{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:53:47Z","timestamp":1793926427984,"version":"4.8.0"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yexmp.2025.105002","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:49:07Z","timestamp":1760014147000},"page":"105002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Genetic and epigenetic determinants of fetal alcohol spectrum disorders: Toward a precision medicine approach"],"prefix":"10.1016","volume":"144","author":[{"given":"Francesco","family":"Sessa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carotenuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Ferorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristoforo","family":"Pomara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2025.105002_bb0005","doi-asserted-by":"crossref","DOI":"10.2174\/1874467208666150817111114","article-title":"Role of CYP2E1 in mitochondrial dysfunction and hepatic injury by alcohol and non-alcoholic substances","volume":"10","author":"Abdelmegeed","year":"2017","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0010","series-title":"Gene-Environment Interactions, Tasmans Psychiatry Fifth Edition","author":"Abubucker","year":"2024"},{"key":"10.1016\/j.yexmp.2025.105002_bb0015","article-title":"Pharmacological activators of ALDH2: a new strategy for the treatment of alcohol use disorders","author":"Adasme-Reyes","year":"2024","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.nsa.2024.104064","article-title":"Translational models of stress and resilience: an applied neuroscience methodology review","volume":"3","author":"Albayrak","year":"2024","journal-title":"Neurosci. Appl."},{"key":"10.1016\/j.yexmp.2025.105002_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.671891","article-title":"Epigenetic impacts of early life stress in fetal alcohol spectrum disorders shape the neurodevelopmental continuum","author":"Alberry","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0030","doi-asserted-by":"crossref","DOI":"10.1007\/s42452-025-06625-x","article-title":"Artificial intelligence in personalized medicine: transforming diagnosis and treatment","author":"Alum","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0035","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2148-8-169","article-title":"Phylogenetic studies of the genus Cebus (Cebidae-Primates) using chromosome painting and G-banding","volume":"8","author":"Amaral","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/biom14060697","article-title":"Exploring therapeutic potential of catalase: strategies in disease prevention and management","volume":"14","author":"Anwar","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.yexmp.2025.105002_bb0045","article-title":"Blood catalase, superoxide dismutase, and glutathione peroxidase activities in alcohol- and opioid-addicted patients","volume":"61","author":"Asatiani","year":"2025","journal-title":"Med. Lithuania"},{"key":"10.1016\/j.yexmp.2025.105002_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020256","article-title":"Impact of prenatal alcohol exposure on the development and myocardium of adult mice: morphometric changes, transcriptional modulation of genes related to cardiac dysfunction, and antioxidant cardioprotection","volume":"12","author":"Atum","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.yexmp.2025.105002_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12121634","article-title":"Effects of genetics and sex on acute gene expression changes in the hippocampus following neonatal ethanol exposure in BXD recombinant inbred mouse strains","volume":"12","author":"Baker","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/genes8060150","article-title":"Maternal factors that induce epigenetic changes contribute to neurological disorders in offspring","author":"Banik","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/genes12060887","article-title":"Epigenetic changes induced by maternal factors during fetal life: implication for type 1 diabetes","author":"Barchetta","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0070","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1038\/npp.2016.119","article-title":"Genotype-dependent effects of COMT inhibition on cognitive function in a highly specific, novel mouse model of altered COMT activity","volume":"41","author":"Barkus","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yexmp.2025.105002_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.884197","article-title":"Acute ethanol challenge differentially regulates expression of growth factors and miRNA expression profile of whole tissue of the dorsal hippocampus","volume":"16","author":"Barney","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0080","article-title":"Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE)","volume":"23","author":"Bonaventure","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.yexmp.2025.105002_bb0085","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.7b00115","article-title":"Class i HDAC inhibitors: potential new epigenetic therapeutics for alcohol use disorder (AUD)","author":"Bourguet","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.yexmp.2025.105002_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-024-00626-y","article-title":"Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton","volume":"15","author":"Bourne","year":"2024","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.yexmp.2025.105002_bb0095","doi-asserted-by":"crossref","DOI":"10.1093\/aje\/kwq226","article-title":"Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001","volume":"172","author":"Boyles","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.alcohol.2011.09.027","article-title":"Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover","volume":"46","author":"Bustamante","year":"2012","journal-title":"Alcohol"},{"key":"10.1016\/j.yexmp.2025.105002_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainresbull.2016.04.006","article-title":"Behavioral