{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:37:43Z","timestamp":1793025463353,"version":"4.5.0"},"reference-count":242,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["77756"],"award-info":[{"award-number":["77756"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.yexmp.2026.105087","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:59:47Z","timestamp":1792223987000},"page":"105087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Advancing nanomaterials for treatment of eye diseases: a review"],"prefix":"10.1016","volume":"148","author":[{"given":"Nazanin","family":"Amiryaghoubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumayeh","family":"Amirsaadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Jaymand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Jahanban","family":"Esfahlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2026.105087_bb0005","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12247-026-10419-y","article-title":"Fabricating niosomes for ocular delivery of clotrimazole: in vitro assessment, ex vivo permeation study, antimicrobial efficacy evaluation, and histopathological investigation","volume":"21","author":"Abdelbari","year":"2026","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.yexmp.2026.105087_bb0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ijpharm.2016.10.006","article-title":"Fabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: in vitro characterization, ex vivo permeation and in vivo safety assessment","volume":"513","author":"Abdelbary","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41746-018-0040-6","article-title":"Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices","volume":"1","author":"Abr\u00e0moff","year":"2018","journal-title":"npj Digit. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113992","article-title":"Innovative solid lipid nanoparticle formulations for ocular therapeutics and related patents: a systematic review","volume":"385","author":"Ahmed","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jps.2600760802","article-title":"Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea","volume":"76","author":"Ahmed","year":"1987","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13111932","article-title":"Explainable AI for retinoblastoma diagnosis: interpreting deep learning models with LIME and SHAP","volume":"13","author":"Aldughayfiq","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0035","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.addr.2006.07.022","article-title":"Industrial perspective in ocular drug delivery","volume":"58","author":"Ali","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116951","article-title":"Recent advances in biomimetic cell membrane\u2013camouflaged nanoparticles for cancer therapy","volume":"177","author":"Alimohammadvand","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexmp.2026.105087_bb0045","article-title":"Considerations for polymers used in ocular drug delivery","volume":"8","author":"Allyn","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0050","first-page":"1181","article-title":"Diffusion of high molecular weight compounds through sclera","volume":"41","author":"Ambati","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0055","article-title":"Marine-derived polysaccharides enhance the drug delivery mechanism in the management of ocular diseases: a review","volume":"340","author":"Anand","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0060","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2025.2489491","article-title":"Harnessing nanofibers for targeted delivery of phytoconstituents in age-related macular degeneration","volume":"32","author":"Andrades","year":"2025","journal-title":"Drug Deliv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0065","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1039\/D0BM00083C","article-title":"Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane","volume":"8","author":"Anton-Sales","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108151","article-title":"Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: evaluation of the surface properties and effect on their distribution","volume":"198","author":"Apaolaza","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0075","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1021\/acs.biomac.5c01704","article-title":"Engineered multifunctional drug-loaded dendrimer nanoparticles for glaucoma: triple mechanism via antioxidant activity, iron chelation, and enhanced ocular transport","volume":"26","author":"Ates","year":"2025","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.yexmp.2026.105087_bb0080","doi-asserted-by":"crossref","first-page":"10492","DOI":"10.1073\/pnas.1919755117","article-title":"Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles","volume":"117","author":"Ban","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yexmp.2026.105087_bb0085","article-title":"Formulation design of quercetin-loaded polyvinyl alcohol nanofibres for ocular drug delivery","volume":"8","author":"Bashir","year":"2025","journal-title":"Food Hydrocoll. Health"},{"key":"10.1016\/j.yexmp.2026.105087_bb0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1515\/znc-2025-0014","article-title":"Native\/modified dextran-based nanogel in delivering drug and management of ocular complications: a review","volume":"81","author":"Basu","year":"2025","journal-title":"Z. fur Naturforsch. - C J. Biosci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0095","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/S2589-7500(19)30004-4","article-title":"Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study","volume":"1","author":"Bellemo","year":"2019","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.yexmp.2026.105087_bb0100","article-title":"Enhanced delivery of coenzyme Q10 for dry eye treatment using alginate stabilized mucous based glycoprotein nanoparticles","volume":"9","author":"Binte Akram","year":"2026","journal-title":"Adv. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14010090","article-title":"Lipid nanoparticles for the posterior eye segment","volume":"14","author":"Bonilla","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0110","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1021\/acs.molpharmaceut.6b00182","article-title":"Novel water-soluble mucoadhesive Carbosilane dendrimers for ocular administration","volume":"13","author":"Bravo-Osuna","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0115","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1001\/jamaophthalmol.2018.1934","article-title":"Automated diagnosis of plus disease in retinopathy of prematurity using deep convolutional neural networks","volume":"136","author":"Brown","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137202","article-title":"Silver nanoparticles and their antibacterial applications","volume":"22","author":"Bruna","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17040424","article-title":"Chitosan-TPP nanogels for ocular delivery of folic acid: release profile, corneal permeation, and mucoadhesion assessment","volume":"17","author":"Bruno","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0130","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamaophthalmol.2017.3782","article-title":"Automated grading of age-related macular degeneration from color fundus images using deep convolutional neural networks","volume":"135","author":"Burlina","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0135","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.3390\/pharmaceutics15122752","article-title":"PLGA nanoparticles containing natural flavanones for ocular inflammation","volume":"15","author":"Bustos-Salgado","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0140","doi-asserted-by":"crossref","first-page":"17817","DOI":"10.1073\/pnas.0908561106","article-title":"An experimental platform for systemic drug delivery to the retina","volume":"106","author":"Campbell","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1167\/tvst.13.7.7","article-title":"Lipid nanoparticle-mediated delivery of mRNA into the mouse and human retina and other ocular