{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:25:12Z","timestamp":1786998312292,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["AGL2016-76069-C2- 2-R"],"award-info":[{"award-number":["AGL2016-76069-C2- 2-R"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["AGL2016-81808-REDT"],"award-info":[{"award-number":["AGL2016-81808-REDT"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021524","name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General and Comparative Endocrinology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ygcen.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T02:15:06Z","timestamp":1549937706000},"page":"65-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Fish pituitary show an active immune response after in vitro stimulation with Vibrio bacterin"],"prefix":"10.1016","volume":"275","author":[{"given":"Xiaohong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R.","family":"Khansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Tort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygcen.2019.02.011_b0005","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI200114660","article-title":"gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways","volume":"108","author":"Arzt","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ygcen.2019.02.011_b0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.fsi.2018.06.022","article-title":"Gene expression analysis of isolated salmonid GALT leucocytes in response to PAMPs and recombinant cytokines","volume":"80","author":"Attaya","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000097202","article-title":"Passage of cytokines across the blood-brain barrier","volume":"2","author":"Banks","year":"1995","journal-title":"Neuroimmunomodulat."},{"key":"10.1016\/j.ygcen.2019.02.011_b0020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fimmu.2014.00136","article-title":"The HPA \u2013 immune axis and the immunomodulatory actions of glucocorticoids in the brain","volume":"5","author":"Bellavance","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-5699(94)90024-8","article-title":"Pituitary control of immune cells","volume":"15","author":"Blalock","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1016\/j.ygcen.2019.02.011_b0030","series-title":"Mucosal health in aquaculture","first-page":"3","article-title":"Overview of fish immunity","author":"Castro","year":"2015"},{"key":"10.1016\/j.ygcen.2019.02.011_b0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2010.09.007","article-title":"Regulation of major histocompatibility complex class II genes","volume":"23","author":"Choi","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0040","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1210\/jc.2003-030377","article-title":"Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways","volume":"88","author":"Crompton","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2019.02.011_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1567-7443(07)00201-3","article-title":"The HPA axis and the immune system: a perspective","volume":"7","author":"Dunn","year":"2007","journal-title":"Neuroimmune Bio."},{"key":"10.1016\/j.ygcen.2019.02.011_b0050","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1096\/fj.02-1103fje","article-title":"Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation","volume":"17","author":"Francis","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.ygcen.2019.02.011_b0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1677\/JOE-08-0110","article-title":"Complement C5a receptors in the pituitary gland: expression and function","volume":"199","author":"Francis","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0060","first-page":"192","article-title":"Cytokine-mediated growth hormone release from cultured ovine pituitary cells","volume":"68","author":"Fry","year":"1998"},{"key":"10.1016\/j.ygcen.2019.02.011_b0065","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbi.2015.07.007","article-title":"Pituitary dendritic cells communicate immune pathogenic signals","volume":"50","author":"Glennon","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"24426","key":"10.1016\/j.ygcen.2019.02.011_b0070","first-page":"2016","article-title":"Stellate cell networks in the teleost pituitary","volume":"6","author":"Golan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygcen.2019.02.011_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(02)00357-0","article-title":"Cytokines and neuro\u2013immune\u2013endocrine interactions: a role for the hypothalamic\u2013pituitary\u2013adrenal revolving axis","volume":"133","author":"Haddad","year":"2002","journal-title":"J Neuroimmunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0080","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj2810251","article-title":"Immunosuppressive activity of corticotrophin-releasing factor. Inhibition of interleukin-1 and interleukin-6 production by human mononuclear cells","volume":"281","author":"Hagan","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.ygcen.2019.02.011_b0085","first-page":"157","article-title":"Fish lymphocytes respond to human IL-1","volume":"5","author":"Hamby","year":"1986","journal-title":"Lymphokine Res."