{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:15:41Z","timestamp":1777529741804,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012014","name":"Kieikai Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22687004"],"award-info":[{"award-number":["JP22687004"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26291066"],"award-info":[{"award-number":["JP26291066"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15KK0259"],"award-info":[{"award-number":["JP15KK0259"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K07440"],"award-info":[{"award-number":["JP16K07440"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25440171"],"award-info":[{"award-number":["JP25440171"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15J03781"],"award-info":[{"award-number":["15J03781"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009090","name":"Indonesia Toray Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ygcen.2017.11.010","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:15:42Z","timestamp":1511136942000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Chronic subcutaneous infusion of neurosecretory protein GM increases body mass gain in chicks"],"prefix":"10.1016","volume":"265","author":[{"given":"Kenshiro","family":"Shikano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Taniuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Iwakoshi-Ukena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Furumitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance J.","family":"Kriegsfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Ukena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2017.11.010_b0005","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1359\/jbmr.060705","article-title":"Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways","volume":"21","author":"Baldock","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ygcen.2017.11.010_b0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ygcen.2017.07.028","article-title":"The growth hormone signaling system: insights into coordinating the anabolic and catabolic actions of growth hormone","volume":"258","author":"Bergan-roller","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2017.11.010_b0015","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1073\/pnas.70.3.684","article-title":"Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone","volume":"70","author":"Burgus","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ygcen.2017.11.010_b0020","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1101\/gad.426007","article-title":"Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression","volume":"21","author":"Engblom","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygcen.2017.11.010_b0025","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1021\/jm00353a009","article-title":"Structure-activity studies on the C-terminal amide of substance P","volume":"25","author":"Escher","year":"1982","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ygcen.2017.11.010_b0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI9397","article-title":"Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency","volume":"106","author":"Farooqi","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ygcen.2017.11.010_b0035","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.beem.2016.11.001","article-title":"Models of GH deficiency in animal studies","volume":"30","author":"Gahete","year":"2016","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2017.11.010_b0040","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.6812220","article-title":"Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly","volume":"218","author":"Guillemin","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.ygcen.2017.11.010_b0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ghir.2016.08.002","article-title":"Genetics of gigantism and acromegaly","volume":"30\u201331","author":"Hannah-Shmouni","year":"2016","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ygcen.2017.11.010_b0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ygcen.2013.01.008","article-title":"Growth hormone and growth?","volume":"190","author":"Harvey","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2017.11.010_b0055","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s00018-013-1313-5","article-title":"Body size regulation and insulin-like growth factor signaling","volume":"70","author":"Hyun","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ygcen.2017.11.010_b0060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28527","article-title":"Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity","volume":"6","author":"Iwakoshi-Ukena","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.ygcen.2017.11.010_b0065","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ygcen.2017.11.010_b0070","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1210\/en.2017-00064","article-title":"Neurosecretory protein GL, a hypothalamic small secretory protein, participates in energy homeostasis in male mice","volume":"158","author":"Matsuura","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2017.11.010_b0075","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.fob.2015.10.002","article-title":"Production and characterization of neurosecretory protein GM using Escherichia coli and Chinese Hamster Ovary cells","volume":"5","author":"Masuda","year":"2015","journal-title":"FEBS Open Biol."},{"key":"10.1016\/j.ygcen.2017.11.010_b0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394C(T) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ygcen.2017.11.010_b0085","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/nm1640","article-title":"Central control of bone remodeling by neuromedin U","volume":"13","author":"Sato","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ygcen.2017.11.010_b0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/1043-2760(89)90031-3","article-title":"Experimental uses of neurohypophysial hormone analogs","volume":"1","author":"Sawyer","year":"1989","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2017.11.010_b0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ygcen.2017.05.016","article-title":"Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks","volume":"256","author":"Shikano","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ygcen.2017.11.010_b0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ygcen.2017.11.010_b0105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbrc.2014.02.090","article-title":"Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum","volume":"446","author":"Ukena","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygcen.2017.11.010_b0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0167-0115(86)90048-0","article-title":"Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides","volume":"13","author":"Wahlestedt","year":"1986","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ygcen.2017.11.010_b0115","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.biotechadv.2011.07.013","article-title":"Disulfide bond formation and its impact on the biological activity and stability of recombinant therapeutic proteins produced by Escherichia coli expression system","volume":"29","author":"Zhang","year":"2011","journal-title":"Biotechnol. Adv."}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648017306573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648017306573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:40:17Z","timestamp":1777394417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648017306573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":23,"alternative-id":["S0016648017306573"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2017.11.010","relation":{},"ISSN":["0016-6480"],"issn-type":[{"value":"0016-6480","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic subcutaneous infusion of neurosecretory protein GM increases body mass gain in chicks","name":"articletitle","label":"Article Title"},{"value":"General and Comparative Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygcen.2017.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}