sensitization to ethanol: neural basis and factors that influence its acquisition and expression","volume":"125","author":"Camarini","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.yexmp.2025.105002_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2015.08.015","article-title":"Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF+\/- mice","volume":"155","author":"Caputi","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.yexmp.2025.105002_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12060792","article-title":"Autism spectrum disorder and fetal alcohol spectrum disorder: a literature review","author":"Carpita","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajcnut.2023.10.027","article-title":"The critical need for novel precision medicine methodologies in fetal alcohol spectrum disorders","author":"Carter","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2025.105002_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148854","article-title":"Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in a south African population","volume":"931","author":"Carter","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.yexmp.2025.105002_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.alcohol.2012.03.003","article-title":"A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in northern Spain","volume":"46","author":"Celorrio","year":"2012","journal-title":"Alcohol"},{"key":"10.1016\/j.yexmp.2025.105002_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2261-12-58","article-title":"Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption","volume":"12","author":"Chang","year":"2012","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.yexmp.2025.105002_bb0140","doi-asserted-by":"crossref","DOI":"10.1080\/03602532.2019.1632889","article-title":"A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism","author":"Chen","year":"2019","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0145","article-title":"Alcohol consumption, ALDH2 polymorphism as risk factors for upper aerodigestive tract cancer progression and prognosis","author":"Chen","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.yexmp.2025.105002_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-024-03390-3","article-title":"First-trimester fetal size, accelerated growth in utero, and child neurodevelopment in a cohort study","volume":"22","author":"Chen","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0155","article-title":"Orexin system: the key for a healthy life","author":"Chieffi","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/hep4.1066","article-title":"Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress","volume":"1","author":"Cho","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.yexmp.2025.105002_bb0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-023-09721-7","article-title":"Genetic influences on alcohol flushing in east Asian populations","volume":"24","author":"Cho","year":"2023","journal-title":"BMC Genomics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0170","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.114.086603","article-title":"High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice","volume":"101","author":"Christensen","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2025.105002_bb0175","article-title":"Toxic and teratogenic effects of prenatal alcohol exposure on fetal development, adolescence and adulthood","author":"Chung","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/genes16050489","article-title":"Interrelation of oxidative stress and genetics in pathophysiology of obesity and obesity-related conditions","volume":"16","author":"\u010colak","year":"2025","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11071258","article-title":"Ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system","author":"Contreras-Zentella","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.yexmp.2025.105002_bb0190","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2013.5811","article-title":"The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease","author":"Dani","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yexmp.2025.105002_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115826","article-title":"Fetal brain-derived Exosomal miRNAs from maternal blood: potential diagnostic biomarkers for fetal alcohol spectrum disorders (FASDs)","volume":"25","author":"Darbinian","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115826","article-title":"Fetal brain-derived exosomal miRNAs from maternal blood: potential diagnostic biomarkers for fetal alcohol spectrum disorders (FASDs)","volume":"25","author":"Darbinian","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0205","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/GRF.0000000000000414","article-title":"Alcohol use in pregnancy","volume":"62","author":"Dejong","year":"2019","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0210","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-024-01635-9","article-title":"Epigenetics of prenatal stress in humans: the current research landscape","author":"Dieckmann","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0215","article-title":"Screening for alcohol use in pregnancy: a review of current practices and perspectives","volume":"1\u201320","author":"Dozet","year":"2021","journal-title":"Int. J. Ment. Heal. Addict."