{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:33:11Z","timestamp":1787797991294,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010036","name":"China-Japan Friendship Hospital Youth Science and Technology Excellence Project","doi-asserted-by":"publisher","award":["2015-QNYC-B-01"],"award-info":[{"award-number":["2015-QNYC-B-01"]}],"id":[{"id":"10.13039\/501100010036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","award":["2010-RC-01"],"award-info":[{"award-number":["2010-RC-01"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","award":["2014-3-QN-22"],"award-info":[{"award-number":["2014-3-QN-22"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400421"],"award-info":[{"award-number":["81400421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.yexmp.2020.104372","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T12:02:34Z","timestamp":1578398554000},"page":"104372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus"],"prefix":"10.1016","volume":"113","author":[{"given":"Ming","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2020.104372_bb0005","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1076\/0271-3683(200007)2111-ZFT543","article-title":"Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats","volume":"21","author":"Agardh","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.yexmp.2020.104372_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/md12010128","article-title":"Astaxanthin: sources, extraction, stability, biological activities and its commercial applications \u2013 a review","volume":"12","author":"Ambati","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.yexmp.2020.104372_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1034\/j.1600-079X.2002.01856.x","article-title":"Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus","volume":"32","author":"Baydas","year":"2002","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yexmp.2020.104372_bb0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00417-006-0293-7","article-title":"Evaluation of advanced glycation end-products in diabetic and inherited canine cataracts","volume":"245","author":"Bras","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.yexmp.2020.104372_bb0025","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1128\/am.17.5.707-709.1969","article-title":"Tube dilution antimicrobial susceptibility testing: efficacy of a microtechnique applicable to diagnostic laboratories","volume":"17","author":"Chitwood","year":"1969","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.yexmp.2020.104372_bb0030","doi-asserted-by":"crossref","first-page":"782137","DOI":"10.1155\/2013\/782137","article-title":"Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care","volume":"2013","author":"Ciccone","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexmp.2020.104372_bb0035","doi-asserted-by":"crossref","first-page":"782137","DOI":"10.1155\/2013\/782137","article-title":"Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care","volume":"2013","author":"Ciccone","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexmp.2020.104372_bb0040","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3390\/md11030960","article-title":"Astaxanthin attenuates the apoptosis of retinal ganglion cells in db\/db mice by inhibition of oxidative stress","volume":"11","author":"Dong","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.yexmp.2020.104372_bb0045","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1093\/emboj\/cdf418","article-title":"Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy","volume":"21","author":"Enge","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.yexmp.2020.104372_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2165\/00024677-200504040-00003","article-title":"Calcium dobesilate in the treatment of diabetic retinopathy","volume":"4","author":"Garay","year":"2005","journal-title":"Treat. Endocrinol."},{"key":"10.1016\/j.yexmp.2020.104372_bb0055","first-page":"453","article-title":"Malondialdehyde (MDA) as a lipid peroxidation marker","volume":"57","author":"Gawe\u0142","year":"2004","journal-title":"Wiad Lek"},{"key":"10.1016\/j.yexmp.2020.104372_bb0060","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.clinbiochem.2007.03.015","article-title":"Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract","volume":"40","author":"Hashim","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.yexmp.2020.104372_bb0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/02713683.2014.935445","article-title":"Effect of astaxanthin on cataract formation induced by glucocorticoids in the chick embryo","volume":"40","author":"Ishikawa","year":"2015","journal-title":"Curr. Eye Res."},{"issue":"9","key":"10.1016\/j.yexmp.2020.104372_bb0070","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3390\/nu10091320","article-title":"Astaxanthin inhibits mitochondrial dysfunction and Interleukin-8 expression in helicobacter pylori-infected gastric epithelial cells","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.yexmp.2020.104372_bb0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0167-7799(00)01433-5","article-title":"Commercial potential for haematococcus microalgae as a natural source of astaxanthin","volume":"18","author":"Lorenz","year":"2000","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.yexmp.2020.104372_bb0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jdiacomp.2010.09.001","article-title":"Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan diabetic rats","volume":"25","author":"Makni","year":"2011","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.yexmp.2020.104372_bb0085","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/md10061391","article-title":"Anti-oxidative, anti-tumor- promoting, and anti-carcinogenesis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite","volume":"10","author":"Maoka","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.yexmp.2020.104372_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/srep17192","article-title":"Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: a comparison with vitamin E","volume":"5","author":"Ni","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2020.104372_bb0095","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.amjcard.2008.02.010","article-title":"Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease","volume":"101","author":"Pashkow","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yexmp.2020.104372_bb0100","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1096\/fasebj.7.11.8370472","article-title":"Pericyte physiology","volume":"7","author":"Shepro","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/j.yexmp.2020.104372_bb0105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.pharep.2014.09.012","article-title":"Ability of natural astaxanthin from shrimp by-products to attenuate liver oxidative stress in diabetic rats","volume":"67","author":"Sila","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.yexmp.2020.104372_bb0110","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/er.2004-0028","article-title":"Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options","volume":"26","author":"Srivastava","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.yexmp.2020.104372_bb0115","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1167\/iovs.04-1304","article-title":"Curcumin and turmeric delaystreptozotocin-induced diabetic cataract in rats","volume":"46","author":"Suryanarayana","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexmp.2020.104372_bb0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cccn.2003.11.004","article-title":"Redox status and lipid peroxidation in alcoholic hypertensive patients and alcoholic hypertensive patients with diabetes","volume":"340","author":"Veerappan","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.yexmp.2020.104372_bb0125","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1021\/jf052651q","article-title":"Astaxanthin protects against oxidative stress and calcium-induced porcine lens protein degradation","volume":"54","author":"Wu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.yexmp.2020.104372_bb0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1476-511X-13-63","article-title":"A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats","volume":"13","author":"Xu","year":"2014","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.yexmp.2020.104372_bb0135","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1017\/S0007114514002554","article-title":"Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice","volume":"112","author":"Yang","year":"2014","journal-title":"Br. J. Nutr."},{"issue":"9","key":"10.1016\/j.yexmp.2020.104372_bb0140","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/jcmm.12609","article-title":"Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission","volume":"19","author":"Zhang","year":"2015","journal-title":"J. Cell. Mol. Med."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019304423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019304423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T03:06:45Z","timestamp":1757992005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019304423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":28,"alternative-id":["S0014480019304423"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2020.104372","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2020.104372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104372"}}