{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:39:21Z","timestamp":1784054361899,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":1053,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.ygeno.2010.05.002","type":"journal-article","created":{"date-parts":[[2010,5,31]],"date-time":"2010-05-31T06:21:44Z","timestamp":1275286904000},"page":"146-153","source":"Crossref","is-referenced-by-count":70,"title":["Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures"],"prefix":"10.1016","volume":"96","author":[{"given":"Raghunandan Dudda","family":"Subramanya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin B.","family":"Coda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2010.05.002_bib1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4065\/70.7.628","article-title":"Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989","volume":"70","author":"Safavi","year":"1995","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ygeno.2010.05.002_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1600-0625.1999.tb00385.x","article-title":"Alopecia areata: an autoimmune disease?","volume":"8","author":"McElwee","year":"1999","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2230.2002.01077.x","article-title":"Epidemiology and genetics of alopecia areata","volume":"27","author":"McDonagh","year":"2002","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/archderm.1963.01590210048007","article-title":"Alopecia areata. An evaluation of 736 patients","volume":"88","author":"Muller","year":"1963","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib5","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1001\/jama.1995.03520420031025","article-title":"Alopecia areata and presence of cytomegalovirus DNA","volume":"273","author":"Skinner","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ygeno.2010.05.002_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/1523-1747.ep12365508","article-title":"No correlation between cytomegalovirus and alopecia areata","volume":"107","author":"Tosti","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1067\/mjd.2000.103909","article-title":"Alopecia areata update","volume":"42","author":"Madani","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0733-8635(05)70368-5","article-title":"Psychophysiology of stress in dermatology. The psychobiologic pattern of psychosomatics","volume":"14","author":"Panconesi","year":"1996","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.ygeno.2010.05.002_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0738-081X(00)00134-6","article-title":"Alopecia areata","volume":"19","author":"McDonagh","year":"2001","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2340\/00015555642630","article-title":"Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata","volume":"64","author":"Perret","year":"1984","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/archderm.1977.01640090144032","article-title":"Alopecia areata and vitiligo associated with Down's syndrome","volume":"113","author":"Brown","year":"1977","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1086\/511442","article-title":"Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata","volume":"80","author":"Martinez-Mir","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygeno.2010.05.002_bib13","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/bioinformatics\/btg468","article-title":"Degrees of differential gene expression: detecting biologically significant expression differences and estimating their magnitudes","volume":"20","author":"Bickel","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2010.05.002_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11010-007-9555-x","article-title":"Selection of DNA aptamers against DC-SIGN protein","volume":"306","author":"Hui","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ygeno.2010.05.002_bib15","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.molimm.2006.03.016","article-title":"Atlantic salmon ISG15: expression and conjugation to cellular proteins in response to interferon, double-stranded RNA and virus infections","volume":"44","author":"Rokenes","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"Honda","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2010.05.002_bib17","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.8493535","article-title":"Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains","volume":"260","author":"Brady","year":"1993","journal-title":"Science"},{"issue":"Pt 6","key":"10.1016\/j.ygeno.2010.05.002_bib18","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1242\/jcs.113.6.1021","article-title":"Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor","volume":"113","author":"Sheikh","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ygeno.2010.05.002_bib19","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1021\/bi00189a029","article-title":"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia","volume":"33","author":"Quaife","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.ygeno.2010.05.002_bib20","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1101\/gad.14.10.1181","article-title":"Wnt signaling maintains the hair-inducing activity of the dermal papilla","volume":"14","author":"Kishimoto","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2010.05.002_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.0022-202X.2004.23215.x","article-title":"Expression of Frizzled genes in developing and postnatal hair follicles","volume":"123","author":"Reddy","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1046\/j.1523-1747.2002.01811.x","article-title":"Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans","volume":"119","author":"Carroll","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib23","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.0022-202X.2005.23919.x","article-title":"Clinical and genetic heterogeneity of erythrokeratoderma variabilis","volume":"125","author":"Common","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib24","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/351662a0","article-title":"The B-cell surface protein CD72\/Lyb-2 is the ligand for CD5","volume":"351","author":"Van de Velde","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2010.05.002_bib25","doi-asserted-by":"crossref","first-page":"106S","DOI":"10.1111\/1523-1747.ep12363020","article-title":"Fibroblast growth factor and epidermal growth factor in hair development","volume":"101","author":"du Cros","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/1381612013398266","article-title":"Current and potential agents for the treatment of alopecia