{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:32:42Z","timestamp":1778661162117,"version":"3.51.4"},"reference-count":77,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":547,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ygeno.2018.07.007","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T20:41:24Z","timestamp":1531255284000},"page":"1124-1133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genome-wide analysis of Excretory\/Secretory proteins in Trypanosoma brucei brucei: Insights into functional characteristics and identification of potential targets by immunoinformatics approach"],"prefix":"10.1016","volume":"111","author":[{"given":"Gowdham","family":"Manivel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Meyyazhagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruban","family":"Durairaj D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmughavel","family":"Piramanayagam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2018.07.007_bb0005","series-title":"Manson's Tropical Diseases","first-page":"1171","article-title":"African trypanosomiasis in man","author":"Molyneux","year":"1996"},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-3305-1-3","article-title":"The history of African trypanosomiasis","volume":"1","author":"Steverding","year":"2008","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0015","series-title":"The Trypanosomes of Mammals, A Zoological Monograph","author":"Hoare","year":"1972"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0020","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature01461","article-title":"Apolipoprotein L-1 is the trypanosome lytic factor of human serum","volume":"422","author":"Vanhamme","year":"2003","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ygeno.2018.07.007_bb0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.pt.2010.05.005","article-title":"The trypanolytic factor-mechanism, impacts and applications","volume":"26","author":"Wheeler","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0030","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/1756-3305-6-322","article-title":"Domestic pigs as potential reservoirs of human and animal trypanosomiasis in northern Tanzania","volume":"6","author":"Hamill","year":"2013","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0035","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/BF02237909","article-title":"Pig trypanosomiasis: effects of infection on feed intake, live weight gain and carcass traits","volume":"13","author":"Ilemobade","year":"1981","journal-title":"Trop. Anita EHth Prod."},{"issue":"2","key":"10.1016\/j.ygeno.2018.07.007_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/MMBR.68.2.207-233.2004","article-title":"Proteomics of protein secretion by Bacillus subtilis\u202f: separating the secrets of the Secretome","volume":"68","author":"Tjalsma","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev 2."},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity","volume":"167","author":"Hewitson","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1756-3305-6-259","article-title":"The predicted secretome and transmembranome of the poultry red mite Dermanyssus gallinae","volume":"6","author":"Schicht","year":"2013","journal-title":"Parasit. Vectors"},{"issue":"Suppl 7","key":"10.1016\/j.ygeno.2018.07.007_bb0055","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1471-2164-13-S7-S8","article-title":"Helminth secretome database (HSD): a collection of helminth excretory\/secretory proteins predicted from expressed sequence tags (ESTs)","volume":"13","author":"Garg","year":"2012","journal-title":"BMC Genomics"},{"issue":"Suppl 3","key":"10.1016\/j.ygeno.2018.07.007_bb0060","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1186\/1471-2164-12-S3-S14","article-title":"In silico secretome analysis approach for next generation sequencing transcriptomic data","volume":"12","author":"Garg","year":"2011","journal-title":"BMC Genomics"},{"issue":"11","key":"10.1016\/j.ygeno.2018.07.007_bb0065","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0020-7519(03)00158-9","article-title":"Progress in the development of a recombinant vaccine for human hookworm disease: the human hookworm vaccine initiative","volume":"33","author":"Hotez","year":"2003","journal-title":"Int. J. Parasitol."},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0070","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14712598.4.4.551","article-title":"Development of secreted proteins as biotherapeutic agents","volume":"4","author":"Bonin-Debs","year":"2004","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micinf.2007.10.008","article-title":"Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics","volume":"10","author":"Holzmuller","year":"2008","journal-title":"Microbes Infect."},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0080","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/biof.1100","article-title":"Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control?","volume":"39","author":"Bossard","year":"2013","journal-title":"Biofactors"},{"issue":"5","key":"10.1016\/j.ygeno.2018.07.007_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000078","article-title":"Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses","volume":"4","author":"Radwanska","year":"2008","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0090","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1590\/S0001-37652006000400004","article-title":"Immunology and immunopathology of African trypanosomiasis","volume":"78","author":"Vincendeau","year":"2006","journal-title":"An. Acad. Bras. Cienc."},{"issue":"778","key":"10.1016\/j.ygeno.2018.07.007_bb0095","article-title":"Trypanosomatid infections: how do parasites and their excreted\u2013secreted factors modulate the inducible metabolism of l-arginine in macrophages?","volume":"9","author":"Philippe","year":"2018","journal-title":"Front. Immunol."