{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:44:55Z","timestamp":1777614295246,"version":"3.51.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Institute of Virology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.yexmp.2019.03.008","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T10:23:04Z","timestamp":1553595784000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Role of the inflammasomes in HIV-associated neuroinflammation and neurocognitive disorders"],"prefix":"10.1016","volume":"108","author":[{"given":"Akhil","family":"Katuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alonso","family":"Heredia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapas K.","family":"Makar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2019.03.008_bb0005","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0010","first-page":"41","article-title":"Inflammasomes in CNS diseases","volume":"108","author":"Albornoz","year":"2018","journal-title":"Exp. Suppl."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/09540260701862037","article-title":"The neuropathology of HIV\/AIDS","volume":"20","author":"Anthony","year":"2008","journal-title":"Int. Rev. Psychiatry."},{"issue":"515","key":"10.1016\/j.yexmp.2019.03.008_bb0020","article-title":"Current scenario of HIV\/AIDS, treatment options, and major challenges with compliance to antiretroviral therapy","volume":"8","author":"Bhatti","year":"2016","journal-title":"Cureus"},{"key":"10.1016\/j.yexmp.2019.03.008_bb0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","article-title":"Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system","volume":"43","author":"Bruttger","year":"2015","journal-title":"Immunity."},{"issue":"3","key":"10.1016\/j.yexmp.2019.03.008_bb0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yexmp.2018.03.005","article-title":"Renal aquaporin-4 associated pathology in TG-26 mice","volume":"104","author":"Bryant","year":"2018","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0035","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1073\/pnas.1615258113","article-title":"Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice","volume":"113","author":"Carroll","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nbd.2018.03.003","article-title":"A stress-enhanced model for discovery of disease-modifying gene: ece1-suppresses the toxicity of alpha-synuclein A30P","volume":"114","author":"Chen","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"13","key":"10.1016\/j.yexmp.2019.03.008_bb0045","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1523\/JNEUROSCI.3045-16.2017","article-title":"HIV-1 Tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation","volume":"37","author":"Chivero","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.21697","article-title":"Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia","volume":"66","author":"Churchill","year":"2009","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.yexmp.2019.03.008_bb0055","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/0271678X17748786","article-title":"Sifting through the surfeit of neuroinflammation tracers","volume":"38","author":"Cumming","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0060","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/WNR.0000000000000148","article-title":"Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection","volume":"25","author":"Curtis","year":"2014","journal-title":"Neuroreport."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0065","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-med-092112-152941","article-title":"Understanding HIV latency: the road to an HIV cure","volume":"66","author":"Dahabieh","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0070","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"ATP mediates rapid microglial response to local brain injury in vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnins.2015.00093","article-title":"Neurotoxic effects of AZT on developing and adult neurogenesis","volume":"9","author":"Demir","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0080","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: a key role for IL-4","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0042-6822(91)90759-5","article-title":"HIV-associated nephropathy in transgenic mice expressing HIV-1 genes","volume":"185","author":"Dickie","year":"1991","journal-title":"Virology."},{"issue":"2","key":"10.1016\/j.yexmp.2019.03.008_bb0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0095","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.conb.2008.04.001","article-title":"Development of neural stem cell in the adult brain","volume":"18","author":"Duan","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0105","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1523\/JNEUROSCI.1460-11.2011","article-title":"Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction dependent mechanism","volume":"31","author":"Eugenin","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0110","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1523\/JNEUROSCI.1208-16.2016","article-title":"HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway","volume":"36","author":"Fan","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0115","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1007\/s00018-014-1702-4","article-title":"The impact of HIV-1 on neurogenesis: implications for HAND","volume":"71","author":"Ferrell","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jmb.2017.12.013","article-title":"Single-molecule fluorescence reveals the oligomerization and folding steps driving the prion-like behavior of ASC","volume":"430","author":"Gambin","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0125","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0130","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/joim.12570","article-title":"Alarmins and central nervous system inflammation in HIV-associated neurological disorders","volume":"281","author":"Gougeon","year":"2017","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0135","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloidbeta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.yexmp.2019.03.008_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ajpath.2015.10.002","article-title":"HIV promotes NLRP3 Inflammasome complex activation in murine HIV-associated