{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:57:00Z","timestamp":1779310620949,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.ygcen.2013.09.024","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T16:01:15Z","timestamp":1381766475000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Expression profile of the aromatase enzyme in the Xenopus brain and localization of estradiol and estrogen receptors in each tissue"],"prefix":"10.1016","volume":"194","author":[{"given":"Junshin","family":"Iwabuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouta","family":"Koshimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2013.09.024_b0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tem.2011.08.002","article-title":"Neuroprotective actions of estradiol revisited","volume":"22","author":"Azcoitia","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2013.09.024_b0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuroscience.2011.02.012","article-title":"Estradiol synthesis within the human brain","volume":"191","author":"Azcoitia","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ygcen.2013.09.024_b0015","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/cercor\/bhq047","article-title":"Roles of 17ss-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus","volume":"20","author":"Bender","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ygcen.2013.09.024_b0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nbd.2009.07.001","article-title":"Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival","volume":"36","author":"Biamonte","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ygcen.2013.09.024_b0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2009.07.032","article-title":"Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes","volume":"314","author":"Bliedtner","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0030","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0035","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1096-4959(02)00162-8","article-title":"Functional genomics and sexual differentiation in amphibians","volume":"133","author":"Bogi","year":"2002","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0040","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1677\/joe.0.1750269","article-title":"Estrogen actions in the ovary revisited","volume":"175","author":"Britt","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jsbmb.2009.03.010","article-title":"Alternative 5\u2032-untranslated first exons of the mouse Cyp19A1 (aromatase) gene","volume":"115","author":"Chow","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0050","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.neuropharm.2006.11.012","article-title":"Neurosteroid estradiol rescues ischemia-induced deficit in the long-term potentiation of rat hippocampal CA1 neurons","volume":"52","author":"Dai","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ygcen.2013.09.024_b0055","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1177\/1933719108322441","article-title":"Novel promoter I.8 and promoter usage in the CYP19 (aromatase) gene","volume":"15","author":"Demura","year":"2008","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ygcen.2013.09.024_b0060","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors and human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ygcen.2013.09.024_b0065","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2826.2010.02047.x","article-title":"Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalis","volume":"22","author":"Duarte-Guterman","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1742-2094-8-81","article-title":"Neuroinflammation induces glial aromatase expression in the uninjured songbird brain","volume":"8","author":"Duncan","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ygcen.2013.09.024_b0075","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1210\/en.138.7.2813","article-title":"Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons","volume":"138","author":"Furbass","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2013.09.024_b0080","first-page":"431","article-title":"A proposed model of cerebrospinal fluid circulation: observations with radionuclide cisternography","volume":"17","author":"Greitz","year":"1996","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jsbmb.2005.04.003","article-title":"Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice","volume":"95","author":"Harada","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0090","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.yjmcc.2006.06.001","article-title":"Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage","volume":"41","author":"Hsieh","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0095","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2108\/zsj.25.1227","article-title":"Isolation of novel isoforms of estrogen receptor genes from Xenopus gonad and brain","volume":"25","author":"Iwabuchi","year":"2008","journal-title":"Zoolog. Sci."},{"key":"10.1016\/j.ygcen.2013.09.024_b0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jsbmb.2007.01.007","article-title":"Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad","volume":"107","author":"Iwabuchi","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0105","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1073\/pnas.201394198","article-title":"Estrogen receptors activate atrial natriuretic peptide in the rat heart","volume":"98","author":"Jankowski","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ygcen.2013.09.024_b0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1043-2760(02)00567-2","article-title":"Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans","volume":"13","author":"Kamat","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2013.09.024_b0115","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ygcen.2009.11.004","article-title":"Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development","volume":"166","author":"Langlois","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0120","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.steroids.2009.01.003","article-title":"Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection","volume":"74","author":"Lebesgue","year":"2009","journal-title":"Steroids"},{"key":"10.1016\/j.ygcen.2013.09.024_b0125","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.ajpath.2010.11.056","article-title":"Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1)","volume":"178","author":"Lin","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0130","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00216-008-1973-4","article-title":"Development, standardization and refinement of procedures for evaluating effects of endocrine active compounds on development and sexual differentiation of