},{"key":"10.1016\/j.yexmp.2025.105002_bb0220","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfn269","article-title":"Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes","volume":"108","author":"Duale","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2013.86","article-title":"Genetics and alcoholism","author":"Edenberg","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0230","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/00952990.2012.694526","article-title":"ADH and ALDH polymorphisms and alcohol dependence in Mexican and native Americans","volume":"38","author":"Ehlers","year":"2012","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.yexmp.2025.105002_bb0235","article-title":"Gene-alcohol interactions in birth defects","author":"Everson","year":"2023","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11010145","article-title":"Alcohol and head and neck cancer: updates on the role of oxidative stress, genetic, epigenetics, oral microbiota, antioxidants, and alkylating agents","author":"Ferraguti","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.yexmp.2025.105002_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/ejcn.2012.173","article-title":"Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European prospective investigation into cancer and nutrition study","volume":"66","author":"Ferrari","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.yexmp.2025.105002_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/acer.14490","article-title":"A systematic review of interventions to improve mental health and substance use outcomes for individuals with prenatal alcohol exposure and fetal alcohol spectrum disorder","author":"Flannigan","year":"2020","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2014.10.002","article-title":"Intestinal CYP2E1: a mediator of alcohol-induced gut leakiness","author":"Forsyth","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2018.00125","article-title":"Prenatal alcohol exposure is associated with adverse cognitive effects and distinct whole-genome DNA methylation patterns in primary school children","volume":"12","author":"Frey","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/jox15010020","article-title":"Effects of chronic alcohol intake on the composition of the ensemble of drug-metabolizing enzymes and transporters in the human liver","volume":"15","author":"Gaither","year":"2025","journal-title":"J. Xenobiot."},{"key":"10.1016\/j.yexmp.2025.105002_bb0270","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.3c00648","article-title":"Wiring and volume transmission: an overview of the dual modality for serotonin neurotransmission","author":"Gianni","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0275","series-title":"Neuroscience of Alcohol: Mechanisms and Treatment","article-title":"Ethanol exposure during development, and brain oxidative stress","author":"Gil-Mohapel","year":"2019"},{"key":"10.1016\/j.yexmp.2025.105002_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2018.05.006","article-title":"Personalized medicine: motivation, challenges, and progress","author":"Goetz","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.yexmp.2025.105002_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25074100","article-title":"Oxidative effects in early stages of embryo development due to alcohol consumption","volume":"25","author":"Gonz\u00e1lez-Flores","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0290","article-title":"Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population","volume":"12","author":"Govind","year":"2020","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0295","doi-asserted-by":"crossref","DOI":"10.1038\/s43856-024-00513-y","article-title":"Machine learning-based health environmental-clinical risk scores in European children","volume":"4","author":"Guimbaud","year":"2024","journal-title":"Commun. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2013.03.010","article-title":"Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer","volume":"37","author":"Hakenewerth","year":"2013","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.tics.2006.02.011","article-title":"Genetics of emotional regulation: the role of the serotonin transporter in neural function","author":"Hariri","year":"2006","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0310","doi-asserted-by":"crossref","DOI":"10.1265\/ehpm.22-00276","article-title":"ALDH2 rs671 variant allele is associated with higher energy intake in middle-aged and elderly Japanese who routinely consume alcohol","volume":"28","author":"Hayashida","year":"2023","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-022-02050-y","article-title":"Aldehyde dehydrogenase 2 rs671 polymorphism and multiple diseases: protocol for a quantitative umbrella review of meta-analyses","volume":"11","author":"He","year":"2022","journal-title":"Syst. Rev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0320","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-007-5881-0_8","article-title":"The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system","volume":"67","author":"Heit","year":"2013","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.yexmp.2025.105002_bb0325","doi-asserted-by":"crossref","DOI":"10.24105\/apr.2019.5.23","article-title":"Twin study confirms virtually identical prenatal alcohol exposures can lead to markedly different fetal alcohol spectrum disorder outcomes-fetal genetics influences fetal vulnerability","volume":"05","author":"Hemingway","year":"2018","journal-title":"Adv. Pediatr. