{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:10:15Z","timestamp":1789564215984,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","award":["1527"],"award-info":[{"award-number":["1527"]}],"id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","award":["1788\/M"],"award-info":[{"award-number":["1788\/M"]}],"id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000161","name":"National Institute of Standards and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yexmp.2026.105060","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:10:30Z","timestamp":1782781830000},"page":"105060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["3D virtual histopathology of human breast tissues using an X-ray grating interferometry micro CT system"],"prefix":"10.1016","volume":"147","author":[{"given":"Alexandre","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Kaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Kroschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Frauenfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantins","family":"Jefimovs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Josell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Stampanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ilar\/ily007","article-title":"Digital microscopy, image analysis, and virtual slide repository","volume":"59","author":"Aeffner","year":"2018","journal-title":"ILAR J."},{"key":"10.1016\/j.yexmp.2026.105060_bb0010","series-title":"Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning","author":"Almagro-P\u00e9rez","year":"2025"},{"issue":"3","key":"10.1016\/j.yexmp.2026.105060_bb0015","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.yexmp.2026.105060_bb0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.32074\/1591-951X-782","article-title":"Fixation in histopathology: the mandate to renew","volume":"114","author":"Bussolati","year":"2022","journal-title":"Pathologica"},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0025","first-page":"1","article-title":"2D-3D deformable image registration of histology slide and micro-CT with DISA-based initialization","volume":"15","author":"Chen","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-56341-6","article-title":"Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis","volume":"14","author":"Donato","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105060_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109077","article-title":"Can grating interferometry-based mammography discriminate benign from malignant microcalcifications in fresh biopsy samples?","volume":"129","author":"Forte","year":"2020","journal-title":"Eur. J. Radiol."},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210291","article-title":"Assessment of intraductal carcinoma in situ (DCIS) using grating-based X-ray phase-contrast CT at conventional X-ray sources: an experimental ex-vivo study","volume":"14","author":"Hellerhoff","year":"2019","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.yexmp.2026.105060_bb0045","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/abba63","article-title":"Pushing the limits of bottom-up gold filling for X-ray grating interferometry","volume":"167","author":"Josell","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.yexmp.2026.105060_bb0050","doi-asserted-by":"crossref","unstructured":"N. Kawamura et al., \u201cLandmark-based reconstruction of 3D smooth structures from serial histological sections,\u201d doi:https:\/\/doi.org\/10.1117\/12.2293510, vol. 10581, pp. 371\u2013377, 2018, doi:https:\/\/doi.org\/10.1117\/12.2293510.","DOI":"10.1117\/12.2293510"},{"issue":"3","key":"10.1016\/j.yexmp.2026.105060_bb0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jso.24047","article-title":"The importance of surgical margins in breast cancer","volume":"113","author":"O\u2019Kelly Priddy","year":"2016","journal-title":"J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.yexmp.2026.105060_bb0060","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1107\/S1600577518010172","article-title":"Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography","volume":"25","author":"Pacil\u00e8","year":"2018","journal-title":"J. Synchrotron Radiat."},{"key":"10.1016\/j.yexmp.2026.105060_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/mp.70069","article-title":"Simultaneous signal optimization of refraction and attenuation in x-ray grating interferometry: a case study for breast imaging","volume":"52","author":"Pereira","year":"2025","journal-title":"Med. Phys."},{"issue":"4","key":"10.1016\/j.yexmp.2026.105060_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nphys265","article-title":"Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources","volume":"2","author":"Pfeiffer","year":"2006","journal-title":"Nat. Phys."