tissues","volume":"13","author":"Chambers","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40199-023-00455-1","article-title":"Lipid nanoparticles for gene therapy in ocular diseases","volume":"31","author":"Chapa Gonz\u00e1lez","year":"2023","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0155","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4155\/tde.11.72","article-title":"Nanoparticle-mediated hyperthermia in cancer therapy","volume":"2","author":"Chatterjee","year":"2011","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117108","article-title":"Advances in the development of lipid nanoparticles for ophthalmic therapeutics","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexmp.2026.105087_bb0160","doi-asserted-by":"crossref","first-page":"13637","DOI":"10.1039\/D0NR03208E","article-title":"Toxicity and mechanism of mesoporous silica nanoparticles in eyes","volume":"12","author":"Chen","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.yexmp.2026.105087_bb0170","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.3390\/jcm11144195","article-title":"More than antibiotics: latest therapeutics in the treatment and prevention of ocular surface infections","volume":"11","author":"Chiang","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2023.07.040","article-title":"An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice","volume":"361","author":"Chou","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15041096","article-title":"Neuroprotective nanoparticles targeting the retina: a polymeric platform for ocular drug delivery applications","volume":"15","author":"Colucci","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050981","article-title":"Metallic engineered nanomaterials and ocular toxicity: a current perspective","volume":"14","author":"Cosert","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2019.06.005","article-title":"Crossing biological barriers with nanogels to improve drug delivery performance","volume":"307","author":"Cuggino","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111383","article-title":"Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy","volume":"118","author":"Cuggino","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.yexmp.2026.105087_bb0200","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s41591-018-0107-6","article-title":"Clinically applicable deep learning for diagnosis and referral in retinal disease","volume":"24","author":"De Fauw","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.omta.2026.201768","article-title":"mRNA delivery to the retina restores REP1 function in choroideremia","volume":"34","author":"de Lemos","year":"2026","journal-title":"Mol. Ther. Adv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030679","article-title":"Noble metals and soft bio-inspired nanoparticles in retinal diseases treatment: a perspective","volume":"9","author":"De Matteis","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.yexmp.2026.105087_bb0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/tvst.8.5.18","article-title":"Magnetic hyperthermia in Y79 retinoblastoma and ARPE-19 retinal epithelial cells: tumor selective apoptotic activity of iron oxide nanoparticle","volume":"8","author":"Demirci","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0220","first-page":"1874","article-title":"The niosomes: an overview in ocular drug delivery system as an advanced approach","volume":"6","author":"Devesh","year":"2023","journal-title":"J. ReAttach Ther. Dev. Divers."},{"key":"10.1016\/j.yexmp.2026.105087_bb0225","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejpb.2019.05.023","article-title":"The obstacle course to the inner retina: hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane","volume":"141","author":"Devoldere","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201801451","article-title":"Size, shape, and protein corona determine cellular uptake and removal mechanisms of gold nanoparticles","volume":"14","author":"Ding","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.yexmp.2026.105087_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110521","article-title":"Regenerative medicine and drug delivery: progress via electrospun biomaterials","volume":"109","author":"Doostmohammadi","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.yexmp.2026.105087_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.115098","article-title":"Micelleplex nucleic acid delivery systems: overcoming barriers for treatment of advanced solid tumors","volume":"260","author":"Doustmihan","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.yexmp.2026.105087_bb0245","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1016\/j.biomaterials.2006.04.022","article-title":"Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions","volume":"27","author":"Duan","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexmp.2026.105087_bb0250","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1167\/iovs.10-5388","article-title":"Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability, and delivery of gatifloxacin","volume":"51","author":"Durairaj","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0255","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1021\/acsabm.4c00585","article-title":"A nanogel formulation of anti-VEGF peptide for ocular neovascularization treatment","volume":"7","author":"Durak","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0260","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nano.2012.05.015","article-title":"Effect of ligand density, receptor density, and nanoparticle size on cell targeting","volume":"9","author":"Elias","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.yexmp.2026.105087_bb0265","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.exer.2014.02.001","article-title":"Cholesterol-poly(ethylene) glycol nanocarriers for the transscleral delivery of sirolimus","volume":"121","author":"Elsaid","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104449","article-title":"Folate-conjugated pH- and redox-responsive magnetic hydrogel based on tragacanth gum for \u201csmart\u201d chemo\/hyperthermia treatment of cancerous cells","volume":"84","author":"Eskandani","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0275","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202400815","article-title":"Preformed vesicle approach to LNP manufacturing enhances retinal mRNA delivery","volume":"20","author":"Eygeris","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.yexmp.2026.105087_bb0280","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.3390\/ijms25179228","article-title":"Formulation and development of nanofiber-based ophthalmic insert for the treatment of bacterial conjunctivitis","volume":"25","author":"Farkas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114194","article-title":"Lipid nanoparticle mediated delivery of dsDNA to the murine retina","volume":"387","author":"Fehrman","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101498","article-title":"Epigallocatechin gallate loaded electrospun silk fibroin scaffold with anti-angiogenic properties for corneal tissue engineering","volume":"56","author":"Forouzideh","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0295","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1517\/17425247.2014.938633","article-title":"Microrobots: a new era in ocular drug delivery","volume":"11","author":"Fusco","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0300","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3390\/pharmaceutics15030745","article-title":"Intraocular siRNA delivery mediated by penetratin derivative to silence orthotopic retinoblastoma gene","volume":"15","author":"Gao","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0305","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"Gaudana","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.yexmp.2026.105087_bb0310","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/biom11081150","article-title":"Nanogel-facilitated in-situ delivery of a cataract inhibitor","volume":"11","author":"Gautam","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.yexmp.2026.105087_bb0320","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1089\/jop.2022.0144","article-title":"Intracameral