{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:36:43Z","timestamp":1790033803665,"version":"4.0.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160627"],"award-info":[{"award-number":["1160627"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ygcen.2017.06.006","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:02:42Z","timestamp":1497373362000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Evolution of the \u03b12-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles"],"prefix":"10.1016","volume":"250","author":[{"given":"H\u00e9ctor A.","family":"C\u00e9spedes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kattina","family":"Zavala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Vandewege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Opazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2017.06.006_b0005","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1124\/pr.113.008219","article-title":"Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease","volume":"66","author":"Ahles","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ygcen.2017.06.006_b0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrg.2016.39","article-title":"Evolution by gene loss","volume":"17","author":"Albalat","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tig.2008.11.006","article-title":"Evolutionary mutant models for human disease","volume":"25","author":"Albertson","year":"2009","journal-title":"Trends Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0025","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/gb-2006-7-5-r43","article-title":"The gain and loss of genes during 600 million years of vertebrate evolution","volume":"7","author":"Blomme","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-2999(94)90785-4","article-title":"Alpha 2D-adrenoceptors modulate renal noradrenaline release in normotensive and spontaneously hypertensive rats","volume":"271","author":"Bohmann","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/YCO.0000000000000137","article-title":"Accelerating Alzheimer's research through 'natural' animal models","volume":"28","author":"Braidy","year":"2015","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.ygcen.2017.06.006_b0040","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/01.CIR.0000036600.39600.66","article-title":"Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure","volume":"106","author":"Brede","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ygcen.2017.06.006_b0045","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/me.2003-0035","article-title":"Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes","volume":"17","author":"Brede","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nature11510","article-title":"Epistasis as the primary factor in molecular evolution","volume":"490","author":"Breen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ygcen.2017.06.006_b0055","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0165-6147(88)90254-4","article-title":"Subtypes of alpha 2-adrenoceptors: pharmacological and molecular biological evidence converge","volume":"9","author":"Bylund","year":"1988","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ygcen.2017.06.006_b0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.bjp.0706060","article-title":"Alpha-2 adrenoceptor subtypes: are more better?","volume":"144","author":"Bylund","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0065","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1093\/gbe\/evv197","article-title":"Early evolution of vertebrate mybs: an integrative perspective combining synteny, phylogenetic, and gene expression analyses","volume":"7","author":"Campanini","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0070","doi-asserted-by":"crossref","first-page":"e1000496","DOI":"10.1371\/journal.pgen.1000496","article-title":"Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes","volume":"5","author":"Ca\u00f1estro","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0075","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jacc.2006.10.016","article-title":"Alpha2cDel322-325 and beta1Arg389 adrenergic polymorphisms are not associated with reduced left ventricular ejection fraction or increased left ventricular volume","volume":"49","author":"Canham","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0080","first-page":"91","article-title":"Octodon degus: a strong attractor for Alzheimer research","volume":"4","author":"Castro-Fuentes","year":"2013","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.ygcen.2017.06.006_b0085","first-page":"155","article-title":"Bacterial molecular phylogeny using supertree approach","volume":"12","author":"Daubin","year":"2001","journal-title":"Genome Inform."},{"key":"10.1016\/j.ygcen.2017.06.006_b0090","doi-asserted-by":"crossref","first-page":"43247","DOI":"10.1074\/jbc.M207495200","article-title":"The third intracellular loop of \u03b12-adrenergic receptors determines subtype specificity of arrestin interaction","volume":"277","author":"DeGraff","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygcen.2017.06.006_b0095","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1371\/journal.pbio.0030314","article-title":"Two rounds of whole genome duplication in the ancestral vertebrate","volume":"3","author":"Dehal","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1474-9726.2011.00772.x","article-title":"Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity","volume":"11","author":"Edrey","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.ygcen.2017.06.006_b0105","doi-asserted-by":"crossref","first-page":"20150185","DOI":"10.1098\/rsbl.2015.0185","article-title":"Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance","volume":"11","author":"Faulkes","year":"2015","journal-title":"Biol. Lett."},{"key":"10.1016\/j.ygcen.2017.06.006_b0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrg3949","article-title":"Pervasive robustness in biological systems","volume":"16","author":"F\u00e9lix","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0115","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/genetics\/151.4.1531","article-title":"Preservation of duplicate genes by complementary, degenerative mutations","volume":"151","author":"Force","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.ygcen.2017.06.006_b0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/gb-2008-9-10-235","article-title":"Large-scale assignment of orthology: back to phylogenetics?","volume":"9","author":"Gabald\u00f3n","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0125","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrg3456","article-title":"Functional and evolutionary implications of gene orthology","volume":"14","author":"Gabald\u00f3n","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0130","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cardiores.2007.05.017","article-title":"Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction","volume":"75","author":"Gilsbach","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ygcen.2017.06.006_b0135","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/molbev\/msm120","article-title":"Evolution of the vertebrate twist family and synfunctionalization: a mechanism for differential gene loss through merging of expression domains","volume":"24","author":"Gitelman","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0140","doi-asserted-by":"crossref","first-page":"19392","DOI":"10.1073\/pnas.1217211109","article-title":"Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism","volume":"109","author":"Gorbunova","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ygcen.2017.06.006_b0145","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1056\/NEJMcibr0911499","article-title":"Alpha2A-adrenergic