{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:14:49Z","timestamp":1773285289603,"version":"3.50.1"},"reference-count":129,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":550,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR16710\/BID\/7\/680\/2016"],"award-info":[{"award-number":["BT\/PR16710\/BID\/7\/680\/2016"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ygeno.2018.05.024","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T17:36:24Z","timestamp":1528133784000},"page":"936-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis"],"prefix":"10.1016","volume":"111","author":[{"given":"S.","family":"Akila Parvathy Dharshini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-8986","authenticated-orcid":false,"given":"Y-h.","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Michael Gromiha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2018.05.024_bb0005","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.6338589","article-title":"Alzheimer's disease: a disorder of cortical cholinergic innervation","volume":"219","author":"Coyle","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0010","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archneur.1985.04060100083029","article-title":"Diagnosis of Alzheimer's disease","volume":"42","author":"Khachaturian","year":"1985","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/ageing\/12.4.296","article-title":"Gait and balance in senile dementia of Alzheimer's type","volume":"12","author":"Visser","year":"1983","journal-title":"Age Ageing"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0020","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer's disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0025","first-page":"32","article-title":"The energy demand of fast neuronal network oscillations: insights from brain slice preparations","author":"Kann","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0030","first-page":"21","article-title":"Evidence of neuronal oxidative damage in Alzheimer's disease","volume":"149","author":"Good","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0035","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1523\/JNEUROSCI.17-12-04612.1997","article-title":"Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease","volume":"17","author":"Sheehan","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0040","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0166-2236(00)01584-8","article-title":"Energetics in the pathogenesis of neurodegenerative diseases","volume":"23","author":"Beal","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2202-10-12","article-title":"Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress","volume":"10","author":"Wang","year":"2009","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004958","article-title":"Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing","volume":"11","author":"Gutierrez-Arcelus","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016266","article-title":"Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease","volume":"6","author":"Twine","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41467-017-00050-4","article-title":"Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis","volume":"8","author":"Sahraeian","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030619","article-title":"NGS QC Toolkit: a toolkit for quality control of next generation sequencing data","volume":"7","author":"Patel","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0070","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058815","article-title":"Development of strategies for SNP detection in RNA-seq data: application to lymphoblastoid cell lines and evaluation using 1000 Genomes data","volume":"8","author":"Quinn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0080","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0085","first-page":"15.14. 11","article-title":"Using VarScan 2 for Germline Variant Calling and Somatic Mutation Detection","author":"Koboldt","year":"2013","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0090","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0095","doi-asserted-by":"crossref","first-page":"D259","DOI":"10.1093\/nar\/gkv1036","article-title":"RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data","volume":"44","author":"Sun","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0100","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1101\/gr.176601","article-title":"Predicting deleterious amino acid substitutions","volume":"11","author":"Ng","year":"2001","journal-title":"Genome Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0105","first-page":"7.20. 21","article-title":"Predicting functional effect of human missense mutations using PolyPhen-2","author":"Adzhubei","year":"2013","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0110","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nmeth0810-575","article-title":"MutationTaster evaluates disease-causing potential of sequence alterations","volume":"7","author":"Schwarz","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0115","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1093\/bioinformatics\/btv195","article-title":"PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels","volume":"16","author":"Choi","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0120","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0125","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp215","article-title":"Human splicing finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"Desmet","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0130","doi-asserted-by":"crossref","first-page":"W239","DOI":"10.1093\/nar\/gkl190","article-title":"CUPSAT: prediction of protein stability upon point mutations","volume":"34","author":"Parthiban","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0135","doi-asserted-by":"crossref","first-page":"W382","DOI":"10.1093\/nar\/gki387","article-title":"The FoldX web server: an online force field","volume":"33","author":"Schymkowitz","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0140","doi-asserted-by":"crossref","first-page":"i63","DOI":"10.1093\/bioinformatics\/bth928","article-title":"A neural-network-based method for predicting protein stability changes upon single point mutations","volume":"20","author":"Capriotti","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0145","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/prot.20810","article-title":"Prediction of protein stability changes for single-site mutations using support vector machines","volume":"62","author":"Cheng","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0150","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0155","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nmeth.2832","article-title":"Functional annotation of noncoding sequence variants","volume":"11","author":"Ritchie","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0160","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nmeth.3547","article-title":"Predicting effects of noncoding variants with deep learning-based sequence model","volume":"12","author":"Zhou","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0165","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0170","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ejhg.2013.274","article-title":"GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies","volume":"22","author":"Beck","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002548","article-title":"Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database","volume":"8","author":"Lill","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0180","doi-asserted-by":"crossref","first-page":"D799","DOI":"10.1093\/nar\/gku1202","article-title":"GRASP v2. 