{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:29:14Z","timestamp":1762176554141,"version":"3.44.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18107002","22132004","22227002"],"award-info":[{"award-number":["18107002","22132004","22227002"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.ygcen.2011.11.020","type":"journal-article","created":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T14:00:09Z","timestamp":1322056809000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["7\u03b1-Hydroxypregnenolone, a new key regulator of amphibian locomotion: Discovery, progress and prospect"],"prefix":"10.1016","volume":"176","author":[{"given":"Kazuyoshi","family":"Tsutsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Haraguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Do Rego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2011.11.020_b0005","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1042\/bj2880959","article-title":"Neurosteroid metabolism: 7\u03b1-hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes","volume":"288","author":"Akwa","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.ygcen.2011.11.020_b0010","first-page":"1","article-title":"Neurosteroids: of the nervous system, by the nervous system, for the nervous system","volume":"52","author":"Baulieu","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0015","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1046\/j.1471-4159.1999.720848.x","article-title":"Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain","volume":"72","author":"Beaujean","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygcen.2011.11.020_b0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1126\/science.174.4006.311","article-title":"Pineal function in sparrows: circadian rhythms and body temperature","volume":"174","author":"Binkley","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2011.11.020_b0370","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchemneu.2009.08.001","article-title":"Immunohistochemical localization and biological activity of 3\u03b2-hydroxysteroid dehydrogenase and 5\u03b1-reductase in the brain of the frog, Rana esculenta, during development","volume":"39","author":"Bruzzone","year":"2010","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.ygcen.2011.11.020_b0035","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1046\/j.1471-4159.1997.68062412.x","article-title":"Neurosteroids modulate nicotinic receptor function in mouse striatal and thalamic synaptosomes","volume":"68","author":"Bullock","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygcen.2011.11.020_b0040","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jez.1402320321","article-title":"Is the avian circadian system a neuroendocrine loop?","volume":"232","author":"Cassone","year":"1984","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ygcen.2011.11.020_b0045","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/074873049200700403","article-title":"Circadian feeding and locomotor rhythms in pigeons and house sparrows","volume":"7","author":"Chabot","year":"1992","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.ygcen.2011.11.020_b0050","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/en.2006-0740","article-title":"Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior","volume":"148","author":"Coddington","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2011.11.020_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/frne.1999.0188","article-title":"Neurosteroids: biosynthesis and function of these novel neuromodulators","volume":"21","author":"Compagnone","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0065","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000124926","article-title":"Distribution of immunoreactive prolactin in the male and female rat brain: effects of hypophysectomy and intraventricular administration of colchicines","volume":"47","author":"De Vito","year":"1988","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ygcen.2011.11.020_b0070","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1677\/joe.0.1550343","article-title":"Effects of cytochrome P450 inhibitors and of steroid hormones on the formation of 7-hydroxylated metabolites of pregnenolone in mouse brain microsomes","volume":"155","author":"Doostzadeh","year":"1997","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1471-4159.2006.04209.x","article-title":"Immunocytochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17\u03b1-hydroxylase\/C17, 20-lyase (P450C17) in the frog brain and pituitary","volume":"100","author":"Do-Rego","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygcen.2011.11.020_b0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.yfrne.2009.05.006","article-title":"Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides","volume":"30","author":"Do-Rego","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0085","first-page":"35","article-title":"The rat prolactin gene is expressed in brain tissue: detection of normal and alternative spliced prolactin messenger RNA","volume":"6","author":"Emanuele","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0090","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1126\/science.323973","article-title":"Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus","volume":"196","author":"Fuxe","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2011.11.020_b0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0016-6480(82)90215-5","article-title":"Prolactin and sexual behavior in the crested newt (Triturus cristatus carnifex Laur)","volume":"47","author":"Giorgio","year":"1982","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2007.01.115","article-title":"Stereological sex difference during development of the magnocelluar subdivision of the medial preoptic nucleus (MPN mag)","volume":"1145","author":"Govek","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0306-4522(02)00574-2","article-title":"Sex differences in the magnocellular subdivision of the medial preoptic nucleus in Syrian hamsters","volume":"116","author":"Govek","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ygcen.2011.11.020_b0110","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1749-6632.2008.03621.x","article-title":"Seasonal changes in the synthesis of the neurosteroid 7\u03b1-hydroxypregnenolone stimulating locomotor activity in newts","volume":"1163","author":"Haraguchi","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0115","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1210\/en.2009-1229","article-title":"Prolactin increases the synthesis of 7\u03b1-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts","volume":"151","author":"Haraguchi","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2011.11.020_b0120","doi-asserted-by":"crossref","unstructured":"S. Haraguchi, T. Koyama, I. Hasunuma, S.I. Okuyama, T. Ubuka, S. Kikuyama, J.L. Do-Rego, H. Vaudry, K. Tsutsui, Acute stress increases the synthesis of 7\u03b1-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts, Endocrinology (2011) in press, doi:10.1210\/en.2011-1422.","DOI":"10.1210\/en.2011-1422"},{"key":"10.1016\/j.ygcen.2011.11.020_b0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00192993","article-title":"Melatonin facilitates synchronization of sparrow circadian rhythms to light","volume":"175","author":"Hau","year":"1994","journal-title":"J. Comp. Physiol. A."