{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:48:29Z","timestamp":1769608109212,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Cancer Center Support","award":["P30CA046934"],"award-info":[{"award-number":["P30CA046934"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.yexmp.2019.104284","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T11:12:29Z","timestamp":1562757149000},"page":"104284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma"],"prefix":"10.1016","volume":"110","author":[{"given":"Crystal L.","family":"Adams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Dimitrova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam D.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacey","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique A.","family":"Spillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian","family":"Behbakht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Bradford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2019.104284_bb0005","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S1470-2045(09)70226-8","article-title":"Clinical management of uterine sarcomas","volume":"10","author":"Amant","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0010","first-page":"1078","article-title":"CA 125 and other tumor markers in uterine leiomyomas and their association with lesion characteristics","volume":"7","author":"Babacan","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.yexmp.2019.104284_bb0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0020","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1158\/0008-5472.CAN-05-1699","article-title":"Gene expression profiling of human sarcomas: insights into sarcoma biology","volume":"65","author":"Baird","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ygyno.2008.02.026","article-title":"The utility of preoperative endometrial sampling for the detection of uterine sarcomas","volume":"110","author":"Bansal","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0030","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/onc.2009.381","article-title":"Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling","volume":"29","author":"Beck","year":"2010","journal-title":"Oncogene."},{"issue":"1","key":"10.1016\/j.yexmp.2019.104284_bb0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ygyno.2014.11.011","article-title":"Impact of morcellation on survival outcomes of patients with unexpected uterine leiomyosarcoma: a systematic review and meta-analysis","volume":"137","author":"Bogani","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0040","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ygyno.2003.12.029","article-title":"Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999","volume":"93","author":"Brooks","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0045","series-title":"Safety Communications. UPDATED Laparoscopic Uterine Power Morcellation in Hysterectomy and Myomectomy","author":"Center for Devices and Radiological Health","year":"2014"},{"key":"10.1016\/j.yexmp.2019.104284_bb0050","first-page":"1353","article-title":"The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer","volume":"27","author":"Chang","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.yexmp.2019.104284_bb0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1479-5876-11-36","article-title":"Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer","volume":"11","author":"de Resende","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yexmp.2019.104284_bb0060","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.fertnstert.2008.03.071","article-title":"Gene expression profiling of multiple leiomyomata uteri and matched normal tissue from a single patient","volume":"91","author":"Dimitrova","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.yexmp.2019.104284_bb0065","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1158\/1078-0432.565.11.2","article-title":"Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays","volume":"11","author":"Dobbin","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0070","doi-asserted-by":"crossref","first-page":"10947","DOI":"10.1073\/pnas.0504934102","article-title":"Knockout mice reveal a tumor suppressor function for Testin","volume":"102","author":"Drusco","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2019.104284_bb0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/1097-0142(19900701)66:1<35::AID-CNCR2820660108>3.0.CO;2-V","article-title":"Treatment of uterine sarcomas","volume":"66","author":"Echt","year":"1990","journal-title":"Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0080","first-page":"229","article-title":"Hysterectomy rates in the United States 1990-1997","volume":"99","author":"Farquhar","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0085","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/gcc.20692","article-title":"Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis","volume":"48","author":"Hodge","year":"2009","journal-title":"Genes Chromosom. Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0090","first-page":"4423","article-title":"High levels of serum HER-2\/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer","volume":"9","author":"Jensen","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0095","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.23245","article-title":"Prognostic factors and survival in 1396 patients with uterine leiomyosarcomas: emphasis on impact of lymphadenectomy and oophorectomy","volume":"112","author":"Kapp","year":"2008","journal-title":"Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/modpathol.3880055","article-title":"Smooth muscle, endometrial stromal, and mixed Mullerian tumors of the uterus","volume":"13","author":"Kempson","year":"2000","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0105","doi-asserted-by":"crossref","first-page":"7201","DOI":"10.1158\/0008-5472.CAN-04-1673","article-title":"A gene expression signature associated with metastatic outcome in human leiomyosarcomas","volume":"64","author":"Lee","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0110","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/modpathol.2009.122","article-title":"A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors","volume":"22","author":"Lee","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0115","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fertnstert.2012.10.048","article-title":"Biomarkers in uterine leiomyoma","volume":"99","author":"Levy","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.yexmp.2019.104284_bb0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/AOG.0000000000000642","article-title":"Unexpected gynecologic malignancy diagnosed after hysterectomy performed for benign indications","volume":"125","author":"Mahnert","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0125","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1158\/1078-0432.CCR-05-2003","article-title":"Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis","volume":"12","author":"Matsumura","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3835(00)00607-8","article-title":"Relative quantitation of p53 and MDM2 gene expression in leiomyosarcoma; real-time semi-quantitative reverse transcription-polymerase chain reaction","volume":"164","author":"Miyajima","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.yexmp.2019.104284_bb0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/gcc.20018","article-title":"Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling","volume":"40","author":"Quade","year":"2004","journal-title":"Genes Chromosom. Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0140","first-page":"1001","article-title":"Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas","volume":"12","author":"Rao","year":"1999","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0145","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ygyno.2017.02.019","article-title":"Uterine leiomyosarcoma: epidemiology, contemporary treatment strategies and the impact of uterine morcellation","volume":"145","author":"Ricci","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fonc.2013.00139","article-title":"Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion","volume":"3","author":"Risinger","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexmp.2019.104284_bb0155","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1158\/1078-0432.806.11.2","article-title":"Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo","volume":"11","author":"Sarti","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0160","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1158\/1078-0432.CCR-11-3058","article-title":"A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma","volume":"18","author":"Shan","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1349-7006.2006.00381.x","article-title":"Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells","volume":"98","author":"Shimo","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.yexmp.2019.104284_bb0170","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/cncr.10425","article-title":"Tumor specific gene expression profiles in human leiomyosarcoma: an evaluation of intratumor heterogeneity","volume":"94","author":"Shmulevich","year":"2002","journal-title":"Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0175","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/cncr.11586","article-title":"Differential gene expression in leiomyosarcoma","volume":"98","author":"Skubitz","year":"2003","journal-title":"Cancer."},{"key":"10.1016\/j.yexmp.2019.104284_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001261","article-title":"Determinants of RNA quality from FFPE samples","volume":"2","author":"von Ahlfen","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2019.104284_bb0185","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1158\/0008-5472.CAN-05-4368","article-title":"15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer","volume":"66","author":"Wolf","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2019.104284_bb0190","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/ijc.21660","article-title":"Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray","volume":"118","author":"Wong","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2019.104284_bb0195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jmig.2014.05.010","article-title":"AAGL practice report: Morcellation during uterine tissue extraction","volume":"21","author":"Worldwide, A. A. M. I. G","year":"2014","journal-title":"J. Minim. Invasive Gynecol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019302436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019302436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:58:09Z","timestamp":1757991489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019302436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":39,"alternative-id":["S0014480019302436"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104284","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104284"}}