclerosis","volume":"13","author":"Andersson","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0015","first-page":"1286","article-title":"Pitrakinra, a dual IL-4\/IL-13 antagonist for the potential treatment of asthma and eczema","volume":"11","author":"Antoniu","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0020","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1074\/jbc.270.15.8452","article-title":"Species-specific agonist\/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain","volume":"270","author":"B\u00f6nsch","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1385\/IR:23:2-3:179","article-title":"IL-4 signaling, gene transcription regulation, and the control of effector T cells","volume":"23","author":"Boothby","year":"2001","journal-title":"Immunol. Res."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0030","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.4049\/jimmunol.179.6.3881","article-title":"Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3","volume":"179","author":"Cortes","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0035","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0002-9440(10)63471-2","article-title":"The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"163","author":"Davenport","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0040","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/1521-4141(200209)32:9<2437::AID-IMMU2437>3.0.CO;2-N","article-title":"Human lung myofibroblasts as effectors of the inflammatory process: the common receptor gamma chain is induced by Th2 cytokines, and CD40 ligand is induced by lipopolysaccharide, thrombin and TNF-alpha","volume":"32","author":"Doucet","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0045","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1074\/jbc.272.3.1480","article-title":"A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction","volume":"272","author":"Grunewald","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0050","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.4049\/jimmunol.166.8.5225","article-title":"Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4-induced hepatitis","volume":"166","author":"Guillot","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1385\/IR:25:3:229","article-title":"Regulation of chemokine expression by antiinflammatory cytokines","volume":"25","author":"Hamilton","year":"2002","journal-title":"Immunol. Res."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0060","doi-asserted-by":"crossref","first-page":"ra17","DOI":"10.1126\/scisignal.1164795","article-title":"Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages","volume":"1","author":"Heller","year":"2008","journal-title":"Sci. Signal."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0065","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1084\/jem.20080452","article-title":"Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4R\u03b1, IL-13R\u03b11, and \u03b3c regulates relative cytokine sensitivity","volume":"205","author":"Junttila","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/exmp.1999.2235","article-title":"Overexpression of p21Waf-1 in vascular smooth muscle cells: regulation of proliferation, differentiation, and cell size","volume":"66","author":"Kato","year":"1999","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0075","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.1085458","article-title":"Interleukin-4 and interleukin-13 signaling connections maps","volume":"300","author":"Kelly-Welch","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0080","first-page":"223","article-title":"Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd","year":"2003","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0085","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/hq0302.104905","article-title":"Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor\u2212\/\u2212 mice","volume":"22","author":"King","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0090","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.2353\/ajpath.2007.060857","article-title":"Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice","volume":"171","author":"King","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5551\/jat.12.138","article-title":"A simple method of isolating mouse aortic endothelial cells","volume":"12","author":"Kobayashi","year":"2005","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0100","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/CIRCRESAHA.106.147256","article-title":"Inhibition of progression and stabilization of plaques by postnatal interferon-gamma function blocking in ApoE-knockout mice","volume":"101","author":"Koga","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ng0596-54","article-title":"Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene","volume":"13","author":"Kozarsky","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0110","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/j.1460-2075.1992.tb05401.x","article-title":"Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement","volume":"11","author":"Kruse","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2007.12.030","article-title":"Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4\/13 system","volume":"132","author":"LaPorte","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02977462","article-title":"Role of interleukin-4 in atherosclerosis","volume":"29","author":"Lee","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0125","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/ATVBAHA.112.249334","article-title":"Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis","volume":"32","author":"Lunov","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0130","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.4049\/jimmunol.145.9.2886","article-title":"IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1","volume":"145","author":"Masinovsky","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0135","doi-asserted-by":"crossref","first-page":"14394","DOI":"10.1074\/jbc.272.22.14394","article-title":"Interleukin-4 and -13 inhibit tumor necrosis factor-alpha mRNA translational activation in lipopolysaccharide-induced mouse macrophages","volume":"272","author":"Mijatovic","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0140","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1365-2133.2009.09069.x","article-title":"IL-4\/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis","volume":"160","author":"Morioka","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0145","first-page":"1229","article-title":"Targeting Th2 cytokines