},{"key":"10.1016\/j.ygcen.2011.11.020_b0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.yhbeh.2009.11.008","article-title":"Brainstem reticulospinal neurons are targets for corticotropin-releasing factor \u2013 induced locomotion in rough skin newts","volume":"57","author":"Hubbard","year":"2010","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0135","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0006-8993(02)03745-9","article-title":"Seasonal changes in neurosteroids in the urodele brain and environmental factors inducing their changes","volume":"959","author":"Inai","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0305-0491(00)00200-5","article-title":"Hormonal control of urodele reproductive behavior","volume":"126","author":"Iwata","year":"2000","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000178896","article-title":"On the role of the pineal in thermoregulation in the pigeon","volume":"9","author":"John","year":"1978","journal-title":"Horm. Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0150","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1073\/pnas.0901176106","article-title":"Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats","volume":"106","author":"Kirby","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ygcen.2011.11.020_b0160","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1749-6632.2008.03622.x","article-title":"Diurnal changes in the synthesis of the neurosteroid 7\u03b1-hydroxypregnenolone stimulating locomotor activity in newts","volume":"1163","author":"Koyama","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0165","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-6147(00)89058-6","article-title":"Neurosteroids and GABAA receptor function","volume":"16","author":"Lambert","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0170","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1460-9568.2001.01458.x","article-title":"GABAA receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems","volume":"13","author":"Laviolette","year":"2001","journal-title":"Eur. J. NeuroSci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0175","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0031-9384(86)90301-X","article-title":"Stress selectively influences center region activity of mice in an open field","volume":"37","author":"Lee","year":"1986","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0180","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/hbeh.2001.1646","article-title":"Rapid changes in monoamine levels following administration of corticotropin-releasing factor or corticosterone are localized in the dorsomedial hypothalamus","volume":"39","author":"Lowry","year":"2001","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0185","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0018-506X(02)00009-0","article-title":"Anatomical and functional evidence for a stress-responsive, monoamine-accumulating area in the dorsomedial hypothalamus of adult rat brain","volume":"43","author":"Lowry","year":"2003","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.yhbeh.2009.04.006","article-title":"Fluoxetine potentiates the effects of corticotropin-releasing factor on locomotor activity and serotonergic systems in the roughskin newt, Taricha granulosa","volume":"56","author":"Lowry","year":"2009","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0195","first-page":"1143","article-title":"Annual changes of plasma prolactin levels in the newt, Cynops pyrrhogaster","volume":"7","author":"Matsuda","year":"1990","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0200","doi-asserted-by":"crossref","first-page":"17282","DOI":"10.1073\/pnas.0407176101","article-title":"7\u03b1-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system","volume":"101","author":"Matsunaga","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ygcen.2011.11.020_b0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0074-7742(01)46058-2","article-title":"Biosynthesis of neurosteroids and regulation of their synthesis","volume":"46","author":"Mellon","year":"2001","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0210","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1523\/JNEUROSCI.14-12-07306.1994","article-title":"Immunocytochemical localization and biological activity of 3\u03b2-hydroxysteroid dehydrogenase in the central nervous system of the frog","volume":"14","author":"Mensah-Nyagan","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0215","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1471-4159.1996.67010413.x","article-title":"In vivo and in vitro evidence for the biosynthesis of testosterone in the telencephalon of the female frog","volume":"67","author":"Mensah-Nyagan","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygcen.2011.11.020_b0220","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1073\/pnas.93.4.1423","article-title":"Localization of 17\u03b2-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog","volume":"93","author":"Mensah-Nyagan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ygcen.2011.11.020_b0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0031-6997(24)01395-4","article-title":"Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system (review)","volume":"51","author":"Mensah-Nyagan","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ygcen.2011.11.020_b0230","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0705615105","article-title":"Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy","volume":"105","author":"Mitra","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ygcen.2011.11.020_b0235","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0018-506X(84)90026-6","article-title":"Stress-induced inhibition of sexual behavior: corticosterone inhibits courtship behaviors of a male amphibian (Taricha granulosa)","volume":"18","author":"Moore","year":"1984","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0240","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/gcen.1994.1132","article-title":"Seasonal changes of plasma prolactin concentration in the reproduction of the crested newt (Triturus carnifex Laur)","volume":"95","author":"Mosconi","year":"1994","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0245","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0006-8993(00)03205-4","article-title":"Effect of melatonin on circadian rhythm, locomotor activity and body temperature in the intact house sparrow, Japanese quail and owl","volume":"889","author":"Murakami","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0250","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1096\/fasebj.6.6.1347506","article-title":"Neuroactive