nephropathy","volume":"186","author":"Haque","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.10.008","article-title":"Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications","volume":"45","author":"Hong","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.yexmp.2019.03.008_bb0155","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2967\/jnumed.116.178996","article-title":"11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain","volume":"58","author":"Ikawa","year":"2017","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0160","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3727\/096368916X691457","article-title":"HIV non-nucleoside reverse transcriptase inhibitor efavirenz reduces neural stem cell proliferation in vitro and in vivo","volume":"25","author":"Jin","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0165","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.2741\/2860","article-title":"HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis","volume":"13","author":"Kaul","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0170","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1073\/pnas.89.5.1577","article-title":"Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes","volume":"89","author":"Kopp","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0175","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41598-017-17634-1","article-title":"Issues with the specificity of immunological reagents for NLRP3: implications for age-related macular degeneration","volume":"8","author":"Kosmidou","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0180","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2217\/fvl.12.57","article-title":"Neuronal toxicity in HIV CNS disease","volume":"7","author":"Kovalevich","year":"2012","journal-title":"Future Virol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0185","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1086\/422008","article-title":"HIV-1 promotes quiescence in human neural progenitor cells","volume":"190","author":"Krathwohl","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0190","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.bbi.2012.06.008","article-title":"Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention","volume":"26","author":"Kumar","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.yexmp.2019.03.008_bb0195","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"32","key":"10.1016\/j.yexmp.2019.03.008_bb0200","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1523\/JNEUROSCI.1487-12.2012","article-title":"Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging","volume":"32","author":"Lavisse","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0205","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1128\/JVI.78.14.7319-7328.2004","article-title":"Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells","volume":"78","author":"Lawrence","year":"2004","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.yexmp.2019.03.008_bb0210","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1177\/0271678X16662043","article-title":"Inflammasomes link vascular disease with neuroinflammation and brain disorders","volume":"36","author":"L\u00e9n\u00e1rt","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0215","first-page":"46","article-title":"Neurologic complications of HIV disease and their treatment","volume":"17","author":"Letendre","year":"2009","journal-title":"Top. HIV Med."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0220","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.yexcr.2017.12.013","article-title":"NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells","volume":"362","author":"Li","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0225","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.mnh.0000222688.69217.8e","article-title":"Animal models of HIV-associated nephropathy","volume":"15","author":"Lu","year":"2006","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0230","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00281-014-0434-8","article-title":"Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease","volume":"36","author":"Lukens","year":"2014","journal-title":"Semin. Immunopathol."},{"issue":"9","key":"10.1016\/j.yexmp.2019.03.008_bb0235","first-page":"2273","article-title":"Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts","volume":"140","author":"Manmeet","year":"2017"},{"issue":"9","key":"10.1016\/j.yexmp.2019.03.008_bb0240","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1474-4422(05)70165-4","article-title":"Neurological complications of HIV infection","volume":"4","author":"McArthur","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0245","doi-asserted-by":"crossref","first-page":"13046","DOI":"10.1073\/pnas.1002396107","article-title":"Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis","volume":"107","author":"Meissner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.yexmp.2019.03.008_bb0250","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1089\/ars.2017.7261","article-title":"Autophagy attenuates angiotensin II-induced pulmonary fibrosis by inhibiting redox imbalance-mediated NLRP3 inflammasome activation","volume":"30","author":"Meng","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"10","key":"10.1016\/j.yexmp.2019.03.008_bb0255","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/infdis\/jiv771","article-title":"The interleukin-1 balance is associated with clinical severity, blood-brain barrier permeability, neuroimaging changes and outcome in encephalitis","volume":"213","author":"Michael","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0260","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0265","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3727\/096368908784423328","article-title":"Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis","volume":"17","author":"Monahan","year":"2008","journal-title":"Cell Transplant."