},{"issue":"31","key":"10.1016\/j.ygeno.2018.07.007_bb0100","doi-asserted-by":"crossref","first-page":"18387","DOI":"10.1074\/jbc.271.31.18387","article-title":"A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting","volume":"271","author":"Bangs","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/EC.2.1.76-83.2003","article-title":"Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei","volume":"2","author":"Triggs","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/212817","article-title":"Excreted\/secreted proteins from trypanosome procyclic strains","volume":"2010","author":"Atyame Nten","year":"2009","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1471-2105-10-194","article-title":"Computational analysis of the interaction between transcription factors and the predicted secreted proteome of the yeast Kluyveromyces lactis","volume":"10","author":"Brustolini","year":"2009","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0120","doi-asserted-by":"crossref","unstructured":"Tsang A, Butler G, Powlowski J, Panisko EA, Baker SE. Analytical and computational approaches to define the Aspergillus niger secretome. Fungal Genet. Biol. 2009;46 (1):S153-S160.","DOI":"10.1016\/j.fgb.2008.07.014"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0125","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00726-013-1649-z","article-title":"SECRETOOL: integrated secretome analysis tool for fungi","volume":"46","author":"Cort\u00e1zar","year":"2014","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033731","article-title":"The predicted secretome of the plant pathogenic fungus Fusarium graminearum: a refined comparative analysis","volume":"7","author":"Brown","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0135","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1038\/srep09683","article-title":"Genome analysis of excretory\/secretory proteins in Taenia solium reveals their abundance of antigenic regions (AAR)","volume":"5","author":"Gomez","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0140","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/s13071-015-1282-7","article-title":"Genome-wide analysis of excretory\/secretory proteins in Echinococcus multilocularis: Insights into functional characteristics of the tapeworm secretome","volume":"8","author":"Wang","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0145","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fmicb.2017.00128","article-title":"Secretome prediction of two M. tuberculosis clinical isolates reveals their high antigenic density and potential drug targets","volume":"8","author":"Cornejo-Granados","year":"2017","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.ygeno.2018.07.007_bb0150","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"Bendtsen","year":"2004","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0160","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1006\/jmbi.2000.3903","article-title":"Predicting subcellular localization of proteins based on their N-terminal amino acid sequence","volume":"300","author":"Emanuelsson","year":"2000","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","article-title":"Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0170","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0175","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","author":"Finn","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2008\/619832","article-title":"Blast2GO: a comprehensive suite for functional analysis in plant genomics","volume":"2008","author":"Conesa","year":"2008","journal-title":"Int. J. Plant Genomics"},{"issue":"18","key":"10.1016\/j.ygeno.2018.07.007_bb0185","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.ygeno.2018.07.007_bb0190","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"G\u00f6tz","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"SUPPL.4","key":"10.1016\/j.ygeno.2018.07.007_bb0195","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1186\/1471-2105-13-S4-S14","article-title":"Argot2: a large scale function prediction tool relying on semantic similarity of weighted gene ontology terms","volume":"13","author":"Falda","year":"2012","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0200","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0210","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-4017(98)00146-0","article-title":"Trypanosoma evansi and T.equiperum: distribution, biology, treatment and phylogenetic relationship (a review)","volume":"79","author":"Brun","year":"1998","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0220","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins Struct. Func. Bioinforma."},{"issue":"2","key":"10.1016\/j.ygeno.2018.07.007_bb0225","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immun. Res."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0230","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6807-7-64","article-title":"Antibody-protein interactions: benchmark datasets and prediction tools evaluation","volume":"7","author":"Ponomarenko","year":"2007","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0235","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","article-title":"Prediction of residues in discontinuous B-cell epitopes using protein 3D structures","volume":"15","author":"Haste Andersen","year":"2006","journal-title":"Protein Sci."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0240","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"issue":"3","key":"10.1016\/j.ygeno.2018.07.007_bb0245","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/jvi.55.3.836-839.1985","article-title":"Induction of hepatitis a virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.ygeno.2018.07.007_bb0250","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteins","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"issue":"1,2","key":"10.1016\/j.ygeno.2018.07.007_bb0255","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic detetermininants on protein antigens","volume":"276","author":"Kolaskar A","year":"1990","journal-title":"Febbs Lett."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0260","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0265","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2105-6-132","article-title":"Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method","volume":"6","author":"Peters","year":"2005","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0270","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-016-0288-x","article-title":"NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets","volume":"8","author":"Nielsen","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0275","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen\u202f: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinforma."},{"issue":"16","key":"10.1016\/j.ygeno.2018.07.007_bb0280","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1093\/bioinformatics\/bts326","article-title":"SORTALLER: predicting allergens using substantially optimized algorithm on allergen family featured peptides","volume":"28","author":"Zhang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0285","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/pro.2494","article-title":"The structural and functional signatures of proteins that undergo multiple events of post-translational modification","volume":"23","author":"Pejaver","year":"2014","journal-title":"Protein Sci."