{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:57:23Z","timestamp":1781686643682,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PID2022-138765OB-I00"],"award-info":[{"award-number":["PID2022-138765OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PID2024-1558550B-100"],"award-info":[{"award-number":["PID2024-1558550B-100"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014180","name":"Government of Castile and Le\u00f3n","doi-asserted-by":"publisher","award":["BIO\/SA83\/13"],"award-info":[{"award-number":["BIO\/SA83\/13"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014180","name":"Government of Castile and Le\u00f3n","doi-asserted-by":"publisher","award":["SA095P24"],"award-info":[{"award-number":["SA095P24"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Spanish Association Against Cancer Scientific Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008061","name":"Mutua Madrile\u00f1a Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/01034"],"award-info":[{"award-number":["PI21\/01034"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI19\/01630"],"award-info":[{"award-number":["PI19\/01630"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.yexmp.2026.105038","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:00:48Z","timestamp":1773680448000},"page":"105038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Vascular growth patterns correlate with histological subtypes in human lung adenocarcinoma"],"prefix":"10.1016","volume":"146","author":[{"given":"In\u00e9s","family":"Solano-SC","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gonz\u00e1lez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Rodr\u00edguez-Barbero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Mu\u00f1oz-F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pericacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2026.105038_bb0005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/path.4845","article-title":"Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models","volume":"241","author":"Bridgeman","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0010","doi-asserted-by":"crossref","first-page":"39795","DOI":"10.18632\/oncotarget.7794","article-title":"Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?","volume":"8","author":"Coelho","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.yexmp.2026.105038_bb0015","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12094-012-0983-z","article-title":"Lung adenocarcinoma in the era of targeted therapies: histological classification, sample prioritization, and predictive biomarkers","volume":"15","author":"Conde","year":"2013","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0020","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cllc.2013.06.007","article-title":"Structural basis for hyperpermeability of tumor vessels in advanced lung adenocarcinoma complicated by pleural effusion","volume":"14","author":"Damianovich","year":"2013","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.yexmp.2026.105038_bb0025","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1309\/AJCPBS85VJEOBPDO","article-title":"Micropapillary lung adenocarcinoma","volume":"131","author":"De Oliveira Duarte Achcar","year":"2009","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrc.2018.14","article-title":"Non-angiogenic tumours and their influence on cancer biology","volume":"18","author":"Donnem","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yexmp.2026.105038_bb0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fonc.2020.00221","article-title":"Resistance mechanisms to anti-angiogenic therapies in cancer","volume":"10","author":"Haibe","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0040","article-title":"Angiogenesis inhibition as a therapeutic strategy in non-small cell lung cancer (NSCLC)","volume":"4","author":"Hall","year":"2015","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.yexmp.2026.105038_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.yexmp.2026.105038_bb0050","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","article-title":"The biology and management of non-small cell lung cancer","volume":"553","author":"Herbst","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2026.105038_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10456-019-09698-6","article-title":"Vessel co-option and resistance to anti-angiogenic therapy","volume":"23","author":"Kuczynski","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.yexmp.2026.105038_bb0060","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw030","article-title":"Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma","volume":"108","author":"Kuczynski","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.yexmp.2026.105038_bb0065","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41571-019-0181-9","article-title":"Vessel co-option in cancer","volume":"16","author":"Kuczynski","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0070","first-page":"5","article-title":"Adenocarcinoma classification: patterns and prognosis","volume":"110","author":"Kuhn","year":"2018","journal-title":"Pathologica"},{"key":"10.1016\/j.yexmp.2026.105038_bb0075","author":"National Comprehensive Cancer Network (NCCN)"},{"key":"10.1016\/j.yexmp.2026.105038_bb0080","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.3390\/cancers15184648","article-title":"Angiogenesis in lung cancer: understanding the roles of growth factors","volume":"15","author":"Ngaha","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.yexmp.2026.105038_bb0085","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1200\/JCO.1997.15.8.2858","article-title":"Immunocytochemical markers in stage I lung cancer: relevance to prognosis","volume":"15","author":"Pastorino","year":"1997","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1157461","article-title":"Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma","volume":"13","author":"Paulsen","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0095","series-title":"Non-Small-Cell Lung Carcinoma Tumor Growth without Morphological Evidence of Neo-Angiogenesis","first-page":"151","author":"Pezzella","year":"1997"},{"key":"10.1016\/j.yexmp.2026.105038_bb0100","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Postmus","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0105","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/JTO.0b013e318221f701","volume":"6","author":"Russell","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0110","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/sj.bjc.6602134","article-title":"Prognostic value of nonangiogenic and angiogenic growth patterns in non-small-cell lung cancer","volume":"91","author":"Sardari Nia","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yexmp.2026.105038_bb0115","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.athoracsur.2007.08.054","article-title":"Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes","volume":"85","author":"Sardari Nia","year":"2008","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.yexmp.2026.105038_bb0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10456-019-09691-z","article-title":"Vessel co-option in glioblastoma: emerging insights and opportunities","volume":"23","author":"Seano","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.yexmp.2026.105038_bb0125","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.yexmp.2026.105038_bb0130","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s00432-016-2168-6","article-title":"Interstitial growth as an aggressive growth pattern in primary lung cancer","volume":"142","author":"Suzuki","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109253","article-title":"Tumor vessel co-option probed by single-cell analysis","volume":"35","author":"Teuwen","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.yexmp.2026.105038_bb0140","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jtho.2021.09.017","article-title":"Introduction to 2021 WHO classification of thoracic tumors","volume":"17","author":"Tsao","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10456-014-9420-y","article-title":"Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions","volume":"17","author":"Vasudev","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.yexmp.2026.105038_bb0150","series-title":"Tumor Vascularization","first-page":"15","article-title":"Nonangiogenic tumor growth","author":"Vermeulen","year":"2020"},{"key":"10.1016\/j.yexmp.2026.105038_bb0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/JTO.0b013e318276274e","article-title":"Prognostic significance of predominant histologic pattern and nuclear grade in resected adenocarcinoma of the lung: potential parameters for a grading system","volume":"8","author":"Von Der Th\u00fcsen","year":"2013","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0160","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105038_bb0165","series-title":"Thoracic Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021"},{"key":"10.1016\/j.yexmp.2026.105038_bb0170","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/modpathol.2010.232","article-title":"Impact of proposed IASLC\/ATS\/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases","volume":"24","author":"Yoshizawa","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.yexmp.2026.105038_bb0175","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/JTO.0b013e3182769aa8","article-title":"Validation of the IASLC\/ATS\/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients","volume":"8","author":"Yoshizawa","year":"2013","journal-title":"J. Thorac. Oncol."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:20:23Z","timestamp":1781684423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S0014480026000171"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105038","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular growth patterns correlate with histological subtypes in human lung adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105038"}}