Xenopus laevis","volume":"390","author":"Lutz","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ygcen.2013.09.024_b0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/physrev.00010.2007","article-title":"Estradiol and the developing brain","volume":"88","author":"McCarthy","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ygcen.2013.09.024_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.06.024","article-title":"Neuroactive steroids: focus on human brain","volume":"191","author":"Melcangi","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.ygcen.2013.09.024_b0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000289568","article-title":"Estrogen actions on neuroendocrine glia","volume":"91","author":"Micevych","year":"2010","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ygcen.2013.09.024_b0150","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bbabio.2010.03.027","article-title":"Estradiol-induced protection against ischemia-induced heart mitochondrial damage and caspase activation is mediated by protein kinase G","volume":"1797","author":"Morkuniene","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ygcen.2013.09.024_b0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jsbmb.2012.05.007","article-title":"Brain-specific promoter\/exon I.f of the cyp19a1 (aromatase) gene in Xenopus laevis","volume":"132","author":"Nakagawa","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jez.616","article-title":"The mechanism of sex determination in vertebrates-are sex steroids the key-factor?","volume":"313","author":"Nakamura","year":"2010","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tox.2008.09.006","article-title":"Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals","volume":"253","author":"Nakamura","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.ygcen.2013.09.024_b0170","series-title":"Normal Table of Xenopus laevis (Daudin)","author":"Nieuwkoop","year":"1994"},{"key":"10.1016\/j.ygcen.2013.09.024_b0175","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1210\/en.2008-0708","article-title":"Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism","volume":"150","author":"Novotny","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2013.09.024_b0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0891-0618(00)00104-6","article-title":"Reelin-immunoreactive neurons in the adult vertebrate pallium","volume":"21","author":"Perez-Garcia","year":"2001","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.ygcen.2013.09.024_b0185","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1897\/06-464R.1","article-title":"Environmentally relevant concentrations of ethynylestradiol cause female-biased sex ratios in Xenopus tropicalis and Rana temporaria","volume":"26","author":"Pettersson","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ygcen.2013.09.024_b0190","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-1119(99)00399-6","article-title":"Zebra finch aromatase gene expression is regulated in the brain through an alternate promoter","volume":"240","author":"Ramachandran","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.ygcen.2013.09.024_b0195","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000111559","article-title":"Rapid estrogen signaling in the brain","volume":"16","author":"Raz","year":"2008","journal-title":"Neurosignals"},{"key":"10.1016\/j.ygcen.2013.09.024_b0200","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2013.09.024_b0205","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0960-0760(03)00360-1","article-title":"Sources of estrogen and their importance","volume":"86","author":"Simpson","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0210","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ygcen.2007.01.041","article-title":"Aromatase, steroid-5-alpha-reductase type 1 and type 2 mRNA expression in gonads and in brain of Xenopus laevis during ontogeny","volume":"153","author":"Urbatzka","year":"2007","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0215","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1432-1327.1999.00734.x","article-title":"Placenta-specific transcripts of the aromatase encoding gene include different untranslated first exons in sheep and cattle","volume":"265","author":"Vanselow","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ygcen.2013.09.024_b0220","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.yhbeh.2010.08.004","article-title":"Estrogen receptor-alpha gene expression in the cortex: sex differences during development and in adulthood","volume":"59","author":"Wilson","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ygcen.2013.09.024_b0225","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0960-0760(95)00157-U","article-title":"Analysis of the expression and the first exon of aromatase mRNA in monkey brain","volume":"55","author":"Yamada-Mouri","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ygcen.2013.09.024_b0230","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1523\/JNEUROSCI.2382-06.2007","article-title":"Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death","volume":"27","author":"Yao","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygcen.2013.09.024_b0235","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1242\/dev.02209","article-title":"Massive loss of Cajal\u2013Retzius cells does not disrupt neocortical layer order","volume":"133","author":"Yoshida","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ygcen.2013.09.024_b0240","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1742-4658.2011.08031.x","article-title":"A ZZ\/ZW-type sex determination in Xenopus laevis","volume":"278","author":"Yoshimoto","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.ygcen.2013.09.024_b0245","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1073\/pnas.0712244105","article-title":"A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis","volume":"105","author":"Yoshimoto","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648013004024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648013004024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T06:20:38Z","timestamp":1539325238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648013004024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":49,"alternative-id":["S0016648013004024"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2013.09.024","relation":{},"ISSN":["0016-6480"],"issn-type":[{"value":"0016-6480","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression profile of the aromatase enzyme in the Xenopus brain and localization of estradiol and estrogen receptors in each tissue","name":"articletitle","label":"Article Title"},{"value":"General and Comparative Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygcen.2013.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}