{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:10:32Z","timestamp":1789564232049,"version":"build-2803163510"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007807","name":"Japan Science Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08318"],"award-info":[{"award-number":["22K08318"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27316"],"award-info":[{"award-number":["23K27316"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yexmp.2026.105072","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:21:43Z","timestamp":1787718103000},"page":"105072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multifaceted renoprotection by SMTP-44D in diabetic nephropathy: Targeting inflammation, oxidative stress, and insulin resistance"],"prefix":"10.1016","volume":"147","author":[{"given":"Taiki","family":"Awane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Saigusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Hasumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2026.105072_bb0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jphs.2025.06.006","article-title":"SMTP-44D prevents negative symptoms of diabetic neuropathy by inhibiting sciatic nerve apoptosis","volume":"159","author":"Aoki","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1248\/bpb.b25-00535","article-title":"SMTP-44D exerts renoprotective effects against diabetic nephropathy via its anti-inflammatory and antioxidant action","volume":"49","author":"Awane","year":"2026","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.yexmp.2026.105072_bb0015","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jcb.10668","article-title":"Phosphorylation of PPARgamma via active ERK1\/2 leads to its physical association with p65 and inhibition of NF-kappabeta","volume":"90","author":"Chen","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2026.1741914","article-title":"Soluble epoxide hydrolase inhibition restores pro-resolving lipid mediators and reduces inflammation in localized provoked vulvodynia","volume":"17","author":"Chrysilla","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0030","doi-asserted-by":"crossref","first-page":"32681","DOI":"10.1074\/jbc.M002577200","article-title":"Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B","volume":"275","author":"Chung","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0035","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.R100030200","article-title":"Epoxygenase pathways of arachidonic acid metabolism","volume":"276","author":"Darryl","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0002-9440(10)63629-2","article-title":"Lysophosphatidic acid prevents renal ischemia-reperfusion injury by inhibition of apoptosis and complement activation","volume":"163","author":"de Vries","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0045","article-title":"Enzymatic synthesis of eicosapentaenoyl-lysophosphatidic acid and evaluation of antioxidant and anti-inflammatory properties","volume":"67","author":"Du","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0050","first-page":"R321","article-title":"Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease","volume":"302","author":"Elmarakby","year":"2012","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.yexmp.2026.105072_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.111149","article-title":"Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-\u03baB-mediated transcription of SGLT2 in renal tubular epithelial cells","volume":"523","author":"Fu","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0060","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6104529","article-title":"Curcumin antagonizes glucose fluctuation-induced renal injury by inhibiting aerobic glycolysis via the miR-489\/LDHA pathway","volume":"2021","author":"Fu","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexmp.2026.105072_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115927","article-title":"Ginsenoside Rh2 mitigates hepatic gluconeogenesis by regulating Akt\/FoxO1 pathway in type 2 diabetic mice","volume":"168","author":"Gao","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0070","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1729941","article-title":"Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions","volume":"16","author":"Gong","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117913","article-title":"Molecular mechanisms of skeletal muscle atrophy: clinical challenges and future therapeutic strategies","volume":"249","author":"Gong","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1254\/jphs.10131FP","article-title":"A novel embolic model of cerebral infarction and evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a novel fungal Triprenyl phenol metabolite","volume":"114","author":"Hashimoto","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0090","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3390\/ijms22020954","article-title":"Impact of SMTP targeting plasminogen and soluble epoxide hydrolase on thrombolysis, inflammation, and ischemic stroke","volume":"22","author":"Hasumi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0095","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1111\/j.1742-4658.2010.07783.x","article-title":"Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems","volume":"277","author":"Hasumi","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.yexmp.2026.105072_bb0100","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ncomms2270","article-title":"PPAR\u03b3 is an E3 ligase that induces the degradation of NF\u03baB\/p65","volume":"3","author":"Hou","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexmp.2026.105072_bb0105","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1021\/acs.jafc.5c10713","article-title":"AFG ameliorates diabetic retinopathy through AMPK-dependent autolysosomal pathway: from network pharmacology to in vivo and in vitro