receptors and type 2 diabetes","volume":"362","author":"Gribble","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygcen.2017.06.006_b0150","doi-asserted-by":"crossref","first-page":"34213","DOI":"10.1074\/jbc.M110.129205","article-title":"{Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice","volume":"285","author":"Haubold","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygcen.2017.06.006_b0155","doi-asserted-by":"crossref","first-page":"e113698","DOI":"10.1371\/journal.pone.0113698","article-title":"Unusual ratio between free thyroxine and free triiodothyronine in a long-lived mole-rat species with bimodal ageing","volume":"9","author":"Henning","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ygcen.2017.06.006_b0160","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw053","article-title":"Ensembl comparative genomics resources","author":"Herrero","year":"2016","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.ygcen.2017.06.006_b0165","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tig.2005.06.004","article-title":"Hox clusters as models for vertebrate genome evolution","volume":"21","author":"Hoegg","year":"2005","journal-title":"Trends Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00239-010-9403-6","article-title":"Evolution of the relaxin\/insulin-like gene family in placental mammals: implications for its early evolution","volume":"72","author":"Hoffmann","year":"2011","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/molbev\/msr207","article-title":"Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates","volume":"29","author":"Hoffmann","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0180","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1098\/rspb.1994.0058","article-title":"The evolution of functionally novel proteins after gene duplication","volume":"256","author":"Hughes","year":"1994","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ygcen.2017.06.006_b0185","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.12226","article-title":"Age progression of neuropathological markers in the brain of the chilean rodent Octodon degus, a natural model of Alzheimer\u2019s disease","author":"Inestrosa","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ygcen.2017.06.006_b9000","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/ng.604","article-title":"Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists","volume":"42","author":"Johnson","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0190","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.coi.2007.07.009","article-title":"The 2R hypothesis: an update","volume":"19","author":"Kasahara","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0195","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuint.2007.06.036","article-title":"Alpha2-adrenoceptor subtypes\u2013unexpected functions for receptors and ligands derived from gene-targeted mouse models","volume":"51","author":"Knaus","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ygcen.2017.06.006_b0205","doi-asserted-by":"crossref","first-page":"H135","DOI":"10.1152\/ajpheart.01074.2003","article-title":"Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats","volume":"287","author":"Kobayashi","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0210","doi-asserted-by":"crossref","first-page":"D966","DOI":"10.1093\/nar\/gkt1026","article-title":"The human phenotype ontology project: linking molecular biology and disease through phenotype data","volume":"42","author":"K\u00f6hler","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygcen.2017.06.006_b0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.semcdb.2012.12.009","article-title":"Impact of asymmetric gene repertoire between cyclostomes and gnathostomes","volume":"24","author":"Kuraku","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/dgd.12258","article-title":"Incorporating tree-thinking and evolutionary time scale into developmental biology","volume":"58","author":"Kuraku","year":"2016","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ygcen.2017.06.006_b0225","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1073\/pnas.94.18.9950","article-title":"Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo","volume":"94","author":"Lakhlani","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ygcen.2017.06.006_b0230","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0235","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1016\/S0021-9258(18)99248-3","article-title":"Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype","volume":"266","author":"Lanier","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygcen.2017.06.006_b0240","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ygcen.2017.06.006_b0245","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0026-895X(25)08854-6","article-title":"Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2\u2013C10 homolog responsible for an interspecies variation in antagonist binding","volume":"42","author":"Link","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0250","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.273.5276.803","article-title":"Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c","volume":"273","author":"Link","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2017.06.006_b0255","doi-asserted-by":"crossref","first-page":"D682","DOI":"10.1093\/nar\/gku1112","article-title":"Genomicus update 2015: KaryoView and MatrixView provide a genome-wide perspective to multispecies comparative genomics","volume":"43","author":"Louis","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygcen.2017.06.006_b0260","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.273.5276.801","article-title":"Central hypotensive effects of the alpha2a-adrenergic receptor subtype","volume":"273","author":"MacMillan","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2017.06.006_b0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1741-7007-11-91","article-title":"Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence","volume":"11","author":"Manov","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0270","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1080\/10635150290069995","article-title":"Perils of paralogy: using HSP70 genes for inferring organismal phylogenies","volume":"51","author":"Martin","year":"2002","journal-title":"Syst. Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0275","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ng884","article-title":"Extensive genomic duplication during early chordate evolution","volume":"31","author":"McLysaght","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0280","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1073\/pnas.1315760110","article-title":"Evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum)","volume":"110","author":"Mehta","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ygcen.2017.06.006_b0285","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejheart.2005.07.009","article-title":"Role of beta1- and alpha2c-adrenergic receptor polymorphisms and their combination in heart failure: a case-control study","volume":"8","author":"Metra","year":"2006","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ygcen.2017.06.006_b0290","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0955-0674(99)00039-3","article-title":"Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions","volume":"11","author":"Meyer","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0295","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/bies.20293","article-title":"From 