{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:28:23Z","timestamp":1791296903004,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2060,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ygeno.2007.09.003","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T15:07:44Z","timestamp":1196953664000},"page":"22-29","source":"Crossref","is-referenced-by-count":152,"title":["Gene expression changes in children with autism"],"prefix":"10.1016","volume":"91","author":[{"given":"Jeffrey P.","family":"Gregg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irva","family":"Hertz-Picciotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wynn","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Croen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Ozonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac N.","family":"Pessah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank R.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2007.09.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.1205707","article-title":"The immune response in autism: a new frontier for autism research","volume":"80","author":"Ashwood","year":"2006","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0165-5728(98)00021-6","article-title":"Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism","volume":"85","author":"Gupta","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF02172828","article-title":"Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics","volume":"26","author":"Gupta","year":"1996","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2003.10.026","article-title":"Prevalence of serum antibodies to caudate nucleus in autistic children","volume":"355","author":"Singh","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ygeno.2007.09.003_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02815207","article-title":"Immunogenetic studies in autism and related disorders","volume":"28","author":"Warren","year":"1996","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1025895925178","article-title":"Immunoglobulin A deficiency in a subset of autistic subjects","volume":"27","author":"Warren","year":"1997","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/088307389300800207","article-title":"Brainstem and cerebellar vermis involvement in autistic children","volume":"8","author":"Hashimoto","year":"1993","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02178163","article-title":"Development of the brainstem and cerebellum in autistic patients","volume":"25","author":"Hashimoto","year":"1995","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib9","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1111\/j.1440-1819.1998.tb03226.x","article-title":"Magnetic resonance imaging study of the brain in autism","volume":"52","author":"Saitoh","year":"1998","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.ygeno.2007.09.003_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1289\/ehp.00108s3401","article-title":"The environment as an etiological factor in autism: a new direction for research","volume":"108","author":"London","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"Suppl. 3","key":"10.1016\/j.ygeno.2007.09.003_bib11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1289\/ehp.00108s3413","article-title":"Does methylmercury have a role in causing developmental disabilities in children?","volume":"108","author":"Myers","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ygeno.2007.09.003_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archpedi.159.2.151","article-title":"Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study","volume":"159","author":"Croen","year":"2005","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.ygeno.2007.09.003_bib13","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1289\/ehp.8483","article-title":"The CHARGE study: an epidemiological investigation of genetic and environmental factors contributing to autism","volume":"114","author":"Hertz-Picciotto","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ygeno.2007.09.003_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ajmg.10041","article-title":"Analysis of ten candidate genes in autism by association and linkage","volume":"114","author":"Philippe","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ygeno.2007.09.003_bib15","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1212\/WNL.57.9.1618","article-title":"Postmortem brain abnormalities of the glutamate neurotransmitter system in autism","volume":"57","author":"Purcell","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.ygeno.2007.09.003_bib16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/sj.mp.4001666","article-title":"Quantitative genome scan and ordered-subsets analysis of autism endophenotypes support language QTLs","volume":"10","author":"Alarcon","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib17","article-title":"Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder","volume":"27","author":"Chen","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib18","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1086\/378778","article-title":"A genomewide screen of 345 families for autism-susceptibility loci","volume":"73","author":"Yonan","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygeno.2007.09.003_bib19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1023\/A:1013290826504","article-title":"The abnormal regulation of gene expression in autistic brain tissue","volume":"31","author":"Purcell","year":"2001","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2007.09.003_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.286.5439.531","article-title":"Molecular classification of cancer: class discovery and class prediction by gene expression monitoring","volume":"286","author":"Golub","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ygeno.2007.09.003_bib22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.20021553","article-title":"Interferon and granulopoiesis signatures in systemic lupus erythematosus blood","volume":"197","author":"Bennett","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ygeno.2007.09.003_bib23","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1073\/pnas.94.6.2150","article-title":"Discovery and analysis of inflammatory disease-related genes using cDNA microarrays","volume":"94","author":"Heller","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2007.09.003_bib24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.med.53.082901.103941","article-title":"Gene expression profiling of lymphoid malignancies","volume":"53","author":"Staudt","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ygeno.2007.09.003_bib25","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0011-5029(00)90029-4","article-title":"Part II. Clinical diagnosis and course of Alzheimer\u2019s disease","volume":"46","author":"Bennett","year":"2000","journal-title":"Dis.-Mon."