{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:13:41Z","timestamp":1789762421755,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.ygcen.2008.03.027","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T16:49:35Z","timestamp":1208018975000},"page":"174-185","source":"Crossref","is-referenced-by-count":103,"title":["Neuropeptide discovery in Ixodoidea: An in silico investigation using publicly accessible expressed sequence tags"],"prefix":"10.1016","volume":"157","author":[{"given":"Andrew E.","family":"Christie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2008.03.027_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ibmb.2006.10.002","article-title":"Transcriptome analysis of the salivary glands of Dermacentor andersoni Stiles (Acari: Ixodidae)","volume":"37","author":"Alarcon-Chaidez","year":"2007","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib3","first-page":"2323","article-title":"Tick-borne disease","volume":"71","author":"Bratton","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.ygcen.2008.03.027_bib4","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0024-3205(75)90133-2","article-title":"Proctolin: a peptide transmitter candidate in insects","volume":"17","author":"Brown","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/j.ygcen.2008.03.027_bib5","series-title":"Invertebrates","author":"Brusca","year":"2003"},{"key":"10.1016\/j.ygcen.2008.03.027_bib6","unstructured":"Cashman, C., Christie, A.E., Messinger, D.I., Dickinson, P.S., Stemmler, E.A., submitted for publication. Identification and comparative analysis of orcokinin neuropeptides in decapod crustaceans. Peptides."},{"key":"10.1016\/j.ygcen.2008.03.027_bib7","unstructured":"Christie, A.E., submitted for publication. In silico analyses of peptide hormones in Aphidoidea. Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ygcen.2008.01.018","article-title":"Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags","volume":"156","author":"Christie","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cne.20932","article-title":"Identification, physiological actions, and distribution of VYRKPPFNGSIFamide (Val1-SIFamide) in the stomatogastric nervous system of the American lobster Homarus americanus","volume":"496","author":"Christie","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ygcen.2006.01.002","article-title":"Binding sites of crustacean hyperglycemic hormone and its second messengers on gills and hindgut of the green shore crab, Carcinus maenas: a possible osmoregulatory role","volume":"147","author":"Chung","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2164-7-201","article-title":"Annotation of novel neuropeptide precursors in the migratory locust based on transcript screening of a public EST database and mass spectrometry","volume":"7","author":"Clynen","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygcen.2008.03.027_bib12","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1242\/jeb.204.10.1795","article-title":"The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly malpighian tubules","volume":"204","author":"Coast","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/cne.21192","article-title":"Strategic expression of ion transport peptide gene products in central and peripheral neurons of insects","volume":"500","author":"Dai","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygcen.2008.01.011","article-title":"SIFamide peptides in clawed lobsters and freshwater crayfish (Crustacea, Decapoda, Astacidea): a combined molecular, mass spectrometric and electrophysiological investigation","volume":"156","author":"Dickinson","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib15","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1242\/jeb.004770","article-title":"Identification and cardiotropic actions of sulfakinin peptides in the American lobster Homarus americanus","volume":"210","author":"Dickinson","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00441-007-0391-9","article-title":"Molecular characterization and cell-specific expression of an ion transport peptide in the tobacco hornworm, Manduca sexta","volume":"329","author":"Drexler","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ygcen.2008.03.027_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.cbpc.2005.11.021","article-title":"Biochemical and functional aspects of crustacean hyperglycemic hormone in decapod crustaceans: review and update","volume":"142","author":"Fanjul-Moles","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ccell.2006.11.001","article-title":"Rickettsial and other tick-borne infections","volume":"19","author":"Flicek","year":"2007","journal-title":"Crit. Care Nurs. Clin. North Am."},{"key":"10.1016\/j.ygcen.2008.03.027_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ibmb.2007.09.009","article-title":"An insight into the sialome of the soft tick, Ornithodorus parkeri","volume":"38","author":"Francischetti","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib20","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.ibmb.2005.05.007","article-title":"The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae)","volume":"35","author":"Francischetti","year":"2005","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/cne.20650","article-title":"Novel insect orcokinins: characterization and neuronal distribution in the brains of selected dicondylian insects","volume":"490","author":"Hofer","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10158-004-0029-5","article-title":"Proctolin in the post-genomic era: new insights and challenges","volume":"5","author":"Isaac","year":"2004","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.ygcen.2008.03.027_bib23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pt.2007.07.006","article-title":"Using genomic approaches to unravel livestock (host)-tick pathogen interactions","volume":"23","author":"Jensen","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib24","series-title":"Handbook of Biologically Active Peptides","author":"Kastin","year":"2006"},{"key":"10.1016\/j.ygcen.2008.03.027_bib25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1515\/bchm3.1991.372.2.929","article-title":"Characterization of a diuretic peptide from Locusta migratoria","volume":"372","author":"Kay","year":"1991","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"10.1016\/j.ygcen.2008.03.027_bib26","doi-asserted-by":"crossref","first-page":"50781","DOI":"10.1074\/jbc.M407842200","article-title":"Drosophila short neuropeptide F regulates food intake and body size","volume":"279","author":"Lee","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygcen.2008.03.027_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10158-007-0060-4","article-title":"Tick neurobiology: recent advances and the post-genomic era","volume":"7","author":"Lees","year":"2007","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.ygcen.2008.03.027_bib28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1046\/j.1471-4159.2003.02031.x","article-title":"Mass spectrometric investigation of the neuropeptide complement and release in the pericardial organs of the crab, Cancer borealis","volume":"87","author":"Li","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygcen.2008.03.027_bib29","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.peptides.2004.11.003","article-title":"An opioid peptide from synganglia of the tick, Amblyomma testindinarium","volume":"26","author":"Liang","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1074\/mcp.M400114-MCP200","article-title":"In silico identification of new secretory peptide genes in Drosophila melanogaster","volume":"5","author":"Liu","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.ygcen.2008.03.027_bib31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ygcen.2008.01.009","article-title":"Mass