{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:14:35Z","timestamp":1787663675152,"version":"build-2736575974"},"reference-count":100,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":554,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ygeno.2020.12.040","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T11:43:16Z","timestamp":1611142996000},"page":"728-739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring the druggable proteome of Candida species through comprehensive computational analysis"],"prefix":"10.1016","volume":"113","author":[{"given":"Shuvechha","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Shankar","family":"Barai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.V.","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Idicula-Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2020.12.040_bb0005","series-title":"Infectious Diseases\u2014Past, Present, and Future","year":"2020"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0010","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.16.17-00454","article-title":"Impact of infectious diseases on population health using incidence-based disability-adjusted life years (DALYs): Results from the burden of communicable diseases in Europe study, European Union and European economic countries, 2009 to 2013","volume":"23","author":"Cassini","year":"2018","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003467","article-title":"Emerging infectious diseases: threats to human health and global stability","volume":"9","author":"Morens","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature02759","article-title":"The challenge of emerging and re-emerging infectious diseases","volume":"430","author":"Morens","year":"2004","journal-title":"Nature."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0025","author":"Jones","year":"2020","journal-title":"LETTERS Glob. Trends Emerging Infect. Dis."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/jof2040026","article-title":"New horizons in antifungal therapy","volume":"2","author":"Pianalto","year":"2016","journal-title":"J. Fungi"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1469-0691.2008.01978.x","article-title":"Changing epidemiology of systemic fungal infections","volume":"14","author":"Richardson","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semdp.2019.04.010","article-title":"Emerging and reemerging fungal infections","volume":"36","author":"Lockhart","year":"2019","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0045","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/504490","article-title":"Invasive fungal pathogens: current epidemiological trends","volume":"43","author":"Pfaller","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0050","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.micpath.2018.02.028","article-title":"Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control \u2013 An update","volume":"117","author":"Dadar","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0055","article-title":"Epidemiology and antifungal susceptibility of Candida species in a tertiary care hospital, Kolkata, India","volume":"2","author":"Bhattacharjee","year":"2016","journal-title":"Curr. Med. Mycol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0060","first-page":"1","article-title":"Candida infections and therapeutic strategies: mechanisms of action for traditional and alternative agents","volume":"9","author":"Santos","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0065","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1086\/504492","article-title":"Pharmacology of systemic antifungal agents","volume":"43","author":"Ashley","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.02173","article-title":"Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species","volume":"7","author":"Whaley","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01585","article-title":"Clinical and laboratory development of echinocandin resistance in Candida glabrata: molecular characterization","volume":"10","author":"Rivero-Menendez","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0080","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S1473-3099(18)30103-8","article-title":"Global burden of recurrent vulvovaginal candidiasis: a systematic review","volume":"18","author":"Denning","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/cid\/cix744","article-title":"Approach to the investigation and management of patients with Candida auris, an emerging multidrug-resistant yeast","volume":"66","author":"Tsay","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"Satoh","year":"2009","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ddr.20413","article-title":"In silico subtractive genomics for target identification in human bacterial pathogens","volume":"72","author":"Barh","year":"2011","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gene.2015.08.044","article-title":"Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis","volume":"575","author":"Hasan","year":"2016","journal-title":"Gene."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0105","first-page":"49","article-title":"Identification of potential drug targets by subtractive genome analysis of Escherichia coli O157:H7: an in silico approach","volume":"8","author":"Mondal","year":"2015","journal-title":"Adv. Appl. Bioinforma. Chem."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0110","article-title":"A network approach to predict pathogenic genes for Fusarium graminearum","volume":"5","author":"Liu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-016-0700-0","article-title":"Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions","volume":"16","author":"Kumar","year":"2016","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0120","series-title":"Prediction of Pathogenicity Genes Involved in Adaptation to a Lupin Host in the Fungal Pathogens Botrytis cinerea and Sclerotinia sclerotiorum via Comparative Genomics","author":"Mousavi-Derazmahalleh","year":"2020"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12539-014-0188-y","article-title":"Application of a subtractive genomics approach for in silico identification and characterization of novel drug targets in Mycobacterium tuberculosis F11","volume":"6","author":"Hosen","year":"2014","journal-title":"Interdiscip. Sci. Comput. Life Sci."