{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:07:23Z","timestamp":1790654843814,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2018dcyj071"],"award-info":[{"award-number":["2018dcyj071"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2018zzts897"],"award-info":[{"award-number":["2018zzts897"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.yexmp.2020.104450","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T13:54:03Z","timestamp":1589464443000},"page":"104450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["miR-155 facilitates calcium oxalate crystal-induced HK-2 cell injury via targeting PI3K associated autophagy"],"prefix":"10.1016","volume":"115","author":[{"given":"Xiong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Nan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Qing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Quan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2020.104450_bb0005","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2020.104450_bb0010","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yexmp.2020.104450_bb0015","doi-asserted-by":"crossref","first-page":"264","DOI":"10.15171\/jnp.2017.42","article-title":"Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis","volume":"6","author":"Ganji-Arjenaki","year":"2017","journal-title":"J. Nephropathol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0020","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaoncol.2015.0735","article-title":"The global burden of Cancer 2013","volume":"1","author":"Global Burden of Disease Cancer C","year":"2015","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0025","doi-asserted-by":"crossref","first-page":"295651","DOI":"10.1155\/2014\/295651","article-title":"Elevated levels of miR-155 in blood and urine from patients with nephrolithiasis","volume":"2014","author":"Hu","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.yexmp.2020.104450_bb0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cca.2017.01.028","article-title":"Autophagy: an overview and its roles in cancer and obesity","volume":"468","author":"Jacob","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.yexmp.2020.104450_bb0035","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1111\/jcmm.14094","article-title":"Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy","volume":"23","author":"Ji","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yexmp.2020.104450_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1615\/CritRevEukaryotGeneExpr.v13.i1.50","article-title":"Mechanisms mediating oxalate-induced alterations in renal cell functions","volume":"13","author":"Jonassen","year":"2003","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.yexmp.2020.104450_bb0045","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.juro.2012.05.078","article-title":"Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations","volume":"189","author":"Khan","year":"2013","journal-title":"J. Urol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0050","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.3892\/mmr.2017.7599","article-title":"Autophagy is activated to protect renal tubular epithelial cells against iodinated contrast mediainduced cytotoxicity","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexmp.2020.104450_bb0055","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000487678","article-title":"Inhibition of autophagy attenuated ethylene glycol induced crystals deposition and renal injury in a rat model of nephrolithiasis","volume":"43","author":"Liu","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.yexmp.2020.104450_bb0060","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.18632\/oncotarget.23383","article-title":"Inhibition of autophagy-attenuated calcium oxalate crystal-induced renal tubular epithelial cell injury in vivo and in vitro","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.yexmp.2020.104450_bb0065","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2020.104450_bb0070","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1884","article-title":"Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney","volume":"4","author":"Lu","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.yexmp.2020.104450_bb0075","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ki.2008.214","article-title":"Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells","volume":"74","author":"Periyasamy-Thandavan","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexmp.2020.104450_bb0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/toxsci\/kfs210","article-title":"Expression, circulation, and excretion profile of microRNA-21, \u2212155, and -18a following acute kidney injury","volume":"129","author":"Saikumar","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yexmp.2020.104450_bb0085","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ajur.2018.08.005","article-title":"Medical therapy for nephrolithiasis: state of the art","volume":"5","author":"Sorokin","year":"2018","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0090","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yexmp.2020.104450_bb0095","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1590\/S0100-879X2012007500165","article-title":"Circulating levels of inflammation-associated miR-155 and endothelial-enriched miR-126 in patients with end-stage renal disease","volume":"45","author":"Wang","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.yexmp.2020.104450_bb0100","first-page":"32","article-title":"miR-155 affects osteosarcoma MG-63 cell autophagy induced by adriamycin through regulating PTEN-PI3K\/AKT\/mTOR signaling pathway","volume":"33","author":"Wang","year":"2018","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.yexmp.2020.104450_bb0105","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1681\/ASN.2009060580","article-title":"Does idiopathic hypercalciuria trigger calcium-sensing receptor-mediated protection from urinary supersaturation?","volume":"20","author":"Worcester","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/02713680903584686","article-title":"Involvement of the PI3K\/Akt signaling pathway in platelet-derived growth factor-induced migration of human lens epithelial cells","volume":"35","author":"Xiong","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.yexmp.2020.104450_bb0115","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tox.2013.07.017","article-title":"Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro","volume":"312","author":"Yang","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.yexmp.2020.104450_bb0120","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1681\/ASN.2004110991","article-title":"Regulation of renal calcium receptor gene expression by 1,25-dihydroxyvitamin D3 in genetic hypercalciuric stone-forming rats","volume":"16","author":"Yao","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2020.104450_bb0125","first-page":"2798","article-title":"MicroRNA155 promotes oxLDLinduced autophagy in human umbilical vein endothelial cells by targeting the PI3K\/Akt\/mTOR pathway","volume":"18","author":"Yin","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yexmp.2020.104450_bb0130","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.molonc.2016.08.005","article-title":"Autophagy inhibition upregulates CD4(+) tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation","volume":"10","author":"Zarogoulidis","year":"2016","journal-title":"Mol. Oncol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019308901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480019308901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:00:23Z","timestamp":1762146023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480019308901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":26,"alternative-id":["S0014480019308901"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2020.104450","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-155 facilitates calcium oxalate crystal-induced HK-2 cell injury via targeting PI3K associated autophagy","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2020.104450","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104450"}}