spectral characterization of peptide transmitters\/hormones in the nervous system and neuroendocrine organs of the American lobster Homarus americanus","volume":"156","author":"Ma","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/bioinformatics\/18.5.769","article-title":"The Sulfinator: predicting tyrosine sulfation sites in protein sequences","volume":"18","author":"Monigatti","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygcen.2008.03.027_bib33","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1242\/jeb.006494","article-title":"Molecular and expression analysis of a family of the Amblyomma americanum tick lospins","volume":"210","author":"Mulenga","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0196-9781(98)00142-9","article-title":"Tachykinin-related peptides in invertebrates: a review","volume":"20","author":"N\u00e4ssel","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib35","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.bbrc.2005.10.165","article-title":"Identification of tick periviscerokinin, the first neurohormone of Ixodidae: single cell analysis by means of MALDI-TOF\/TOF mass spectrometry","volume":"338","author":"Neupert","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygcen.2008.03.027_bib36","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.ibmb.2004.07.005","article-title":"Orcokinins in insects and other invertebrates","volume":"34","author":"Pascual","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0196-9781(94)00144-U","article-title":"Periviscerokinin (Pea-PVK): a novel myotropic neuropeptide from the perisympathetic organs of the American cockroach","volume":"16","author":"Predel","year":"1995","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib38","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1111\/j.1742-4658.2005.04752.x","article-title":"Tachykinin-related peptide precursors in two cockroach species","volume":"272","author":"Predel","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.ygcen.2008.03.027_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.peptides.2006.10.011","article-title":"Corazonin in insects","volume":"28","author":"Predel","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib40","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s00018-006-6187-3","article-title":"Biology of the CAPA peptides in insects","volume":"63","author":"Predel","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ygcen.2008.03.027_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks","volume":"36","author":"Ribeiro","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/jn.00772.2006","article-title":"Modulation of rhythmic motor activity by pyrokinin peptides","volume":"97","author":"Saideman","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0196-9781(92)90041-Z","article-title":"Orcokinin: a novel myotropic peptide from the nervous system of the crayfish, Orconectes limosus","volume":"13","author":"Stangier","year":"1992","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib44","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0024-3205(75)90134-4","article-title":"Structure of the pentapeptide proctolin, a proposed neurotransmitter in insects","volume":"17","author":"Starratt","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/j.ygcen.2008.03.027_bib45","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.peptides.2007.08.019","article-title":"High-mass-resolution direct-tissue MALDI-FTMS reveals broad conservation of three neuropeptides (APSGFLGMRamide, GYRKPPFNGSIFamide and pQDLDHVFLRFamide) across members of seven decapod crustacean infraorders","volume":"28","author":"Stemmler","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ygcen.2008.03.027_bib46","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1128\/CMR.00011-06","article-title":"Coinfections acquired from ixodes ticks","volume":"19","author":"Swanson","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ygcen.2008.03.027_bib47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/neu.10301","article-title":"Identification of a proctolin preprohormone gene (Proct) of Drosophila melanogaster: expression and predicted prohormone processing","volume":"58","author":"Taylor","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1432-1327.2001.01858.x","article-title":"Pyrokinin neuropeptides in a crustacean Isolation and identification in the white shrimp Penaeus vannamei","volume":"268","author":"Torfs","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ygcen.2008.03.027_bib49","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00002281-200107000-00009","article-title":"Lyme disease","volume":"13","author":"Van Solingen","year":"2001","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-5793(89)80727-6","article-title":"Isolation and structure of corazonin, a cardioactive peptide from the American cockroach","volume":"250","author":"Veenstra","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ygcen.2008.03.027_bib51","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/bbrc.1994.2458","article-title":"Isolation and structure of the Drosophila corazonin gene","volume":"204","author":"Veenstra","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygcen.2008.03.027_bib52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/(SICI)1520-6327(200002)43:2<49::AID-ARCH1>3.0.CO;2-M","article-title":"Mono- and dibasic proteolytic cleavage sites in insect neuroendocrine peptide precursors","volume":"43","author":"Veenstra","year":"2000","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib53","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1017\/S0950268807008527","article-title":"Emerging zoonoses and vector-borne infections affecting humans in Europe","volume":"135","author":"Vorou","year":"2007","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ygcen.2008.03.027_bib54","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/1471-2164-8-368","article-title":"Global comparative analysis of ESTs from the southern cattle tick, Rhipicephalus (Boophilus) microplus","volume":"8","author":"Wang","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygcen.2008.03.027_bib55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ygcen.2003.10.001","article-title":"Identification of GYRKPPFNGSIFamide (crustacean-SIFamide) in the crayfish Procambarus clarkii by topological mass spectrometry analysis","volume":"135","author":"Yasuda","year":"2004","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/gcen.1999.7453","article-title":"Identification of orcokinin gene-related peptides in the brain of the crayfish Procambarus clarkii by the combination of MALDI-TOF and on-line capillary HPLC\/Q-Tof mass spectrometries and molecular cloning","volume":"118","author":"Yasuda-Kamatani","year":"2000","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2008.03.027_bib57","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1023\/A:1020664211999","article-title":"Cockroach allatostatin-like immunoreactivity in the synganglion of the American dog tick Dermacentor variabilis (Acari: Ixodidae)","volume":"25","author":"Zhu","year":"2001","journal-title":"Exp. Appl. Acarol."}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648008001366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648008001366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T02:36:18Z","timestamp":1631068578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648008001366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0016648008001366"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2008.03.027","relation":{},"ISSN":["0016-6480"],"issn-type":[{"value":"0016-6480","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}