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0130","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/bioinformatics\/btw760","article-title":"PBIT: pipeline builder for identification of drug targets for infectious diseases","volume":"33","author":"Shende","year":"2017","journal-title":"Bioinformatics."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0135","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"Bateman","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0140","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/bioinformatics\/btq003","article-title":"CD-HIT suite: a web server for clustering and comparing biological sequences","volume":"26","author":"Huang","year":"2010","journal-title":"Bioinformatics."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ddtec.2004.10.004","article-title":"In silico antitarget screening","volume":"1","author":"Recanatini","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0150","series-title":"targetTB: A Target Identification Pipeline for Mycobacterium tuberculosis Through an Interactome, Reactome and Genome-scale Structural Analysis","author":"Raman","year":"2008"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059126","article-title":"Identification and characterization of potential therapeutic candidates in emerging human pathogen Mycobacterium abscessus: a novel hierarchical in silico approach","volume":"8","author":"Shanmugham","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0160","doi-asserted-by":"crossref","first-page":"D574","DOI":"10.1093\/nar\/gkt1131","article-title":"DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements","volume":"42","author":"Luo","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0165","article-title":"VFDB: A reference database for bacterial virulence factors","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bas032","article-title":"DFVF: database of fungal virulence factors","author":"Lu","year":"2012","journal-title":"Database (Oxford)"},{"issue":"2018","key":"10.1016\/j.ygeno.2020.12.040_bb0175","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0180","doi-asserted-by":"crossref","first-page":"D1069","DOI":"10.1093\/nar\/gkv1230","article-title":"Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information","volume":"44","author":"Yang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0185","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0190","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0195","series-title":"The Igraph Software Package for Complex Network Research","author":"Cs\u00e1rdi","year":"2020"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103047","article-title":"Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson\u2019s Disease","volume":"9","author":"Rakshit","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12936-015-0562-1","article-title":"Identification of important interacting proteins (IIPs) in Plasmodium falciparum using large-scale interaction network analysis and in-silico knock-out studies","volume":"14","author":"Bhattacharyya","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0210","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1752-0509-7-132","article-title":"A multi-level multi-scale approach to study essential genes in Mycobacterium tuberculosis","volume":"7","author":"Ghosh","year":"2013","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0215","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nbt.1614","article-title":"Ines thiele, what is flux balance?","volume":"28","author":"Orth","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0220","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/bit.25955","article-title":"Genome-scale metabolic modeling and in silico analysis of lipid accumulating yeast Candida tropicalis for dicarboxylic acid production","volume":"113","author":"Mishra","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0225","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1752-0509-7-74","article-title":"COBRApy: COnstraints-based reconstruction and analysis for Python","volume":"7","author":"Ebrahim","year":"2013","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0230","doi-asserted-by":"crossref","first-page":"D592","DOI":"10.1093\/nar\/gkw924","article-title":"The Candida genome database (CGD): incorporation of assembly 22, systematic identifiers and visualization of high throughput sequencing data","volume":"45","author":"Skrzypek","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0235","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0240","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02048-18","article-title":"Gene essentiality analyzed by in vivo transposon mutagenesis and machine learning in a stable haploid isolate of Candida albicans","volume":"9","author":"Segal","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0245","doi-asserted-by":"crossref","first-page":"0835","DOI":"10.1371\/journal.ppat.0030092","article-title":"Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans","volume":"3","author":"Xu","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0250","first-page":"78","article-title":"Cloning of structural genes involved in riboflavin synthesis of the yeast Candida famata","volume":"76","author":"Dmytruk","year":"1999","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0255","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF00270777","article-title":"Production of \u03b1-aminoadipate-\u03b4-semialdehyde by a mutant from Candida maltosa","volume":"31","author":"Schmidt","year":"1989","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0260","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1128\/aem.56.12.3785-3792.1990","article-title":"Oxygen requirements of yeasts","volume":"56","author":"Visser","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0265","article-title":"In vitro and in vivo activity of a novel antifungal small molecule against Candida infections","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0270","series-title":"Evaluating the Concentration of a Candida albicans Suspension","author":"Rodrigues","year":"1993"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0275","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1128\/IAI.67.7.3193-3198.1999","article-title":"Unanticipated