2R to 3R: evidence for a fish-specific genome duplication (FSGD)","volume":"27","author":"Meyer","year":"2005","journal-title":"BioEssays"},{"key":"10.1016\/j.ygcen.2017.06.006_b0300","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1161\/CIRCRESAHA.107.151563","article-title":"Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice","volume":"101","author":"Muthig","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ygcen.2017.06.006_b0305","doi-asserted-by":"crossref","first-page":"e113445","DOI":"10.1371\/journal.pone.0113445","article-title":"Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum)","volume":"9","author":"Nah","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ygcen.2017.06.006_b0310","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.1236862","article-title":"Epistasis among adaptive mutations in deer mouse hemoglobin","volume":"340","author":"Natarajan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2017.06.006_b0315","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.bjp.0705636","article-title":"Modulation of the baroreceptor reflex by alpha 2A-adrenoceptors: a study in alpha 2A knockout mice","volume":"141","author":"Niederhoffer","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0320","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2125.2005.02447.x","article-title":"No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population","volume":"60","author":"Nonen","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0325","series-title":"Evolution by Gene Duplication","author":"Ohno","year":"1970"},{"key":"10.1016\/j.ygcen.2017.06.006_b0330","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1601-5223.1968.tb02169.x","article-title":"Evolution from fish to mammals by gene duplication","volume":"59","author":"Ohno","year":"1968","journal-title":"Hereditas"},{"key":"10.1016\/j.ygcen.2017.06.006_b0335","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/molbev\/msi117","article-title":"Adaptive evolution of the insulin gene in caviomorph rodents","volume":"22","author":"Opazo","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0340","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/molbev\/msv054","article-title":"Ancient duplications and expression divergence in the globin gene superfamily of vertebrates: insights from the elephant shark genome and transcriptome","volume":"32","author":"Opazo","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0345","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng919","article-title":"Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo","volume":"31","author":"Philipp","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0350","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature06967","article-title":"The amphioxus genome and the evolution of the chordate karyotype","volume":"453","author":"Putnam","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ygcen.2017.06.006_b0355","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/1471-2164-12-325","article-title":"Unresolved orthology and peculiar coding sequence properties of lamprey genes: the KCNA gene family as test case","volume":"12","author":"Qiu","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygcen.2017.06.006_b0365","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1176827","article-title":"Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes","volume":"327","author":"Rosengren","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2017.06.006_b0370","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10641-010-9628-7","article-title":"Teleost fish with specific genome duplication as unique models of vertebrate evolution","volume":"88","author":"Sato","year":"2010","journal-title":"Environ. Biol. Fishes"},{"key":"10.1016\/j.ygcen.2017.06.006_b0375","doi-asserted-by":"crossref","first-page":"e1004394","DOI":"10.1371\/journal.pcbi.1004394","article-title":"Identification of Ohnolog genes originating from whole genome duplication in early vertebrates, based on synteny comparison across multiple genomes","volume":"11","author":"Singh","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0380","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJMoa020803","article-title":"Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure","volume":"347","author":"Small","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ygcen.2017.06.006_b0385","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng.2568","article-title":"Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution","volume":"45","author":"Smith","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygcen.2017.06.006_b0390","doi-asserted-by":"crossref","first-page":"e773","DOI":"10.7717\/peerj.773","article-title":"Comprehensive, structurally-informed alignment and phylogeny of vertebrate biogenic amine receptors","volume":"3","author":"Spielman","year":"2015","journal-title":"Peer J."},{"key":"10.1016\/j.ygcen.2017.06.006_b0395","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ympev.2012.07.013","article-title":"Gene duplication, genome duplication, and the functional diversification of vertebrate globins","volume":"66","author":"Storz","year":"2013","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0400","doi-asserted-by":"crossref","first-page":"W232","DOI":"10.1093\/nar\/gkw256","article-title":"W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis","volume":"44","author":"Trifinopoulos","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygcen.2017.06.006_b0405","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.gene.2016.07.036","article-title":"Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage","volume":"591","author":"Wichmann","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.ygcen.2017.06.006_b0410","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnana.2011.00021","article-title":"The evolution of dopamine systems in chordates","volume":"5","author":"Yamamoto","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.ygcen.2017.06.006_b0415","doi-asserted-by":"crossref","first-page":"e26729","DOI":"10.1371\/journal.pone.0026729","article-title":"RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice","volume":"6","author":"Yu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ygcen.2017.06.006_b0420","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ygcen.2016.10.005","article-title":"Evolution of the \u03b2-adrenoreceptors in vertebrates","volume":"240","author":"Zavala","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2017.06.006_b0425","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0169-5347(03)00033-8","article-title":"Evolution by gene duplication: an update","volume":"18","author":"Zhang","year":"2003","journal-title":"Trends Ecol. Evol."}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648017300667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648017300667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:10:56Z","timestamp":1758046256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648017300667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":85,"alternative-id":["S0016648017300667"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2017.06.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/106526","asserted-by":"object"}]},"ISSN":["0016-6480"],"issn-type":[{"value":"0016-6480","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolution of the \u03b12-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles","name":"articletitle","label":"Article Title"},{"value":"General and Comparative Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygcen.2017.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}