drug delivery: a review of agents, indications, and outcomes","volume":"39","author":"Gautam","year":"2023","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb0315","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1038\/s41467-023-42189-3","article-title":"Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina","volume":"14","author":"Gautam","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexmp.2026.105087_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123164","article-title":"Alginate-functionalized nanoceria as ion-responsive eye drop formulation to treat corneal abrasion","volume":"352","author":"Ger","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.yexmp.2026.105087_bb0330","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.drudis.2021.02.027","article-title":"Advanced nanodelivery platforms for topical ophthalmic drug delivery","volume":"26","author":"Gholizadeh","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2025.101634","article-title":"Hollow nanoarchitectures: materials engineering, nanochemistry, and biomedical applications","volume":"158","author":"Ghosh","year":"2026","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0340","doi-asserted-by":"crossref","first-page":"43092","DOI":"10.1038\/srep43092","article-title":"Magnetic nanoparticles: a strategy to target the choroidal layer in the posterior segment of the eye","volume":"7","author":"Giannaccini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105087_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/polym15102249","article-title":"Pluronic F127 and P104 polymeric micelles as efficient nanocarriers for loading and release of single and dual antineoplastic drugs","volume":"15","author":"Guti\u00e9rrez-Saucedo","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.yexmp.2026.105087_bb0350","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/pharmaceutics13070967","article-title":"Drug delivery via the suprachoroidal space for the treatment of retinal diseases","volume":"13","author":"Haim","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0355","doi-asserted-by":"crossref","first-page":"19606","DOI":"10.1038\/s41598-025-03804-z","article-title":"Toxicity analysis of gold nanoparticle formulations used for intraocular applications","volume":"15","author":"Hajrasouliha","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105087_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2025.108006","article-title":"A lightweight method for precise small lesion detection in diabetic retinopathy","volume":"109","author":"Han","year":"2025","journal-title":"Biomed. Signal Process. Control"},{"key":"10.1016\/j.yexmp.2026.105087_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TCSS.2025.3635655","article-title":"PEGSYS: a portable and easy-to-operate smart screening and grading system for glaucoma","author":"Han","year":"2025","journal-title":"IEEE Trans. Comput. Soc. Syst."},{"key":"10.1016\/j.yexmp.2026.105087_bb0375","article-title":"Dendrimer-based nanoplatforms for cancer diagnosis and therapy: from liquid biopsy to targeted protein degradation","volume":"16","author":"Hasannejad Alibaglou","year":"2026","journal-title":"BioNanoScience"},{"key":"10.1016\/j.yexmp.2026.105087_bb0380","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/aafbf9","article-title":"Photoluminescent functionalized carbon dots for CRISPR delivery: synthesis, optimization and cellular investigation","volume":"30","author":"Hasanzadeh","year":"2019","journal-title":"Nanotechnology"},{"key":"10.1016\/j.yexmp.2026.105087_bb0385","article-title":"4D-printed photochromic contact lenses for ultraviolet monitoring and protection","volume":"5","author":"Hisham","year":"2024","journal-title":"Cell Rep. Phys. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0390","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ejpb.2004.12.007","article-title":"Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation","volume":"60","author":"Hosoya","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0395","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1089\/jop.2015.0157","article-title":"Nanofiber scaffold-based tissue-engineered retinal pigment epithelium to treat degenerative eye diseases","volume":"32","author":"Hotaling","year":"2016","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb0400","doi-asserted-by":"crossref","first-page":"0256","DOI":"10.34133\/cbsystems.0256","article-title":"Neuromorphic floating-gate memory based on 2D materials","volume":"6","author":"Hu","year":"2025","journal-title":"Cyborg Bionic Syst."},{"key":"10.1016\/j.yexmp.2026.105087_bb0420","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jconrel.2024.02.043","article-title":"Mucoadhesive liposomal delivery system synergizing anti-inflammation and anti-oxidation for enhanced treatment against dry eye disease","volume":"368","author":"Huang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0405","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.drudis.2019.05.005","article-title":"Intravitreal nanoparticles for retinal delivery","volume":"24","author":"Huang","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107711","article-title":"Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles","volume":"186","author":"Huang","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0415","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/acs.molpharmaceut.0c00992","article-title":"Enhanced delivery of siRNA to retinal ganglion cells by intravitreal lipid nanoparticles of positive charge","volume":"18","author":"Huang","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0425","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.biomaterials.2011.10.010","article-title":"Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration","volume":"33","author":"Iezzi","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexmp.2026.105087_bb0430","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.ijbiomac.2017.11.090","article-title":"Nanogel-based natural polymers as smart carriers for the controlled delivery of Timolol Maleate through the cornea for glaucoma","volume":"109","author":"Ilka","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0435","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1248\/bpb.b22-00452","article-title":"Feasibility study of dendrimer-based TTR-CRISPR pDNA polyplex for ocular amyloidosis in vitro","volume":"45","author":"Inoue","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.yexmp.2026.105087_bb0440","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030533","article-title":"Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy\u2014an overview on recent advances","volume":"14","author":"Jacob","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0445","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","article-title":"Nanoparticles for drug delivery to the anterior segment of the eye","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0450","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1021\/acsnano.7b01023","article-title":"Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis","volume":"11","author":"Jian","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb0455","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.drudis.2019.03.027","article-title":"Targeting drug delivery within the suprachoroidal space","volume":"24","author":"Jung","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0460","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1097\/IAE.0b013e3182899258","article-title":"Feasibility of a novel remote daily monitoring system for age-related macular degeneration using mobile handheld devices: results of a pilot study","volume":"33","author":"Kaiser","year":"2013","journal-title":"Retina (Philadelphia, Pa.)"