{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:31:21Z","timestamp":1789785081427,"version":"4.0.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.yexmp.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T10:06:20Z","timestamp":1531821980000},"page":"150-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Piecemeal necrosis is due to the immunologic synapse formation and internalization of intact TCR-MHC II complexes by CD4 T cells"],"prefix":"10.1016","volume":"105","author":[{"given":"Samuel W.","family":"French","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie G.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2018.07.004_bb0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1530-0277.1998.tb04322.x","article-title":"Cytochrome P4502E1, hydroxyethyl free radicals, and immune reactions associated with alcoholic liver disease","volume":"22","author":"Albano","year":"1998","journal-title":"Alcoholism"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0010","series-title":"Frontiers Bio Science 4: dA533-540","article-title":"Hydroxyethyl radicals in ethanol hepatotoxicity","author":"Albano","year":"1999"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4254\/wjh.v2.i11.410","article-title":"Acute liver injury induced by weight-loss herbal supplements","volume":"12","author":"Chen","year":"2010","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0020","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1158\/2326-6066.CIR-14-0161","article-title":"The immunological synapse","volume":"2","author":"Dustin","year":"2014","journal-title":"Cancer Immunol. Res"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.yexmp.2014.03.003","article-title":"Mechanism of hepatotoxicity due to black cohosh and electron microscopy analysis of two liver biopsies with clinical correlation","volume":"96","author":"Enbom","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0030","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.191.7.1137","article-title":"T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells","volume":"191","author":"Huang","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0035","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.286.5441.952","article-title":"TCR-mediated internalization of peptide-MHC complexes acquired by T cell","volume":"286","author":"Huang","year":"1999","journal-title":"Sciences"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0040","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.4049\/jimmunol.166.8.5099","article-title":"Role of the actin cytoskeleton in T cell in T cell absorption and internalization of ligands from APC","volume":"166","author":"Hwang","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1124\/mol.55.2.223","article-title":"Autoantibodies against cytochrome P-4502E1 and P-4503A in alcoholics","volume":"55","author":"Lytton","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.immuni.2011.06.003","article-title":"T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis","volume":"35","author":"Martinez-Martin","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0055","series-title":"Second International Symposium on Immunopathology. Grune and Stratton. New York","first-page":"303","article-title":"Mechanism of cell and tissue damage produced by immune reactions","author":"Popper","year":"1962"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0060","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.4049\/jimmunol.1102594","article-title":"Antigen recognition is facilitated by invadosome-like protrusions formed by memory\/effector T cells","volume":"188","author":"Saga","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0065","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1126\/science.aai8231","article-title":"Can immunotherapy treat neurodegeneration?","volume":"357","author":"Schartz","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.yexmp.2018.07.004_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/exmp.2001.2397","article-title":"\u201cPiecemeal\u201d necrosis: Renamed Troxis Necrosis","volume":"71","author":"Wang","year":"2001","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2018.07.004_bb0075","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.yexmp.2015.08.006","article-title":"Troxis necrosis is a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy","volume":"99","author":"Wei","year":"2016","journal-title":"Exp. Mol. Pathol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018302703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018302703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T23:16:24Z","timestamp":1532474184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480018302703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0014480018302703"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2018.07.004","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piecemeal necrosis is due to the immunologic synapse formation and internalization of intact TCR-MHC II complexes by CD4 T cells","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2018.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}