steroids","volume":"6","author":"Paul","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.ygcen.2011.11.020_b0255","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0166-4328(87)90019-2","article-title":"MPOA and BNST lesions in male Syrian hamsters: differential effects on copulatory and chemoinvestigatory behaviors","volume":"23","author":"Powers","year":"1987","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0375","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.physbeh.2010.04.022","article-title":"Acute stressors increase plasma corticosterone and decrease locomotor activity in a terrestrial salamander (Desmognathus ochrophaeus)","volume":"101","author":"Ricciardella","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0265","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1460-9568.2002.02084.x","article-title":"The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens","volume":"16","author":"Roug\u00e9-Pont","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0270","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tins.2004.12.009","article-title":"The hypothalamic integrator for circadian rhythms","volume":"28","author":"Saper","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0275","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1210\/endo.140.4.6641","article-title":"Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes","volume":"140","author":"Takase","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2011.11.020_b0380","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0006-8993(02)03054-8","article-title":"Expression and localization of cytochrome P45011\u03b2,aldo mRNA in the frog brain","volume":"950","author":"Takase","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0285","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ygcen.2010.10.019","article-title":"Expression of cytochrome P450 side-chain cleavage enzyme mRNA in the brain of the red-bellied newt Cynops pyrrhogaster","volume":"170","author":"Takase","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0295","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/hbeh.1993.1037","article-title":"Hormonal induction of male courtship behavior in the Japanese newt, Cynops pyrrhogaster","volume":"27","author":"Toyoda","year":"1993","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2011.11.020_b0300","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ygcen.2004.12.015","article-title":"Prolactin acts centrally to enhance newt courtship behavior","volume":"141","author":"Toyoda","year":"2005","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2011.11.020_b0385","first-page":"159","article-title":"Notes on the behavior of the common Japanese newt, Diemyctylus pyrrhogaster BOIE. I. Breeding habit","volume":"7","author":"Tsutsui","year":"1931","journal-title":"Mem. Col. Sci. Kyoto Imp. Univ. Ser. B"},{"key":"10.1016\/j.ygcen.2011.11.020_b0330","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/187152406776056555","article-title":"Review: neurosteroids in the brain neuron: biosynthesis, action and medicinal impact on neurodegenerative disease","volume":"6","author":"Tsutsui","year":"2006","journal-title":"Central Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.ygcen.2011.11.020_b0310","first-page":"121","article-title":"Review: neurosteroid biosynthesis in vertebrate brains","volume":"124","author":"Tsutsui","year":"1999","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.ygcen.2011.11.020_b0315","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0168-0102(99)00132-7","article-title":"Novel brain function: biosynthesis and actions of neurosteroids in neurons (review)","volume":"36","author":"Tsutsui","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0320","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3184\/147020603783641297","article-title":"Review: Biosynthesis and biological actions of neurosteroids in the avian brain","volume":"14","author":"Tsutsui","year":"2003","journal-title":"Avian Poultry Biol Rev."},{"key":"10.1016\/j.ygcen.2011.11.020_b0325","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jez.a.302","article-title":"Review: neurosteroid biosynthesis in the quail brain","volume":"305A","author":"Tsutsui","year":"2006","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ygcen.2011.11.020_b0335","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1523\/JNEUROSCI.3562-07.2008","article-title":"7\u03b1-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms","volume":"28","author":"Tsutsui","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygcen.2011.11.020_b0340","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2010.00009","article-title":"7\u03b1-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: identification, mode of action, and functional significance","volume":"1","author":"Tsutsui","year":"2010","journal-title":"Front. Endocrin."},{"key":"10.1016\/j.ygcen.2011.11.020_b0345","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/074873049501000106","article-title":"The pineal gland: photoreception and coupling of behavioral, metabolic, and cardiovascular circadian outputs","volume":"10","author":"Warren","year":"1995","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.ygcen.2011.11.020_b0390","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(03)02288-1","article-title":"In vitro metabolism of dehydroepiandrosterone (DHEA) to 7\u03b1-hydroxy-DHEA and \u03945-androstene-3\u03b2,17\u03b2-diol in specific regions of the aging brain from Alzheimer\u2019s and non-demented patients","volume":"969","author":"Weill-Engerer","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ygcen.2011.11.020_b0355","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02245251","article-title":"Comparative behavioral characterization of the neuroactive steroids 3\u03b1-OH, 5\u03b1-pregnan-20-one and 3\u03b1-OH, 5\u03b2-pregnan-20-one in rodents","volume":"118","author":"Wieland","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ygcen.2011.11.020_b0360","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-4522(03)00438-X","article-title":"Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer\u2019s disease","volume":"121","author":"Yau","year":"2003","journal-title":"Neuroscience"}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648011004345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648011004345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:04:59Z","timestamp":1758045899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648011004345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0016648011004345"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2011.11.020","relation":{},"ISSN":["0016-6480"],"issn-type":[{"type":"print","value":"0016-6480"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7\u03b1-Hydroxypregnenolone, a new key regulator of amphibian locomotion: Discovery, progress and prospect","name":"articletitle","label":"Article Title"},{"value":"General and Comparative Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygcen.2011.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}