{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:33:59Z","timestamp":1761676439940},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science of Republic of Serbia","award":["175033"],"award-info":[{"award-number":["175033"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.yexmp.2016.11.003","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T07:33:00Z","timestamp":1478935980000},"page":"323-331","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1\u03b1 production in sporadic clear-cell renal cell carcinoma"],"prefix":"10.1016","volume":"101","author":[{"given":"Svetozar S","family":"Damjanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojana B","family":"Ilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojana B","family":"Beleslin Cokic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadranka A","family":"Antic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana Z","family":"Bankovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana T","family":"Milicevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana S","family":"Rodic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusan S","family":"Ilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera N","family":"Todorovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nela","family":"Puskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cane D","family":"Tulic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2016.11.003_bb0005","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1158\/0008-5472.CAN-05-3074","article-title":"Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer","volume":"66","author":"Banks","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0010","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nrc2540","article-title":"The impact of O2 availability on human cancer","volume":"8","author":"Bertout","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0015","first-page":"1","article-title":"Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features","volume":"149","author":"Bjornsson","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1535-6108(03)00187-9","article-title":"TSC2 regulates VEGF through mTOR-dependent and -independent pathways","volume":"4","author":"Brugarolas","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0025","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1256804","article-title":"Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1\/TSC2 tumor suppressor complex","volume":"18","author":"Brugarolas","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012636","article-title":"Ubiquitin\/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization","volume":"5","author":"Cai","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009720","article-title":"Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-mediated SUMO modification","volume":"5","author":"Cai","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0040","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/S1677-5538.IBJU.2013.01.11","article-title":"Differential proteome of clear-cell renal cell carcinoma (ccRCC) tissues","volume":"39","author":"De Ribeiro","year":"2013","journal-title":"Int. Braz. J. Urol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0050","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1038\/sj.onc.1208636","article-title":"Accumulation of hypoxia-inducible factor-1a is limited by transcription-dependent depletion","volume":"24","author":"Demidenko","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0055","series-title":"AJCC Cancer Staging Manual","first-page":"479","article-title":"Kidney","year":"2010"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0060","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/hmg\/3.12.2169","article-title":"Somatic mutations of the von Hippel - Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma","volume":"3","author":"Foster","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0065","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00000478-198210000-00007","article-title":"Prognostic significance of morphologic parameters in renal cell carcinoma","volume":"6","author":"Fuhrman","year":"1982","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ccr.2008.10.016","article-title":"HIF-\u03b1 effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma","volume":"14","author":"Gordan","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0075","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation\u2013specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"PNAS"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0080","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa066838","article-title":"Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma","volume":"356","author":"Hudes","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0085","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0090","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/modpathol.3880286","article-title":"Hamartin and tuberin expression in human tissues","volume":"14","author":"Johnson","year":"2001","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0095","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.4161\/cc.8.9.8303","article-title":"HAF: the new player in oxygen-independent HIF-1\u03b1 degradation","volume":"8","author":"Koh","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0100","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gcc.10054","article-title":"Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters","volume":"34","author":"Kondo","year":"2002","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0105","doi-asserted-by":"crossref","first-page":"15498","DOI":"10.1074\/jbc.M700704200","article-title":"Constitutive\/hypoxic degradation of HIF-\u03b1 proteins by the proteasome independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein","volume":"282","author":"Kong","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0110","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1158\/1541-7786.MCR-11-0302","article-title":"Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma","volume":"9","author":"Kucejova","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0115","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1038\/sj.onc.1206683","article-title":"Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein","volume":"22","author":"Lewis","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","article-title":"Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells","volume":"15","author":"Li","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molcel.2007.01.001","article-title":"RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1alpha","volume":"25","author":"Liu","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0130","first-page":"2089","article-title":"Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients","volume":"149","author":"Lubensky","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0135","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1535-6108(02)00071-5","article-title":"HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron","volume":"1","author":"Mandriota","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0140","first-page":"651","article-title":"Immuno-morphological characteristics of renal cell carcinoma (RCC)","volume":"10","author":"Markovic-Lipkovski","year":"1995","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0145","first-page":"642","article-title":"HIF activation by PH-dependent nucleolar sequestration of VHL","volume":"6","author":"Mekhail","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0150","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(08)61039-9","article-title":"Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial","volume":"372","author":"Motzer","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0155","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1158\/1078-0432.CCR-07-4921","article-title":"Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors","volume":"14","author":"Nickerson","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1155\/2010\/562491","article-title":"VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2\/B1 and osteopontin","volume":"33","author":"Nyhan","year":"2010","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0165","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/cncr.22677","article-title":"Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy","volume":"109","author":"Pantuck","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0170","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1054\/bjoc.2001.2072","article-title":"Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas","volume":"85","author":"Parry","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0175","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1476-4598-5-64","article-title":"Pathway analysis of kidney cancer using proteomics and metabolic profiling","volume":"5","author":"Perroud","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0180","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature04871","article-title":"Hypoxia signaling in cancer and approaches to enforce tumour regression","volume":"441","author":"Pouyss\u00e9gur","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0185","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1128\/MCB.25.13.5675-5686.2005","article-title":"Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma","volume":"25","author":"Raval","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0190","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1158\/0008-5472.CAN-11-0757","article-title":"VHL gene mutations and their effects on hypoxia inducible factor HIF\u03b1: identification of potential driver and passenger mutations","volume":"71","author":"Rechsteiner","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0195","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4161\/epi.26701","article-title":"Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines","volume":"8","author":"Sanchez-Vega","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0200","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/path.1034","article-title":"VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma","volume":"196","author":"Schraml","year":"2002","journal-title":"J. Pathol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0205","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/carcin\/bgl143","article-title":"Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha","volume":"28","author":"Shinojima","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0210","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K","article-title":"Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene","volume":"12","author":"Stolle","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0215","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","author":"The Cancer Genome Atlas Research Network","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0225","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2887","article-title":"Targeting the dynamic HSP90 complex in cancer","volume":"10","author":"Trepel","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0230","first-page":"2957","article-title":"Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation","volume":"62","author":"Turner","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0235","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1074\/jbc.M400461200","article-title":"Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1 alpha","volume":"279","author":"Uchida","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0240","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/s12864-015-1768-x","article-title":"Quantitative proteomic analysis of formalin\u2013fixed, paraffin\u2013embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines","volume":"16","author":"Wei\u00dfer","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.yexmp.2016.11.003_bb0245","first-page":"5215","article-title":"Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1a in clear cell renal carcinomas","volume":"61","author":"Wiesener","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2016.11.003_bb0250","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1158\/1078-0432.CCR-09-2131","article-title":"Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma","volume":"15","author":"Young","year":"2009","journal-title":"Clin. Cancer Res."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448001630096X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448001630096X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T19:30:14Z","timestamp":1536262214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448001630096X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S001448001630096X"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2016.11.003","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1\u03b1 production in sporadic clear-cell renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2016.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}