{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:25:33Z","timestamp":1785684333425,"version":"3.56.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009231","name":"Audrey and Theodor Geisel School of Medicine at Dartmouth","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008325","name":"Dartmouth-Hitchcock Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009230","name":"Norris Cotton Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.yexmp.2019.104320","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T10:57:27Z","timestamp":1571482647000},"page":"104320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease"],"prefix":"10.1016","volume":"111","author":[{"given":"Brian S.","family":"Hoyt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos D.","family":"Linos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Momtahen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravindhan","family":"Sriharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Anh N.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Tsongalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"O'Meara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2019.104320_bb0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1182\/asheducation-2015.1.565","article-title":"Treatment of Langerhans cell histiocytosis: role of BRAF\/MAPK inhibition","volume":"2015","author":"Abla","year":"2015","journal-title":"Hematology Am Soc Hematol Educ Program."},{"issue":"11","key":"10.1016\/j.yexmp.2019.104320_bb0010","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis","volume":"116","author":"Badalian-Very","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.yexmp.2019.104320_bb0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hon.2388","article-title":"The use of BRAF V600E mutation-specific immunohistochemistry in pediatric Langerhans cell histiocytosis","volume":"36","author":"Ballester","year":"2018","journal-title":"Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.yexmp.2019.104320_bb0020","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/bjd.17420","article-title":"BRAF V600E expression in juvenile xanthogranuloma occurring after Langerhans cell histiocytosis","volume":"180","author":"Bellinato","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"10","key":"10.1016\/j.yexmp.2019.104320_bb0025","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood-2014-05-577361","article-title":"High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis","volume":"124","author":"Brown","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.yexmp.2019.104320_bb0030","first-page":"201","article-title":"The non-Langerhans\u2019 cell histiocytoses in childhood","volume":"58","author":"Burgdorf","year":"1996","journal-title":"Cutis"},{"issue":"19","key":"10.1016\/j.yexmp.2019.104320_bb0035","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2014-05-577825","article-title":"Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis","volume":"124","author":"Chakraborty","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.yexmp.2019.104320_bb0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jaad.2015.11.007","article-title":"Cutaneous manifestations of Erdheim-Chester disease (ECD): clinical, pathological, and molecular features in a monocentric series of 40 patients","volume":"74","author":"Chasset","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.yexmp.2019.104320_bb0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/2159-8290.CD-15-0913","article-title":"Diverse and targetable kinase alterations drive histiocytic neoplasms","volume":"6","author":"Diamond","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.yexmp.2019.104320_bb0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1182\/blood-2018-99-114248","article-title":"Activating mutations in CSF1R and additional receptor tyrosine kinases in sporadic and familial histiocytic neoplasms","volume":"132","author":"Durham","year":"2018","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.yexmp.2019.104320_bb0060","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1182\/blood-2014-04-570937","article-title":"Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease","volume":"124","author":"Emile","year":"2014","journal-title":"Blood"},{"issue":"22","key":"10.1016\/j.yexmp.2019.104320_bb0065","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","volume":"127","author":"Emile","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.yexmp.2019.104320_bb0070","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.3324\/haematol.2018.190934","article-title":"BRAF V600E mutation detected in a case of Rosai-Dorfman disease","volume":"103","author":"Fatobene","year":"2018","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.yexmp.2019.104320_bb0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/his.12416","article-title":"Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms","volume":"65","author":"Go","year":"2014","journal-title":"Histopathology"},{"issue":"13","key":"10.1016\/j.yexmp.2019.104320_bb0080","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","article-title":"High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses","volume":"120","author":"Haroche","year":"2012","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.yexmp.2019.104320_bb0085","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1182\/blood-2015-01-625491","article-title":"Common cancer-associated PIK3CA activating mutations rarely occur in Langerhans cell histiocytosis","volume":"125","author":"Heritier","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.yexmp.2019.104320_bb0090","article-title":"Erdheim-Chester disease: expanding the spectrum of cutaneous manifestations","author":"Kobic","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"12","key":"10.1016\/j.yexmp.2019.104320_bb0095","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/bloodadvances.2019000093","article-title":"BRAF-V600E-mutated Rosai-Dorfman-Destombes disease and Langerhans cell histiocytosis with response to BRAF inhibitor","volume":"3","author":"Mastropolo","year":"2019","journal-title":"Blood Adv."},{"issue":"12","key":"10.1016\/j.yexmp.2019.104320_bb0100","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1097\/PAS.0000000000000304","article-title":"Activating BRAF V600E mutation in aggressive pediatric Langerhans cell histiocytosis: demonstration by allele-specific PCR\/direct sequencing and immunohistochemistry","volume":"38","author":"Mehes","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"issue":"3","key":"10.1016\/j.yexmp.2019.104320_bb0105","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.3324\/haematol.2018.201194","article-title":"Highly sensitive methods are required to detect mutations in histiocytoses","volume":"104","author":"Melloul","year":"2019","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.yexmp.2019.104320_bb0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/modpathol.2017.160","article-title":"The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort","volume":"31","author":"Ozkaya","year":"2018","journal-title":"Modern pathology\u202f: an official journal of the United States and Canadian Academy of Pathology, Inc."},{"key":"10.1016\/j.yexmp.2019.104320_bb0115","article-title":"Genomic analysis of C-group juvenile Xanthogranuloma family lesions identifies novel kinase alterations and distinctive morphologic patterns","volume":"66","author":"Picarsic","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"issue":"1","key":"10.1016\/j.yexmp.2019.104320_bb0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.25281","article-title":"BRAF mutation leading to central nervous system rosai-dorfman disease","volume":"84","author":"Richardson","year":"2018","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.yexmp.2019.104320_bb0125","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.semdp.2015.02.010","article-title":"BRAF V600E mutation-specific antibody: a review","volume":"32","author":"Ritterhouse","year":"2015","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.yexmp.2019.104320_bb0130","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.humpath.2017.04.026","article-title":"BRAF V600E mutation in pediatric intracranial and cranial juvenile xanthogranuloma","volume":"69","author":"Techavichit","year":"2017","journal-title":"Hum. Pathol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019306446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019306446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:53:07Z","timestamp":1757991187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019306446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":25,"alternative-id":["S0014480019306446"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104320","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BRAF V600E mutations are not an oncogenic driver of solitary xanthogranuloma and reticulohistiocytoma: Testing may be useful in screening for Erdheim-Chester disease","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2019.104320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104320"}}