validation","volume":"74","author":"Hu","year":"2026","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0110","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphs.2024.12.004","article-title":"SMTP-44D alleviates diabetic retinopathy by suppressing inflammation and oxidative stress in in vivo and in vitro models","volume":"157","author":"Ishibashi","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0115","doi-asserted-by":"crossref","first-page":"F971","DOI":"10.1152\/ajprenal.00256.2014","article-title":"Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation","volume":"307","author":"Kim","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.2040-1124.2010.00018.x","article-title":"Molecular mechanisms of diabetic vascular complications","volume":"1","author":"Kitada","year":"2010","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.yexmp.2026.105072_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1378175","article-title":"Collaborative power of Nrf2 and PPAR\u03b3 activators against metabolic and drug-induced oxidative injury","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yexmp.2026.105072_bb0130","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jaci.2006.03.021","article-title":"Peroxisome proliferator activated receptor-gamma modulates reactive oxygen species generation and activation of nuclear factor-kappaB and hypoxia-inducible factor 1alpha in allergic airway disease of mice","volume":"118","author":"Lee","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0135","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00676.2007","article-title":"Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice","volume":"294","author":"Lee","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yexmp.2026.105072_bb0140","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.3390\/ijms20112850","article-title":"Lysophosphatidic acid signaling in diabetic nephropathy","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0145","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.18632\/aging.204249","article-title":"Effect of BBT-877, a novel inhibitor of ATX, on a mouse model of type 1 diabetic nephropathy","volume":"14","author":"Lee","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.yexmp.2026.105072_bb0150","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jare.2022.03.004","article-title":"CRISPR\/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury","volume":"43","author":"Leuillier","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0155","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1007\/s10495-017-1399-6","article-title":"Lysophosphatidic acid enhances human umbilical cord mesenchymal stem cell viability without differentiation via LPA receptor mediating manner","volume":"22","author":"Li","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.yexmp.2026.105072_bb0160","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1142\/S0192415X2550034X","article-title":"Ginsenoside Rg2 alleviates HFD\/STZ-induced diabetic nephropathy by inhibiting pyroptosis via NF-\u03baB\/NLRP3 signaling pathways","volume":"2025","author":"Li","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.yexmp.2026.105072_bb0165","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/ph19071091","article-title":"Mechanisms of impaired skeletal muscle regeneration and therapeutic approaches in aging and chronic disease","volume":"19","author":"Li","year":"2026","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.yexmp.2026.105072_bb0170","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.3390\/jcm12082834","article-title":"Sex-related aspects in diabetic kidney disease\u2014an update","volume":"12","author":"Loeffler","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.yexmp.2026.105072_bb0175","doi-asserted-by":"crossref","first-page":"35826","DOI":"10.1074\/jbc.M114.588087","article-title":"Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7","volume":"289","author":"Matsumoto","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0180","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ja.2015.58","article-title":"Structure-activity relationships of the plasminogen modulator SMTP with respect to the inhibition of soluble epoxide hydrolase","volume":"68","author":"Matsumoto","year":"2015","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.yexmp.2026.105072_bb0185","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.tem.2020.01.007","article-title":"Chronic diabetes complications: the need to move beyond classical concepts","volume":"31","author":"Mauricio","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.yexmp.2026.105072_bb0190","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.3390\/ijms25073969","article-title":"Molecular targets of novel therapeutics for diabetic kidney disease: a new era of Nephroprotection","volume":"25","author":"Mazzieri","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1073\/pnas.0135855100","article-title":"Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist","volume":"100","author":"McIntyre","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexmp.2026.105072_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.166378","article-title":"Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?","volume":"904","author":"Medkova","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.yexmp.2026.105072_bb0205","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1007\/s12325-022-02223-0","article-title":"A narrative review of diabetic kidney disease: previous and current evidence-based therapeutic approaches","volume":"39","author":"Mima","year":"2022","journal-title":"Adv. Ther."