},{"key":"10.1016\/j.yexmp.2026.105087_bb0465","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.21037\/atm-21-1772","article-title":"Prediction of keratoconus progression using deep learning of anterior segment optical coherence tomography maps","volume":"9","author":"Kamiya","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0470","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archophthalmol.2009.185","article-title":"Subconjunctival nanoparticle carboplatin in the treatment of murine retinoblastoma","volume":"127","author":"Kang","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0475","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tiv.2016.08.013","article-title":"Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line","volume":"37","author":"Karako\u00e7ak","year":"2016","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.yexmp.2026.105087_bb0480","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1021\/acsanm.8b00799","article-title":"Optimizing the synthesis of red-emissive nitrogen-doped carbon dots for use in bioimaging","volume":"1","author":"Karako\u00e7ak","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0485","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-14704-7","article-title":"Dual-loaded niosome-dendrimer nanoplatform enhances Tirapazamine delivery to hypoxic breast cancer cells","volume":"15","author":"Kaveh Zenjanab","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105087_bb0490","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.2147\/IJN.S190502","article-title":"Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization","volume":"14","author":"Khames","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.yexmp.2026.105087_bb0495","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1039\/C1CS15242D","article-title":"Multifunctional dendritic polymers in nanomedicine: opportunities and challenges","volume":"41","author":"Khandare","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0500","article-title":"Emerging nano-formulations and nanomedicines applications for ocular drug delivery","volume":"11","author":"Khiev","year":"2021","journal-title":"Nanomaterials (Basel, Switzerland)"},{"key":"10.1016\/j.yexmp.2026.105087_bb0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118551","article-title":"Innovative nanotechnology for infectious and inflammatory disease control: from diagnostics to therapeutics","volume":"191","author":"Khosravi","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yexmp.2026.105087_bb0520","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40005-024-00716-4","article-title":"Dendrimer nanoplatforms for oral drug delivery applications","volume":"55","author":"Kim","year":"2025","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.yexmp.2026.105087_bb0510","article-title":"Ocular drug delivery to the retina: current innovations and future perspectives","volume":"13","author":"Kim","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0515","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12272-018-1008-4","article-title":"Recent progress in dendrimer-based nanomedicine development","volume":"41","author":"Kim","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0525","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/acsabm.9b00897","article-title":"Fiber diameter differentially regulates function of retinal pigment and corneal epithelial cells on nanofibrous tissue scaffolds","volume":"3","author":"Krishna","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0530","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1080\/17435889.2026.2715756","article-title":"Considerations for nanoscale drug-delivery systems for the cornea","volume":"21","author":"Kumar","year":"2026","journal-title":"Nanomedicine"},{"key":"10.1016\/j.yexmp.2026.105087_bb0535","doi-asserted-by":"crossref","first-page":"19412","DOI":"10.1021\/acsnano.2c09087","article-title":"Melanin-like nanoparticles as an alternative to natural melanin in retinal pigment epithelium cells and their therapeutic effects against age-related macular degeneration","volume":"16","author":"Kwon","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb0540","doi-asserted-by":"crossref","first-page":"18630","DOI":"10.1021\/acsami.2c22860","article-title":"Enhanced and extended ophthalmic drug delivery by pH-triggered drug-eluting contact lenses with large-pore mesoporous silica nanoparticles","volume":"15","author":"Lai","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.yexmp.2026.105087_bb0545","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1021\/acs.molpharmaceut.8b00401","article-title":"DenTimol as a dendrimeric timolol analogue for glaucoma therapy: synthesis and preliminary efficacy and safety assessment","volume":"15","author":"Lancina","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0550","doi-asserted-by":"crossref","DOI":"10.3390\/polym13193324","article-title":"Hyaluronic acid-based gold nanoparticles for the topical delivery of therapeutics to the retina and the retinal pigment epithelium","volume":"13","author":"Laradji","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.yexmp.2026.105087_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145356","article-title":"Fabrication of an alginate-poloxamer 407 thermosensitive carboxymethyl chitosan stabilized nanosuspension hydrogel for enhanced ocular delivery of clobetasol propionate in uveitis management","volume":"319","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0580","first-page":"2348","article-title":"Biomimetic nano-platform for enhanced drug delivery in retinal diseases","volume":"66","author":"Li","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100900","article-title":"Digital technology, tele-medicine and artificial intelligence in ophthalmology: a global perspective","volume":"82","author":"Li","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0555","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1039\/D0BM01599G","article-title":"Dasatinib loaded nanostructured lipid carriers for effective treatment of corneal neovascularization","volume":"9","author":"Li","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0565","article-title":"Nanotechnology-based ocular drug delivery systems: recent advances and future prospects","volume":"21","author":"Li","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114027","article-title":"Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye","volume":"385","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0585","doi-asserted-by":"crossref","first-page":"16747","DOI":"10.1039\/D0TA05100D","article-title":"Recent advances in electrospun nanofibers for supercapacitors","volume":"8","author":"Liang","year":"2020","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.yexmp.2026.105087_bb0590","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.1039\/C7TB01217A","article-title":"Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma","volume":"5","author":"Liao","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.yexmp.2026.105087_bb0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.mser.2025.101126","article-title":"Stimuli-responsive smart materials for biomedical applications","volume":"167","author":"Lin","year":"2026","journal-title":"Mater. Sci. Eng.: R: Rep."},{"key":"10.1016\/j.yexmp.2026.105087_bb0605","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1001\/jamaophthalmol.2019.3501","article-title":"Development and validation of a deep learning system to detect glaucomatous optic neuropathy using fundus photographs","volume":"137","author":"Liu","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2021.128053","article-title":"Gold nanoparticles-loaded contact lenses for laser protection and Meibomian Gland Dysfunction (MGD) dry eye treatment","volume":"635","author":"Liu","year":"2022","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.yexmp.2026.105087_bb0610","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0161-6420(03)00074-5","article-title":"Replacing the Amsler grid: a new method for monitoring patients with age-related macular degeneration","volume":"110","author":"Loewenstein","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.yexmp.2026.105087_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104847","article-title":"Development and evaluation of biodegradable nanofiber insert containing hyaluronic acid for treatment of dry eye syndrome","volume":"87","author":"Lokhande","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0620","doi-asserted-by":"crossref","DOI":"10.3390\/ma12020229","article-title":"Nepafenac-loaded