},{"issue":"3","key":"10.1016\/j.yexmp.2019.03.008_bb0270","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbagen.2017.11.015","article-title":"The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release","volume":"1862","author":"Mugisho","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexmp.2019.03.008_bb0275","doi-asserted-by":"crossref","DOI":"10.1177\/1536012118792317","article-title":"Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: outlook beyond TSPO","volume":"17","author":"Narayanaswami","year":"2018","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.yexmp.2019.03.008_bb0280","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: microglia of the aged brain: primed to be activated and resistant to regulation","volume":"39","author":"Norden","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0290","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.stem.2007.07.010","article-title":"HIV\/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest","volume":"1","author":"Okamoto","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"8","key":"10.1016\/j.yexmp.2019.03.008_bb0295","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2006.06.005","article-title":"Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function","volume":"27","author":"Papadopoulos","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0300","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.coi.2017.10.011","article-title":"Recent advances in inflammasome biology","volume":"50","author":"Place","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.yexmp.2019.03.008_bb0305","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12974-018-1322-2","article-title":"Adult neurogenic deficits in HIV 1 Tg26 transgenic mice","volume":"15","author":"Putatunda","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.yexmp.2019.03.008_bb0310","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.yexmp.2019.03.008_bb0315","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneuroim.2012.03.015","article-title":"Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat","volume":"247","author":"Royal","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"12","key":"10.1016\/j.yexmp.2019.03.008_bb0320","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nrd3295","article-title":"Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders","volume":"9","author":"Rupprecht","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0325","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.06.008","article-title":"Sublime microglia: expanding roles for the guardians of the CNS","volume":"158","author":"Salter","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0330","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.161.12.6480","article-title":"IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells","volume":"161","author":"Samoilova","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0335","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fimmu.2012.00288","article-title":"NLRP3- Inflammasome activating DAMPs stimulate an inflammatory response in Glia in the absence of priming which contributes to brain inflammation after injury","volume":"3","author":"Savage","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0340","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrneurol.2016.53","article-title":"HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment","volume":"12","author":"Saylor","year":"2016","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.yexmp.2019.03.008_bb0345","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11910-017-0733-2","article-title":"Neuroinflammation in neurodegenerative disorders-a review","volume":"17","author":"Schain","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0350","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/157016206777709438","article-title":"Neural progenitors and HIV-1-associated central nervous system disease in adults and children","volume":"4","author":"Schwartz","year":"2006","journal-title":"Curr. HIV Res."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0355","first-page":"274","article-title":"Evidence of human immunodeficiency virus type 1 infection of nestin-positive neural progenitors in archival pediatric brain tissue","volume":"13","author":"Schwartz","year":"2007","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0360","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fphar.2015.00262","article-title":"NLRP3 inflammasome and its inhibitors: a review","volume":"6","author":"Shao","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0365","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.autrev.2018.01.020","article-title":"NLRP3: a promising therapeutic target for autoimmune diseases","volume":"17","author":"Shen","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0370","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0380","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-4690-11-35","article-title":"Rapid inflammasome activation in microglia contributes to brain disease in HIV\/AIDS","volume":"11","author":"Walsh","year":"2014","journal-title":"Retrovirology"},{"issue":"2","key":"10.1016\/j.yexmp.2019.03.008_bb0385","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/bpa.12478","article-title":"1. Inflammasomes as therapeutic targets for Alzheimer's disease","volume":"27","author":"White","year":"2017","journal-title":"Brain Pathol."},{"issue":"3","key":"10.1016\/j.yexmp.2019.03.008_bb0390","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nbd.2003.07.002","article-title":"Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro","volume":"14","author":"Wilms","year":"2003","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.yexmp.2019.03.008_bb0395","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s11481-017-9755-4","article-title":"Combined medication of antiretroviral drugs tenofovir disoproxil fumarate, emtricitabine, and raltegravir reduces neural progenitor cell proliferation in vivo and in vitro","volume":"12","author":"Xu","year":"2017","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"9","key":"10.1016\/j.yexmp.2019.03.008_bb0400","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3389\/fphar.2018.01346","article-title":"Gastrodin. Ameliorates cognitive dysfunction in diabetes rat model via the suppression of endoplasmic reticulum stress and NLRP3 inflammasome activation","volume":"22","author":"Ye","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0405","first-page":"5463","article-title":"NLRP1 and NLRP3 inflammasomes mediate LPS\/ATPinduced pyroptosis in knee osteoarthritis","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexmp.2019.03.008_bb0410","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nn1629","article-title":"Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood","volume":"9","author":"Ziv","year":"2006","journal-title":"Nat. Neurosci."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019300577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019300577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:59:47Z","timestamp":1762145987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019300577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":80,"alternative-id":["S0014480019300577"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.03.008","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of the inflammasomes in HIV-associated neuroinflammation and neurocognitive disorders","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}