},{"key":"10.1016\/j.yexmp.2026.105072_bb0210","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/STROKEAHA.110.598359","article-title":"Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion","volume":"42","author":"Miyazaki","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.yexmp.2026.105072_bb0215","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bbrc.2012.02.108","article-title":"Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids","volume":"419","author":"Morisseau","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2026.105072_bb0220","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41392-025-02423-4","article-title":"Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks","volume":"10","author":"Nadhan","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yexmp.2026.105072_bb0225","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000505025","article-title":"A study of morphological changes in renal afferent arterioles induced by angiotensin II Type 1 receptor blockers in hypertensive patients","volume":"45","author":"Nagai","year":"2020","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0230","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1161\/STROKEAHA.124.048464","article-title":"Anti-inflammatory thrombolytic JX10 (TMS-007) in late presentation of acute ischemic stroke","volume":"55","author":"Niizuma","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.yexmp.2026.105072_bb0235","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2021.02.004","article-title":"Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity","volume":"546","author":"Ochiai","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yexmp.2026.105072_bb0240","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1194\/jlr.D048439","article-title":"Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS\/MS","volume":"55","author":"Okudaira","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0245","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/641087","article-title":"PPAR\u03b3 and oxidative stress: con(\u03b2) Catenating NRF2 and FOXO","volume":"2012","author":"Polvani","year":"2012","journal-title":"PPAR Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0250","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbalip.2008.04.001","article-title":"Lysophosphatidic acid and renal fibrosis","volume":"1781","author":"Prad\u00e8re","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yexmp.2026.105072_bb0255","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jare.2025.01.003","article-title":"Ginseng-derived GABAFG ameliorates type 2 diabetes mellitus by modulating autophagy-lysosome pathway and gut microbiota","volume":"77","author":"Qi","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0260","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1497449","article-title":"Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment","volume":"2021","author":"Samsu","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.yexmp.2026.105072_bb0265","doi-asserted-by":"crossref","DOI":"10.1038\/srep17376","article-title":"Genetic-deletion of Cyclooxygenase-2 downstream prostacyclin synthase suppresses inflammatory reactions but facilitates carcinogenesis, unlike deletion of microsomal prostaglandin E Synthase-1","volume":"5","author":"Sasaki","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105072_bb0270","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/dom.14007","article-title":"An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines","volume":"22","author":"Selby","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.yexmp.2026.105072_bb0275","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.prostaglandins.2009.04.004","article-title":"8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier","volume":"89","author":"Sharma","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.yexmp.2026.105072_bb0280","first-page":"204","article-title":"The importance and strategy of diabetes prevention","volume":"2","author":"Shi","year":"2016","journal-title":"Chronic Dis. Transl. Med."},{"key":"10.1016\/j.yexmp.2026.105072_bb0285","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00210-010-0542-5","article-title":"A novel finding of a low- molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice","volume":"382","author":"Shibata","year":"2010","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0290","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00210-011-0642-x","article-title":"Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice","volume":"384","author":"Shibata","year":"2011","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0295","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2017.10.055","article-title":"Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model","volume":"818","author":"Shibata","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174496","article-title":"Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury","volume":"910","author":"Shibata","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0305","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jphs.2025.07.006","article-title":"Therapeutic potential of SMTP-27 in attenuating diabetic nephropathy with anti-inflammatory activity","volume":"159","author":"Shibata","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0310","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.648","article-title":"SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities","volume":"8","author":"Shinouchi","year":"2020","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.yexmp.2026.105072_bb0315","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.3390\/ijms23095187","article-title":"SMTP-44D exerts antioxidant and anti-inflammatory effects through its soluble epoxide hydrolase inhibitory action in immortalized mouse Schwann cells upon high glucose treatment","volume":"23","author":"Shinouchi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2025.109061","article-title":"Antioxidant and anti-inflammatory effects of SMTP-44D in a streptozotocin-induced diabetic neuropathy mouse model","volume":"39","author":"Shinouchi","year":"2025","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.yexmp.2026.105072_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.yexmp.2026.105072_bb0330","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7265486","article-title":"Epoxyeicosatrienoic