0: an update on the genome-wide repository of associations between SNPs and phenotypes","volume":"43","author":"Eicher","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0185","doi-asserted-by":"crossref","first-page":"D139","DOI":"10.1093\/nar\/gkw1064","article-title":"SNP2TFBS\u2013a database of regulatory SNPs affecting predicted transcription factor binding site affinity","volume":"45","author":"Kumar","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0190","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","article-title":"HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease","volume":"44","author":"Ward","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0195","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1093\/bioinformatics\/btv470","article-title":"motifbreakR: an R\/Bioconductor package for predicting variant effects at transcription factor binding sites","volume":"31","author":"Coetzee","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0200","doi-asserted-by":"crossref","first-page":"D1033","DOI":"10.1093\/nar\/gkt1167","article-title":"rSNPBase: a database for curated regulatory SNPs","volume":"42","author":"Guo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0205","doi-asserted-by":"crossref","first-page":"D51","DOI":"10.1093\/nar\/gkl797","article-title":"PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits","volume":"35","author":"Bao","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0210","series-title":"BMC Bioinformatics","first-page":"A2","article-title":"miRNASNP: a database of miRNA related SNPs and their effects on miRNA function","author":"Gong","year":"2012"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/humu.21482","article-title":"miRvar: a comprehensive database for genomic variations in microRNAs","volume":"32","author":"Bhartiya","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0220","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.4572.1","article-title":"GeneMANIA: fast gene network construction and function prediction for Cytoscape","volume":"3","author":"Montojo","year":"2014","journal-title":"F1000Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0225","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1093\/bioinformatics\/btq596","article-title":"GLay: community structure analysis of biological networks","volume":"26","author":"Su","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0230","article-title":"ReactomeFIViz: a Cytoscape app for pathway and network-based data analysis","volume":"3","author":"Wu","year":"2014","journal-title":"F1000Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0235","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0240","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1007\/s00018-012-0990-9","article-title":"Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements","volume":"69","author":"Barrett","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0245","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1750-1326-6-70","article-title":"Alzheimer-specific variants in the 3\u2032UTR of Amyloid precursor protein affect microRNA function","volume":"6","author":"Delay","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0250","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ygeno.2017.02.006","article-title":"Altered gene expression in late-onset Alzheimer's disease due to SNPs within 3\u2032 UTR microRNA response elements","volume":"109","author":"Roy","year":"2017","journal-title":"Genomics"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0255","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-009-0571-7","article-title":"TARDBP 3\u2032-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy","volume":"118","author":"Gitcho","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0260","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1896849","article-title":"The medial temporal lobe memory system","volume":"253","author":"Squire","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0265","first-page":"241","article-title":"Forkhead transcription factors: new considerations for Alzheimer's disease and dementia","volume":"2","author":"Maiese","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0270","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0169-328X(02)00519-3","article-title":"Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase\/MEF2 pathway","volume":"108","author":"Burton","year":"2002","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0275","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fncel.2015.00426","article-title":"Role of TGF\u03b2 signaling in the pathogenesis of Alzheimer's disease","volume":"9","author":"Von Bernhardi","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0280","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0285","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3233\/JAD-141731","article-title":"A regulatory role for the insulin-and BDNF-linked RORA in the hippocampus: implications for Alzheimer's disease","volume":"44","author":"Acquaah-Mensah","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0290","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0295","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0896-6273(00)80194-4","article-title":"GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination","volume":"17","author":"Liedtke","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0300","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/cells5020020","article-title":"Role of intermediate filaments in vesicular traffic","volume":"5","author":"Margiotta","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0305","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1471-4159.2004.02869.x","article-title":"Direct interaction of myosin regulatory light chain with the NMDA receptor","volume":"92","author":"Amparan","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0310","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fnins.2014.00338","article-title":"Axon growth inhibition by RhoA\/ROCK in the central nervous system","volume":"8","author":"Fujita","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0315","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/cn900029p","article-title":"Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism","volume":"1","author":"Mehta","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0320","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ydbio.2013.09.028","article-title":"Maturin is a novel protein required for differentiation during primary neurogenesis","volume":"384","author":"Martinez-De Luna","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0325","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF03256432","article-title":"A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury","volume":"16","author":"Schiff","year":"2012","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0330","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0335","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature09614","article-title":"Myelination and support of axonal integrity by