},{"key":"10.1016\/j.ygeno.2007.09.003_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ana.10042","article-title":"Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease","volume":"50","author":"Tang","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/01.CIR.0000152105.79665.C6","article-title":"Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation","volume":"111","author":"Moore","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ygeno.2007.09.003_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ygeno.2006.02.003","article-title":"Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome","volume":"87","author":"Du","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.ygeno.2007.09.003_bib29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1526-4610.2004.04193.x","article-title":"Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalities","volume":"44","author":"Hershey","year":"2004","journal-title":"Headache"},{"key":"10.1016\/j.ygeno.2007.09.003_bib30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/archneur.62.2.210","article-title":"Blood gene expression profiling of neurologic diseases: a pilot microarray study","volume":"62","author":"Tang","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib31","first-page":"6069","article-title":"Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma","volume":"63","author":"Twine","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygeno.2007.09.003_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jneuroim.2004.01.017","article-title":"Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells","volume":"150","author":"Iglesias","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1289\/ehp.7635","article-title":"Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers","volume":"113","author":"Forrest","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ygeno.2007.09.003_bib34","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1073\/pnas.0409768102","article-title":"Application of genome-wide expression analysis to human health and disease","volume":"102","author":"Cobb","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2007.09.003_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molbrainres.2003.10.014","article-title":"Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1","volume":"132","author":"Tang","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.ygeno.2007.09.003_bib36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/ana.20291","article-title":"Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down\u2019s syndrome","volume":"56","author":"Tang","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng1235","article-title":"Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder","volume":"35","author":"Kakiuchi","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygeno.2007.09.003_bib38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2164-7-118","article-title":"Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes","volume":"7","author":"Hu","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygeno.2007.09.003_bib39","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10803-006-0134-x","article-title":"Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism","volume":"36","author":"Baron","year":"2006","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib40","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/hmg\/ddl004","article-title":"Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin\u2013proteasome pathway processes","volume":"15","author":"Baron","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ygeno.2007.09.003_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1015405914950","article-title":"Descriptive epidemiology of autism in a California population: who is at risk?","volume":"32","author":"Croen","year":"2002","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1023\/A:1025873925661","article-title":"Diagnosing autism: analyses of data from the Autism Diagnostic Interview","volume":"27","author":"Lord","year":"1997","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4","article-title":"Quantifying the phenotype in autism spectrum disorders","volume":"105","author":"Lord","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ygeno.2007.09.003_bib44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/00004583-200111000-00009","article-title":"Multisite, double-blind, placebo-controlled trial of porcine secretin in autism","volume":"40","author":"Owley","year":"2001","journal-title":"J. Am. Acad. Child Adolesc. Psych."},{"key":"10.1016\/j.ygeno.2007.09.003_bib45","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/1469-7610.00092","article-title":"Cognitive profiles and social-communicative functioning in children with autism spectrum disorder","volume":"43","author":"Joseph","year":"2002","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1469-7610.1992.tb00908.x","article-title":"Abnormal psychosocial situations and ICD-10 diagnoses in children and adolescents attending a psychiatric service","volume":"33","author":"Steinhausen","year":"1992","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib47","series-title":"Mullen Scales of Early Learning","author":"Mullen","year":"1995"},{"key":"10.1016\/j.ygeno.2007.09.003_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jpepsy\/10.2.215","article-title":"Diagnostic uses of the Vineland Adaptive Behavior Scales","volume":"10","author":"Sparrow","year":"1985","journal-title":"J. Pediatr. Psychol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib49","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ygeno.2007.09.003_bib50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1440-1711.2005.01409.x","article-title":"Addressing the mysteries of perforin function","volume":"84","author":"Voskoboinik","year":"2006","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib51","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1182\/blood-2006-02-001412","article-title":"Variations of the perforin gene in patients with autoimmunity\/lymphoproliferation and defective Fas function","volume":"108","author":"Clementi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ygeno.2007.09.003_bib52","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1073\/pnas.0511025103","article-title":"Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss","volume":"103","author":"Boyson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2007.09.003_bib53","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1021\/bi0524868","article-title":"Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair","volume":"45","author":"Yang","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib54","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.4049\/jimmunol.175.12.8003","article-title":"IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation","volume":"175","author":"Janas","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib55","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0006-291X(02)02378-1","article-title":"The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells","volume":"297","author":"Yamamoto","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2007.09.003_bib56","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/ni1242","article-title":"Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor","volume":"6","author":"Roncagalli","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.mp.4001385","article-title":"Genome-wide scan for loci of Asperger syndrome","volume":"9","author":"Ylisaukko-oja","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib58","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jcb.20813","article-title":"RUNX3: a new player in myeloid gene expression and immune response","volume":"98","author":"Puig-Kroger","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ygeno.2007.09.003_bib59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2005.01.012","article-title":"Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes","volume":"22","author":"Sato","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.ygeno.2007.09.003_bib60","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.4049\/jimmunol.174.5.2627","article-title":"Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage","volume":"174","author":"Kohu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gene.2004.07.005","article-title":"Comparative analysis of the human gimap gene cluster encoding a novel GTPase family","volume":"341","author":"Krucken","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.ygeno.2007.09.003_bib62","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.176.8.4562","article-title":"DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion","volume":"176","author":"Chappell","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib63","doi-asserted-by":"crossref","first-page":"16016","DOI":"10.1073\/pnas.0407180101","article-title":"Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia","volume":"101","author":"Brenner","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2007.09.003_bib64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/10446670410001722096","article-title":"A review of autism and the immune response","volume":"11","author":"Ashwood","year":"2004","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/ar1203","article-title":"Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus","volume":"6","author":"Alarcon-Riquelme","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ygeno.2007.09.003_bib66","first-page":"557","article-title":"Is autism an autoimmune disease?","volume":"3","author":"Ashwood","year":"2004","journal-title":"Autoimmune Dis."