{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:57:34Z","timestamp":1762012654640,"version":"build-2065373602"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"US Public Health","award":["RO1 NS42011"],"award-info":[{"award-number":["RO1 NS42011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.yexmp.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T20:43:18Z","timestamp":1555101798000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis"],"prefix":"10.1016","volume":"108","author":[{"given":"William H.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia D.","family":"Cudrici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dallas","family":"Boodhoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Tatomir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Rus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horea","family":"Rus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2019.04.008_bb0005","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1074\/jbc.M109354200","article-title":"RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase","volume":"277","author":"Badea","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11892-008-0041-y","article-title":"Effects of insulin and free fatty acids on matrix metalloproteinases","volume":"8","author":"Boden","year":"2008","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0015","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.2337\/dc13-1904","article-title":"Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children","volume":"37","author":"Cameron","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1081\/ERC-120004541","article-title":"Diabetic ketoacidosis depletes plasma tryptophan","volume":"28","author":"Carl","year":"2002","journal-title":"Endo. Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/micc.12053","article-title":"Diabetic ketoacidosis elicits systemic inflammation associated with cerebrovascular endothelial dysfunction","volume":"20","author":"Close","year":"2013","journal-title":"Microcirculation."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0030","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3727\/096368916X694184","article-title":"Regulator of cell cycle (RGCC) expression during the progression of Alzheimer's disease","volume":"26","author":"Counts","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0035","first-page":"1574928","article-title":"Neutrophils release metalloproteinases during adhesion in the presence of insulin, but cathepsin G in the presence of glucagon","volume":"14","author":"Fedorova","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/716c0fb2-dbdd-4da5-ad8a-d2b1cdac4ec6","article-title":"Matrix metalloproteinase-2 and-9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins","volume":"6","author":"Feng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yexmp.2004.11.001","article-title":"Overexpression of RGC-32 in colon cancer and other tumors","volume":"78","author":"Fosbrink","year":"2005","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0050","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/pedi.12359","article-title":"Circulating matrix metalloproteinases in children with diabetic ketoacidosids","volume":"18","author":"Garro","year":"2017","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0055","first-page":"233","article-title":"Inflammation in childhood Type 1 diabetes; influence of glycemic control","volume":"38","author":"Heier","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(02)00816-9","article-title":"Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells","volume":"334","author":"Hoffman","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0009-9120(03)00030-4","article-title":"Diabetic ketoacidosis and its treatment increase plasma 3-deoxyglucosone","volume":"36","author":"Hoffman","year":"2003","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1521-6616(03)00144-X","article-title":"Cytokine response to diabetic ketoacidosis and its treatment","volume":"108","author":"Hoffman","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0075","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yexmp.2005.12.007","article-title":"Complement activation in diabetic ketoacidosis brains","volume":"80","author":"Hoffman","year":"2006","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0080","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yexmp.2007.01.006","article-title":"Neuroinflammatory response of the choroid plexus epithelium in fatal diabetic ketoacidosis","volume":"83","author":"Hoffman","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainres.2008.08.041","article-title":"Receptor for advanced glycation end products and neuronal deficit in fatal brain edema of diabetic ketoacidosis","volume":"1238","author":"Hoffman","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0090","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2008.11.100","article-title":"Inflammatory mediators and blood brain disruption in fatal brain edema of diabetic ketoacidosis","volume":"1254","author":"Hoffman","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071905","article-title":"Increased systemic Th17 cytokine are associated with diastolic dysfunction in children and adolescents with diabetic ketoacidosis","volume":"8","author":"Hoffman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12035-013-8442-6","article-title":"High glucose induces reactive oxygen species-dependent matrix metalloproteinase-9 expression and cell migration in brain astrocytes","volume":"48","author":"Hsieh","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0105","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s12035-013-8628-y","article-title":"Up-regulation of ROS-dependent matrix metalloproteinase-9 from high-glucose-challenged astrocytes contributes to the neuronal apoptosis","volume":"50","author":"Hsieh","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0110","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2017.0020","article-title":"Acute kidney injury in children with type 1 diabetes hospitalized for diabetic ketoacidosis","volume":"171","author":"Hursh","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1056-8727(99)00030-6","article-title":"Acetoacetate and beta-hydroxybutyrate differentially regulate endothelin-1 and vascular endothelial growth factor in mouse brain microvascular endothelial cells","volume":"13","author":"Isales","year":"1999","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cca.2005.11.029","article-title":"Elevated circulating levels of matrix metalloproteinase-9 in type 1 diabetic patients with and without retinopathy","volume":"367","author":"Jacqueminet","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clim.2005.03.004","article-title":"Complement activation in diabetic ketoacidosis and its treatment","volume":"116","author":"Jerath","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4274\/jcrpe.2158","article-title":"Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes","volume":"7","author":"Jessup","year":"2015","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2013.12.009","article-title":"Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration","volume":"81","author":"Kaplan","year":"2014","journal-title":"Neuron."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0140","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1507\/endocrj.EJ11-0024","article-title":"Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)","volume":"58","author":"Karavanaki","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0145","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00417-011-1912-5","article-title":"Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases","volume":"250","author":"Kim","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1254\/jphs.11R13CP","article-title":"Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains","volume":"118","author":"Koyama","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1124\/mol.116.107300","article-title":"Dexamethasone downregulates endothelin receptors and reduces endothelin-induced production of matrix metalloproteinases in cultured rat astrocytes","volume":"92","author":"Koyama","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0160","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41598-017-00923-0","article-title":"MMP integrates multiple immunoregulatory pathways that discriminate high suppressive activity of human mesenchymal cells","volume":"7","author":"Lavini-Ramos","year":"2017","journal-title":"Sci. Report."