{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:53:24Z","timestamp":1755035604909},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":1722,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ygeno.2008.06.003","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T13:31:39Z","timestamp":1220016699000},"page":"301-308","source":"Crossref","is-referenced-by-count":7,"title":["Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs"],"prefix":"10.1016","volume":"92","author":[{"given":"M.","family":"Kapasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Serafimidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gavalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kossida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2008.06.003_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrg1043","article-title":"Comparative genomics: genome-wide analysis in metazoan eukaryotes","volume":"4","author":"Ureta-Vidal","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ygeno.2008.06.003_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2003.050948","article-title":"Comparative genomic analysis as a tool for biological discovery","volume":"554","author":"Nobrega","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature01858","article-title":"Comparative analyses of multi-species sequences from targeted genomic regions","volume":"424","author":"Thomas","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2008.06.003_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1101\/gr.1327604","article-title":"Eukaryotic regulatory element conservation analysis and identification using comparative genomics","volume":"14","author":"Liu","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.ygeno.2008.06.003_bib5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1471-2105-7-270","article-title":"Improving the specificity of high-throughput ortholog prediction","volume":"7","author":"Fulton","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ygeno.2008.06.003_bib6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(01)00365-8","article-title":"Epithelial mesenchymal interactions in cancer and development","volume":"105","author":"Arias","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2008.06.003_bib7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1101\/gad.14.5.585","article-title":"WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene","volume":"14","author":"Xu","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1101\/gad.942902","article-title":"WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase","volume":"16","author":"Su","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib9","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/bies.1045","article-title":"Wnt signalling: a theme with nuclear variations","volume":"23","author":"Sharpe","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.ygeno.2008.06.003_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/excr.1999.4456","article-title":"The CCN family of angiogenic regulators: the integrin connection","volume":"248","author":"Lau","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ygeno.2008.06.003_bib12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/mgme.2000.3059","article-title":"Connective tissue growth factor: what's in a name?","volume":"71","author":"Moussad","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ygeno.2008.06.003_bib13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0945-053X(02)00055-0","article-title":"Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?","volume":"21","author":"Blom","year":"2002","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/mp.56.2.127","article-title":"Proposal for a unified CCN nomenclature","volume":"56","author":"Brigstock","year":"2003","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-2867-3-15","article-title":"A structural approach to the role of CCN (CYR61\/CTGF\/NOV) proteins in tumourigenesis","volume":"3","author":"Planque","year":"2003","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ygeno.2008.06.003_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/joe.0.1780169","article-title":"The CCN family: a new stimulus package","volume":"178","author":"Brigstock","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib17","first-page":"RA277","article-title":"The role of connective tissue growth factor in skeletal growth and development","volume":"12","author":"Kanaan","year":"2006","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ygeno.2008.06.003_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/stemcells.2007-0194","article-title":"Novel effectors of directed and Ngn3 mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors","volume":"26","author":"Serafimidis","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ygeno.2008.06.003_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00597-7","article-title":"Nuclear localization of beta-catenin by interaction with transcription factor LEF-1","volume":"59","author":"Huber","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib20","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.005132","article-title":"Wnt signaling mediates regional specification in the vertebrate face","volume":"134","author":"Brugmann","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ygeno.2008.06.003_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0955-2235(91)90003-M","article-title":"Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)","volume":"3","author":"Shimasaki","year":"1991","journal-title":"Prog. Growth Factors Res."},{"key":"10.1016\/j.ygeno.2008.06.003_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/oxfordjournals.bmb.a072335","article-title":"Structural and functional analysis of insulin-like growth factors","volume":"45","author":"Clemmons","year":"1989","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.ygeno.2008.06.003_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.113.1.195","article-title":"Assembly and routing of von Willebrand factor variants: the requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids","volume":"113","author":"Voorberg","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib24","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/01.CIR.100.13.1423","article-title":"Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats","volume":"100","author":"Iruela- Arispe","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ygeno.2008.06.003_bib25","first-page":"1735","article-title":"Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells","volume":"57","author":"Guo","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygeno.2008.06.003_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/prot.340170405","article-title":"Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?","volume":"17","author":"Bork","year":"1993","journal-title":"Proteins"},{"key":"10.1016\/j.ygeno.2008.06.003_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-5793(93)80155-N","article-title":"The modular architecture of a new family of growth regulators related to connective tissue growth factor","volume":"327","author":"Bork","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ygeno.2008.06.003_bib28","first-page":"189","article-title":"The connective tissue growth factor\/cysteine-rich 61\/nephroblastoma overexpressed (CCN) family","volume":"20","author":"Brigstock","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0925-4773(02)00333-7","article-title":"Gene expression cascades in pancreatic development","volume":"120","author":"Wilson","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2337\/diabetes.55.01.06.db05-0681","article-title":"A vHNF1\/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells","volume":"55","author":"Poll","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ygeno.2008.06.003_bib31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/dmrr.429","article-title":"The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors","volume":"20","author":"Wilding","year":"2004","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib32","doi-asserted-by":"crossref","first-page":"38254","DOI":"10.1074\/jbc.M302229200","article-title":"Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4","volume":"278","author":"Smith","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2008.06.003_bib33","doi-asserted-by":"crossref","first-page":"16798","DOI":"10.1074\/jbc.M414381200","article-title":"Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes","volume":"280","author":"Iype","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2008.06.003_bib34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bbrc.2003.09.108","article-title":"Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis","volume":"310","author":"Miyatsuka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2008.06.003_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ydbio.2003.12.008","article-title":"The role of Brn4\/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity","volume":"268","author":"Heller","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib36","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1074\/jbc.M107124200","article-title":"Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells","volume":"277","author":"Hussain","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2008.06.003_bib37","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1242\/dev.02366","article-title":"Stabilization of b-catenin impacts pancreas growth","volume":"133","author":"Heiser","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ygeno.2008.06.003_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1101\/gad.14.1.67","article-title":"A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons","volume":"14","author":"Fode","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2008.06.003_bib39","doi-asserted-by":"crossref","first-page":"W6","DOI":"10.1093\/nar\/gkl164","article-title":"BLAST: improvements for better sequence analysis","volume":"34","author":"Ye","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2008.06.003_bib40","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/bioinformatics\/btg213","article-title":"Detecting putative orthologs","volume":"19","author":"Wall","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2008.06.003_bib41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","article-title":"MUSCLE: a multiple sequence alignment method with reduced time and space complexity","volume":"5","author":"Edgar","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ygeno.2008.06.003_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/bib\/5.1.82","article-title":"Analysis for free: comparing programs for sequence analysis","volume":"5","author":"Tippmann","year":"2004","journal-title":"Brief Bioinform."},{"key":"10.1016\/j.ygeno.2008.06.003_bib43","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib44","first-page":"729","article-title":"A note on the neighbor-joining algorithm of Saitou and Nei","volume":"5","author":"Studier","year":"1988","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ygeno.2008.06.003_bib45","unstructured":"J. Felsenstein, PHYLIP, Phylogeny Inference Package, Version 3.6, 2002."},{"key":"10.1016\/j.ygeno.2008.06.003_bib46","first-page":"357","article-title":"TreeView: an application to display phylogenetic trees on personal computers","volume":"12","author":"Page","year":"1996","journal-title":"Comput. Appl. Biosci."},{"key":"10.1016\/j.ygeno.2008.06.003_bib47","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754308001389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754308001389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T19:51:45Z","timestamp":1684525905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754308001389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0888754308001389"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2008.06.003","relation":{},"ISSN":["0888-7543"],"issn-type":[{"type":"print","value":"0888-7543"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}