{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:26:48Z","timestamp":1793662008972,"version":"4.5.1"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020137","name":"Ningxia Normal University Ningxia Natural Medicine Engineering Technology Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Molecular Pathology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.yexmp.2026.105089","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:57:49Z","timestamp":1792616269000},"page":"105089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["EGFR: A promising therapeutic target in renal fibrosis"],"prefix":"10.1016","volume":"148","author":[{"given":"Yangyang","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yexmp.2026.105089_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26216677","article-title":"Globally approved EGFR inhibitors: insights into their syntheses, target kinases, biological activities, receptor interactions, and metabolism","volume":"26","author":"Abourehab","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.yexmp.2026.105089_bb0010","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1476-5381.2011.01613.x","article-title":"Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a mas receptor-dependent pathway","volume":"165","author":"Akhtar","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0015","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/15376516.2025.2598564","article-title":"Renoprotective properties of resveratrol in the treatment of renal fibrosis, renal cell carcinoma, diabetic nephropathy and nephrotoxicity: a review of current evidence based on underlying cellular mechanisms","volume":"36","author":"AlRamadneh","year":"2026","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.yexmp.2026.105089_bb0020","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1681\/ASN.2015091014","article-title":"Stat3 controls Tubulointerstitial communication during CKD","volume":"27","author":"Bienaim\u00e9","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00560","article-title":"Klotho, aging, and the failing kidney","volume":"11","author":"Buchanan","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.yexmp.2026.105089_bb0030","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1038\/s41467-023-43226-x","article-title":"Epidermal growth factor receptor activation is essential for kidney fibrosis development","volume":"14","author":"Cao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexmp.2026.105089_bb0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1681\/ASN.2011070645","article-title":"EGFR signaling promotes TGF-\u03b2-dependent renal fibrosis","volume":"23","author":"Chen","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0040","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1681\/ASN.2014020192","article-title":"EGF receptor deletion in podocytes attenuates diabetic nephropathy","volume":"26","author":"Chen","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104547","article-title":"Urolithin a attenuates renal fibrosis by inhibiting TGF-\u03b21\/Smad and MAPK signaling pathways","volume":"83","author":"Cheng","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.yexmp.2026.105089_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108496","article-title":"Amivantamab plus lazertinib versus osimertinib as first-line treatment in EGFR-mutated advanced non-small cell lung cancer: MARIPOSA Asian subset","volume":"204","author":"Cho","year":"2025","journal-title":"Lung Cancer"},{"key":"10.1016\/j.yexmp.2026.105089_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","article-title":"EGF-ERBB signalling: towards the systems level","volume":"7","author":"Citri","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0065","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1158\/2159-8290.CD-14-0337","article-title":"AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer","volume":"4","author":"Cross","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.yexmp.2026.105089_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101266","article-title":"Molecular mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer","volume":"82","author":"Du","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.yexmp.2026.105089_bb0075","doi-asserted-by":"crossref","first-page":"9662","DOI":"10.1021\/acs.jmedchem.2c00704","article-title":"Discovery of BLU-945, a reversible, potent, and wild-type-sparing next-generation EGFR mutant inhibitor for treatment-resistant non-small-cell lung Cancer","volume":"65","author":"Eno","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000509670","article-title":"Synergistic inhibition of renal fibrosis by Nintedanib and Gefitinib in a murine model of obstructive nephropathy","volume":"7","author":"Feng","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.yexmp.2026.105089_bb0085","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1146\/annurev-pharmtox-070115-095427","article-title":"Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system","volume":"56","author":"Forrester","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0090","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.26898","article-title":"Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma","volume":"59","author":"Fuchs","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.yexmp.2026.105089_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117677","article-title":"Annual review of EGFR inhibitors in 2024","volume":"292","author":"Gao","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0100","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.yexmp.2026.105089_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.609158","article-title":"The blockade of TACE-dependent EGF receptor activation by losartan-Erlotinib combination attenuates renal fibrosis formation in 5\/6-Nephrectomized rats under vitamin D