{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:51Z","timestamp":1789977831563,"version":"4.0.1"},"reference-count":335,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ABC Alzheimer Nederland"},{"DOI":"10.13039\/501100008398","name":"ISAO","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008398","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Frontiers in Neuroendocrinology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.yfrne.2015.12.001","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T17:16:18Z","timestamp":1451495778000},"page":"153-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"special_numbering":"C","title":["Depression as a risk factor for Alzheimer\u2019s disease: Genes, steroids, cytokines and neurogenesis \u2013 What do we need to know?"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-6465","authenticated-orcid":false,"given":"Joe","family":"Herbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Lucassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yfrne.2015.12.001_b0005","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.archger.2009.07.001","article-title":"Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer\u2019s disease (AD) patients","volume":"51","author":"Aldred","year":"2010","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b0010","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1210\/jc.2004-1667","article-title":"Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications","volume":"90","author":"Alesci","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b0015","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/hipo.20566","article-title":"Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons","volume":"19","author":"Alfarez","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.yfrne.2015.12.001_b0020","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.psyneuen.2009.09.001","article-title":"Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed","volume":"35","author":"Alt","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(07)63001-5","article-title":"The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)","volume":"163","author":"Amaral","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b0030","doi-asserted-by":"crossref","unstructured":"A.P. Association, 2013. Diagnostic and Statistical Manual of Mental Disorders. Arlington, VA.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.yfrne.2015.12.001_b0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0040","doi-asserted-by":"crossref","first-page":"16945","DOI":"10.1523\/JNEUROSCI.1445-13.2013","article-title":"NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH","volume":"33","author":"Andres","year":"2013","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0045","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1097\/00001756-199611250-00050","article-title":"Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer\u2019s disease","volume":"7","author":"Arendt","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.yfrne.2015.12.001_b0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1385\/ENDO:22:2:113","article-title":"Alzheimer\u2019s disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors","volume":"22","author":"Armanini","year":"2003","journal-title":"Endocrine"},{"key":"10.1016\/j.yfrne.2015.12.001_b0055","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neurobiolaging.2008.07.011","article-title":"Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer\u2019s disease","volume":"31","author":"Arsenault-Lapierre","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/JAD-2010-100390","article-title":"Depression and Alzheimer\u2019s disease: is stress the initiating factor in a common neuropathological cascade?","volume":"23","author":"Aznar","year":"2011","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1212\/WNL.43.3_Part_1.515","article-title":"Incidence of dementia and probable Alzheimer\u2019s disease in a general population: the Framingham study","volume":"43","author":"Bachman","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.biopsych.2012.12.003","article-title":"Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology","volume":"74","author":"Baglietto-Vargas","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0075","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0083-6729(10)82018-7","article-title":"Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus","volume":"82","author":"Bao","year":"2010","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.yfrne.2015.12.001_b0080","first-page":"1","article-title":"Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis","volume":"11","author":"Barlinn","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.yfrne.2015.12.001_b0085","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/archgenpsychiatry.2011.1481","article-title":"Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia","volume":"69","author":"Barnes","year":"2012","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b0090","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats","volume":"32","author":"Barrientos","year":"2012","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.yfrne.2015.12.001_b0100","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pneurobio.2013.10.005","article-title":"Stress and trauma: BDNF control of dendritic-spine formation and regression","volume":"112","author":"Bennett","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.trsl.2014.05.006","article-title":"Epigenomics of Alzheimer\u2019s disease","volume":"165","author":"Bennett","year":"2015","journal-title":"Transl. Res.: J. Lab. Clin. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3233\/JAD-2012-112003","article-title":"Apathy and depression in mild Alzheimer\u2019s disease: a cross-sectional study using diagnostic criteria","volume":"31","author":"Benoit","year":"2012","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00213-005-0062-z","article-title":"Increased salivary cortisol after waking in depression","volume":"182","author":"Bhagwagar","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0120","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biopsych.2014.10.014","article-title":"Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients","volume":"78","author":"Black","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jad.2009.03.017","article-title":"Depression, traumatic stress and interleukin-6","volume":"120","author":"Bob","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.yfrne.2015.12.001_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2006.04.017","article-title":"Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus","volume":"24","author":"Boekhoorn","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.yfrne.2015.12.001_b0145","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/npp.2009.75","article-title":"Antidepressants increase neural progenitor cells in the human hippocampus","volume":"34","author":"Boldrini","year":"2009","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0150","doi-asserted-by":"crossref","first-page":"e0131266","DOI":"10.1371\/journal.pone.0131266","article-title":"Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory","volume":"10","author":"Bonds","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b0155","doi-asserted-by":"crossref","first-page":"e599","DOI":"10.1038\/tp.2015.88","article-title":"Serum proteomic profiling of major depressive disorder","volume":"5","author":"Bot","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0160","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/archgenpsychiatry.2007.26","article-title":"Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene","volume":"65","author":"Bradley","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s001270050067","article-title":"Genetic and population perspectives on life events and depression","volume":"33","author":"Brown","year":"1998","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1192\/bjp.150.1.30","article-title":"Life events, vulnerability and onset of depression: some refinements","volume":"150","author":"Brown","year":"1987","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(99)00790-9","article-title":"The effect of corticosteroids on amyloid beta precursor protein\/amyloid precursor-like protein expression and processing in vivo","volume":"276","author":"Budas","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yfrne.2015.12.001_b0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1139\/H08-013","article-title":"Impact of DHEA(S) and cortisol on immune function in aging: a brief review","volume":"33","author":"Buford","year":"2008","journal-title":"Appl. Physiol., Nutr., Metab.=Physiol. Appliquee, Nutr. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b0185","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.psyneuen.2005.02.010","article-title":"Depression and cortisol responses to psychological stress: a meta-analysis","volume":"30","author":"Burke","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0306-4522(97)00303-5","article-title":"Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway","volume":"82","author":"Cameron","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b0195","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00439-011-0949-1","article-title":"Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions","volume":"129","author":"Cao-Lei","year":"2011","journal-title":"Hum. Genet."