areata","volume":"7","author":"Freyschmidt-Paul","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ygeno.2010.05.002_bib27","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1172\/JCI11517","article-title":"Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses","volume":"107","author":"Fraticelli","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ygeno.2010.05.002_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1365-3083.2003.01214.x","article-title":"The chemokines CCL5, CCL2 and CXCL12 play significant roles in the migration of Th1 cells into rheumatoid synovial tissue","volume":"57","author":"Shadidi","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nri1182","article-title":"DC-SIGN: escape mechanism for pathogens","volume":"3","author":"van Kooyk","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib30","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1046\/j.1365-2133.2000.03464.x","article-title":"The human hair follicle immune system: cellular composition and immune privilege","volume":"142","author":"Christoph","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib31","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1084\/jem.187.12.2009","article-title":"Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3","volume":"187","author":"Cole","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ygeno.2010.05.002_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nm1176","article-title":"Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease","volume":"11","author":"Lang","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ygeno.2010.05.002_bib33","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1064890","article-title":"Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus","volume":"294","author":"Blanco","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ygeno.2010.05.002_bib34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu Rev Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.ygeno.2010.05.002_bib35","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/S0923-1811(00)00141-9","article-title":"Regulation of keratinocyte function by growth factors","volume":"24","author":"Hashimoto","year":"2000","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ygeno.2010.05.002_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(95)90405-0","article-title":"Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling","volume":"80","author":"Hunter","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2010.05.002_bib37","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1021\/bi027343p","article-title":"Analysis of the cruciform binding activity of recombinant 14-3-3zeta-MBP fusion protein, its heterodimerization profile with endogenous 14-3-3 isoforms, and effect on mammalian DNA replication in vitro","volume":"42","author":"Alvarez","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.ygeno.2010.05.002_bib38","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/44188","article-title":"14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage","volume":"401","author":"Chan","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2010.05.002_bib39","doi-asserted-by":"crossref","first-page":"16624","DOI":"10.1074\/jbc.M007753200","article-title":"p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts","volume":"276","author":"Jakobi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2010.05.002_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0962-8924(00)01874-2","article-title":"Stress management \u2014 heat shock protein-70 and the regulation of apoptosis","volume":"11","author":"Beere","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1534-5807(02)00167-3","article-title":"WNT signals are required for the initiation of hair follicle development","volume":"2","author":"Andl","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ygeno.2010.05.002_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0925-4773(01)00452-X","article-title":"Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis","volume":"107","author":"Reddy","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ygeno.2010.05.002_bib43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.0022-202X.2005.23693.x","article-title":"Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles","volume":"124","author":"Kawano","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib44","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0092-8674(94)90276-3","article-title":"FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations","volume":"78","author":"Hebert","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2010.05.002_bib45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ng0897-372","article-title":"Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix","volume":"16","author":"Winter","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygeno.2010.05.002_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0923-1811(96)00541-5","article-title":"Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins","volume":"14","author":"Emonet","year":"1997","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ygeno.2010.05.002_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2230.2003.01218.x","article-title":"A novel homozygous nonsense deletion\/insertion mutation in the keratin 14 gene (Y248X; 744delC\/insAG) causes recessive epidermolysis bullosa simplex type Kobner","volume":"28","author":"Lanschuetzer","year":"2003","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.ygeno.2010.05.002_bib48","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1001\/jama.286.18.2280","article-title":"Gene expression profile analysis by DNA microarrays: promise and pitfalls","volume":"286","author":"King","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ygeno.2010.05.002_bib49","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1086\/512017","article-title":"Gene-expression variation within and among human populations","volume":"80","author":"Storey","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ygeno.2010.05.002_bib50","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jaad.2003.09.032","article-title":"Alopecia areata investigational assessment guidelines \u2014 Part II. National Alopecia Areata Foundation","volume":"51","author":"Olsen","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ygeno.2010.05.002_bib51","doi-asserted-by":"crossref","unstructured":"A.B. Coda, V. Qafalijaj Hysa, et al., (2010). \"Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity.\" Genes Immun. (in press).","DOI":"10.1038\/gene.2010.32"}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754310001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754310001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T04:35:17Z","timestamp":1711514117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754310001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0888754310001151"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2010.05.002","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}