{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:33:09Z","timestamp":1776439989635,"version":"3.51.2"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009388","name":"Jazan University","doi-asserted-by":"publisher","award":["1437\/7\/000148"],"award-info":[{"award-number":["1437\/7\/000148"]}],"id":[{"id":"10.13039\/100009388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.yexmp.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T01:36:35Z","timestamp":1529544995000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice"],"prefix":"10.1016","volume":"105","author":[{"given":"Mohammad Firoz","family":"Alam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M.","family":"Safhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarique","family":"Anwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-6941","authenticated-orcid":false,"given":"Rahimullah","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyas","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivakumar Sivagurunathan","family":"Moni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2018.06.001_bb0005","first-page":"285","article-title":"Hepatoprotective activity of Capparis spinosa root bark against ccl4 induced hepatic damage in mice Iran","volume":"6","author":"Aghel","year":"2007","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-8741(01)00349-X","article-title":"Evaluation of hepatoprotective potential of jigrine post treatment against thioacetamide induced hepatic damage","volume":"79","author":"Ahmad","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0135","first-page":"2","article-title":"Therapeutic action mechanism of Zingerone against CCl4 induced liver mitochondrial toxicity in Swiss albino mice 4th international conference on hepatology Dubai, UAE","volume":"6","author":"Alam","year":"2017","journal-title":"J Liver"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0015","series-title":"Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation Cardiology Research and Practice","first-page":"1","volume":"vol. 2018","author":"Alam","year":"2018"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0020","first-page":"02","article-title":"Cytokines - master regulators of the immune system","volume":"2008","author":"Noosheen","year":"2007","journal-title":"eBioscience"},{"issue":"17","key":"10.1016\/j.yexmp.2018.06.001_bb0025","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1073\/pnas.160099797","article-title":"Ivashkiv. Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids","volume":"97","author":"Bianchi","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0030","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Glutathione reductase levels in rat brain","volume":"250","author":"Carlberg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0035","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ajcn\/80.3.742","article-title":"Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived pro-oxidants","volume":"80","author":"Chen","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0040","series-title":"CRC Handbook of Methods for Oxygen Radical Research","first-page":"283","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0045","doi-asserted-by":"crossref","first-page":"16466","DOI":"10.1074\/jbc.C300089200","article-title":"Oligomerization is a general mechanism for the activation of initiator and inflammatory procaspases","volume":"278","author":"David","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.yexmp.2018.06.001_bb0050","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.2174\/092986709788803024","article-title":"TNF \u2013 alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma","volume":"16","author":"Esposito","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0055","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab. Invest."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0060","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jep.2010.04.021","article-title":"Hepatoprotective and antioxidant activity of Phaseolus trilobus, Ait on bile duct ligation induced liver fibrosis in rats","volume":"129","author":"Fursule","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0065","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1016\/j.lfs.2005.10.030","article-title":"Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia-reperfusion in mice","volume":"78","author":"Gao","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0070","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0092-8674(00)80748-5","article-title":"Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation","volume":"97","author":"Gervais","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0075","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1590\/S1807-59322008000600017","article-title":"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats","volume":"63","author":"Habib","year":"2008","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0080","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0085","first-page":"377","article-title":"Protective effects of zingiber officinale against carbon tetrachloride induced liver fibrosis","volume":"8","author":"Iman","year":"2016","journal-title":"Int J Pharm Pharm Sci"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0090","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0367-326X(02)00217-4","article-title":"Protective effect of rutin on paracetamol and CCl4 induced hepatotoxicity in rodents","volume":"73","author":"Janbaz","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"6","key":"10.1016\/j.yexmp.2018.06.001_bb0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.exger.2010.03.005","article-title":"Modulation of age related NF-KappaB activation by Zingerone via MAPK pathway","volume":"45","author":"Kim","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0105","first-page":"507","article-title":"Mechanisms of Interleukin-2-.Induced hepatic toxicity","volume":"56","author":"Koji","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0110","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/hep.1840170420","article-title":"Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats","volume":"17","author":"Liu","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0120","article-title":"Nephroprotective effect of zingerone against ccl4-induced renal toxicity in Swiss albino mice","volume":"1\u20137","author":"Mohammed","year":"2018","journal-title":"Mol. Mech. Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0125","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jep.2014.08.004","article-title":"Cathinone, an active principle of Catha edulis accelerates oxidative stress in limbic area of Swiss albino mice","volume":"156","author":"Mohammed","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0130","first-page":"675","article-title":"Repeated exposure of sodium tellurite on the rat liver and on the potential mechanisms of the metalloid-induced hepatotoxicity","author":"Mohammed","year":"2016","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0140","first-page":"5086","article-title":"Differential distribution of glutathione and glutathione related enzymes in rabbit kidneys: possible implication in analgesic neuropathy","volume":"44","author":"Mohandas","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Level of glutathione, glutathione reductase and glutathone-S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.yexmp.2018.06.001_bb0150","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/hep.1840100606","article-title":"Soluble interleukin 2 receptor in acute viral hepatitis and chronic liver disease","volume":"10","author":"M\u00fcller","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0155","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National, Research Council","year":"1996"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0160","series-title":"Use of Ozone Depleting Substances in Laboratories","first-page":"516","author":"Nordic Council of Ministers, Copenhagen","year":"2003"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0165","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.meegid.2014.08.021","article-title":"Association of IL-2 polymorphisms and IL-2 serum levels with susceptibility to HBV-related hepatocellular carcinoma in a Chinese Zhuang population","volume":"27","author":"Peng","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2010.10.016","article-title":"Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress","volume":"11","author":"Qiao","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0175","first-page":"284","article-title":"Protective activity of Glycrrhiza glabra Linn on carbon tetrachloride induced peroxidative damae","volume":"36","author":"Rajesh","year":"2004","journal-title":"Indian J. Pharmacol."},{"issue":"1","key":"10.1016\/j.yexmp.2018.06.001_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jceh.2012.12.001","article-title":"Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management","volume":"3","author":"Vidyasagar","year":"2013","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.pa.30.040190.003131","article-title":"Glutathione: toxicological implications","volume":"30","author":"Reed","year":"1990","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0190","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","article-title":"Molecular mechanisms of caspase regulation during apoptosis","volume":"5","author":"Riedl","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0195","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1248\/bpb.35.171","article-title":"The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury","volume":"35","author":"Ryutaro","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0200","first-page":"62","article-title":"The protective effect of date seeds on nephrotoxicity induced by carbon tetrachloride in rats","volume":"26","author":"Sahar","year":"2014","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0205","first-page":"1","article-title":"Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes","volume":"12","author":"Sebastian","year":"2012","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0210","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hep.1840190129","article-title":"Vitamin a deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats","volume":"19","author":"Seifert","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.taap.2011.02.004","article-title":"Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis","volume":"252","author":"Shaker","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0220","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jep.2009.01.027","article-title":"The protective effect of Zizyphus jujube fruit on carbon tetrachloride induced hepatic injury in mice by antioxidative activities","volume":"122","author":"Shen","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0225","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.taap.2009.11.005","article-title":"Protective action of the immunomodulator ginsan against carbon tetrachlorideinduced liver injury via control of oxidative stress and the inflammatory response","volume":"242","author":"Shim","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0230","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2337\/diabetes.49.6.1006","article-title":"Effects of DL-alpa-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative, blood flow, energy metabolism and oxidative stress in experimental diabetic neuropathy","volume":"49","author":"Stevens","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0235","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1743-7075-8-40","article-title":"Zingiber officinale acts as a nutraceutical agent against liver fibrosis","volume":"8","author":"Tarek","year":"2011","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2010.04.014","article-title":"Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice","volume":"273","author":"Tipoe","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.yexmp.2018.06.001_bb0245","first-page":"521","article-title":"Effect of sulfhydryl reagent on peroxidation in microsome","volume":"260","author":"Utley","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0250","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yexmp.2018.06.001_bb0255","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-2008-1040483","article-title":"Carbon tetrachloride hepatotoxicity: an example of free radicals mediated injury","volume":"10","author":"Williams","year":"1990","journal-title":"Semin. Liver Dis."},{"issue":"2","key":"10.1016\/j.yexmp.2018.06.001_bb0260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/AIA.0b013e318034194e","article-title":"Cytokines, inflammation, and pain","volume":"45","author":"Zhang","year":"2007","journal-title":"Int. Anesthesiol. Clin."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018300777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018300777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T13:40:54Z","timestamp":1617457254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480018300777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0014480018300777"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2018.06.001","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2018.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}