},{"key":"10.1016\/j.yfrne.2015.12.001_b0200","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1200\/JCO.2000.18.10.2143","article-title":"Early depressive symptoms in cancer patients receiving interleukin 2 and\/or interferon alfa-2b therapy","volume":"18","author":"Capuron","year":"2000","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0205","first-page":"10","article-title":"Informed use of the dexamethasone suppression test","volume":"47","author":"Carroll","year":"1986","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0210","doi-asserted-by":"crossref","first-page":"14436","DOI":"10.1523\/JNEUROSCI.3836-11.2011","article-title":"Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy","volume":"31","author":"Carroll","year":"2011","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0215","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.yfrne.2015.12.001_b0220","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/dneu.20758","article-title":"The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity","volume":"70","author":"Castren","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0225","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.mp.4002101","article-title":"The amyloidogenic potential and behavioral correlates of stress","volume":"14","author":"Catania","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0230","doi-asserted-by":"crossref","first-page":"e90980","DOI":"10.1371\/journal.pone.0090980","article-title":"A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b0235","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0165-0327(85)90026-6","article-title":"Spontaneous afternoon plasma cortisol in depression","volume":"8","author":"Christensen","year":"1985","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.yfrne.2015.12.001_b0240","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/jamaneurol.2015.0606","article-title":"Clinical features of Alzheimer disease with and without Lewy bodies","volume":"72","author":"Chung","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0245","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1111\/bph.13181","article-title":"Amyloid \u03b2: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease","volume":"172","author":"Clark","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0250","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exger.2006.08.009","article-title":"The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer\u2019s disease","volume":"42","author":"Cole","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0255","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.jnen.0000202887.22082.63","article-title":"Microglia in the aging brain","volume":"65","author":"Conde","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0260","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2826.2010.02051.x","article-title":"Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus","volume":"22","author":"Conway-Campbell","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0265","doi-asserted-by":"crossref","first-page":"e557","DOI":"10.1038\/tp.2015.49","article-title":"Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins","volume":"5","author":"Cordova-Palomera","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0270","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1523\/JNEUROSCI.5818-10.2011","article-title":"Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes","volume":"31","author":"Cortese","year":"2011","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033291709005558","article-title":"Not fade away: the HPA axis and depression","volume":"40","author":"Cowen","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0280","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/wps.20229","article-title":"What has serotonin to do with depression?","volume":"14","author":"Cowen","year":"2015","journal-title":"World Psychiatry: Off. J. World Psychiatr. Assoc."},{"key":"10.1016\/j.yfrne.2015.12.001_b0285","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","author":"Cross-Disorder Group of the Psychiatric Genomics","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.yfrne.2015.12.001_b0290","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000362724","article-title":"One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids","volume":"22","author":"Cruz-Topete","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.yfrne.2015.12.001_b0295","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00406-007-0728-0","article-title":"What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?","volume":"257","author":"Czeh","year":"2007","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0300","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pnpbp.2015.04.004","article-title":"Animal models of major depression and their clinical implications","volume":"64","author":"Czeh","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0305","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/hipo.22382","article-title":"Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal\u2013ventral and region-specific differences","volume":"25","author":"Czeh","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.yfrne.2015.12.001_b0310","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yfrne.2005.08.001","article-title":"Fast glucocorticoid actions on brain: back to the future","volume":"26","author":"Dallman","year":"2005","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0315","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0320","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","article-title":"Inflammation-associated depression: from serotonin to kynurenine","volume":"36","author":"Dantzer","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0325","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fnbeh.2014.00136","article-title":"Learning and memory impairments in a neuroendocrine mouse model of anxiety\/depression","volume":"8","author":"Darcet","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0330","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.yfrne.2015.12.001_b0335","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1176\/ajp.143.3.300","article-title":"Cortisol and Alzheimer\u2019s disease, I: Basal studies","volume":"143","author":"Davis","year":"1986","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0340","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3233\/JAD-140186","article-title":"Insulin-like growth factor-I receptor stimulating activity is associated with dementia","volume":"42","author":"de Bruijn","year":"2014","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b0345","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer\u2019s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0350","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ncpendmet0403","article-title":"Therapy insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?","volume":"3","author":"de Kloet","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b0355","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-2094-11-34","article-title":"Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation","volume":"11","author":"de Pablos","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.yfrne.2015.12.001_b0360","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/29542","article-title":"Stress and glucocorticoids impair retrieval of long-term spatial memory","volume":"394","author":"de Quervain","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.yfrne.2015.12.001_b0365","doi-asserted-by":"crossref","first-page":"e0126423","DOI":"10.1371\/journal.pone.0126423","article-title":"MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer\u2019s disease","volume":"10","author":"Denk","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2014.11.002","article-title":"Global changes in DNA methylation in Alzheimer\u2019s disease peripheral blood mononuclear cells","volume":"45","author":"Di Francesco","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yfrne.2015.12.001_b0375","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","article-title":"Late-life depression and risk of vascular dementia and Alzheimer\u2019s disease: systematic review and meta-analysis of community-based cohort studies","volume":"202","author":"Diniz","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0380","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/geronb\/gbu096","article-title":"Reduced cerebrospinal fluid levels of brain-derived neurotrophic factor is associated with cognitive impairment in late-life major depression","volume":"69","author":"Diniz","year":"2014","journal-title":"J. Gerontol.. Ser. B: Psychol. Sci. Soc. Sci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0385","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1523\/JNEUROSCI.4437-12.2013","article-title":"Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer\u2019s disease","volume":"33","author":"Douaud","year":"2013","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0390","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0395","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.yfrne.2015.12.001_b0400","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.psyneuen.2013.01.002","article-title":"Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA)","volume":"38","author":"Duivis","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0405","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0410","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0140-6736(05)66552-X","article-title":"Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months","volume":"365","author":"Edwards","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.yfrne.2015.12.001_b0415","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.biopsych.2014.05.021","article-title":"Research council cognitive, and s. ageing neuropathology, stage-specific changes in neurogenic and glial markers in Alzheimer\u2019s disease","volume":"77","author":"Ekonomou","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0420","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/npp.2013.132","article-title":"Increased hippocampal neurogenesis and p21 expression in depression: dependent on antidepressants, sex, age, and antipsychotic exposure","volume":"38","author":"Epp","year":"2013","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0425","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1389450111314050004","article-title":"Genetics of serotonin receptors and depression: state of the art","volume":"14","author":"Fabbri","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.yfrne.2015.12.001_b0430","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1017\/S0033291704002612","article-title":"Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR\u2217D","volume":"34","author":"Fava","year":"2004","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0435","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphys.2015.00040","article-title":"The emerging role of microRNAs in Alzheimer\u2019s disease","volume":"6","author":"Femminella","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0440","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrn3209","article-title":"The many faces of insulin-like peptide signalling in the brain","volume":"13","author":"Fernandez","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0445","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0531-5565(00)00160-1","article-title":"Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia","volume":"35","author":"Ferrari","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0450","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10571-011-9788-9","article-title":"Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress","volume":"32","author":"Filipcik","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0455","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1750-1326-9-25","article-title":"Epigenetic regulation of adult neural stem cells: implications for Alzheimer\u2019s disease","volume":"9","author":"Fitzsimons","year":"2014","journal-title":"Mol. Neurodegeneration"},{"issue":"Suppl. 