{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:02:44Z","timestamp":1793977364409,"version":"4.8.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2020-67017-37723"],"award-info":[{"award-number":["2020-67017-37723"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD030269"],"award-info":[{"award-number":["S10OD030269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.yexmp.2025.104953","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:30:24Z","timestamp":1738884624000},"page":"104953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A\/J mice"],"prefix":"10.1016","volume":"141","author":[{"given":"Weimin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Crossland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy W.","family":"Crott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2025.104953_bb0005","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/pmic.200800971","article-title":"Generation of high-quality protein extracts from formalin-fixed, paraffin-embedded tissues","volume":"9","author":"Addis","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.yexmp.2025.104953_bb0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1534\/genetics.117.300536","article-title":"Improving metabolic health through precision dietetics in mice","volume":"208","author":"Barrington","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.yexmp.2025.104953_bb0015","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/carcin\/21.11.1965","article-title":"Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats","volume":"21","author":"Caderni","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2025.104953_bb0020","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1017\/S0007114511005812","article-title":"Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people","volume":"108","author":"Camargo","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.yexmp.2025.104953_bb0025","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00394-018-1674-5","article-title":"Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer","volume":"58","author":"Castello","year":"2019","journal-title":"Eur. J. Nutr."},{"issue":"1999\u20132014","key":"10.1016\/j.yexmp.2025.104953_bb0030","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2025.104953_bb0035","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.292.12.1440","article-title":"Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial","volume":"292","author":"Esposito","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.yexmp.2025.104953_bb0040","first-page":"4446","article-title":"Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase","volume":"40","author":"Feinberg","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2025.104953_bb0045","doi-asserted-by":"crossref","first-page":"G1150","DOI":"10.1152\/ajpgi.00269.2006","article-title":"Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt\/beta-catenin signaling in rats","volume":"292","author":"Fujise","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mrfmmm.2004.04.021","article-title":"Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1","volume":"569","author":"Gonzalez","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yexmp.2025.104953_bb0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/joim.13333","article-title":"The Mediterranean diet and health: a comprehensive overview","volume":"290","author":"Guasch-Ferre","year":"2021","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.yexmp.2025.104953_bb0060","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/ije\/dyx155","article-title":"The Mediterranean diet and risk of colorectal cancer in the UK Women\u2019s cohort study","volume":"46","author":"Jones","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0065","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2025.104953_bb0070","doi-asserted-by":"crossref","first-page":"E1118","DOI":"10.1152\/ajpendo.00585.2012","article-title":"Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver","volume":"304","author":"Konstandi","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yexmp.2025.104953_bb0075","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","article-title":"Role of CYP2E1 in the hepatotoxicity of acetaminophen","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2025.104953_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.yexmp.2025.104953_bb0085","article-title":"Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on liver lipid disorders in obese mice","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.yexmp.2025.104953_bb0090","first-page":"G455","article-title":"Azoxymethane-induced fulminant hepatic failure in C57BL\/6J mice: characterization of a new animal model","volume":"277","author":"Matkowskyj","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0095","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/carcin\/12.6.969","article-title":"Effect of disulfiram on 1,2-dimethylhydrazine- and azoxymethane-induced aberrant crypt foci","volume":"12","author":"McLellan","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2025.104953_bb0100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1021\/tx4004769","article-title":"Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice","volume":"27","author":"Megaraj","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0105","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1158\/1940-6207.CAPR-16-0026","article-title":"Effects of walnut consumption on Colon carcinogenesis and microbial community structure","volume":"9","author":"Nakanishi","year":"2016","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.yexmp.2025.104953_bb0110","first-page":"145","article-title":"Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic\/knockout progenitors","volume":"22","author":"Nambiar","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0115","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/ijc.31837","article-title":"Chemopreventive role of olive oil in colon carcinogenesis by targeting noncoding RNAs and methylation machinery","volume":"144","author":"Nanda","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yexmp.2025.104953_bb0120","first-page":"E4","article-title":"Foods of the Mediterranean diet: tomato, olives, chili pepper, wheat flour and wheat germ","volume":"63","author":"Naureen","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"10.1016\/j.yexmp.2025.104953_bb0125","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/nprot.2007.279","article-title":"An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression","volume":"2","author":"Neufert","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yexmp.2025.104953_bb0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1369\/jhc.2009.954321","article-title":"The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells","volume":"58","author":"Paavilainen","year":"2010","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.yexmp.2025.104953_bb0135","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fonc.2019.00140","article-title":"A Mediterranean diet mix has Chemopreventive effects in a murine model of colorectal Cancer modulating apoptosis and the gut microbiota","volume":"9","author":"Piazzi","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0140","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/bjc.2016.245","article-title":"Mediterranean diet and colorectal cancer risk: a pooled analysis of three Italian case-control studies","volume":"115","author":"Rosato","year":"2016","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.yexmp.2025.104953_bb0150","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/bph.14778","article-title":"Mediterranean diet and health status: active ingredients and pharmacological mechanisms","volume":"177","author":"Schwingshackl","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.yexmp.2025.104953_bb0145","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/nu9101063","article-title":"Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis","volume":"9","author":"Schwingshackl","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.yexmp.2025.104953_bb0155","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.3748\/wjg.v20.i23.7339","article-title":"Mediterranean diet and non-alcoholic fatty liver disease: new therapeutic option around the corner?","volume":"20","author":"Sofi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yexmp.2025.104953_bb0160","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/carcin\/12.1.127","article-title":"Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1","volume":"12","author":"Sohn","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yexmp.2025.104953_bb0165","first-page":"8435","article-title":"Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol","volume":"61","author":"Sohn","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.yexmp.2025.104953_bb0170","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2010.01.058","article-title":"Inflammation and colon cancer","volume":"138","author":"Terzic","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yexmp.2025.104953_bb0175","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1158\/1940-6207.CAPR-16-0209","article-title":"Targeting inflammation in Cancer prevention and therapy","volume":"9","author":"Todoric","year":"2016","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.yexmp.2025.104953_bb0180","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/mnfr.201200130","article-title":"Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-kappaB and regulating Nrf2\/HO-1 pathway","volume":"56","author":"Tuzcu","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.yexmp.2025.104953_bb0185","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-024-01296-9","article-title":"Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2217404 participants","author":"Ungvari","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.yexmp.2025.104953_bb0190","doi-asserted-by":"crossref","first-page":"1402S","DOI":"10.1093\/ajcn\/61.6.1402S","article-title":"Mediterranean diet pyramid: a cultural model for healthy eating","volume":"61","author":"Willett","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2025.104953_bb0195","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00204-021-02972-x","article-title":"Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in collaborative cross mice","volume":"95","author":"Zhong","year":"2021","journal-title":"Arch. Toxicol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:48:16Z","timestamp":1749944896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480025000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":39,"alternative-id":["S0014480025000024"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.104953","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A\/J mice","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.104953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104953"}}