},{"key":"10.1016\/j.ygeno.2007.09.003_bib67","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nn925","article-title":"Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons","volume":"5","author":"Inoue","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ygeno.2007.09.003_bib68","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1079-9796(03)00032-9","article-title":"Runx3 is essential for the target-specific axon pathfinding of TrkC-expressing dorsal root ganglion neurons","volume":"30","author":"Inoue","year":"2003","journal-title":"Blood Cells Mol. Diseases"},{"key":"10.1016\/j.ygeno.2007.09.003_bib69","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1093\/emboj\/cdf370","article-title":"The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons","volume":"21","author":"Levanon","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.ygeno.2007.09.003_bib70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.neuron.2005.12.028","article-title":"Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord","volume":"49","author":"Chen","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ygeno.2007.09.003_bib71","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrm1740","article-title":"Semaphorins command cells to move","volume":"6","author":"Kruger","year":"2005","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib72","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/bbrc.2000.4080","article-title":"Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75","volume":"280","author":"Ohoka","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2007.09.003_bib73","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1074\/jbc.M009051200","article-title":"Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95","volume":"276","author":"Inagaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2007.09.003_bib74","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn1517","article-title":"PDZ domain proteins of synapses","volume":"5","author":"Kim","year":"2004","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.ygeno.2007.09.003_bib75","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1523\/JNEUROSCI.4645-04.2005","article-title":"Edg8\/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival","volume":"25","author":"Jaillard","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygeno.2007.09.003_bib76","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10803-006-0121-2","article-title":"Corpus callosum morphometrics in young children with autism spectrum disorder","volume":"36","author":"Boger-Megiddo","year":"2006","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib77","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biopsych.2005.11.011","article-title":"Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity","volume":"60","author":"Vidal","year":"2006","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.ygeno.2007.09.003_bib78","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroimage.2004.08.049","article-title":"Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation","volume":"24","author":"Waiter","year":"2005","journal-title":"NeuroImage"},{"key":"10.1016\/j.ygeno.2007.09.003_bib79","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroimage.2004.04.037","article-title":"Less white matter concentration in autism: 2D voxel-based morphometry","volume":"23","author":"Chung","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.ygeno.2007.09.003_bib80","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.20032","article-title":"Localization of white matter volume increase in autism and developmental language disorder","volume":"55","author":"Herbert","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib81","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.biopsych.2003.10.022","article-title":"White matter structure in autism: preliminary evidence from diffusion tensor imaging","volume":"55","author":"Barnea-Goraly","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib82","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.brainresbull.2003.06.001","article-title":"Brain anatomy and development in autism: review of structural MRI studies","volume":"61","author":"Brambilla","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ygeno.2007.09.003_bib83","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/S0140-6736(99)01239-8","article-title":"Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association","volume":"353","author":"Taylor","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ygeno.2007.09.003_bib84","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ana.410430106","article-title":"Neurobiology of autism","volume":"43","author":"Rapin","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib85","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1023\/B:JADD.0000005998.47370.ef","article-title":"Language and other regression: assessment and timing","volume":"33","author":"Goldberg","year":"2003","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib86","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1362361305057880","article-title":"Parental report of the early development of children with regressive autism: the delays-plus-regression phenotype","volume":"9","author":"Ozonoff","year":"2005","journal-title":"Autism"},{"key":"10.1016\/j.ygeno.2007.09.003_bib87","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1021991718423","article-title":"Research on screening and diagnosis in autism: a work in progress","volume":"29","author":"Bristol-Power","year":"1999","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.ygeno.2007.09.003_bib88","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1469-7610.2004.t01-1-00287.x","article-title":"Regression and word loss in autistic spectrum disorders","volume":"45","author":"Lord","year":"2004","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib89","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1207\/s15326942dn2703_2","article-title":"Early regression in social communication in autism spectrum disorders: a CPEA study","volume":"27","author":"Luyster","year":"2005","journal-title":"Dev. Neuropsychol."},{"key":"10.1016\/j.ygeno.2007.09.003_bib90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00787-004-0397-8","article-title":"Validity of childhood disintegrative disorder apart from autistic disorder with speech loss","volume":"13","author":"Kurita","year":"2004","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.ygeno.2007.09.003_bib91","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archpsyc.62.8.889","article-title":"Validation of the phenomenon of autistic regression using home videotapes","volume":"62","author":"Werner","year":"2005","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754307002327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754307002327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T01:51:04Z","timestamp":1546393864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754307002327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0888754307002327"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2007.09.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1096929.552883","asserted-by":"object"}]},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}