heterogeneity in growth rate and virulence among Candida albicans AAF1 null mutants","volume":"67","author":"Rieg","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.00357","article-title":"Genetic modification of closely related Candida species","volume":"10","author":"Mancera","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0285","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tim.2011.12.004","article-title":"A metabolic network approach for the identification and prioritization of antimicrobial drug targets","volume":"20","author":"Chavali","year":"2012","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0290","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1128\/AAC.48.7.2350-2354.2004","article-title":"Defined anaerobic growth medium for studying Candida albicans basic biology and resistance to eight antifungal drugs","volume":"48","author":"Dumitru","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0295","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/AAC.01432-05","article-title":"Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci","volume":"50","author":"Jones","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0300","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1073\/pnas.0700041104","article-title":"Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity","volume":"104","author":"Davidovich","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0305","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1128\/AAC.01568-15","article-title":"In vitro activity of retapamulin and antimicrobial susceptibility patterns in a longitudinal collection of methicillin-resistant Staphylococcus aureus isolates from a veterans affairs medical center","volume":"60","author":"Harrington","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0310","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/AAC.50.1.379-381.2006","article-title":"Comparative in vitro activities of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium spp., including 117 P. acnes isolates","volume":"50","author":"Goldstein","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0315","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1128\/AAC.00178-06","article-title":"Selection of retapamulin, a novel pleuromutilin for topical use","volume":"50","author":"Rittenhouse","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0320","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2174\/138945011501140115112242","article-title":"Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agents","volume":"15","author":"Tripathi","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0325","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-12-75","article-title":"Comparative genomics allowed the identification of drug targets against human fungal pathogens","volume":"12","author":"Abadio","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0330","doi-asserted-by":"crossref","first-page":"209","DOI":"10.18388\/abp.2017_2327","article-title":"Prioritizing and modelling of putative drug target proteins of Candida albicans by systems biology approach","volume":"65","author":"Ismail","year":"2018","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0335","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3923\/tb.2015.52.62","article-title":"Identification of putative therapeutic targets in Candida tropicalis: An in silico approach","volume":"8","author":"Ravinarayanan","year":"2015","journal-title":"Trends Bioinform."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0340","series-title":"Pacific Symp. Biocomput. 2009, PSB 2009, NIH Public Access","first-page":"391","article-title":"High throughput interaction data reveals degree conservation of hub proteins","author":"Fox","year":"2009"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/srep00900","article-title":"Network rewiring is an important mechanism of gene essentiality change","volume":"2","author":"Kim","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0350","series-title":"Network Analysis of Hyphae Forming Proteins in Candida albicans Identifies Important Proteins Responsible for Pathovirulence in the Organism","author":"Das","year":"2017"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0355","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-017-1073-8","article-title":"An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions","volume":"17","author":"Senior","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0360","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fcimb.2018.00264","article-title":"Modeling the metabolic state of Mycobacterium tuberculosis upon infection","volume":"8","author":"Rienksma","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0365","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1750291","article-title":"Computational identification of metabolic pathways of Plasmodium falciparum using the k -shortest path algorithm","volume":"2019","author":"Oyelade","year":"2019","journal-title":"Int. J. Genomics"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mSphere.00913-19","article-title":"Metabolic reprogramming in the opportunistic yeast Candida albicans in response to hypoxia","volume":"5","author":"Burgain","year":"2020","journal-title":"MSphere."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0375","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/brv.12140","article-title":"The return of metabolism: biochemistry and physiology of the pentose phosphate pathway HHS public access","volume":"90","author":"Stincone","year":"2015","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0380","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00294-015-0487-9","article-title":"Insights into the cellular responses to hypoxia in filamentous fungi","volume":"61","author":"Hillmann","year":"2015","journal-title":"Curr. Genet."