cyclodextrin\/polymer nanoaggregates: a new approach to eye drop formulation","volume":"12","author":"Lorenzo-Veiga","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.yexmp.2026.105087_bb0625","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0301-4738.181742","article-title":"A novel smartphone ophthalmic imaging adapter: user feasibility studies in Hyderabad, India","volume":"64","author":"Ludwig","year":"2016","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0645","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12951-025-03448-1","article-title":"Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives","volume":"23","author":"Luo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0630","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jcis.2018.10.041","article-title":"Dual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis","volume":"536","author":"Luo","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119961","article-title":"Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: a push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy","volume":"243","author":"Luo","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.yexmp.2026.105087_bb0640","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/10717544.2022.2048134","article-title":"Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study","volume":"29","author":"Luo","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0650","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/jop.2019.0105","article-title":"Ophthalmic applications of cerium oxide nanoparticles","volume":"36","author":"Maccarone","year":"2020","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb0655","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/jop.2012.0138","article-title":"The vitreous humor as a barrier to nanoparticle distribution","volume":"29","author":"Mains","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb0660","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11095-018-2556-5","article-title":"Ocular pharmacokinetics of a topical ophthalmic nanomicellar solution of cyclosporine (Cequa\u00ae) for dry eye disease","volume":"36","author":"Mandal","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb0665","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/med.21509","article-title":"Gold nanoparticles in ophthalmology","volume":"39","author":"Masse","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0670","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12221-021-0178-8","article-title":"Polymers, electrically conductive nanofibers composed of chitosan-grafted polythiophene and poly (\u03b5-caprolactone) as tissue engineering scaffold","volume":"22","author":"Massoumi","year":"2021","journal-title":"Fibers Polym."},{"key":"10.1016\/j.yexmp.2026.105087_bb0675","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.yexmp.2026.105087_bb0680","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.msec.2010.06.018","article-title":"Electrospinning of PLGA\/gelatin randomly-oriented and aligned nanofibers as potential scaffold in tissue engineering","volume":"30","author":"Meng","year":"2010","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.yexmp.2026.105087_bb0685","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jconrel.2024.08.015","article-title":"Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models","volume":"374","author":"Mi","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0690","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144512","article-title":"Drug-loaded polymeric particulated systems for ophthalmic drugs release","volume":"27","author":"Mihailovici","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.yexmp.2026.105087_bb0695","first-page":"208","article-title":"Carbon quantum dots as next-generation nanocarriers for targeted ocular drug delivery: innovations and therapeutic potential - a review","volume":"8","author":"Mirghaffari","year":"2025","journal-title":"Progr. Chem. Biochem."},{"key":"10.1016\/j.yexmp.2026.105087_bb0700","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4103\/1735-5362.355196","article-title":"Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye","volume":"17","author":"Mirzaeei","year":"2022","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103676","article-title":"Ocular application of electrospun materials for drug delivery and cellular therapies","volume":"28","author":"Mishra","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0705","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ijpharm.2013.11.043","article-title":"Acetazolamide encapsulated dendritic nano-architectures for effective glaucoma management in rabbits","volume":"461","author":"Mishra","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0715","article-title":"Dual-stage acting dendrimeric nanoparticle for deepened chemotherapeutic drug delivery to tumor cells","author":"Mohammad Shahpouri","year":"2024","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.yexmp.2026.105087_bb0720","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/21691401.2016.1138483","article-title":"Electrospun mat with eyelid fat-derived stem cells as a scaffold for ocular epithelial regeneration","volume":"45","author":"Momenzadeh","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2026.125223","article-title":"Recent advances in the polysaccharide nanogel design for dry eye therapy","volume":"382","author":"Mousavi","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.yexmp.2026.105087_bb0730","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/mp500332m","article-title":"On the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein","volume":"11","author":"Mun","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0735","doi-asserted-by":"crossref","first-page":"26074","DOI":"10.1038\/s41598-025-10960-9","article-title":"Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA","volume":"15","author":"Naik","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105087_bb0740","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900702","article-title":"Dendritic effects of injectable biodegradable thermogels on pharmacotherapy of inflammatory glaucoma-associated degradation of extracellular matrix","volume":"8","author":"Nguyen","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111497","article-title":"Toward understanding the purely geometric effects of silver nanoparticles on potential application as ocular therapeutics via treatment of bacterial keratitis","volume":"119","author":"Nguyen","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.yexmp.2026.105087_bb0745","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.actbio.2020.04.055","article-title":"Effects of shell thickness of hollow poly(lactic acid) nanoparticles on sustained drug delivery for pharmacological treatment of glaucoma","volume":"111","author":"Nguyen","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0755","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/acsnano.2c05824","article-title":"Highly retina-permeating and long-acting resveratrol\/metformin nanotherapeutics for enhanced treatment of macular degeneration","volume":"17","author":"Nguyen","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb0760","doi-asserted-by":"crossref","first-page":"2104123","DOI":"10.1002\/adfm.202104123","article-title":"Advanced bioresponsive multitasking hydrogels in the new era of biomedicine","volume":"30","author":"Niazi","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0765","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1021\/acsnano.4c14061","article-title":"Intravitreally injected plasmonic nanorods activate bipolar cells with patterned near-infrared laser projection","volume":"19","author":"Nie","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.optlastec.2020.106850","article-title":"Synergistic effect in a two-phase laser procedure for production of silver nanoparticles colloids applicable in ophthalmology","volume":"138","author":"Nikolov","year":"2021","journal-title":"Opt. Laser Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0775","doi-asserted-by":"crossref","first-page":"27888","DOI":"10.1021\/acsomega.3c07033","article-title":"Magnetically