1","key":"10.1016\/j.yfrne.2015.12.001_b0460","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.bbi.2011.01.005","article-title":"Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse","volume":"25","author":"Frank","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yfrne.2015.12.001_b0465","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fpsyg.2015.00309","article-title":"Problematic assumptions have slowed down depression research: why symptoms, not syndromes are the way forward","volume":"6","author":"Fried","year":"2015","journal-title":"Front. Psychol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0470","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1091\/mbc.E14-12-1612","article-title":"Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Abeta oligomer-treated hippocampal neurons","volume":"26","author":"Gan","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yfrne.2015.12.001_b0475","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12888-014-0371-z","article-title":"Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies","volume":"14","author":"Gan","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0480","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.biopsych.2014.12.009","article-title":"MicroRNA and posttranscriptional dysregulation in psychiatry","volume":"78","author":"Geaghan","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0485","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1192\/bjp.176.6.568","article-title":"Depression and risk of cognitive decline and Alzheimer\u2019s disease. Results of two prospective community-based studies in The Netherlands","volume":"176","author":"Geerlings","year":"2000","journal-title":"Br. J. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b0490","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3233\/JAD-2010-100663","article-title":"HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer\u2019s disease","volume":"22","author":"Gil-Bea","year":"2010","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b0495","doi-asserted-by":"crossref","first-page":"11500","DOI":"10.1523\/JNEUROSCI.0343-15.2015","article-title":"Blocking IGF signaling in adult neurons alleviates Alzheimer\u2019s disease pathology through amyloid-b clearance","volume":"35","author":"Gontier","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0500","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1046\/j.1471-4159.1996.66051836.x","article-title":"Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons","volume":"66","author":"Goodman","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yfrne.2015.12.001_b0505","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S0033291700034644","article-title":"Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation","volume":"26","author":"Goodyer","year":"1996","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0510","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1192\/bjp.bp.110.077750","article-title":"Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents","volume":"197","author":"Goodyer","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0515","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ng.2555","article-title":"Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease","volume":"45","author":"Gratten","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yfrne.2015.12.001_b0520","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nn.3708","article-title":"Large-scale genomics unveils the genetic architecture of psychiatric disorders","volume":"17","author":"Gratten","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0525","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.60.5.753","article-title":"Depression as a risk factor for Alzheimer disease: the MIRAGE study","volume":"60","author":"Green","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0530","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1523\/JNEUROSCI.2797-06.2006","article-title":"Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Green","year":"2006","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0535","first-page":"3951","article-title":"Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age","volume":"81","author":"Guazzo","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b0540","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1212\/WNL.0000000000001684","article-title":"Depression and subsequent risk of Parkinson disease: a nationwide cohort study","volume":"84","author":"Gustafsson","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0545","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1460-9568.2010.07379.x","article-title":"Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer\u2019s disease","volume":"32","author":"Hamilton","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0550","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1469-7610.2009.02177.x","article-title":"Chronic and acute stress, gender, and serotonin transporter gene\u2013environment interactions predicting depression symptoms in youth","volume":"51","author":"Hammen","year":"2010","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0555","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.yfrne.2015.12.001_b0560","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0565","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior","volume":"37","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0570","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1192\/bjp.177.6.505","article-title":"Morning cortisol as a risk factor for subsequent major depressive disorder in adult women","volume":"177","author":"Harris","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0575","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.mp.4001799","article-title":"The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills","volume":"11","author":"Harris","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0580","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0197-0186(01)00051-1","article-title":"Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo","volume":"39","author":"Harris-White","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.yfrne.2015.12.001_b0585","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0197-4580(97)80309-0","article-title":"Twenty-four hour cortisol release profiles in patients with Alzheimer\u2019s and Parkinson\u2019s disease compared to normal controls: ultradian secretory pulsatility and diurnal variation","volume":"18","author":"Hartmann","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b0590","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/089198879901200206","article-title":"Association between premorbid history of depression and current depression in Alzheimer\u2019s disease","volume":"12","author":"Harwood","year":"1999","journal-title":"J. Geriatr. Psychiatr. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0595","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/brain\/awh129","article-title":"Disrupted daily activity\/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer\u2019s dementia","volume":"127","author":"Hatfield","year":"2004","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0600","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/aje\/153.2.132","article-title":"Is the risk of developing Alzheimer\u2019s disease greater for women than for men?","volume":"153","author":"Hebert","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0605","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0610","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0033291712000955","article-title":"Cortisol and depression: three questions for psychiatry","volume":"43","author":"Herbert","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0615","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2826.2006.01429.x","article-title":"Do corticosteroids damage the brain?","volume":"18","author":"Herbert","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0620","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/070674371506000406","article-title":"Outcomes study in dementia, risk factors for progression of Alzheimer disease in a Canadian population: the Canadian outcomes study in dementia (COSID)","volume":"60","author":"Herrmann","year":"2015","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0625","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nn.4017","article-title":"The case for rejecting the amyloid cascade hypothesis","volume":"18","author":"Herrup","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0630","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1017\/S0033291712002449","article-title":"Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)","volume":"43","author":"Heser","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0635","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0924-9338(02)00678-8","article-title":"Depression in Alzheimer\u2019s disease: is there a temporal relationship between the onset of depression and the onset of dementia?","volume":"17","author":"Heun","year":"2002","journal-title":"Eur. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b0640","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.biopsych.2009.06.023","article-title":"Cognitive impairment in major depression: association with salivary cortisol","volume":"66","author":"Hinkelmann","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0645","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3174\/ajnr.A3601","article-title":"Disease neuroimaging, higher rates of decline for women and apolipoprotein E epsilon4 carriers","volume":"34","author":"Holland","year":"2013","journal-title":"AJNR \u2013 Am. J. Neuroradiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0650","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuroscience.2005.09.037","article-title":"11Beta-hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids","volume":"137","author":"Holmes","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b0655","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2005.07.017","article-title":"Increased cerebrospinal fluid cortisol level in Alzheimer\u2019s disease is not related to depression","volume":"27","author":"Hoogendijk","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b0665","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b0670","doi-asserted-by":"crossref","first-page":"16207","DOI":"10.1523\/JNEUROSCI.0747-14.2014","article-title":"Social interaction rescues memory deficit in an animal model of Alzheimer\u2019s disease by increasing BDNF-dependent hippocampal neurogenesis","volume":"34","author":"Hsiao","year":"2014","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0675","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopsych.2005.09.016","article-title":"Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone","volume":"59","author":"Huang","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0680","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/bs.acc.2014.11.003","article-title":"Advances in biomarkers of major depressive disorder","volume":"68","author":"Huang","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.yfrne.2015.12.001_b0685","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jocn.2008.12.026","article-title":"Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer\u2019s disease","volume":"16","author":"Huang","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0690","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biopsych.2013.01.005","article-title":"Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study","volume":"74","author":"Huang","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0695","first-page":"CD000304","article-title":"Dehydroepiandrosterone (DHEA) supplementation for cognitive function","author":"Huppert","year":"2001","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b0700","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fneur.2015.00090","article-title":"The potential of pathological protein fragmentation in blood-based biomarker development for dementia \u2013 with emphasis on Alzheimer\u2019s disease","volume":"6","author":"Inekci","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0705","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.mp.4000712","article-title":"Adult brain neurogenesis and psychiatry: a novel theory of depression","volume":"5","author":"Jacobs","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0710","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0715","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopsycho.2013.01.018","volume":"93","author":"Jarcho","year":"2013","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0720","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.0403678101","article-title":"Enhanced neurogenesis in Alzheimer\u2019s disease transgenic (PDGF-APPSw, Ind) mice","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0725","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1124\/pr.112.005892","article-title":"Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes","volume":"64","author":"Joels","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b0730","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-2012-120328","article-title":"Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer\u2019s disease","volume":"31","author":"Joshi","year":"2012","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b0735","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s002130000549","article-title":"Prefrontal cortical hypometabolism during low-dose interferon alpha treatment","volume":"152","author":"Juengling","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0740","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1523\/JNEUROSCI.3333-14.2015","article-title":"Posttraumatic stress disorder-like induction elevates beta-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses","volume":"35","author":"Justice","year":"2015","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0745","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.metabol.2014.10.026","article-title":"Biomarkers of psychiatric diseases: current status and future prospects","volume":"64","author":"Kalia","year":"2015","journal-title":"Metab., Clin. Exp."},{"key":"10.1016\/j.yfrne.2015.12.001_b0750","doi-asserted-by":"crossref","first-page":"10673","DOI":"10.1073\/pnas.0700148104","article-title":"Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity","volume":"104","author":"Kang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0755","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1212\/WNL.0b013e31822dc7e1","article-title":"Magnetic resonance spectroscopy, beta-amyloid load, and cognition in a population-based sample of cognitively normal older adults","volume":"77","author":"Kantarci","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0760","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.1018375108","article-title":"Disruption of circadian clocks has ramifications for metabolism, brain, and behavior","volume":"108","author":"Karatsoreos","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0765","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0770","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1001\/archgenpsychiatry.2010.189","article-title":"The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation","volume":"68","author":"Karg","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0775","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1001\/jamapsychiatry.2015.0082","article-title":"Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study","volume":"72","author":"Katon","year":"2015","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b0780","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archgenpsychiatry.2011.60","article-title":"Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder","volume":"68","author":"Kempton","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0785","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","article-title":"Causal relationship between stressful life events and the onset of major depression","volume":"156","author":"Kendler","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0790","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/YIC.0b013e32834ace0f","article-title":"Do continued antidepressants protect against dementia in patients with severe depressive disorder?","volume":"26","author":"Kessing","year":"2011","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0795","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0022-3999(02)00309-4","article-title":"Depression and immune function: central pathways to morbidity and mortality","volume":"53","author":"Kiecolt-Glaser","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b0800","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3758\/s13415-015-0343-x","article-title":"Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory","volume":"15","author":"Kim","year":"2015","journal-title":"Cogn., Affect. Behav. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0805","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1073\/pnas.95.4.1852","article-title":"Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity","volume":"95","author":"Kimonides","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0810","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1073\/pnas.1411269112","article-title":"Reading the unique DNA methylation landscape of the brain: non-CpG methylation, hydroxymethylation, and MeCP2","volume":"112","author":"Kinde","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b0815","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0079-6123(08)61974-3","article-title":"Selective vulnerability of the hippocampus to ischemia \u2013 reversible and irreversible types of ischemic cell damage","volume":"63","author":"Kirino","year":"1985","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b0820","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0825","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnmol.2015.00041","article-title":"Gene\u2013environment interaction in programming hippocampal plasticity: focus on adult neurogenesis","volume":"8","author":"Koehl","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0830","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.euroneuro.2014.12.013","article-title":"IGF-I in major depression and antidepressant treatment response","volume":"25","author":"Kopczak","year":"2015","journal-title":"Eur. Neuropsychopharmacol.: J. Eur. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0835","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/gerona\/gls187","article-title":"The role of peripheral inflammatory markers in dementia and Alzheimer\u2019s disease: a meta-analysis","volume":"68","author":"Koyama","year":"2013","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0840","doi-asserted-by":"crossref","first-page":"e76497","DOI":"10.1371\/journal.pone.0076497","article-title":"Modifications of hippocampal circuits and early disruption of adult neurogenesis in the tg2576 mouse model of Alzheimer\u2019s disease","volume":"8","author":"Krezymon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b0845","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/jnnp-2011-301779","article-title":"Depression: an inflammatory illness?","volume":"83","author":"Krishnadas","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0850","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/7854_2010_108","article-title":"Animal models of depression: molecular perspectives","volume":"7","author":"Krishnan","year":"2011","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0855","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/jnen\/64.2.139","article-title":"Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque","volume":"64","author":"Kulstad","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0860","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yfrne.2015.12.001_b0865","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/mp.2012.144","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression","volume":"18","author":"Lamers","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0870","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0531-5565(94)90058-2","article-title":"Nathan Shock Memorial Lecture 1990. The role of glucocorticoids in brain aging and Alzheimer\u2019s disease: an integrative physiological hypothesis","volume":"29","author":"Landfield","year":"1994","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0875","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","article-title":"The epigenetics of aging and neurodegeneration","volume":"131","author":"Lardenoije","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0880","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/10253890.2013.817552","article-title":"State variation in the cortisol awakening response","volume":"16","author":"Law","year":"2013","journal-title":"Stress"},{"key":"10.1016\/j.yfrne.2015.12.001_b0885","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroscience.2012.04.021","article-title":"Stress, anxiety, and dendritic spines: what are the connections?","volume":"251","author":"Leuner","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b0890","first-page":"547","article-title":"Infection, systemic inflammation, and Alzheimer\u2019s disease","volume":"17","author":"Lim","year":"2015","journal-title":"Microb. Infect.\/Institut Pasteur"},{"key":"10.1016\/j.yfrne.2015.12.001_b0895","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopsych.2009.01.030","article-title":"Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity","volume":"66","author":"Lindqvist","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0900","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neubiorev.2015.05.007","article-title":"Psychiatric disorders and leukocyte telomere length: underlying mechanisms linking mental illness with cellular aging","volume":"55","author":"Lindqvist","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b0905","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/1871527311201070818","article-title":"Insulin growth factor-I promotes functional recovery after a focal lesion in the dentate gyrus","volume":"11","author":"Liquitaya-Montiel","year":"2012","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.yfrne.2015.12.001_b0910","doi-asserted-by":"crossref","first-page":"e17562","DOI":"10.1371\/journal.pone.0017562","article-title":"Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b0915","first-page":"46","article-title":"GSK-3beta, a pivotal kinase in Alzheimer disease","volume":"7","author":"Llorens-Martin","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0920","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4088\/JCP.13m08564","article-title":"Depressive symptoms in healthy apolipoprotein E epsilon4 carriers and noncarriers: a longitudinal study","volume":"74","author":"Locke","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0925","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0002-9440(10)63988-0","article-title":"Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure","volume":"158","author":"Lucassen","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0930","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuropharm.2010.01.012","article-title":"Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients","volume":"58","author":"Lucassen","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0935","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00401-013-1223-5","article-title":"Neuropathology of stress","volume":"127","author":"Lucassen","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0940","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021303","article-title":"Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation","volume":"7","author":"Lucassen","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.yfrne.2015.12.001_b0945","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/271","article-title":"Cortisol levels during human aging predict hippocampal atrophy and memory deficits","volume":"1","author":"Lupien","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0950","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0955","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1515\/revneuro-2014-0035","article-title":"Chronic stress as a risk factor for Alzheimer\u2019s disease","volume":"25","author":"Machado","year":"2014","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0960","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pnpbp.2010.06.014","article-title":"Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0965","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0306-4530(94)00066-J","article-title":"The monocyte-T-lymphocyte hypothesis of major depression","volume":"20","author":"Maes","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b0970","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.pnpbp.2010.12.017","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0975","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1523\/JNEUROSCI.16-10-03534.1996","article-title":"Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews","volume":"16","author":"Magarinos","year":"1996","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0980","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0006-8993(98)00882-8","article-title":"Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox","volume":"809","author":"Magarinos","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b0985","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/mp.2012.21","article-title":"A mega-analysis of genome-wide association studies for major depressive disorder","volume":"18","author":"Ripke","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b0990","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b0995","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1147851","article-title":"Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain","volume":"318","author":"Manganas","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yfrne.2015.12.001_b1000","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2174\/156720510790691362","article-title":"Neurogenesis and Alzheimer\u2019s disease: biology and pathophysiology in mice and men","volume":"7","author":"Marlatt","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b1005","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1010","first-page":"3","article-title":"Stress effects on neuronal structure: hippocampus, amygdala and prefrontal cortex","volume":"41","author":"McEwen","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3233\/JAD-2010-1219","article-title":"Neuroinflammation in Alzheimer\u2019s disease and mild cognitive impairment: a field in its infancy","volume":"19","author":"McGeer","year":"2010","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b1020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1517\/14728222.2014.988707","article-title":"Targeting microglia for the treatment of Alzheimer\u2019s disease","volume":"19","author":"McGeer","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.yfrne.2015.12.001_b1025","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1030","doi-asserted-by":"crossref","first-page":"e14739","DOI":"10.1371\/journal.pone.0014739","article-title":"Broad epigenetic signature of maternal care in the brain of adult rats","volume":"6","author":"McGowan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b1035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3181\/00379727-221-44405","article-title":"Opposing actions of dehydroepiandrosterone and corticosterone in rats","volume":"221","author":"McIntosh","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b1040","article-title":"Pathogenesis of depression: insights from human and rodent studies","author":"Menard","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b1045","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0006-3223(00)00955-0","article-title":"Altered salivary dehydroepiandrosterone levels in major depression in adults","volume":"48","author":"Michael","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1050","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jamda.2013.05.009","article-title":"Proinflammatory cytokines, aging, and age-related diseases","volume":"14","author":"Michaud","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.yfrne.2015.12.001_b1055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/CLEP.S37929","article-title":"Clinical epidemiology of Alzheimer\u2019s disease: assessing sex and gender differences","volume":"6","author":"Mielke","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.conb.2014.08.012","article-title":"The current state of the neurogenic theory of depression and anxiety","volume":"30","author":"Miller","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.psyneuen.2015.08.028","article-title":"Immobility in the forced swim test is adaptive and does not reflect depression","volume":"62","author":"Molendijk","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/jcbfm.2013.183","article-title":"Elevated CNS inflammation in patients with preclinical Alzheimer\u2019s disease","volume":"34","author":"Monson","year":"2014","journal-title":"J. Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b1075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. A rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1080","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer\u2019s disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegeneration"},{"key":"10.1016\/j.yfrne.2015.12.001_b1085","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1046\/j.0953-816x.2001.01784.x","article-title":"Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus","volume":"14","author":"Muller","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.nbd.2014.11.023","article-title":"Increased acetyl and total histone levels in post-mortem Alzheimer\u2019s disease brain","volume":"74","author":"Narayan","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.yfrne.2015.12.001_b1095","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1038\/tp.2015.32","article-title":"Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi","volume":"5","author":"Nemoda","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0306-4530(02)00150-6","article-title":"Salivary cortisol and dehydroepiandrosterone in relation to puberty and gender","volume":"29","author":"Netherton","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1105","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-148009","article-title":"Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults","volume":"45","author":"Nho","year":"2015","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b1110","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1192\/bjp.165.5.650","article-title":"The function of the hypothalamic\u2013pituitary\u2013adrenal axis in Alzheimer\u2019s disease. Response to insulin hypoglycaemia","volume":"165","author":"O\u2019Brien","year":"1994","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1115","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1176\/appi.ajp.161.11.2081","volume":"161","author":"O\u2019Brien","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cellimm.2007.09.010","article-title":"Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology","volume":"252","author":"O\u2019Connor","year":"2008","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1125","doi-asserted-by":"crossref","first-page":"E4467","DOI":"10.1073\/pnas.1421182112","article-title":"Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly","volume":"112","author":"Ohnishi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1130","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.neubiorev.2010.10.013","article-title":"Sensitivity to the depressogenic effect of stress and HPA-axis reactivity in adolescence: a review of gender differences","volume":"35","author":"Oldehinkel","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1586\/14737175.3.1.99","article-title":"Provisional diagnostic criteria for depression of Alzheimer\u2019s disease: description and review","volume":"3","author":"Olin","year":"2003","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.yfrne.2015.12.001_b1140","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1210\/jcem-59-3-551","article-title":"Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood","volume":"59","author":"Orentreich","year":"1984","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b1145","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b1150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.04984.x","article-title":"Cytokines and glucocorticoid receptor signaling. Relevance to major depression","volume":"1179","author":"Pace","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1155","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/070674371405900306","article-title":"The mistreatment of major depressive disorder","volume":"59","author":"Paris","year":"2014","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b1160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbi.2013.10.007","article-title":"Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features","volume":"36","author":"Patas","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yfrne.2015.12.001_b1165","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer\u2019s disease","volume":"93","author":"Peng","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yfrne.2015.12.001_b1170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.nbd.2012.03.033","article-title":"Neurogenic abnormalities in Alzheimer\u2019s disease differ between stages of neurogenesis and are partly related to cholinergic pathology","volume":"47","author":"Perry","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.yfrne.2015.12.001_b1175","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/WNL.56.8.1094","article-title":"Increased CSF cortisol in AD is a function of APOE genotype","volume":"56","author":"Peskind","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1180","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.1523\/JNEUROSCI.2680-04.2004","article-title":"The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology","volume":"24","author":"Pezawas","year":"2004","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1185","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1111\/j.1460-9568.2008.06250.x","article-title":"Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone","volume":"27","author":"Pinnock","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.npp.1301245","article-title":"Interactions between nitric oxide and corticosterone in the regulation of progenitor cell proliferation in the dentate gyrus of the adult rat","volume":"32","author":"Pinnock","year":"2007","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1195","doi-asserted-by":"crossref","first-page":"e13652","DOI":"10.1371\/journal.pone.0013652","article-title":"The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine","volume":"5","author":"Pinnock","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b1200","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroscience.2013.01.025","article-title":"Steroid hormones and BDNF","volume":"239","author":"Pluchino","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b1205","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neurobiolaging.2007.07.007","article-title":"CSF cortisol in Alzheimer\u2019s disease and mild cognitive impairment","volume":"30","author":"Popp","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b1210","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1215","doi-asserted-by":"crossref","first-page":"E5078","DOI":"10.1073\/pnas.1514486112","article-title":"Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1b in the aged hippocampus","volume":"112","author":"Prieto","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1220","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/S0024-3205(97)01008-4","article-title":"Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity","volume":"61","author":"Pruessner","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1225","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neurobiolaging.2007.01.010","article-title":"Aging of the brain, neurotrophin signaling, and Alzheimer\u2019s disease: is IGF1-R the common culprit?","volume":"29","author":"Puglielli","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b1230","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/hmg\/ddg361","article-title":"Glucocorticoid-related genetic susceptibility for Alzheimer\u2019s disease","volume":"13","author":"Quervain","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yfrne.2015.12.001_b1235","doi-asserted-by":"crossref","first-page":"E1640","DOI":"10.1210\/jc.2012-1945","article-title":"Long-term cognitive impairments and attentional deficits in patients with Cushing\u2019s disease and cortisol-producing adrenal adenoma in remission","volume":"97","author":"Ragnarsson","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b1240","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1192\/bjp.bp.112.112482","article-title":"Country- and individual-level socioeconomic determinants of depression: multilevel cross-national comparison","volume":"202","author":"Rai","year":"2013","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1245","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0140-6736(96)91272-6","article-title":"Alzheimer\u2019s disease in Finnish twins","volume":"347","author":"Raiha","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.yfrne.2015.12.001_b1250","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/brain\/awu354","article-title":"Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer\u2019s disease","volume":"138","author":"Richetin","year":"2015","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1255","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1523\/JNEUROSCI.5173-06.2007","article-title":"Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation","volume":"27","author":"Rissman","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1260","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1073\/pnas.1203140109","article-title":"Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation","volume":"109","author":"Rissman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1265","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10571-014-0074-5","article-title":"Parallels between major depressive disorder and Alzheimer\u2019s disease: role of oxidative stress and genetic vulnerability","volume":"34","author":"Rodrigues","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1270","doi-asserted-by":"crossref","first-page":"e2935","DOI":"10.1371\/journal.pone.0002935","article-title":"Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer\u2019s disease","volume":"3","author":"Rodriguez","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.yfrne.2015.12.001_b1275","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/mp.2015.100","article-title":"De novo deleterious genetic variations target a biological network centered on Abeta peptide in early-onset Alzheimer disease","volume":"20","author":"Rovelet-Lecrux","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archpsyc.1973.01750310011002","article-title":"Disrupted 24-hour patterns of cortisol secretion in psychotic depression","volume":"28","author":"Sachar","year":"1973","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1285","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.0306996101","article-title":"11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics","volume":"101","author":"Sandeep","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1290","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fncel.2015.00028","article-title":"Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration","volume":"9","author":"Sankowski","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10253899609001092","article-title":"Stress, glucocorticoids, and damage to the nervous system: the current