glia","volume":"468","author":"Nave","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0340","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrn3316","article-title":"Glia: oligodendrocyte transporters feed axons","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0345","doi-asserted-by":"crossref","first-page":"28917","DOI":"10.1074\/jbc.M109.050856","article-title":"Degradation of amyloid \u03b2 protein by purified myelin basic protein","volume":"284","author":"Liao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-3932(94)00098-A","article-title":"Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man","volume":"33","author":"Owen","year":"1995","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2010.68","article-title":"Alterations of brain and cerebellar proteomes linked to A\u03b2 and tau pathology in a female triple-transgenic murine model of Alzheimer's disease","volume":"1","author":"Ciavardelli","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0360","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1084\/jem.20131274","article-title":"SIRP\u03b1 polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells","volume":"210","author":"Nuvolone","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0365","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2015.03.012","article-title":"SIRP\/CD47 signaling in neurological disorders","volume":"1623","author":"Zhang","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00103","article-title":"Aging, Alzheimer's, and APOE genotype influence the expression and neuronal distribution patterns of microtubule motor protein dynactin-P50","volume":"9","author":"Aboud","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0375","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1093\/hmg\/ddv107","article-title":"Impaired retrograde transport by the Dynein\/Dynactin complex contributes to Tau-induced toxicity","volume":"24","author":"Butzlaff","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0380","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2005.09.021","article-title":"Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD","volume":"27","author":"Sultana","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0385","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1210\/me.2010-0455","article-title":"Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I","volume":"25","author":"Liu","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0390","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13214","article-title":"A protective factor for the ageing brain","volume":"507","author":"Tsai","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0395","article-title":"Vitamin D and Alzheimer's disease: neurocognition to therapeutics","volume":"2015","author":"Banerjee","year":"2015","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0400","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fnmol.2016.00069","article-title":"Aberration of miRNAs expression in leukocytes from sporadic amyotrophic lateral sclerosis","volume":"9","author":"Chen","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0405","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/exnr.1997.6600","article-title":"Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease","volume":"147","author":"MacGibbon","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0410","first-page":"7","article-title":"Activating transcription factor 3 and the nervous system","volume":"5","author":"Anderson","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0415","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12035-014-8714-9","article-title":"Increase of zinc finger protein 179 in response to CCAAT\/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease","volume":"51","author":"Wang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0420","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1073\/pnas.1516604113","article-title":"A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation","volume":"113","author":"Ciryam","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0425","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer's disease","volume":"5","author":"Lau","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069807","article-title":"Circulating miRNA biomarkers for Alzheimer's disease","volume":"8","author":"Kumar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0435","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.15109","article-title":"Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer's disease patients from non-demented subjects","volume":"8","author":"Nagaraj","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0440","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1046\/j.1471-4159.1999.0732286.x","article-title":"CTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neurons","volume":"73","author":"Yang","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0445","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.nbd.2011.06.010","article-title":"Dysregulation of SREBP2 induces BACE1 expression","volume":"44","author":"Mastrocola","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0450","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nn.2785","article-title":"A\u03b21-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3\u03b2","volume":"14","author":"Jo","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0455","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1073\/pnas.0509863103","article-title":"Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins","volume":"103","author":"Moriguchi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0460","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0465","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2006.09.106","article-title":"Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease","volume":"1127","author":"Brooks","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0470","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1440-1681.2011.05599.x","article-title":"GAPDH: a common enzyme with uncommon functions","volume":"39","author":"Nicholls","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0475","doi-asserted-by":"crossref","first-page":"26072","DOI":"10.1074\/jbc.M115.669291","article-title":"Glyceraldehyde-3-phosphate dehydrogenase aggregates accelerate amyloid-\u03b2 Amyloidogenesis in Alzheimer disease","volume":"290","author":"Itakura","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0480","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.1096485","article-title":"Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis","volume":"305","author":"Kasischke","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0485","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1073\/pnas.0709259105","article-title":"Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons","volume":"105","author":"Liang","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0490","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1046\/j.1471-4159.2000.0751487.x","article-title":"Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice","volume":"75","author":"Herms","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0495","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1073\/pnas.0609621104","article-title":"Cellular prion protein regulates \u03b2-secretase cleavage of the Alzheimer's amyloid precursor protein","volume":"104","author":"Parkin","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007208","article-title":"Evolutionary