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0385","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-61729-1","article-title":"New therapeutic candidates for the treatment of Malassezia pachydermatis -Associated infections","volume":"10","author":"Sastoque","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0390","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s10989-019-09953-w","article-title":"Subtractive proteome analysis of Candida albicans divulges promising antifungal targets","volume":"26","author":"Jha","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0395","doi-asserted-by":"crossref","first-page":"104196","DOI":"10.1016\/j.meegid.2020.104196","article-title":"Genome-wide screening and in silico gene knockout to predict potential candidates for drug designing against Candida albicans","volume":"80","author":"Verma","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0400","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1752-0509-3-37","article-title":"Connecting extracellular metabolomic measurements to intracellular flux states in yeast","volume":"3","author":"Mo","year":"2009","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0405","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/AAC.47.3.956-964.2003","article-title":"Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei","volume":"47","author":"Onyewu","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0410","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/13693780903390208","article-title":"Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase","volume":"48","author":"Hata","year":"2010","journal-title":"Med. Mycol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0415","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.00864","article-title":"Palmitic acid inhibits the virulence factors of Candida tropicalis: biofilms, cell surface hydrophobicity, ergosterol biosynthesis, and enzymatic activity","volume":"11","author":"Prasath","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0420","doi-asserted-by":"crossref","first-page":"17231","DOI":"10.1074\/jbc.M701724200","article-title":"Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design","volume":"282","author":"Morgunova","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0425","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/AAC.01809-12","article-title":"Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents","volume":"57","author":"Richie","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0430","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4265\/bio.19.51","article-title":"Evaluation of Mdh1 protein as an antigenic candidate for a vaccine against candidiasis","volume":"19","author":"Shibasaki","year":"2014","journal-title":"Biocontrol Sci."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006487","article-title":"Bypass of Candida albicans filamentation\/biofilm regulators through diminished expression of protein kinase Cak1","volume":"12","author":"Woolford","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0440","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.fgb.2011.04.005","article-title":"The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans","volume":"48","author":"Legrand","year":"2011","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0445","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1091\/mbc.e04-12-1081","article-title":"The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans","volume":"16","author":"Bensen","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000612","article-title":"Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans","volume":"5","author":"Askew","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0455","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fmicb.2019.00099","article-title":"Sugar sensing and signaling in Candida albicans and Candida glabrata","volume":"10","author":"Van Ende","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007823","article-title":"A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans","volume":"15","author":"Burgain","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-39117-1","article-title":"Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata","volume":"9","author":"Chew","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007976","article-title":"Mitochondrial proline catabolism activates Ras1\/cAMP\/PKA-induced filamentation in Candida albicans","volume":"15","author":"Silao","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0475","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/mmi.13933","article-title":"Methionine is required for cAMP-PKA-mediated morphogenesis and virulence of Candida albicans","volume":"108","author":"Schrevens","year":"2018","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0480","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1128\/EC.3.5.1076-1087.2004","article-title":"Transcriptional response of Candida albicans upon internalization by macrophages","volume":"3","author":"Lorenz","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.ygeno.2020.12.040_bb0485","first-page":"6585","article-title":"Sterol uptake and sterol biosynthesis act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0490","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1021\/pr300979r","article-title":"Alanine-metabolizing enzyme Alt1 is critical in determining yeast life span, as revealed by combined metabolomic and genetic studies","volume":"12","author":"Yu","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0495","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1432-1033.1992.tb16937.x","article-title":"YmL9, a nucleus-encoded mitochondrial ribosomal protein of yeast, is homologous to L3 ribosomal proteins from all natural kingdoms and photosynthetic organelles","volume":"206","author":"Graack","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ygeno.2020.12.040_bb0500","series-title":"Characterization of Virulence-Related Phenotypes in Candida Species of the CUG Clade","author":"Priest","year":"2015"}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754321000240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754321000240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:29:04Z","timestamp":1760164144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754321000240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0888754321000240"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2020.12.040","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the druggable proteome of Candida species through comprehensive computational analysis","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2020.12.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}