controlled intraocular delivery of dexamethasone using silica-coated magnetic nanoparticles","volume":"9","author":"Noh","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.yexmp.2026.105087_bb0780","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2023.01.018","article-title":"Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases","volume":"354","author":"Onugwu","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0785","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.1167\/iovs.12-10743","article-title":"Effects of gold nanoparticles on endotoxin-induced uveitis in rats","volume":"53","author":"Pereira","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2025.114660","article-title":"\u0392-Cyclodextrin nanosponges for the ocular delivery of therapeutic Micro-RNA in a mouse model of retinitis pigmentosa: a proof of concept study","volume":"208","author":"Piano","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0795","article-title":"Poloxamer-based drug delivery systems: frontiers for treatment of solid tumors","volume":"32","author":"Pourbakhsh","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.yexmp.2026.105087_bb0805","first-page":"4988","article-title":"Se & N co-doped carbon dots for high-performance fluorescence imaging agent of angiography","volume":"5","author":"Qu","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0800","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.msec.2017.03.036","article-title":"EpCAM antibody-conjugated mesoporous silica nanoparticles to enhance the anticancer efficacy of carboplatin in retinoblastoma","volume":"76","author":"Qu","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.yexmp.2026.105087_bb0810","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017452","article-title":"Evaluation of magnetic micro- and nanoparticle toxicity to ocular tissues","volume":"6","author":"Raju","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yexmp.2026.105087_bb0815","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.addr.2006.07.025","article-title":"Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling","volume":"58","author":"Ranta","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0820","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11100517","article-title":"Hyperthermia-triggered doxorubicin release from polymer-coated magnetic nanorods","volume":"11","author":"Reyes-Ortega","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0825","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/acs.biomac.0c00726","article-title":"Exploring the impact of morphology on the properties of biodegradable nanoparticles and their diffusion in complex biological medium","volume":"22","author":"Ridolfo","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.yexmp.2026.105087_bb0830","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1021\/acsbiomaterials.0c01347","article-title":"Emerging trends in nanomedicine for improving ocular drug delivery: light-responsive nanoparticles, mesoporous silica nanoparticles, and contact lenses","volume":"6","author":"Rodrigues","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.yexmp.2026.105087_bb0835","article-title":"Microbots as a potential treatment for vitreous hemorrhage","volume":"22","author":"Rogowski","year":"2025","journal-title":"Retin. Physician"},{"key":"10.1016\/j.yexmp.2026.105087_bb0840","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/pharmaceutics16111398","article-title":"Revolutionizing eye care: exploring the potential of microneedle drug delivery","volume":"16","author":"Rojekar","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213124","article-title":"Recent advancements in polymeric nanofibers for ophthalmic drug delivery and ophthalmic tissue engineering","volume":"141","author":"Sakpal","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0850","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejpb.2016.10.013","article-title":"Lipid nanoparticles (SLN, NLC): overcoming the anatomical and physiological barriers of the eye\u2013part II-ocular drug-loaded lipid nanoparticles","volume":"110","author":"S\u00e1nchez-L\u00f3pez","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0855","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/nano15070552","article-title":"Hydrophobic silicon quantum dots for potential imaging of tear film lipid layer","volume":"15","author":"Sarwat","year":"2025","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.yexmp.2026.105087_bb0860","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1586\/eop.09.70","article-title":"Drug delivery to the posterior segment of the eye for pharmacologic therapy","volume":"5","author":"Shah","year":"2010","journal-title":"Expert Rev. Ophthalmol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0865","series-title":"Progress in Molecular Biology and Translational Science","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/bs.pmbts.2024.08.003","article-title":"Chapter eight - delivery of therapeutic proteins to ocular tissues: barriers, approaches, regulatory considerations and future perspectives","author":"Shastri","year":"2025"},{"key":"10.1016\/j.yexmp.2026.105087_bb0870","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.apsb.2025.12.011","article-title":"Machine learning empowered formulation design, optimization and characterization of nanoparticulate drug delivery systems: current applications, challenges, and future perspectives","volume":"16","author":"Shen","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.yexmp.2026.105087_bb0875","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2017.11.028","article-title":"RNA nanoparticle distribution and clearance in the eye after subconjunctival injection with and without thermosensitive hydrogels","volume":"270","author":"Shi","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0880","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1021\/acsabm.2c00809","article-title":"Noninvasive delivery of self-regenerating cerium oxide nanoparticles to modulate oxidative stress in the retina","volume":"5","author":"Shin","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb0885","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-030-27378-1_18","article-title":"Systemic delivery of genes to retina using adeno-associated viruses","volume":"1185","author":"Simpson","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0895","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2026.108472","article-title":"Harnessing polysaccharide-based approaches for posterior ocular disorders: therapeutic applications, regulatory perspectives, challenges, and future directions","volume":"123","author":"Singh","year":"2026","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.yexmp.2026.105087_bb0890","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s12668-026-02733-z","article-title":"AI-enabled teleophthalmology ecosystems for diabetic retinopathy: bridging intelligent screening with scalable and equitable eye care","volume":"16","author":"Singh","year":"2026","journal-title":"BioNanoScience"},{"key":"10.1016\/j.yexmp.2026.105087_bb0900","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.1038\/s41467-025-63553-5","article-title":"Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexmp.2026.105087_bb0905","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/pharmaceutics13060901","article-title":"Distribution of gold nanoparticles in the anterior chamber of the eye after intracameral injection for glaucoma therapy","volume":"13","author":"Sonntag","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0910","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103647","article-title":"Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery","volume":"28","author":"Srivastava","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110726","article-title":"Nanoscale poly (acrylic acid)-based hydrogels prepared via a green single-step approach for application as low-viscosity biomimetic fluid tears","volume":"110","author":"Swilem","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.yexmp.2026.105087_bb0920","article-title":"Natural polymeric nanofibers in transdermal drug