acids inhibit the activation of murine fibroblasts by blocking the TGF-\u03b21-Smad2\/3 signaling in a PPAR\u03b3-dependent manner","volume":"2022","author":"Tao","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yexmp.2026.105072_bb0335","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.3390\/ijms24076505","article-title":"SMTP-44D inhibits atherosclerotic plaque formation in apolipoprotein-E null mice partly by suppressing the AGEs-RAGE Axis","volume":"24","author":"Terasaki","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0340","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2443.2012.01607.x","article-title":"Ligand-dependent nucleo-cytoplasmic shuttling of peroxisome proliferator-activated receptors, PPAR\u03b1 and PPAR\u03b3","volume":"17","author":"Umemoto","year":"2012","journal-title":"Genes Cells"},{"key":"10.1016\/j.yexmp.2026.105072_bb0345","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9173090","article-title":"Autotaxin-lysophosphatidic acid: from inflammation to cancer development","volume":"2017","author":"Vald\u00e9s-Rives","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yexmp.2026.105072_bb0350","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1096\/fj.14-262659","article-title":"Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment","volume":"29","author":"Venkatraman","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.yexmp.2026.105072_bb0355","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/ijms20153683","article-title":"Arachidonic acid metabolism and kidney inflammation","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105072_bb0360","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12791","article-title":"Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice","volume":"90","author":"Wang","year":"2019","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0365","article-title":"VDR activation attenuates renal tubular epithelial cell Ferroptosis by regulating Nrf2\/HO-1 signaling pathway in diabetic nephropathy","volume":"11","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.yexmp.2026.105072_bb0370","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2010.08.015","article-title":"Insulin signaling to the glomerular podocyte is critical for normal kidney function","volume":"12","author":"Welsh","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.yexmp.2026.105072_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108421","article-title":"Lysophosphatidic acid, a simple phospholipid with myriad functions","volume":"246","author":"Yanagida","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105072_bb0380","article-title":"The dual pathological roles and targeted therapy of PGE2: from receptor signaling networks to disease microenvironment modulation","volume":"17","author":"Yang","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0385","first-page":"1005","article-title":"Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in Type II diabetic patients","volume":"42","author":"Yokoyama","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.yexmp.2026.105072_bb0390","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","article-title":"Pharmacological inhibitors of the NLRP3 Inflammasome","volume":"10","author":"Zahid","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0395","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.semnephrol.2018.01.002","article-title":"The Warburg effect in diabetic kidney disease","volume":"38","author":"Zhang","year":"2018","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0400","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4709715","article-title":"Hyperinsulinemia can cause kidney disease in the IGT stage of OLETF rats via the INS\/IRS-1\/PI3-K\/Akt signaling pathway","volume":"2019","author":"Zhang","year":"2019","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.yexmp.2026.105072_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461634","article-title":"\u201cmodeling-prediction\u201d strategy for deep profiling of lysophosphatidic acids by liquid chromatography-mass spectrometry: exploration biomarkers of breast cancer","volume":"1634","author":"Zhang","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.yexmp.2026.105072_bb0410","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12882-025-03953-3","article-title":"New insights in the treatment of DKD: recent advances and future prospects","volume":"26","author":"Zhao","year":"2025","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.yexmp.2026.105072_bb0415","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.fshw.2023.03.020","article-title":"Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation","volume":"12","author":"Zhou","year":"2023","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.yexmp.2026.105072_bb0420","doi-asserted-by":"crossref","first-page":"8428","DOI":"10.1021\/acs.jafc.1c02476","article-title":"Ginsenoside Rg5 improves insulin resistance and mitochondrial biogenesis of liver via regulation of the Sirt1\/PGC-1\u03b1 signaling pathway in db\/db mice","volume":"69","author":"Zhu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.yexmp.2026.105072_bb0425","article-title":"Hyperglycemia-regulated tRNA-derived fragment tRF-3001a propels neurovascular dysfunction in diabetic mice","volume":"4","author":"Zhu","year":"2023","journal-title":"Cell Rep. Med."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:54:07Z","timestamp":1789563247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":85,"alternative-id":["S0014480026000511"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105072","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifaceted renoprotection by SMTP-44D in diabetic nephropathy: Targeting inflammation, oxidative stress, and insulin resistance","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105072"}}