in fibrotic diseases","volume":"11","author":"Morishima","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0167-4889(02)00318-X","article-title":"Structure, binding, and antagonists in the IL-4\/IL-13 receptor system","volume":"1592","author":"Mueller","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1470-8744.1992.tb00219.x","article-title":"Immortalization of human aortic smooth muscle cells with origin-minus simian virus 40 DNA","volume":"16","author":"Murahashi","year":"1992","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0160","first-page":"13","article-title":"Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system","volume":"69","author":"Murata","year":"1999","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0165","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","article-title":"ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree","volume":"14","author":"Nakashima","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0175","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/sj.gt.3302131","article-title":"A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma","volume":"10","author":"Nishikubo","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0180","first-page":"357","article-title":"Interleukin-4 enhances interferon-gamma synthesis but inhibits development of interferon-gamma-producing cells","volume":"85","author":"Noble","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0185","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.bcp.2010.01.027","article-title":"Progenitor cell-derived smooth muscle cells in vascular disease","volume":"79","author":"Orlandi","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0190","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.V77.9.1859.1859","article-title":"Interleukin-4: a prototypic immunoregulatory lymphokine","volume":"7","author":"Paul","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ni1544","article-title":"Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain","volume":"9","author":"Ramalingam","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0200","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1002\/1521-3773(20000818)39:16<2834::AID-ANIE2834>3.0.CO;2-K","article-title":"The interleukin-4-receptor: from recognition mechanism to pharmacological target structure","volume":"39","author":"Reinemer","year":"2000","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0210","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.4049\/jimmunol.166.4.2173","article-title":"Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production","volume":"166","author":"Rutschman","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-9150(97)00296-7","article-title":"A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells","volume":"138","author":"Sasaguri","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0220","first-page":"1369","article-title":"Biochemical and morphological characterization of vascular and lymphocytic interleukin-4 receptors","volume":"149","author":"Schnyder","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0225","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1073\/pnas.95.16.9454","article-title":"An immune cell-selective interleukin 4 agonist","volume":"95","author":"Shanafelt","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0230","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1020275114185","article-title":"Successful transfection of lymphocytes by ternary lipoplexes","volume":"19","author":"Sim\u00f5es","year":"1999","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0235","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/HYPERTENSIONAHA.109.134213","article-title":"Endothelial-regenerating cells: an expanding universe","volume":"55","author":"Steinmetz","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0240","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ijc.2910170504","article-title":"Establishment and characterization of a human histiocytic lymphoma cell line (U-937)","volume":"17","author":"Sundstr\u00f6m","year":"1976","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0245","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.4049\/jimmunol.166.9.5792","article-title":"A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness","volume":"166","author":"Tomkinson","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0250","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.2910260208","article-title":"Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)","volume":"26","author":"Tsuchiya","year":"1980","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0255","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(88)90536-3","article-title":"Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene","volume":"52","author":"Williams","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2015.06.007_bb0260","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/(SICI)1097-4652(199909)180:3<381::AID-JCP9>3.0.CO;2-F","article-title":"Induction of vascular cell adhesion molecule-1 expression by IL-4 in human aortic smooth muscle cells is not associated with increased nuclear NF-\u03baB levels","volume":"180","author":"Wright","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1525-0016(02)00050-3","article-title":"Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13","volume":"7","author":"Zavorotinskaya","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0270","first-page":"359","article-title":"Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice","volume":"149","author":"Zhou","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2015.06.007_bb0275","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1172\/JCI1216","article-title":"Hypercholesterolemia is associated with a T helper (Th) 1\/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice","volume":"101","author":"Zhou","year":"1998","journal-title":"J. Clin. Invest."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480015001252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480015001252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T15:45:52Z","timestamp":1717947952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480015001252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0014480015001252"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2015.06.007","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Receptor-selective IL-4 mutein modulates inflammatory vascular cell phenotypes and attenuates atherogenesis in apolipoprotein E-knockout mice","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2015.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}