{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:41:32Z","timestamp":1784731292958,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.yexmp.2019.104282","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T19:11:56Z","timestamp":1562785916000},"page":"104282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K\/AKT signaling pathway"],"prefix":"10.1016","volume":"110","author":[{"given":"Yao","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kui","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Min","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Feng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.yexmp.2019.104282_bb0005","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cbin.10779","article-title":"Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K\/AKT\/GSK3beta\/beta-catenin pathway","volume":"41","author":"Chen","year":"2017","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yexmp.2019.104282_bb0010","first-page":"75","article-title":"MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones","volume":"8","author":"De-Ugarte","year":"2015","journal-title":"BMC Med. Genet."},{"issue":"11","key":"10.1016\/j.yexmp.2019.104282_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208131","article-title":"Pro-osteoporotic miR-320a impairs osteoblast function and induces oxidative stress","volume":"13","author":"De-Ugarte","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.yexmp.2019.104282_bb0020","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/01.med.0000436194.10599.94","article-title":"Postmenopausal osteoporosis","volume":"20","author":"Diab","year":"2013","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"13","key":"10.1016\/j.yexmp.2019.104282_bb0025","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa035725","article-title":"The effects of parathyroid hormone, alendronate, or both in men with osteoporosis","volume":"349","author":"Finkelstein","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.yexmp.2019.104282_bb0030","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.4161\/cc.27944","article-title":"Microtubule-associated protein 9 (Map9\/Asap) is required for the early steps of zebrafish development","volume":"13","author":"Fontenille","year":"2014","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.yexmp.2019.104282_bb0035","first-page":"115","article-title":"Management of postmenopausal osteoporosis and the prevention of fractures","volume":"56","author":"Gambacciani","year":"2014","journal-title":"Panminerva Med."},{"issue":"11","key":"10.1016\/j.yexmp.2019.104282_bb0040","doi-asserted-by":"crossref","first-page":"11269","DOI":"10.1007\/s13277-014-2283-4","article-title":"MicroRNA-320a suppresses in GBM patients and modulates glioma cell functions by targeting IGF-1R","volume":"35","author":"Guo","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.yexmp.2019.104282_bb0045","series-title":"MiR-320a Induces Diabetic Nephropathy via Inhibiting MafB","author":"He","year":"2019"},{"key":"10.1016\/j.yexmp.2019.104282_bb0050","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12868-016-0243-1","article-title":"miR-320a affects spinal cord edema through negatively regulating aquaporin-1 of blood-spinal cord barrier during bimodal stage after ischemia reperfusion injury in rats","volume":"17","author":"Li","year":"2016","journal-title":"BMC Neurosci."},{"issue":"3","key":"10.1016\/j.yexmp.2019.104282_bb0055","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/abbs\/gmy006","article-title":"MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation","volume":"50","author":"Li","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"5","key":"10.1016\/j.yexmp.2019.104282_bb0060","doi-asserted-by":"crossref","first-page":"496","DOI":"10.5582\/bst.2017.01216","article-title":"Chinese single herbs and active ingredients for postmenopausal osteoporosis: from preclinical evidence to action mechanism","volume":"11","author":"Lin","year":"2017","journal-title":"Biosci. Trends"},{"issue":"4","key":"10.1016\/j.yexmp.2019.104282_bb0065","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1515\/hsz-2014-0268","article-title":"MicroRNA-210 is involved in the regulation of postmenopausal osteoporosis through promotion of VEGF expression and osteoblast differentiation","volume":"396","author":"Liu","year":"2015","journal-title":"Biol. Chem."},{"issue":"4","key":"10.1016\/j.yexmp.2019.104282_bb0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4149\/av_2018_412","article-title":"MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population","volume":"62","author":"Liu","year":"2018","journal-title":"Acta Virol."},{"issue":"4","key":"10.1016\/j.yexmp.2019.104282_bb0075","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.bbrc.2016.04.069","article-title":"miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3","volume":"473","author":"Lu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2019.104282_bb0080","doi-asserted-by":"crossref","first-page":"798170","DOI":"10.1155\/2014\/798170","article-title":"Expression of the microtubule-associated protein MAP9\/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers","volume":"2014","author":"Rouquier","year":"2014","journal-title":"Dis. Markers"},{"issue":"3","key":"10.1016\/j.yexmp.2019.104282_bb0085","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PPO.0b013e318258b78f","article-title":"The role of microRNAs in colorectal cancer","volume":"18","author":"Schetter","year":"2012","journal-title":"Cancer J."},{"issue":"6","key":"10.1016\/j.yexmp.2019.104282_bb0090","first-page":"607","article-title":"Liensinine induces gallbladder cancer apoptosis and G2\/M arrest by inhibiting ZFX-induced PI3K\/AKT pathway","volume":"51","author":"Shen","year":"2019","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"4","key":"10.1016\/j.yexmp.2019.104282_bb0095","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2012.03.075","article-title":"MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting beta-catenin","volume":"420","author":"Sun","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2019.104282_bb0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.yexmp.2019.104282_bb0105","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/1471-2164-9-406","article-title":"Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9)","volume":"9","author":"Venoux","year":"2008","journal-title":"BMC Genomics"},{"issue":"9","key":"10.1016\/j.yexmp.2019.104282_bb0110","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1158\/1538-7445.AM2015-2719","article-title":"MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A","volume":"5","author":"Wang","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"5","key":"10.1016\/j.yexmp.2019.104282_bb0115","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1139\/bcb-2017-0243","article-title":"Reduced miR-144-3p expression in serum and bone mediates osteoporosis pathogenesis by targeting RANK","volume":"96","author":"Wang","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.yexmp.2019.104282_bb0120","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1472-6882-13-277","article-title":"Si-Wu-tang extract stimulates bone formation through PI3K\/Akt\/NF-kappaB signaling pathways in osteoblasts","volume":"13","author":"Wu","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"issue":"6","key":"10.1016\/j.yexmp.2019.104282_bb0125","first-page":"7789","article-title":"MicroRNA148a inhibition protects against ovariectomyinduced osteoporosis through PI3K\/AKT signaling by estrogen receptor alpha","volume":"17","author":"Xiao","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.yexmp.2019.104282_bb0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.18632\/aging.100876","article-title":"miR-320a mediates doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway","volume":"8","author":"Yin","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"17","key":"10.1016\/j.yexmp.2019.104282_bb0135","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1242\/dev.137075","article-title":"Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination","volume":"143","author":"Yu","year":"2016","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.yexmp.2019.104282_bb0140","first-page":"126","article-title":"MicroRNA-221 is involved in the regulation of osteoporosis through regulates RUNX2 protein expression and osteoblast differentiation","volume":"9","author":"Zhang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.yexmp.2019.104282_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.gene.2018.05.100","article-title":"MiR-320a-3p\/ELF3 axis regulates cell metastasis and invasion in non-small cell lung cancer via PI3K\/Akt pathway","volume":"670","author":"Zhao","year":"2018","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.yexmp.2019.104282_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/abbs\/gmy165","article-title":"miR-188-5p regulates proliferation and invasion via PI3K\/Akt\/MMP-2\/9 signaling in keloids","volume":"51","author":"Zhu","year":"2019","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019304009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019304009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:55:13Z","timestamp":1757991313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019304009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":30,"alternative-id":["S0014480019304009"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104282","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104282"}}