{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:27:25Z","timestamp":1786998445386,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.yexmp.2016.05.015","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T18:31:30Z","timestamp":1477506690000},"page":"303-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis"],"prefix":"10.1016","volume":"101","author":[{"given":"Harm","family":"HogenEsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Stearns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Sundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2016.05.015_bb0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000327556","article-title":"Content of vascular endothelial growth factor in stratum corneum well correlates to local severity of acute inflammation in patients with atopic dermatitis","volume":"157","author":"Amarbayasgalan","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fimmu.2012.00283","article-title":"Podoplanin: emerging functions in development, the immune system, and cancer","volume":"3","author":"Astarita","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/10739680701418416","article-title":"The progression of inflammation parallels the dermal angiogenesis in a keratin 14 IL-4-transgenic model of atopic dermatitis","volume":"15","author":"Chen","year":"2008","journal-title":"Microcirculation"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/biostatistics\/kxh018","article-title":"Improved statistical tests for differential gene expression by shrinking variance components estimates","volume":"6","author":"Cui","year":"2005","journal-title":"Biostatistics"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1124\/pr.115.011833","volume":"68","author":"Davenport","year":"2016","journal-title":"Endothelin. Pharmacol. Rev."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0035","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/ar3274","article-title":"The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis","volume":"13","author":"Ekwall","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0040","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.molcel.2013.06.004","article-title":"OTULIN restricts Met1-linked ubiquitination to control innate immune signaling","volume":"50","author":"Fiil","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1098-2744(199709)20:1<10::AID-MC3>3.0.CO;2-M","article-title":"Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis","volume":"20","author":"Gandarillas","year":"1997","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/rep.0.1210181","article-title":"Human endometrial angiogenesis","volume":"121","author":"Gargett","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0055","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature09816","article-title":"Linear ubiquitination prevents inflammation and regulates immune signalling","volume":"471","author":"Gerlach","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0060","first-page":"972","article-title":"A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice","volume":"143","author":"HogenEsch","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0065","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/1521-4141(200103)31:3<734::AID-IMMU734>3.0.CO;2-9","article-title":"Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12","volume":"31","author":"HogenEsch","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0070","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1084\/jem.20100559","article-title":"Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation","volume":"207","author":"Huggenberger","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0075","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature09814","article-title":"SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis","volume":"471","author":"Ikeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0080","first-page":"129","article-title":"Angiogenesis and the tumor vasculature as antitumor immune modulators: the role of vascular endothelial growth factor and endothelin","volume":"344","author":"Kandalaft","year":"2011","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0085","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2013.05.014","article-title":"OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin","volume":"153","author":"Keusekotten","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0090","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1172\/JCI67323","article-title":"Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus","volume":"124","author":"Kido-Nakahara","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0095","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00011-012-0543-6","article-title":"Increased plasma concentration of vascular endothelial growth factor in patients with atopic dermatitis and its relation to disease severity and platelet activation","volume":"61","author":"Koczy-Baron","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-014-9416-7","article-title":"Inflammation-induced lymphangiogenesis and lymphatic dysfunction","volume":"17","author":"Liao","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cell.2013.05.046","article-title":"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis","volume":"154","author":"Mevissen","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1523-1747.ep12514346","article-title":"The structure of normal skin and the morphology of atopic eczema","volume":"67","author":"Mihm","year":"1976","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085666","article-title":"Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4\/IL13 signaling","volume":"9","author":"Potter","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/jid.1960.21","article-title":"Morphologic and histochemical studies of atopic eczema in infants and children","volume":"34","author":"Prose","year":"1960","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0125","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3892\/ijo.2013.1887","article-title":"Significance of podoplanin expression in cancer-associated fibroblasts: a comprehensive review","volume":"42","author":"Pula","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0130","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature12296","article-title":"The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis","volume":"498","author":"Rivkin","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0135","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1530\/REP-09-0283","article-title":"Angiogenesis and vascular function in the ovary","volume":"138","author":"Robinson","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0140","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.1073\/pnas.0701910104","article-title":"Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling","volume":"104","author":"Roosterman","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0150","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.gene.6364403","article-title":"Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis","volume":"8","author":"Seymour","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0155","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1549-8719.2012.00189.x","article-title":"Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model","volume":"19","author":"Shi","year":"2012","journal-title":"Microcirculation"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J. R. Stat. Soc. B"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrrheum.2015.164","article-title":"Targeting of proangiogenic signalling pathways in chronic inflammation","volume":"12","author":"Tas","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0170","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature09815","article-title":"SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex","volume":"471","author":"Tokunaga","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0175","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaad.2015.03.041","article-title":"Angiogenesis and lymphangiogenesis in inflammatory skin disorders","volume":"73","author":"Varricchi","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0180","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/emboj\/20.6.1223","article-title":"Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice","volume":"20","author":"Veikkola","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0185","article-title":"SHARPIN is essential for cytokine production, NF-kappaB signaling, and induction of Th1 differentiation by dendritic cells","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0190","series-title":"The Analysis of Gene Expression Data","first-page":"313","article-title":"MAANOVA: a software package for the analysis of spotted cDNA microarray experiments","author":"Wu","year":"2003"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1182\/blood-2002-12-3793","article-title":"Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis","volume":"102","author":"Xia","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2016.05.015_bb0200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0205","doi-asserted-by":"crossref","first-page":"11536","DOI":"10.1073\/pnas.1107577108","article-title":"Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage toll-like receptor 2 (TLR2) responses","volume":"108","author":"Zak","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2016.05.015_bb0210","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00403-006-0641-9","article-title":"Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis","volume":"297","author":"Zhang","year":"2006","journal-title":"Arch. Dermatol. Res."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480016300843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480016300843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T22:27:40Z","timestamp":1568500060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480016300843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0014480016300843"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2016.05.015","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2016.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}