},{"key":"10.1016\/j.ygcen.2019.02.011_b0090","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1210\/jcem.85.11.7122","article-title":"Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas","volume":"85","author":"Hanisch","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ygcen.2019.02.011_b0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1677\/JOE-08-0488","article-title":"Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55\u201370 years","volume":"202","author":"Hodkinson","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-2427(01)00328-2","article-title":"The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant IL-1 beta","volume":"81","author":"Hong","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-5728(96)00178-6","article-title":"CRH and the immune system","volume":"72","author":"Karalis","year":"1997","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.ygcen.2019.02.011_b0115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cbpb.2003.10.011","article-title":"Saturated fatty acids suppress adrenocorticotropic hormone (ACTH) release from rat anterior pituitary cells in vitro","volume":"137","author":"Katoh","year":"2004","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0014-5793(04)00303-5","article-title":"Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs","volume":"563","author":"Kovalovsky","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ygcen.2019.02.011_b0125","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0169-328X(94)90197-X","article-title":"Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice","volume":"27","author":"Laye","year":"1994","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ygcen.2019.02.011_b0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1677\/joe.1.06640","article-title":"Central and peripheral interleukin-1beta and interleukin-1 receptor I expression and their role in the acute stress response of common carp, Cyprinus carpio L","volume":"191","author":"Metz","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0135","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic. Acids Res."},{"key":"10.1016\/j.ygcen.2019.02.011_b0140","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/fsim.2001.0348","article-title":"Rainbow trout (Oncorhynchus mykiss) recombinant IL-1\u03b2 and derived peptides induce migration of head-kidney leucocytes in vitro","volume":"11","author":"Peddie","year":"2001","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fimmu.2014.00143","article-title":"Neuro-endocrine networks controlling immune system in health and disease","volume":"5","author":"Procaccini","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fnint.2013.00056","article-title":"Hypothalamic neurohormones and immune responses","volume":"7","author":"Quintanar","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.ygcen.2019.02.011_b0155","first-page":"33","article-title":"Immunomodulatory role of the corticotropin-releasing factor","volume":"49","author":"Radulovic","year":"2001","journal-title":"Arch. Immunol. Et. Ther. Exp."},{"key":"10.1016\/j.ygcen.2019.02.011_b0160","doi-asserted-by":"crossref","unstructured":"Romieu-Mourez, R., Francois, M., Boivin, M. N., et al. 2007. Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-.","DOI":"10.4049\/jimmunol.179.3.1549"},{"key":"10.1016\/j.ygcen.2019.02.011_b0165","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-2427(86)90109-1","article-title":"Phylogenetic studies on lymphokines. Fish lymphocytes respond to human IL-1 and epithelial cells produce an IL-1 like factor","volume":"12","author":"Sigel","year":"1986","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/vim.2005.18.41","article-title":"Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection","volume":"18","author":"Silverman","year":"2005","journal-title":"Viral Immunol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3940(90)90025-5","article-title":"Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2","volume":"120","author":"Singh","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ygcen.2019.02.011_b0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1743-3150.2004.00490.x","article-title":"Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function","volume":"16","author":"Tache","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.ygcen.2019.02.011_b0185","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1210\/endo-121-4-1580","article-title":"Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing-factor","volume":"121","author":"Uehara","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.ygcen.2019.02.011_b0190","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0531-5565(01)00208-X","article-title":"Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice","volume":"37","author":"Utsuyama","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ygcen.2019.02.011_b0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0039-6060(99)70182-0","article-title":"Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes","volume":"126","author":"Wang","year":"1999","journal-title":"Surgery"},{"key":"10.1016\/j.ygcen.2019.02.011_b0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/08916939209146125","article-title":"The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes","volume":"12","author":"Wicks","year":"1992","journal-title":"Autoimmunity"}],"container-title":["General and Comparative Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648018305872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016648018305872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:08:15Z","timestamp":1762164495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016648018305872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":39,"alternative-id":["S0016648018305872"],"URL":"https:\/\/doi.org\/10.1016\/j.ygcen.2019.02.011","relation":{},"ISSN":["0016-6480"],"issn-type":[{"value":"0016-6480","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fish pituitary show an active immune response after in vitro stimulation with Vibrio bacterin","name":"articletitle","label":"Article Title"},{"value":"General and Comparative Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygcen.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}