delivery","volume":"30","author":"Talebi","year":"2023","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.yexmp.2026.105087_bb0925","article-title":"Ocular nanomedicine","volume":"9","author":"Tang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0935","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.molpharmaceut.0c00411","article-title":"Diffusion and protein corona formation of lipid-based nanoparticles in the vitreous humor: profiling and pharmacokinetic considerations","volume":"18","author":"Tavakoli","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb0930","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jconrel.2020.10.028","article-title":"Ocular barriers to retinal delivery of intravitreal liposomes: impact of vitreoretinal interface","volume":"328","author":"Tavakoli","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0940","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejps.2017.07.001","article-title":"Electrospun polymeric nanofibers: new horizons in drug delivery","volume":"107","author":"Thakkar","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb0945","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/17425247.2016.1218460","article-title":"Minimally invasive microneedles for ocular drug delivery","volume":"14","author":"Thakur Singh","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.yexmp.2026.105087_bb0950","doi-asserted-by":"crossref","first-page":"667","DOI":"10.55730\/1300-0527.3570","article-title":"Phosphorus-carrying cascade molecules: inner architecture to biomedical applications","volume":"47","author":"Thirumalai","year":"2023","journal-title":"Turk. J. Chem."},{"key":"10.1016\/j.yexmp.2026.105087_bb0955","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114899","article-title":"Advances in development of exosomes for ophthalmic therapeutics","volume":"199","author":"Tian","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.yexmp.2026.105087_bb0960","series-title":"The Contribution of Nanomedicine in Ocular Oncology","first-page":"1186","volume":"17","author":"Tsoplaktsoglou","year":"2025"},{"key":"10.1016\/j.yexmp.2026.105087_bb0965","doi-asserted-by":"crossref","DOI":"10.1002\/nano.70045","article-title":"Exosome-loaded contact lenses: a novel approach for sustained ocular drug delivery","volume":"6","author":"Turk","year":"2025","journal-title":"Nano Select"},{"key":"10.1016\/j.yexmp.2026.105087_bb0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114396","article-title":"Tiny tools, big vision: a minireview on carbonized nanomaterials in ophthalmology","volume":"388","author":"Unnikrishnan","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0975","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/pharmaceutics15041062","article-title":"Nanofibers in ocular drug targeting and tissue engineering: their importance, advantages, advances, and future perspectives","volume":"15","author":"Uzel","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb0980","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3390\/jcm11082170","article-title":"Mesoporous silica-based nanoparticles as non-viral gene delivery platform for treating retinitis pigmentosa","volume":"11","author":"Vald\u00e9s-S\u00e1nchez","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.yexmp.2026.105087_bb0985","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jconrel.2004.09.015","article-title":"Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide","volume":"102","author":"Vandamme","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0990","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jconrel.2025.01.068","article-title":"Lipid nanoparticle-mediated intracameral mRNA delivery facilitates gene expression and editing in the anterior chamber of the eye","volume":"379","author":"Vasudevan","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb0995","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/cancers16203516","article-title":"Artificial intelligence and machine learning in ocular oncology, retinoblastoma (ArMOR): experience with a multiracial cohort","volume":"16","author":"Vempuluru","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.yexmp.2026.105087_bb1000","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120717","article-title":"Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window","volume":"310","author":"Vincze","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.yexmp.2026.105087_bb1005","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/pharmaceutics13020288","article-title":"Suprachoroidal delivery of small molecules, nanoparticles, gene and cell therapies for ocular diseases","volume":"13","author":"Wan","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.yexmp.2026.105087_bb1010","article-title":"Nano-in-nano dendrimer gel particles for efficient topical delivery of antiglaucoma drugs into the eye","volume":"425","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.yexmp.2026.105087_bb1015","first-page":"e30","article-title":"Dendrimer and dendrimer gel-derived drug delivery systems: breaking bottlenecks of topical administration of glaucoma medications","volume":"2","author":"Wang","year":"2023","journal-title":"MedComm Biomater. Appl."},{"key":"10.1016\/j.yexmp.2026.105087_bb1040","article-title":"4D-printed intelligent reconfigurable occluder with anti-thrombotic and rapid-repairing capabilities for patent foramen ovale","volume":"15","author":"Wang","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.yexmp.2026.105087_bb1035","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1021\/acsnano.4c12327","article-title":"Hybrid biomembrane-functionalized nanorobots penetrate the vitreous body of the eye for the treatment of retinal vein occlusion","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb1045","article-title":"Cholesterol analogs modulate lipid nanoparticle performance for mRNA delivery after lyophilization and enable ocular disease therapy","volume":"38","author":"Wang","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.yexmp.2026.105087_bb1020","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102236","article-title":"Lipid nanoparticle technology-mediated therapeutic gene manipulation in the eyes","volume":"35","author":"Wang","year":"2024","journal-title":"Mol. Ther. Nucl. Acids"},{"key":"10.1016\/j.yexmp.2026.105087_bb1030","doi-asserted-by":"crossref","DOI":"10.1063\/5.0264382","article-title":"Recent advancements in polymer science for retinal diseases: new frontiers in drug delivery systems","volume":"9","author":"Wang","year":"2025","journal-title":"APL Bioeng."},{"key":"10.1016\/j.yexmp.2026.105087_bb1025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13287-024-03653-z","article-title":"The application of a 4D-printed chitosan-based stem cell carrier for the repair of corneal alkali burns","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.yexmp.2026.105087_bb1050","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1039\/D3TB00598D","article-title":"Mucin-targeting-aptamer functionalized liposomes for delivery of cyclosporin a for dry eye diseases","volume":"11","author":"Wong","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.yexmp.2026.105087_bb1060","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3390\/gels9040292","article-title":"Advances in nanogels for topical drug delivery in ocular diseases","volume":"9","author":"Wu","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.yexmp.2026.105087_bb1065","first-page":"2142","article-title":"Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye, drug Deliv","volume":"13","author":"Wu","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb1070","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/08923973.2025.2461056","article-title":"Clinical characteristics, treatment, and outcomes of nivolumab-induced uveitis","volume":"47","author":"Wu","year":"2025","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.yexmp.2026.105087_bb1055","doi-asserted-by":"crossref","first-page":"eaat4388","DOI":"10.1126\/sciadv.aat4388","article-title":"A swarm of slippery micropropellers penetrates the vitreous body of the