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0165","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1056-8727(01)00215-X","article-title":"Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis","volume":"16","author":"Lee","year":"2002","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0170","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2337\/dc11-2040","article-title":"High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy of type 1 diabetes","volume":"35","author":"Lopes-Virella","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2007.07.003","article-title":"Matrix metalloproteinases as modulators of inflammation","volume":"19","author":"Manicone","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0180","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1464-5491.2001.00542.x","article-title":"Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetes","volume":"18","author":"Maxwell","year":"2001","journal-title":"Diabet. Med."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0185","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0008-6363(00)00287-X","article-title":"Effects of interleukin-10 on monocyte\/endothelial cell adhesion and MMP-9\/TIMP-1 secretion","volume":"49","author":"Mostafa Mtairag","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0190","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/j.bbagen.2014.03.007","article-title":"Matrix metalloproteinases in inflammation","volume":"1840","author":"Nissinen","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0195","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2337\/dc15-0041","article-title":"Clinically relevant cognitive impairment in middle-aged adults with childhood-onset type 1 diabetes","volume":"38","author":"Nunley","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0200","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.clinbiochem.2005.05.011","article-title":"Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein","volume":"38","author":"Oglesbee","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0205","doi-asserted-by":"crossref","first-page":"E1077","DOI":"10.1152\/ajpendo.00659.2013","article-title":"CXCL1\/CXCL8 (GRO\u03b1\/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro","volume":"306","author":"Omatsu","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0210","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0009922815617975","article-title":"Incidence, trends, and outcomes of cerebral edema among children with diabetic ketoacidosis in the United States","volume":"55","author":"Patel","year":"2016","journal-title":"Clin. Pediatr."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12933-017-0539-1","article-title":"Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study","volume":"16","author":"Peeters","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0220","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jdiacomp.2017.12.011","article-title":"Associations between advanced glycation end-products and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes","volume":"32","author":"Peeters","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0225","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10715760902751902","article-title":"Involvement of ROS in BBB dysfunction","volume":"43","author":"Pun","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0230","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10875-006-9022-6","article-title":"Matrix metalloproteinase-9 and autoimmune diseases","volume":"26","author":"Ram","year":"2006","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0235","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0031-1283161","article-title":"Relationship of soluble RAGE and RAGE ligands HMGB1 and EN-RAGE to endothelial dysfunction in type 1 and type 2 diabetes mellitus","volume":"120","author":"Skrha","year":"2012","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0240","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/bs.pmbts.2017.01.003","article-title":"Matrix metalloproteinases and leukocyte activation","volume":"147","author":"Smigiel","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1096\/fj.10-156083","article-title":"The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro","volume":"25","author":"Speidl","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0250","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/jnen\/62.12.1254","article-title":"Pro-inflammatory cytokines modulate matrix metalloproteinase secretion and organic anion transport at the blood-cerebrospinal fluid barrier","volume":"62","author":"Strazielle","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0255","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0003319706290742","article-title":"Systemic versus coronary levels of inflammation in acute coronary syndromes","volume":"57","author":"Suzuki","year":"2006","journal-title":"Angiology"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0260","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00417-012-2221-3","article-title":"Matrix metalloproteinase (MMP-2,-9) and tissue inhibitor (TIMP-1,-2) activity in tear samples of pediatric type 1 diabetic patients: MMPs in tear samples from type 1 diabetes","volume":"251","author":"Symeonidis","year":"2013","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0265","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/pedi.12153","article-title":"Cerebral edema in children with diabetic ketoacidosis: vasogenic rather than cellular?","volume":"15","author":"Tasker","year":"2014","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.yexmp.2019.04.008_bb0270","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1262-3636(07)70266-5","article-title":"Elevated level of methylglyoxal during diabetic ketoacidosis and its recovery phase","volume":"32","author":"Turk","year":"2006","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0275","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and Hemorrhagic transformation following ischemic stroke","volume":"10","author":"Turner","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0280","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1189\/jlb.0607338","article-title":"Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration","volume":"82","author":"Van Lint","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0285","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.clinbiochem.2015.07.021","article-title":"MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer","volume":"48","author":"Wieczorek","year":"2015","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0290","doi-asserted-by":"crossref","first-page":"e846","DOI":"10.1097\/CCM.0000000000001720","article-title":"Elevated leukocyte azurophilic enzymes in human diabetic ketoacidosis plasma degrade cerebrovascular endothelial junctional proteins","volume":"44","author":"Woo","year":"2016","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0295","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/pr.2015.215","article-title":"Dynamic regulation of plasma matrix metalloproteinases in human diabetic ketoacidosis","volume":"79","author":"Woo","year":"2016","journal-title":"Ped. Res."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0300","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1161\/CIRCULATIONAHA.108.844589","article-title":"Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice","volume":"121","author":"Wu","year":"2010","journal-title":"Circulation."},{"key":"10.1016\/j.yexmp.2019.04.008_bb0305","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-014-2086-3","article-title":"Knockdown of response gene to complement 32 (RGC-32) induces apoptosis and inhibits cell growth, migration, and invasion in human lung cancer cells","volume":"394","author":"Xu","year":"2014","journal-title":"Mol. Cell. Biochem."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018304696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480018304696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:51:35Z","timestamp":1757991095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480018304696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":61,"alternative-id":["S0014480018304696"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.04.008","relation":{},"ISSN":["0014-4800"],"issn-type":[{"type":"print","value":"0014-4800"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}