deficiency","volume":"7","author":"Gon\u00e7alves","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0110","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0115","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1172\/JCI31680","article-title":"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia","volume":"117","author":"Groenestege","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2026.105089_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10142-025-01816-6","article-title":"Honokiol attenuates renal fibrosis via SIRT3-mediated regulation of Wnt\/\u03b2-catenin signaling","volume":"26","author":"Guo","year":"2026","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.yexmp.2026.105089_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease - a systematic review and Meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.yexmp.2026.105089_bb0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s10637-025-01507-w","article-title":"A novel anti-HER2\/EGFR bispecific antibody-drug conjugate demonstrates promising antitumor efficacy and overcomes resistance to HER2- or EGFR-targeted ADCs","volume":"43","author":"Huang","year":"2025","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.yexmp.2026.105089_bb0135","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.2147\/DMSO.S450094","article-title":"Luteolin alleviates diabetic nephropathy fibrosis involving AMPK\/NLRP3\/TGF-\u03b2 pathway","volume":"17","author":"Huang","year":"2024","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.yexmp.2026.105089_bb0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0145","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/ndt\/gfw467","article-title":"Adverse kidney effects of epidermal growth factor receptor inhibitors","volume":"32","author":"Izzedine","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.yexmp.2026.105089_bb0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.yexmp.2026.105089_bb0155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nature17960","article-title":"Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors","volume":"534","author":"Jia","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.yexmp.2026.105089_bb0160","article-title":"D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis","volume":"12","author":"Jing","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"key":"10.1016\/j.yexmp.2026.105089_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-4827(02)00098-8","article-title":"Epidermal growth factor receptor: mechanisms of activation and signalling","volume":"284","author":"Jorissen","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yexmp.2026.105089_bb0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0175","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87023","article-title":"ADAM17 substrate release in proximal tubule drives kidney fibrosis","volume":"1","author":"Kefaloyianni","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.yexmp.2026.105089_bb0180","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexmp.2026.105089_bb0185","article-title":"Angiotensin-(1-7) attenuates kidney injury due to obstructive nephropathy in rats","volume":"10","author":"Kim","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.yexmp.2026.105089_bb0195","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1172\/JCI117152","article-title":"Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice","volume":"93","author":"Korfhagen","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2026.105089_bb0200","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI44595","article-title":"Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?","volume":"121","author":"Kriz","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yexmp.2026.105089_bb0205","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2353\/ajpath.2010.090123","article-title":"Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis","volume":"176","author":"Le Cras","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0210","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.32604\/biocell.2024.058340","article-title":"Exploring the mechanistic role of epidermal growth factor receptor activation in non-cancer kidney disease","volume":"49","author":"Lee","year":"2025","journal-title":"Biocell"},{"key":"10.1016\/j.yexmp.2026.105089_bb0220","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yexmp.2026.105089_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157998","article-title":"Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2\/SIRT1\/p53 signaling axis","volume":"153","author":"Li","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.yexmp.2026.105089_bb0230","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.2147\/DDDT.S243420","article-title":"Isoliquiritigenin attenuates UUO-induced renal inflammation and fibrosis by inhibiting Mincle\/Syk\/NF-kappa B signaling pathway","volume":"14","author":"Liao","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.yexmp.2026.105089_bb0235","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40360-025-00855-w","article-title":"Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification","volume":"26","author":"Liu","year":"2025","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0240","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1681\/ASN.2011050493","article-title":"Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis","volume":"23","author":"Liu","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0245","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1002\/ptr.70091","article-title":"Artesunate enhances DUSP1-dependent mitochondrial integrity to mitigate renal fibrosis in diabetic kidney disease","volume":"39","author":"Liu","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.yexmp.2026.105089_bb0250","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0255","article-title":"(\u2212)-Epigallocatechin-3-gallate (EGCG) attenuates salt-induced hypertension and renal injury in dahl salt-sensitive rats","volume":"10","author":"Luo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yexmp.2026.105089_bb0260","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s13577-019-00314-9","article-title":"Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-\u03b2 