eye","volume":"4","author":"Wu","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.yexmp.2026.105087_bb1075","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jconrel.2024.07.012","article-title":"Dexamethasone-loaded ROS stimuli-responsive nanogels for topical ocular therapy of corneal neovascularization","volume":"372","author":"Xiang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb1095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117800","article-title":"Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye","volume":"260","author":"Xu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.yexmp.2026.105087_bb1085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2013.01.018","article-title":"Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo","volume":"167","author":"Xu","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb1100","doi-asserted-by":"crossref","DOI":"10.1007\/s13346-026-02195-6","article-title":"Dissecting corneal drug permeability under experimental variability and drug cold-start challenges via hybrid machine learning","author":"Xu","year":"2026","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.yexmp.2026.105087_bb1090","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.actbio.2016.02.041","article-title":"Multifunctional properties of organic-inorganic hybrid nanocomposites based on chitosan derivatives and layered double hydroxides for ocular drug delivery","volume":"36","author":"Xu","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.yexmp.2026.105087_bb1080","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/08853282221090880","article-title":"In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma","volume":"37","author":"Xu","year":"2022","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.yexmp.2026.105087_bb1105","article-title":"Personalized nanovaccines from tumor cells: reshaping the microenvironment and defeating heterogeneity","author":"Xuehai Ou","year":"2026","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.yexmp.2026.105087_bb1125","doi-asserted-by":"crossref","first-page":"25118","DOI":"10.1021\/acsnano.3c07817","article-title":"Unveiling the power of gabapentin-loaded nanoceria with multiple therapeutic capabilities for the treatment of dry eye disease","volume":"17","author":"Yang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb1120","doi-asserted-by":"crossref","first-page":"2302174","DOI":"10.1002\/advs.202302174","article-title":"Poly(l-histidine)-mediated on-demand therapeutic delivery of roughened ceria nanocages for treatment of chemical eye injury","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb1110","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1021\/nn301873v","article-title":"Hybrid dendrimer hydrogel\/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration","volume":"6","author":"Yang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.yexmp.2026.105087_bb1115","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.nano.2016.12.021","article-title":"Biology, medicine, potential of CeCl3@ mSiO2 nanoparticles in alleviating diabetic cataract development and progression","volume":"13","author":"Yang","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.yexmp.2026.105087_bb1130","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acsmaterialslett.4c02327","article-title":"An injectable copolymer for in situ lubrication effectively relieves dry eye disease","volume":"7","author":"Yang","year":"2025","journal-title":"ACS Mater. Lett."},{"key":"10.1016\/j.yexmp.2026.105087_bb1135","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3109\/03639041003610799","article-title":"Preparation and characterization of puerarin-dendrimer complexes as an ocular drug delivery system","volume":"36","author":"Yao","year":"2010","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.yexmp.2026.105087_bb1140","article-title":"Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: in vitro and in vivo studies","volume":"7","author":"Yasser","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.yexmp.2026.105087_bb1155","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/jphp.12587","article-title":"Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation","volume":"68","author":"Yavuz","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105087_bb1145","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/732340","article-title":"Dendrimeric systems and their applications in ocular drug delivery","volume":"2013","author":"Yavuz","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.yexmp.2026.105087_bb1150","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1002\/jps.24588","article-title":"In vitro\/in vivo evaluation of dexamethasone\u2014PAMAM dendrimer complexes for retinal drug delivery","volume":"104","author":"Yavuz","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.yexmp.2026.105087_bb1160","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2019.10.039","article-title":"A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease","volume":"315","author":"Yu","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb1165","doi-asserted-by":"crossref","first-page":"495101","DOI":"10.1088\/1361-6528\/abb0b4","article-title":"Investigation of magnetically driven passage of magnetic nanoparticles through eye tissues for magnetic drug targeting","volume":"31","author":"Zahn","year":"2020","journal-title":"Nanotechnology"},{"key":"10.1016\/j.yexmp.2026.105087_bb1170","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/00914037.2025.2546870","article-title":"Polyglycerols-based hydrogels for biomedical applications: a comprehensive review","volume":"75","author":"Zare","year":"2025","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.yexmp.2026.105087_bb1180","article-title":"Metallic nano-warriors: innovations in nanoparticle-based ocular antimicrobials","volume":"28","author":"Zhang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.yexmp.2026.105087_bb1175","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1007\/s13577-024-01111-9","article-title":"Carbon quantum dots for the diagnosis and treatment of ophthalmic diseases","volume":"37","author":"Zhang","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.yexmp.2026.105087_bb1185","article-title":"Corneal mucin-targeting liposome nanoplatforms enable effective treatment of dry eye diseases by integrated regulation of ferroptosis and inflammation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.yexmp.2026.105087_bb1190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jconrel.2016.12.038","article-title":"An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration","volume":"247","author":"Zhao","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb1195","article-title":"A multifunctional mitochondria-targeted nanoparticle for the effective treatment of dry eye disease via reactive oxygen species scavenging","volume":"37","author":"Zhao","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.yexmp.2026.105087_bb1200","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1016\/j.apsb.2024.05.004","article-title":"Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease","volume":"14","author":"Zheng","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.yexmp.2026.105087_bb1205","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2024.07.026","article-title":"Rosmarinic acid-grafted gelatin nanogels for efficient diquafosol delivery in dry eye disease therapy","volume":"373","author":"Zhou","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.yexmp.2026.105087_bb1210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.actbio.2024.07.003","article-title":"Multifunctional cerium oxide nanozymes with high ocular surface retention for dry eye disease treatment achieved by restoring redox balance","volume":"185","author":"Zou","year":"2024","journal-title":"Acta Biomater."}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:23:59Z","timestamp":1793024639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":242,"alternative-id":["S0014480026000663"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105087","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing nanomaterials for treatment of eye diseases: a review","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105087"}}