descent of prion genes from the ZIP family of metal ion transporters","volume":"4","author":"Schmitt-Ulms","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0505","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bbrc.2002.6649","article-title":"Motor discoordination in mutant mice lacking junctophilin type 3","volume":"292","author":"Nishi","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0510","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/mp.2016.33","article-title":"Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole","volume":"22","author":"Pereira","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0515","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0896-6273(03)00627-5","article-title":"Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles","volume":"40","author":"Cruz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0520","first-page":"4","article-title":"Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease","volume":"6","author":"Levine","year":"2013","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0525","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2174\/092986711797200426","article-title":"Hypoxia inducible factor-1 as a target for neurodegenerative diseases","volume":"18","author":"Zhang","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0530","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2010.01.015","article-title":"Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex","volume":"18","author":"Burgos","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0535","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1750-1326-5-36","article-title":"Increased expression of RXR\u03b1 in dementia: an early harbinger for the cholesterol dyshomeostasis?","volume":"5","author":"Akram","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0540","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S1461145711000149","article-title":"Increased NF-\u03baB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease","volume":"15","author":"Chen","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0545","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/pr800667a","article-title":"Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD","volume":"8","author":"Owen","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0550","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/jdb4030027","article-title":"Control of hedgehog signalling by the cilia-regulated proteasome","volume":"4","author":"Gerhardt","year":"2016","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0555","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7709","article-title":"Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms","volume":"6","author":"Cohen","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0560","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1073\/pnas.90.20.9247","article-title":"Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa BI kappa B complex","volume":"90","author":"Li","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0565","doi-asserted-by":"crossref","first-page":"8586","DOI":"10.1523\/JNEUROSCI.23-24-08586.2003","article-title":"Reciprocal inhibition of p53 and nuclear factor-\u03baB transcriptional activities determines cell survival or death in neurons","volume":"23","author":"Culmsee","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0570","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.0903359","article-title":"Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation","volume":"184","author":"Goh","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0575","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/cr.2007.117","article-title":"DNA polymerase zeta (pol \u03b6) in higher eukaryotes","volume":"18","author":"Gan","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0580","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molmed.2004.09.005","article-title":"Alzheimer's disease meets the ubiquitin\u2013proteasome system","volume":"10","author":"Song","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0585","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1073\/pnas.84.9.3033","article-title":"Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains","volume":"84","author":"Perry","year":"1987","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0590","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1432-1033.1992.tb16961.x","article-title":"Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms","volume":"206","author":"Kanayama","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0595","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0600","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152342","article-title":"Identification of differentially expressed genes through integrated study of Alzheimer's disease affected brain regions","volume":"11","author":"Puthiyedth","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0605","doi-asserted-by":"crossref","first-page":"35702","DOI":"10.1074\/jbc.M302004200","article-title":"Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0610","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jcp.20899","article-title":"Regulation of cyclin-dependent kinase 5 and p53 by ERK1\/2 pathway in the DNA damage-induced neuronal death","volume":"210","author":"Lee","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0615","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2007.09.009","article-title":"Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder","volume":"187","author":"DeLorey","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0620","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbadis.2006.04.002","article-title":"Axonal transport and neurodegenerative disease","volume":"1762","author":"Chevalier-Larsen","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0625","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature06172","article-title":"ESCRT-III recognition by vps4 ATPases","volume":"449","author":"Stuchell-Brereton","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0630","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1073\/pnas.0701585104","article-title":"Lipocalin-type prostaglandin D synthase\/\u03b2-trace is a major amyloid \u03b2-chaperone in human cerebrospinal fluid","volume":"104","author":"Kanekiyo","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0635","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-1119(03)00766-2","article-title":"Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells","volume":"318","author":"Renbaum","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.ygeno.2018.05.024_bb0640","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12031-009-9214-7","article-title":"L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro","volume":"39","author":"Xin","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ygeno.2018.05.024_bb0645","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754318301873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754318301873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:21:16Z","timestamp":1760163676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754318301873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":129,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0888754318301873"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2018.05.024","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2018.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}