{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:48:39Z","timestamp":1782953319500,"version":"3.54.5"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305287\/2023-0"],"award-info":[{"award-number":["305287\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["152770\/2024-0"],"award-info":[{"award-number":["152770\/2024-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["441634\/2024-9"],"award-info":[{"award-number":["441634\/2024-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/201.654\/2021"],"award-info":[{"award-number":["E-26\/201.654\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/203.931\/2024"],"award-info":[{"award-number":["E-26\/203.931\/2024"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/010.000983\/2019"],"award-info":[{"award-number":["E-26\/010.000983\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yexmp.2025.105006","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:00:11Z","timestamp":1761876011000},"page":"105006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Histopathological analysis reveals mild to moderate changes in BALB\/c mice after short-term administration of a microemulsion loaded with epoxy-\u03b1-lapachone"],"prefix":"10.1016","volume":"144","author":[{"given":"Luiz Filipe","family":"Gon\u00e7alves-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Figueiredo","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Ac\u00e1cio Santini","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia Silva Carlos","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"de Oliveira Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davyson","family":"de Lima Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Silva-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Roberto","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2025.105006_bb0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpddr.2019.08.002","article-title":"The combination therapy of meglumine antimoniate and oxiranes (epoxy-\u03b1-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis","volume":"10","author":"Gon\u00e7alves-Oliveira","year":"2019","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.yexmp.2025.105006_bb0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.colsurfb.2016.12.026","article-title":"Influence of surfactin on physical and oxidative stability of microemulsions with docosahexaenoic acid","volume":"151","author":"He","year":"2017","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.yexmp.2025.105006_bb0015","first-page":"3171","article-title":"Formulation and characterization of surfactin-containing self-microemulsifying drug delivery systems","volume":"30","author":"Kural","year":"2010","journal-title":"Hacet. Univ. Eczac. Fak. Derg."},{"key":"10.1016\/j.yexmp.2025.105006_bb0020","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/DDDT.S232325","article-title":"Potential use of microbial surfactant in microemulsion drug delivery system: a systematic review","volume":"14","author":"Ohadi","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"issue":"2","key":"10.1016\/j.yexmp.2025.105006_bb0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World","volume":"118","author":"Oliveira","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.yexmp.2025.105006_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9840210","article-title":"Evidence for tissue toxicity in BALB\/c exposed to a long-term treatment with oxiranes compared to meglumine antimoniate","volume":"2017","author":"Oliveira","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.yexmp.2025.105006_bb0035","series-title":"Diretrizes Para o Tratamento das Leishmanioses na Regi\u00e3o das Am\u00e9ricas","author":"OPAS","year":"2023"},{"issue":"2","key":"10.1016\/j.yexmp.2025.105006_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjid.2023.102743","article-title":"Epoxy-\u03b1-lapachone(2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2\u2032-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites","volume":"27","author":"Peixoto","year":"2023","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.yexmp.2025.105006_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122864","article-title":"Development of a microemulsion loaded with epoxy-\u03b1-lapachone against Leishmania (Leishmania) amazonensis murine infection","volume":"636","author":"Peixoto","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.yexmp.2025.105006_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpddr.2024.100525","article-title":"Efficacy of the treatment using a microemulsion loaded with epoxy-\u03b1-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis","volume":"24","author":"Peixoto","year":"2024","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.yexmp.2025.105006_bb0055","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760240115","article-title":"Epoxy-a-lapachone in nanosystem: a prototype drug for leishmaniasis assessed in the binomial BALB\/c - Leishmania (Leishmania) amazonensis","volume":"119","author":"Peixoto","year":"2024","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"3","key":"10.1016\/j.yexmp.2025.105006_bb0060","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/ced.14919","article-title":"Treatment options for leishmaniasis","volume":"47","author":"Pradhan","year":"2022","journal-title":"Clin. Exp. Dermatol."},{"issue":"10","key":"10.1016\/j.yexmp.2025.105006_bb0065","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3390\/nano12101683","article-title":"Fish oil Nanoemulsion supplementation attenuates bleomycin-induced pulmonary fibrosis BALB\/c mice","volume":"12","author":"Souza","year":"2022","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.yexmp.2025.105006_bb0070","author":"Strovel"},{"key":"10.1016\/j.yexmp.2025.105006_bb0075","series-title":"Control of the Leishmaniases: Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases","author":"WHO","year":"2023"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480025000565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:36:05Z","timestamp":1782952565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480025000565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":15,"alternative-id":["S0014480025000565"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.105006","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathological analysis reveals mild to moderate changes in BALB\/c mice after short-term administration of a microemulsion loaded with epoxy-\u03b1-lapachone","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2025.105006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105006"}}