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0290","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2014.05.001","article-title":"Antigenic variation in African trypanosomes","volume":"195","author":"Horn","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"issue":"2","key":"10.1016\/j.ygeno.2018.07.007_bb0295","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/0006-291X(90)90392-Z","article-title":"JED. sequences population of three VSG mRNAs expressed in a mixed of Trypanosoma Brucei Rhodesiense","volume":"169","author":"Lekkala","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0300","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-2836(05)80066-X","article-title":"2.9 A resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei","volume":"216","author":"Freymann","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0305","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-6851(97)00209-0","article-title":"Multiple mechanisms of immune evasion by African trypanosomes","volume":"91","author":"Donelson","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0310","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0166-6851(01)00417-0","article-title":"The physiological significance of transferrin receptor variations in Trypanosoma brucei","volume":"119","author":"Gerrits","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0315","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/362603a0","article-title":"A structural motif in the variant surface glycoproteins of Trypanosoma brucei","volume":"362","author":"Blum","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2018.07.007_bb0320","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0166-6851(96)02672-2","article-title":"Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei","volume":"81","author":"Carruthers","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00242-0","article-title":"The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts","volume":"114","author":"Pays","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0330","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.micinf.2011.11.012","article-title":"Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective","volume":"14","author":"McVeigh","year":"2012","journal-title":"Microbes Infect."},{"issue":"6","key":"10.1016\/j.ygeno.2018.07.007_bb0335","first-page":"1895","article-title":"Thermostability and aliphatic index of globular proteins","volume":"1898","author":"Ikai","year":"1980","journal-title":"J. Biochem."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0340","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7774\/cevr.2014.3.1.50","article-title":"Vaccine allergies","volume":"3","author":"Chung","year":"2014","journal-title":"Clin. Exp. Vaccine Res."},{"issue":"10","key":"10.1016\/j.ygeno.2018.07.007_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002467","article-title":"Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of Glycosyl hydrolases","volume":"7","author":"Wang","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.ygeno.2018.07.007_bb0350","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbapap.2013.01.039","article-title":"Bioinformatics tools for secretome analysis","volume":"1834","author":"Caccia","year":"2013","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"issue":"7","key":"10.1016\/j.ygeno.2018.07.007_bb0355","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/AEM.03652-13","article-title":"Temporal alterations in the secretome of the selective ligninolytic fungus ceriporiopsis subvermispora during growth on aspen wood reveal this organism's strategy for degrading lignocellulose","volume":"80","author":"Hori","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"issue":"8","key":"10.1016\/j.ygeno.2018.07.007_bb0360","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1021\/pr070153m","article-title":"Comprehensive analysis of proteins secreted by Trichophyton rubrum and Trichophyton violaceum under in vitro conditions","volume":"6","author":"Giddey","year":"2007","journal-title":"J. Proteome Res."},{"issue":"10","key":"10.1016\/j.ygeno.2018.07.007_bb0365","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/pmic.200600853","article-title":"Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv","volume":"7","author":"Malen","year":"2007","journal-title":"Proteomics"},{"issue":"14","key":"10.1016\/j.ygeno.2018.07.007_bb0370","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.vaccine.2015.02.023","article-title":"Identification of secreted proteins as novel antigenic vaccine candidates of Haemophilus parasuis serovar 5","volume":"33","author":"Li","year":"2015","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.ygeno.2018.07.007_bb0375","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1073\/pnas.92.5.1530","article-title":"Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis","volume":"92","author":"Horwitz","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2018.07.007_bb0380","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biologicals.2017.08.004","article-title":"Towards a peptide-based vaccine against Shigella sonnei: a subtractive reverse vaccinology based approach","volume":"50","author":"Baseer","year":"2017","journal-title":"Biologicals"},{"issue":"1","key":"10.1016\/j.ygeno.2018.07.007_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-08842-w","article-title":"Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach","volume":"7","author":"Khatoon","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754318301022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754318301022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:16:46Z","timestamp":1760163406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754318301022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0888754318301022"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2018.07.007","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide analysis of Excretory\/Secretory proteins in Trypanosoma brucei brucei: Insights into functional characteristics and identification of potential targets by immunoinformatics approach","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2018.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}