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66048-z","article-title":"Genetic variants associated with alcohol dependence co-ordinate regulation of ADH genes in gastrointestinal and adipose tissues","volume":"10","author":"Hibberd","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2025.105002_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2021.12.024","article-title":"Behavioral consequences of the downstream products of ethanol metabolism involved in alcohol use disorder","volume":"133","author":"Holbrook","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfma.2018.03.007","article-title":"No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population","volume":"117","author":"Huang","year":"2018","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.yexmp.2025.105002_bb0345","doi-asserted-by":"crossref","DOI":"10.1176\/appi.neuropsych.19100211","article-title":"Effect of functional bdnf and comt polymorphisms on symptoms and regional brain volume in frontotemporal dementia and corticobasal syndrome","volume":"32","author":"Huey","year":"2020","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0350","series-title":"Alcohol and Alcohol-Related Diseases","article-title":"The genetics of alcohol-related liver disease","author":"Innes","year":"2023"},{"key":"10.1016\/j.yexmp.2025.105002_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108359","article-title":"The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse","author":"James","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yexmp.2025.105002_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12020448","article-title":"The orexin\/hypocretin system, the peptidergic regulator of vigilance, orchestrates adaptation to stress","author":"J\u00e1szber\u00e9nyi","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.yexmp.2025.105002_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105086","article-title":"A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals","volume":"103","author":"Jennings","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.yexmp.2025.105002_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8030050","article-title":"Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease","author":"Jiang","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.yexmp.2025.105002_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.hrthm.2022.05.008","article-title":"Aldehyde dehydrogenase 2 and arrhythmogenesis","volume":"19","author":"Jin","year":"2022","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.yexmp.2025.105002_bb0380","article-title":"Identifying prenatal alcohol exposure and children affected by it: a review of biomarkers and screening tools","volume":"43","author":"Kable","year":"2023","journal-title":"Alcohol Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.advms.2018.08.010","article-title":"Serotonin transporter gene linked polymorphism (5-HTTLPR) determines progredience of alcohol dependence in Belarusian young males","volume":"64","author":"Kapitau","year":"2019","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0390","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.326","article-title":"Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population","volume":"5","author":"Katsarou","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.yexmp.2025.105002_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2012.00078","article-title":"The role of orexins\/hypocretins in alcohol use and abuse: an appetitive-reward relationship","author":"Kim","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0400","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-0716-2613-9_10","article-title":"Nutrition intervention as a preventative approach to fetal alcohol spectrum disorder","author":"Kloss","year":"2022","journal-title":"Neuromethods"},{"key":"10.1016\/j.yexmp.2025.105002_bb0405","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.763363","article-title":"Maintenance of complex trait variation: classic theory and modern data","author":"Koch","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.yexmp.2025.105002_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-021-01137-9","article-title":"Development of prefrontal cortex","author":"Kolk","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yexmp.2025.105002_bb0415","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2025.2493865","article-title":"Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes","volume":"20","author":"Koo","year":"2025","journal-title":"Epigenetics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2024.1397352","article-title":"Inside the genome: understanding genetic influences on oxidative stress","volume":"15","author":"Krishnamurthy","year":"2024","journal-title":"Front. Genet."},{"key":"10.1016\/j.yexmp.2025.105002_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/genes14071392","article-title":"ADH1B, ADH1B\/C and CYP2E1 gene polymorphism and the risk of fetal alcohol spectrum disorder","volume":"14","author":"Kukowka","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0430","doi-asserted-by":"crossref","DOI":"10.1093\/alcalc\/agad077","article-title":"Alcohol metabolism in alcohol use disorder: a potential therapeutic target","author":"Lehner","year":"2024","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0435","doi-asserted-by":"crossref","DOI":"10.1186\/s40659-023-00473-y","article-title":"Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming","author":"Liu","year":"2023","journal-title":"Biol. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0440","article-title":"The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in east Asian population: an updated meta-analysis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0445","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/a-2551-3320","article-title":"Alcohol-metabolizing enzymes, liver diseases and Cancer","volume":"45","author":"Liu","year":"2025","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.yexmp.2025.105002_bb0450","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfs164","article-title":"Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway","volume":"128","author":"Lu","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2008.12.021","article-title":"Origin and dispersal of atypical aldehyde dehydrogenase ALDH2*487Lys","volume":"435","author":"Luo","year":"2009","journal-title":"Gene"},{"key":"10.1016\/j.yexmp.2025.105002_bb0460","doi-asserted-by":"crossref","DOI":"10.2217\/epi-2016-0163","article-title":"Epigenetics studies of fetal alcohol spectrum disorder: where are we now?","author":"Lussier","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00610","article-title":"Prenatal alcohol exposure: profiling developmental DNA methylation patterns in central and peripheral tissues","volume":"9","author":"Lussier","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.yexmp.2025.105002_bb0470","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.788630","article-title":"Intersection of epigenetic and immune alterations: implications for fetal alcohol spectrum disorder and mental health","author":"Lussier","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0475","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-80734-y","article-title":"Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders","volume":"11","author":"Mahnke","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2025.105002_bb0480","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-80734-y","article-title":"Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders","volume":"11","author":"Mahnke","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2025.105002_bb0485","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2009.92","article-title":"Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge","volume":"34","author":"Markus","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yexmp.2025.105002_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16030332","article-title":"Advancing precision medicine: a review of innovative in silico approaches for drug development, clinical pharmacology and personalized healthcare","author":"Marques","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0495","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13121610","article-title":"Exploring the role of neuroplasticity in development, aging, and neurodegeneration","author":"Marzola","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0500","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0332-6","article-title":"Impaired dopamine metabolism in Parkinson\u2019s disease pathogenesis","author":"Masato","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.yexmp.2025.105002_bb0505","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-025-01569-7","article-title":"Ethanol-induced depression: exploring the underlying molecular mechanisms","volume":"45","author":"Mashayekhi-sardoo","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0510","doi-asserted-by":"crossref","DOI":"10.1111\/acer.14040","article-title":"Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure","author":"Mattson","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0515","doi-asserted-by":"crossref","first-page":"208.e1","DOI":"10.1016\/j.anpede.2020.12.012","article-title":"Neurocognitive and behavioral profile of fetal alcohol spectrum disorder","volume":"95","author":"Maya-Enero","year":"2021","journal-title":"Anal. Pediatr. (English Edition)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0520","doi-asserted-by":"crossref","DOI":"10.1007\/s00787-018-1264-3","article-title":"The causal web of foetal alcohol spectrum disorders: a review and causal diagram","author":"McQuire","year":"2020","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.yexmp.2025.105002_bb0525","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/acer.15487","article-title":"Maternal alcohol consumption during pregnancy and child development: role of ADH1B and ALDH2 gene polymorphisms\u2014the Yamanashi adjunct study of the Japan environment and children\u2019s study","volume":"49","author":"Miyake","year":"2025","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0530","doi-asserted-by":"crossref","DOI":"10.1007\/s00438-013-0808-y","article-title":"Genetics and genomics of alcohol sensitivity","author":"Morozova","year":"2014","journal-title":"Mol. Gen. Genomics."},{"key":"10.1016\/j.yexmp.2025.105002_bb0535","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1093\/nutrit\/nuab119","article-title":"Effects of nutrition and gestational alcohol consumption on fetal growth and development","volume":"80","author":"Naik","year":"2022","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.mjafi.2021.06.021","article-title":"Precision medicine: concept and tools","author":"Naithani","year":"2021","journal-title":"Med. J. Armed Forces India"},{"key":"10.1016\/j.yexmp.2025.105002_bb0545","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9613090","article-title":"Role of catalase in oxidative stress- and age-associated degenerative diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0550","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9613090","article-title":"Role of catalase in oxidative stress- and age-associated degenerative diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0555","article-title":"Impaired regulation of ALDH2 protein expression revealing a yet unknown epigenetic impact of rs886205 on specific methylation of a negative regulatory promoter region in alcohol-dependent patients","volume":"22","author":"Nassab","year":"2016","journal-title":"Eur. Addict. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0560","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214529","article-title":"Alcohol drinking patterns and laboratory indices of health: does type of alcohol preferred make a difference?","volume":"14","author":"Niemel\u00e4","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.yexmp.2025.105002_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2014.07.010","article-title":"Maternal aldehyde elimination during pregnancy preserves the fetal genome","volume":"55","author":"Oberbeck","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yexmp.2025.105002_bb0570","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0575","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/00952990.2024.2361442","article-title":"New therapeutics for the prevention or amelioration of fetal alcohol spectrum disorders: a narrative review of the preclinical literature","volume":"50","author":"Olivares-Costa","year":"2024","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.yexmp.2025.105002_bb0580","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1054333","article-title":"Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features","volume":"13","author":"Papasavva","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0585","doi-asserted-by":"crossref","DOI":"10.1080\/09637486.2019.1680958","article-title":"Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer","volume":"71","author":"Pascual-Geler","year":"2020","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.yexmp.2025.105002_bb0590","article-title":"Promoter polymorphism rs886205 genotype interacts with DNA methylation of the ALDH2 regulatory region in alcohol dependence","volume":"52","author":"Pathak","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0595","series-title":"Systems Biology of Free Radicals and Antioxidants","article-title":"Oxidative stress in fetal alcohol spectrum disorders - Insights for the development of antioxidant-based therapies","author":"Patten","year":"2012"},{"key":"10.1016\/j.yexmp.2025.105002_bb0600","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2017.00081","article-title":"Mystic acetaldehyde: the never-ending story on alcoholism","volume":"11","author":"Peana","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0605","doi-asserted-by":"crossref","DOI":"10.1007\/s13277-013-0788-x","article-title":"Associations of CYP2E1 rs2031920 and rs3813867 polymorphisms with colorectal cancer risk: a systemic review and meta-analysis","volume":"34","author":"Peng","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0610","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.26501","article-title":"Examining the effects of prenatal alcohol exposure on performance of the sustained attention to response task in children with an FASD","volume":"44","author":"Pinner","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.yexmp.2025.105002_bb0615","doi-asserted-by":"crossref","DOI":"10.1093\/alcalc\/agu088","article-title":"Genetic variability in CYP2E1 and catalase gene among currently and formerly alcohol-dependent male subjects","volume":"50","author":"Plemenitas","year":"2015","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0620","doi-asserted-by":"crossref","first-page":"171","DOI":"10.17816\/fm16109","article-title":"Facial changes in individuals deceased from ethanol poisoning","volume":"10","author":"Plis","year":"2024","journal-title":"Russ. J. Forens. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0625","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.32523","article-title":"ADH1B: from alcoholism, natural selection, and cancer to the human phenome","author":"Polimanti","year":"2018","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.yexmp.2025.105002_bb0630","doi-asserted-by":"crossref","DOI":"10.1007\/s10517-013-2239-5","article-title":"CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse","volume":"155","author":"Polonikov","year":"2013","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0635","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1016\/S2214-109X(17)30021-9","article-title":"Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis","volume":"5","author":"Popova","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.yexmp.2025.105002_bb0640","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103452","article-title":"Alcohol\u2019s impact on the fetus","author":"Popova","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.yexmp.2025.105002_bb0645","doi-asserted-by":"crossref","DOI":"10.1111\/acer.15266","article-title":"A critical review of ethanol effects on neuronal firing: a metabolic perspective","author":"Popova","year":"2024","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0650","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neubiorev.2018.07.004","article-title":"Environmental stressors and alcoholism development: focus on molecular targets and their epigenetic regulation","volume":"106","author":"Pucci","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0655","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00187.2007","article-title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective","volume":"293","author":"Quintanilla","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yexmp.2025.105002_bb0660","doi-asserted-by":"crossref","first-page":"G123","DOI":"10.1152\/ajpgi.00144.2021","article-title":"Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites","volume":"321","author":"Ramamoorthy","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0665","article-title":"Neurotoxic effects of alcohol and acetaldehyde during embryonic development","volume":"68","author":"Rhee","year":"2005","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.yexmp.2025.105002_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2023.100603","article-title":"Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: translational outcomes in brain and behavior","volume":"29","author":"Rice","year":"2024","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.yexmp.2025.105002_bb0675","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022578","article-title":"Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD)","volume":"8","author":"Roozen","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.yexmp.2025.105002_bb0680","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/npp.2014.147","article-title":"Developmental