signaling pathway","volume":"33","author":"Ma","year":"2020","journal-title":"Hum. Cell"},{"key":"10.1016\/j.yexmp.2026.105089_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100641","article-title":"Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET","volume":"296","author":"Neijssen","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"2005","key":"10.1016\/j.yexmp.2026.105089_bb0270","first-page":"0010","article-title":"A comprehensive pathway map of epidermal growth factor receptor signaling","volume":"1","author":"Oda","year":"2005","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0275","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ki.2010.154","article-title":"A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"78","author":"Pang","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexmp.2026.105089_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117796","article-title":"Exploring the structural activity relationship of the Osimertinib: a covalent inhibitor of double mutant EGFRL858R\/T790M tyrosine kinase for the treatment of non-small cell lung Cancer (NSCLC)","volume":"109","author":"Patil","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0285","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2036.2008.03717.x","article-title":"Review article: panitumumab--a fully human anti-EGFR monoclonal antibody for treatment of metastatic colorectal cancer","volume":"28","author":"Peeters","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.yexmp.2026.105089_bb0290","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ki.2015.30","article-title":"New drug toxicities in the onco-nephrology world","volume":"87","author":"Perazella","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.yexmp.2026.105089_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/8739473","article-title":"Role of epidermal growth factor receptor (EGFR) and its ligands in kidney inflammation and damage","volume":"2018","author":"Rayego-Mateos","year":"2018","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.yexmp.2026.105089_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167957","article-title":"EGFR inhibitor suppresses tumor growth by blocking lipid uptake and cholesterol synthesis in non-small cell lung cancer","volume":"1871","author":"Rhie","year":"2025","journal-title":"Biochimica et biophysica acta. Molecular basis of disease"},{"key":"10.1016\/j.yexmp.2026.105089_bb0305","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2174\/1568026620666200303123102","article-title":"Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors","volume":"20","author":"Sabbah","year":"2020","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0310","doi-asserted-by":"crossref","first-page":"454","DOI":"10.33545\/26174693.2025.v9.i12f.6532","article-title":"Cellular senescence and fibrosis as key drivers in the aftermath of acute kidney injury","volume":"9","author":"Salem","year":"2025","journal-title":"Int. J. Adv. Biochem. Res."},{"key":"10.1016\/j.yexmp.2026.105089_bb0315","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.12155","article-title":"Emerging functions of the EGFR in cancer","volume":"12","author":"Sigismund","year":"2018","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0320","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9025.1","article-title":"EGF receptor ligands: recent advances","volume":"5","author":"Singh","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.yexmp.2026.105089_bb0325","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/jpet.112.197756","article-title":"Target binding properties and cellular activity of Afatinib (BIBW 2992), an irreversible ErbB family blocker","volume":"343","author":"Solca","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yexmp.2026.105089_bb0330","doi-asserted-by":"crossref","first-page":"46265","DOI":"10.1074\/jbc.M207135200","article-title":"Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-Anilinoquinazoline inhibitor","volume":"277","author":"Stamos","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0335","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2538798","article-title":"Mechanisms of NLRP3 inflammasome in chronic kidney disease and the effects of traditional Chinese medicines","volume":"47","author":"Sun","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.yexmp.2026.105089_bb0340","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/HYPERTENSIONAHA.115.05344","article-title":"Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II","volume":"65","author":"Takayanagi","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.yexmp.2026.105089_bb0345","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajpath.2013.04.005","article-title":"Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury","volume":"183","author":"Tang","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0350","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1681\/ASN.2020111561","article-title":"Kim-1 targeted extracellular vesicles: a new therapeutic platform for RNAi to treat AKI","volume":"32","author":"Tang","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1394997","article-title":"Targeting the epidermal growth factor receptor (EGFR\/ErbB) for the potential treatment of renal pathologies","volume":"15","author":"Tawengi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0360","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1021\/acscentsci.0c00763","article-title":"Kidney-targeted cytosolic delivery of siRNA using a small-sized Mirror DNA tetrahedron for enhanced potency","volume":"6","author":"Thai","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.yexmp.2026.105089_bb0365","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2215\/CJN.0000000000000365","article-title":"Circulating Activin a, kidney fibrosis, and adverse