state of confusion","volume":"1","author":"Sapolsky","year":"1996","journal-title":"Stress"},{"key":"10.1016\/j.yfrne.2015.12.001_b1300","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0006-3223(00)00971-9","article-title":"The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death","volume":"48","author":"Sapolsky","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1305","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1523\/JNEUROSCI.10-09-02897.1990","article-title":"Hippocampal damage associated with prolonged glucocorticoid exposure in primates","volume":"10","author":"Sapolsky","year":"1990","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1310","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv042","article-title":"Biomarkers for psychiatry: the journey from fantasy to fact, a report of the 2013 CINP think tank","volume":"18","author":"Scarr","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1315","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(98)01010-5","article-title":"Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone","volume":"813","author":"Schaaf","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b1320","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.10265","article-title":"Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study","volume":"52","author":"Schmidt","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1325","first-page":"1","article-title":"Sex differences in Alzheimer\u2019s disease","volume":"22","author":"Schmidt","year":"2008","journal-title":"Neuropsych.: Klinik, Diagn., Ther. Rehab.: Organ Gesellschaft Osterreichischer Nervenarzte Psychiater"},{"key":"10.1016\/j.yfrne.2015.12.001_b1330","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/npp.2011.151","article-title":"Functional biomarkers of depression: diagnosis, treatment, and pathophysiology","volume":"36","author":"Schmidt","year":"2011","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1335","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuroscience.2013.02.065","article-title":"MicroRNAs and the regulation of neuronal plasticity under stress conditions","volume":"241","author":"Schouten","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.yfrne.2015.12.001_b1340","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3233\/JAD-2011-110224","article-title":"Associations of serum cortisol with cognitive function and dementia: the Rotterdam Study","volume":"25","author":"Schrijvers","year":"2011","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b1345","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0169-328X(93)90195-U","article-title":"Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer\u2019s disease","volume":"18","author":"Seckl","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.yfrne.2015.12.001_b1350","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1355","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/10253890500504557","article-title":"Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety","volume":"8","author":"Shekhar","year":"2005","journal-title":"Stress"},{"key":"10.1016\/j.yfrne.2015.12.001_b1360","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.biopsych.2011.06.006","article-title":"Depression and the hippocampus: cause or effect?","volume":"70","author":"Sheline","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1365","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/mp.2010.52","article-title":"Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression","volume":"16","author":"Shelton","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1370","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.npp.1300335","article-title":"Gene expression profiling of depression and suicide in human prefrontal cortex","volume":"29","author":"Sibille","year":"2004","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1375","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.euroneuro.2007.06.004","article-title":"A detailed examination of cytokine abnormalities in Major Depressive Disorder","volume":"18","author":"Simon","year":"2008","journal-title":"Eur. Neuropsychopharmacol.: J. Eur. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1380","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1385","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/hipo.20805","article-title":"GSK3beta overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus","volume":"21","author":"Sirerol-Piquer","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.yfrne.2015.12.001_b1390","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nlm.2007.05.001","article-title":"Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function","volume":"88","author":"Siwak-Tapp","year":"2007","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.yfrne.2015.12.001_b1395","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-Z","article-title":"The macrophage theory of depression","volume":"35","author":"Smith","year":"1991","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.yfrne.2015.12.001_b1400","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-015-0750-x","article-title":"A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status","volume":"16","author":"Sood","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1405","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2009.09.032","article-title":"The stressed CNS: when glucocorticoids aggravate inflammation","volume":"64","author":"Sorrells","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.yfrne.2015.12.001_b1410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2015.01.019","article-title":"Determination of seven selected neuro- and immunomodulatory steroids in human cerebrospinal fluid and plasma using LC-MS\/MS","volume":"98","author":"Sosvorova","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.yfrne.2015.12.001_b1415","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neubiorev.2008.05.007","article-title":"Stress and glucocorticoid footprints in the brain \u2013 the path from depression to Alzheimer\u2019s disease","volume":"32","author":"Sotiropoulos","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1420","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-4159.2008.05613.x","article-title":"Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau","volume":"107","author":"Sotiropoulos","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yfrne.2015.12.001_b1425","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.yfrne.2015.12.001_b1430","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00001648-199507000-00006","article-title":"History of depression as a risk factor for Alzheimer\u2019s disease","volume":"6","author":"Speck","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1435","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11920-013-0364-5","article-title":"Comorbid sleep disorders in neuropsychiatric disorders across the life cycle","volume":"15","author":"Spiegelhalder","year":"2013","journal-title":"Curr. Psychiatry. Rep."},{"key":"10.1016\/j.yfrne.2015.12.001_b1440","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1210\/me.2009-0466","article-title":"Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis","volume":"24","author":"Spokoini","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1445","first-page":"1","article-title":"Childhood adversity subtypes and depressive symptoms in early and late adolescence","author":"St Clair","year":"2014","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1450","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ecl.2013.05.010","article-title":"Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration","volume":"42","author":"Starkman","year":"2013","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.yfrne.2015.12.001_b1455","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0006-3223(92)90079-F","article-title":"Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing\u2019s syndrome","volume":"32","author":"Starkman","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1460","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1742-2094-8-94","article-title":"Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?","volume":"8","author":"Steiner","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.yfrne.2015.12.001_b1465","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2007.03.011","article-title":"The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis","volume":"21","author":"Steptoe","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yfrne.2015.12.001_b1470","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PSY.0b013e31820ad12b","article-title":"Depression and hypothalamic\u2013pituitary\u2013adrenal activation: a quantitative summary of four decades of research","volume":"73","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b1475","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1210\/jc.2003-031235","article-title":"Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype","volume":"89","author":"Stevens","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.yfrne.2015.12.001_b1480","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn3151","article-title":"Recruiting adaptive cellular stress responses for successful brain ageing","volume":"13","author":"Stranahan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1485","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: a meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1490","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1495","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S1041610206003498","article-title":"Increased risk of dementia following mild head injury for carriers but not for non-carriers of the APOE epsilon4 allele","volume":"19","author":"Sundstrom","year":"2007","journal-title":"Int. Psychogeriatr.