consequences of fetal exposure to drugs: what we know and what we still must learn","volume":"40","author":"Ross","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yexmp.2025.105002_bb0685","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-024-05507-x","article-title":"Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge","volume":"22","author":"Rwere","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0690","doi-asserted-by":"crossref","DOI":"10.3390\/cells14100699","article-title":"Molecular effect of variants in serotonin transporter gene in women with alcohol use disorder","volume":"14","author":"Rychel","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.yexmp.2025.105002_bb0695","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12071316","article-title":"N-acetylcysteine pharmacology and applications in rare diseases\u2014repurposing an old antioxidant","author":"Sahasrabudhe","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.yexmp.2025.105002_bb0700","doi-asserted-by":"crossref","DOI":"10.3390\/genes14010195","article-title":"Genetic influences on fetal alcohol Spectrum disorder","author":"Sambo","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0705","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.alcohol.2021.10.004","article-title":"The role of context on responding to an alcohol-predictive cue in female and male rats","volume":"99","author":"Segal","year":"2022","journal-title":"Alcohol"},{"key":"10.1016\/j.yexmp.2025.105002_bb0710","article-title":"Understanding the relationship between fetal alcohol spectrum disorder (FASD) and criminal justice: a systematic review","volume":"10","author":"Sessa","year":"2022","journal-title":"Healthcare (Switzerland)"},{"key":"10.1016\/j.yexmp.2025.105002_bb0715","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076781","article-title":"New insight into mechanisms of cardiovascular diseases: an integrative analysis approach to identify TheranoMiRNAs","volume":"24","author":"Sessa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0720","article-title":"Ethical, legal and social implications (ELSI) regarding forensic genetic investigations (FGIs)","author":"Sessa","year":"2024","journal-title":"J. Acad. Ethics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0725","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2017.0717","article-title":"BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders","author":"Shen","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.yexmp.2025.105002_bb0730","doi-asserted-by":"crossref","DOI":"10.1002\/ped4.12367","article-title":"Developmental origins of health and disease: impact of paternal nutrition and lifestyle","author":"Shi","year":"2023","journal-title":"Pediatr. Investig."},{"key":"10.1016\/j.yexmp.2025.105002_bb0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121720","article-title":"Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease","volume":"288","author":"Shi","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexmp.2025.105002_bb0740","doi-asserted-by":"crossref","DOI":"10.3349\/ymj.2017.58.4.689","article-title":"Alcohol consumption, aldehyde dehydrogenase 2 gene polymorphisms, and cardiovascular health in Korea","author":"Shin","year":"2017","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.yexmp.2025.105002_bb0745","article-title":"Postnatal ethanol exposure activates hdacmediated histone deacetylation, impairs synaptic plasticity gene expression and behavior in mice","volume":"23","author":"Shivakumar","year":"2021","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0750","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084262","article-title":"The molecular basis of alcohol use disorder (Aud). genetics, epigenetics, and nutrition in aud: an amazing triangle","author":"Siomek-Gorecka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0755","doi-asserted-by":"crossref","DOI":"10.35946\/arcr.v45.1.07","article-title":"Nonconceptus mechanisms of prenatal alcohol exposure that disrupt embryo-fetal development: an integrative view","author":"Smith","year":"2025","journal-title":"Alcohol Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0760","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.reprotox.2022.03.002","article-title":"Prenatal ethanol exposure induces dynamic changes of expression and activity of hepatic cytochrome P450 isoforms in male rat offspring","volume":"109","author":"Sun","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0765","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtho.2018.12.023","article-title":"Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk","volume":"14","author":"Suo","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0770","article-title":"Italian guidelines for the diagnosis and treatment of fetal alcohol spectrum disorders: structural abnormalities","volume":"221\u2013229","author":"Terracina","year":"2024","journal-title":"Riv. Psichiatr."},{"key":"10.1016\/j.yexmp.2025.105002_bb0775","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13040410","article-title":"The impact of oxidative stress on the epigenetics of fetal alcohol spectrum disorders","volume":"13","author":"Terracina","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.yexmp.2025.105002_bb0780","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800252","article-title":"Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation","volume":"2","author":"Tseng","year":"2019","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.yexmp.2025.105002_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-813125-1.00004-0","article-title":"ADH and ALDH polymorphisms in alcoholism and alcohol misuse\/dependence","author":"Vaswani","year":"2019","journal-title":"Neurosci. Alcohol Mech. Treat."