},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-35854-6","article-title":"Towards virtual histology with X-ray grating interferometry","volume":"13","author":"Polikarpov","year":"2023","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.yexmp.2026.105060_bb0080","doi-asserted-by":"crossref","DOI":"10.1063\/1.3465334","article-title":"Noise analysis of grating-based x-ray differential phase contrast imaging","volume":"81","author":"Revol","year":"2010","journal-title":"Rev. Sci. Instrum."},{"issue":"11","key":"10.1016\/j.yexmp.2026.105060_bb0085","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/mp.13763","article-title":"Performance evaluation of computed tomography systems: summary of AAPM task group 233","volume":"46","author":"Samei","year":"2019","journal-title":"Med. Phys."},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/srep36991","article-title":"Improved diagnostics by assessing the micromorphology of breast calcifications via x-ray dark-field radiography","volume":"6","author":"Scherer","year":"2016","journal-title":"Sci. Rep."},{"issue":"2\u20133","key":"10.1016\/j.yexmp.2026.105060_bb0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000442387","article-title":"The role of Micro-CT in 3D histology imaging","volume":"83","author":"Senter-Zapata","year":"2016","journal-title":"Pathobiology"},{"issue":"9","key":"10.1016\/j.yexmp.2026.105060_bb0100","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/mi11090864","article-title":"Towards the fabrication of high-aspect-ratio silicon gratings by deep reactive ion etching","volume":"11","author":"Shi","year":"2020","journal-title":"Micromachines (Basel)."},{"key":"10.1016\/j.yexmp.2026.105060_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.mssp.2025.110041","article-title":"Deep-reactive-ion-etching in X-ray grating fabrication: a review","volume":"201","author":"Shi","year":"2026","journal-title":"Mater. Sci. Semicond. Process."},{"issue":"22","key":"10.1016\/j.yexmp.2026.105060_bb0110","doi-asserted-by":"crossref","first-page":"25129","DOI":"10.1364\/OE.24.025129","article-title":"Fast and flexible X-ray tomography using the ASTRA toolbox","volume":"24","author":"van Aarle","year":"2016","journal-title":"Opt. Express"},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nima.2011.01.079","article-title":"Low-dose multiple-information retrieval algorithm for X-ray grating-based imaging","volume":"635","author":"Wang","year":"2011","journal-title":"Nucl. Instrum. Methods Phys. Res. A"},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0120","article-title":"Non-invasive classification of microcalcifications with phase-contrast X-ray mammography","volume":"5","author":"Wang","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.yexmp.2026.105060_bb0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s44303-024-00021-7","article-title":"Deep learning-based virtual H& E staining from label-free autofluorescence lifetime images","volume":"2","author":"Wang","year":"2024","journal-title":"npj Imaging"},{"key":"10.1016\/j.yexmp.2026.105060_bb0130","doi-asserted-by":"crossref","unstructured":"T. Weitkamp, C. David, C. Kottler, O. Bunk, and F. Pfeiffer, \u201cTomography with grating interferometers at low-brilliance sources,\u201d Developments in X-Ray Tomography V, vol. 6318, no. September 2006, p. 63180S, 2006, doi:https:\/\/doi.org\/10.1117\/12.683851.","DOI":"10.1117\/12.683851"},{"issue":"3","key":"10.1016\/j.yexmp.2026.105060_bb0135","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1118\/1.1450132","article-title":"Parker weights revisited","volume":"29","author":"Wesarg","year":"2002","journal-title":"Med. Phys."},{"issue":"1069","key":"10.1016\/j.yexmp.2026.105060_bb0140","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160594","article-title":"Microcalcification on mammography: approaches to interpretation and biopsy","volume":"90","author":"Wilkinson","year":"2017","journal-title":"Br. J. Radiol."},{"issue":"7","key":"10.1016\/j.yexmp.2026.105060_bb0145","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1088\/0031-9155\/59\/7\/1557","article-title":"Quantitative breast tissue characterization using grating-based x-ray phase-contrast imaging","volume":"59","author":"Willner","year":"2014","journal-title":"Phys. Med. Biol."},{"issue":"25","key":"10.1016\/j.yexmp.2026.105060_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.2103126118","article-title":"High-resolution multicontrast tomography with an X-ray microarray anode\u2013structured target source","volume":"118","author":"Zan","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:51:51Z","timestamp":1789563111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0014480026000390"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105060","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D virtual histopathology of human breast tissues using an X-ray grating interferometry micro CT system","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105060"}}