events","volume":"19","author":"Tsai","year":"2024","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14768","article-title":"Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer","volume":"8","author":"Uchibori","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yexmp.2026.105089_bb0380","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.2147\/DDDT.S321879","article-title":"Puerarin alleviates UUO-induced inflammation and fibrosis by regulating the NF-\u03baB P65\/STAT3 and TGF\u03b21\/Smads signaling pathways","volume":"15","author":"Wang","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.yexmp.2026.105089_bb0385","article-title":"Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p\/HMGA2 axis","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0390","article-title":"Schisandrin a attenuates diabetic nephropathy via EGFR\/AKT\/GSK3\u03b2 signaling pathway based on network pharmacology and experimental validation","volume":"13","author":"Wang","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.yexmp.2026.105089_bb0395","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ptr.7599","article-title":"Quercetin inhibits the amphiregulin\/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy","volume":"37","author":"Wang","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.yexmp.2026.105089_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107500","article-title":"Discovery of a prominent dual-target DDR1\/EGFR inhibitor aimed DDR1\/EGFR-positive NSCLC","volume":"149","author":"Wang","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0405","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1080\/13880209.2020.1809462","article-title":"Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4\/NF-\u043aB and PI3K\/AKT signalling pathways","volume":"58","author":"Wang","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0410","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9050052","article-title":"Epidermal growth factor receptor cell proliferation signaling pathways","volume":"9","author":"Wee","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.yexmp.2026.105089_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176799","article-title":"Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-\u03baB pathway","volume":"978","author":"Wen","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156324","article-title":"Inhibition of PKM2 by shikonin impedes TGF-\u03b21 expression by repressing histone lactylation to alleviate renal fibrosis","volume":"136","author":"Xiang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.yexmp.2026.105089_bb0425","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.30541","article-title":"Continuous genetic monitoring of transient mesenchymal gene activities in distal tubule and collecting duct epithelial cells during renal fibrosis","volume":"125","author":"Xu","year":"2024","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0430","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11684-024-1117-z","article-title":"Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions","volume":"19","author":"Yang","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.yexmp.2026.105089_bb0435","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0440","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ccr.2006.12.017","article-title":"Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity","volume":"11","author":"Yun","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yexmp.2026.105089_bb0445","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2025.2481392","article-title":"Fourth-generation EGFR-TKI to overcome C797S mutation: past, present, and future","volume":"40","author":"Zhang","year":"2025","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.yexmp.2026.105089_bb0450","doi-asserted-by":"crossref","first-page":"F788","DOI":"10.1152\/ajprenal.00184.2024","article-title":"Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers","volume":"327","author":"Zhang","year":"2024","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0455","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1111\/bph.14842","article-title":"Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation-related signalling pathways","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yexmp.2026.105089_bb0460","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12906-023-04330-z","article-title":"Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-\u03baB p65 nuclear translocation","volume":"24","author":"Zhao","year":"2024","journal-title":"BMC Complement Med. Ther."},{"key":"10.1016\/j.yexmp.2026.105089_bb0465","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/0886022X.2017.1305409","article-title":"Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro","volume":"39","author":"Zhou","year":"2017","journal-title":"Ren. Fail."},{"key":"10.1016\/j.yexmp.2026.105089_bb0470","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1248\/bpb.b23-00924","article-title":"New directions for advanced targeting strategies of EGFR signaling in Cancer","volume":"47","author":"Zhou","year":"2024","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.yexmp.2026.105089_bb0475","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/kisup.2014.13","article-title":"EGFR signaling in renal fibrosis","volume":"4","author":"Zhuang","year":"2014","journal-title":"Kidney Int. Suppl"}],"container-title":["Experimental and Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014480026000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:02:29Z","timestamp":1793660549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014480026000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":92,"alternative-id":["S0014480026000687"],"URL":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105089","relation":{},"ISSN":["0014-4800"],"issn-type":[{"value":"0014-4800","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EGFR: A promising therapeutic target in renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Experimental and Molecular Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yexmp.2026.105089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105089"}}