},{"key":"10.1016\/j.yexmp.2025.105002_bb0790","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-020-03628-2","article-title":"Serotonin functions as a bidirectional guidance molecule regulating growth cone motility","volume":"78","author":"Vicenzi","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0795","article-title":"Analysis of alcohol-metabolizing enzymes genetic variants and RAR\/RXR expression in patients diagnosed with fetal alcohol syndrome: a case-control study","volume":"25","author":"Vieiros","year":"2024","journal-title":"BMC Genomics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118138","article-title":"Effects of maternal drinking patterns and epigallocatechin-3-gallate treatment on behavioural and molecular outcomes in a mouse model of fetal alcohol spectrum disorders","volume":"187","author":"Vieiros","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexmp.2025.105002_bb0805","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.3c00045","article-title":"Aldehyde-associated mutagenesiscurrent state of knowledge","author":"Vijayraghavan","year":"2023","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yexmp.2025.105002_bb0810","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac570","article-title":"Acetaldehyde makes a distinct mutation signature in single-stranded DNA","volume":"50","author":"Vijayraghavan","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0815","doi-asserted-by":"crossref","DOI":"10.1002\/wps.21073","article-title":"Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention","volume":"22","author":"Volkow","year":"2023","journal-title":"World Psychiatry"},{"key":"10.1016\/j.yexmp.2025.105002_bb0820","doi-asserted-by":"crossref","first-page":"59","DOI":"10.35946\/arcr.v38.1.08","article-title":"Biology, genetics, and environment: underlying factors influencing alcohol metabolism","volume":"38","author":"Wall","year":"2016","journal-title":"Alcohol Res."},{"key":"10.1016\/j.yexmp.2025.105002_bb0825","article-title":"Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2025.105002_bb0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2023.09.010","article-title":"Epigenetic regulation of early human embryo development","author":"Wilkinson","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yexmp.2025.105002_bb0835","doi-asserted-by":"crossref","DOI":"10.3390\/biom14121569","article-title":"Organ-on-a-Chip models\u2014new possibilities in experimental science and disease modeling","author":"Wysocza\u0144ski","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.yexmp.2025.105002_bb0840","doi-asserted-by":"crossref","DOI":"10.1158\/1055-9965.EPI-09-0398","article-title":"A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population","volume":"18","author":"Yang","year":"2009","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.yexmp.2025.105002_bb0845","doi-asserted-by":"crossref","DOI":"10.1186\/1479-7364-5-6-569","article-title":"The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese","volume":"5","author":"Yao","year":"2011","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.yexmp.2025.105002_bb0850","article-title":"Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yexmp.2025.105002_bb0855","doi-asserted-by":"crossref","DOI":"10.2302\/kjm.59.115","article-title":"Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in east asians","volume":"59","author":"Yokoyama","year":"2010","journal-title":"Keio J. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0860","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66521-z","article-title":"Epidemiologic relationship between alcohol flushing and smoking in the Korean population: the Korea National Health and nutrition examination survey","volume":"14","author":"Yook","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2025.105002_bb0865","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.alcohol.2024.08.004","article-title":"Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking","volume":"123","author":"Yoon","year":"2025","journal-title":"Alcohol"},{"key":"10.1016\/j.yexmp.2025.105002_bb0870","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-024-09537-w","article-title":"An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders","volume":"16","author":"Zeng","year":"2024","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.yexmp.2025.105002_bb0875","article-title":"DNA methylation in alcohol use disorder","author":"Zheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2025.105002_bb0880","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172885","article-title":"Human genetics and epigenetics of alcohol use disorder","volume":"134","author":"Zhou","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2025.105002_bb0885","article-title":"Towards precision medicine: leading with big data and multidisciplinary collaboration","volume":"1","author":"Zhu","year":"2024","journal-title":"Precis. Med."},{"key":"10.1016\/j.yexmp.2025.105002_bb0890","article-title":"Effect of ALDH2 polymorphism on cancer risk in Asians: a meta-analysis","volume":"98","author":"Zuo","year":"2019","journal-title":"Medicine (United States)"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:38:14Z","timestamp":1782952694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480025000528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":178,"alternative-id":["S0014480025000528"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.105002","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic and epigenetic determinants of fetal alcohol spectrum disorders: Toward a precision medicine approach","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.105002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105002"}}