\/IPA"},{"key":"10.1016\/j.yfrne.2015.12.001_b1500","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/mp.2011.48","article-title":"Antidepressants recruit new neurons to improve stress response regulation","volume":"16","author":"Surget","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1505","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.arr.2005.03.003","article-title":"The stress system in the human brain in depression and neurodegeneration","volume":"4","author":"Swaab","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1510","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0149-7634(01)00046-X","article-title":"Role of CRF(1) and CRF(2) receptors in fear and anxiety","volume":"25","author":"Takahashi","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1515","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pnpbp.2009.10.005","article-title":"An MRI study of the superior temporal subregions in patients with current and past major depression","volume":"34","author":"Takahashi","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1520","first-page":"E2518","article-title":"Ab induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","author":"Talantova","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.yfrne.2015.12.001_b1525","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4088\/JCP.12084su1c.01","article-title":"The multifactorial presentation of depression in acute care","volume":"74","author":"Thase","year":"2013","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.yfrne.2015.12.001_b1530","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1176\/appi.ajp.162.1.175","article-title":"Increase in interleukin-1beta in late-life depression","volume":"162","author":"Thomas","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.yfrne.2015.12.001_b1535","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1601-183X.2007.00379.x","article-title":"Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?","volume":"7","author":"Thompson","year":"2008","journal-title":"Genes, Brain, Behav."},{"key":"10.1016\/j.yfrne.2015.12.001_b1540","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1471-4159.1992.tb08884.x","article-title":"Glucocorticoids exacerbate hypoxic and hypoglycemic hippocampal injury in vitro: biochemical correlates and a role for astrocytes","volume":"59","author":"Tombaugh","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yfrne.2015.12.001_b1545","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.mp.4002067","article-title":"The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis","volume":"13","author":"Uher","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.yfrne.2015.12.001_b1550","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/hbeh.1994.1030","article-title":"Neurotoxicity of glucocorticoids in the primate brain","volume":"28","author":"Uno","year":"1994","journal-title":"Horm. Behav."},{"key":"10.1016\/j.yfrne.2015.12.001_b1555","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/ajmg.b.32088","article-title":"Rare copy number variants in neuropsychiatric disorders: specific phenotype or not?","volume":"159B","author":"Van Den Bossche","year":"2012","journal-title":"Am. J. Med. Genet. Part B, Neuropsychiatr. Genet.: Off. Publ. Int. Soc. Psychiatr. Genet."},{"key":"10.1016\/j.yfrne.2015.12.001_b1560","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neurobiolaging.2013.10.082","article-title":"Epigenetically regulated microRNAs in Alzheimer\u2019s disease","volume":"35","author":"Van den Hove","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b1565","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.nicl.2014.01.017","article-title":"Widespread reductions of white matter integrity in patients with long-term remission of Cushing\u2019s disease","volume":"4","author":"van der Werff","year":"2014","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.yfrne.2015.12.001_b1570","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnins.2015.00173","article-title":"Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration","volume":"9","author":"van Dijk","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1575","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1093\/brain\/awm264","article-title":"Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin","volume":"130","author":"Verwer","year":"2007","journal-title":"Brain: J. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.yfrne.2015.12.001_b1580","first-page":"S349","article-title":"Long night\u2019s journey into the day: amyloid-beta imaging in Alzheimer\u2019s disease","volume":"33","author":"Villemagne","year":"2013","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.yfrne.2015.12.001_b1585","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1017\/S0033291712001213","article-title":"The cortisol awakening response predicts major depression: predictive stability over a 4-year follow-up and effect of depression history","volume":"43","author":"Vrshek-Schallhorn","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.yfrne.2015.12.001_b1590","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1124\/pr.113.008144","article-title":"Neuroinflammation and comorbidity of pain and depression","volume":"66","author":"Walker","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1595","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1210\/en.2011-0145","article-title":"Glucocorticoids facilitate astrocytic amyloid-beta peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-beta-degrading proteases","volume":"152","author":"Wang","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.yfrne.2015.12.001_b1600","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.neurobiolaging.2012.11.019","article-title":"Glucocorticoid receptor protein expression in human hippocampus; stability with age","volume":"34","author":"Wang","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yfrne.2015.12.001_b1605","doi-asserted-by":"crossref","first-page":"13314","DOI":"10.1523\/JNEUROSCI.2848-14.2014","article-title":"The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons","volume":"34","author":"Wang","year":"2014","journal-title":"J. Neurosc.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1610","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1615","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jalz.2015.04.005","article-title":"Impact of the Alzheimer\u2019s disease neuroimaging initiative, 2004 to 2014","volume":"11","author":"Weiner","year":"2015","journal-title":"Alzheimer\u2019s Dementia: J. Alzheimer\u2019s Assoc."},{"key":"10.1016\/j.yfrne.2015.12.001_b1620","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/jamaneurol.2013.4781","article-title":"Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study","volume":"71","author":"Weinstein","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1625","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-009-0498-z","article-title":"Microvasculature changes and cerebral amyloid angiopathy in Alzheimer\u2019s disease and their potential impact on therapy","volume":"118","author":"Weller","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1630","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1074\/jbc.M407498200","article-title":"FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear transformation of the glucocorticoid receptor in mammalian cells","volume":"280","author":"Wochnik","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yfrne.2015.12.001_b1635","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbi.2004.10.003","article-title":"Acute inflammation and negative mood: mediation by cytokine activation","volume":"19","author":"Wright","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.yfrne.2015.12.001_b1640","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biocel.2015.05.009","article-title":"Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies","volume":"67","author":"Yang","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1645","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn3230","article-title":"Insights into CNS ageing from animal models of senescence","volume":"13","author":"Yeoman","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yfrne.2015.12.001_b1650","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.neubiorev.2013.04.009","article-title":"Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy","volume":"37","author":"Yildirim","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.yfrne.2015.12.001_b1655","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/BST20120260","article-title":"Metabolic triad in brain aging: mitochondria, insulin\/IGF-1 signalling and JNK signalling","volume":"41","author":"Yin","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.yfrne.2015.12.001_b1660","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yfrne.2004.07.001","article-title":"Cortisol pulsatility and its role in stress regulation and health","volume":"25","author":"Young","year":"2004","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1665","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jad.2014.07.032","article-title":"A review of the relationship between proinflammatory cytokines and major depressive disorder","volume":"169","author":"Young","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.yfrne.2015.12.001_b1670","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1210\/me.2002-0106","article-title":"The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene","volume":"16","author":"Yudt","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.yfrne.2015.12.001_b1675","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nn.3713","article-title":"One gene, many neuropsychiatric disorders: lessons from Mendelian diseases","volume":"17","author":"Zhu","year":"2014","journal-title":"Nat. Neurosci."}],"container-title":["Frontiers in Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091302215300108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091302215300108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:47:32Z","timestamp":1718286452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091302215300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":335,"alternative-id":["S0091302215300108"],"URL":"https:\/\/doi.org\/10.1016\/j.yfrne.2015.12.001","relation":{},"ISSN":["0091-3022"],"issn-type":[{"value":"0091-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depression as a risk factor for Alzheimer\u2019s disease: Genes, steroids, cytokines and neurogenesis \u2013 What do we need to know?","name":"articletitle","label":"Article Title"},{"value":"Frontiers in Neuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yfrne.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2015 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}