{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:16:09Z","timestamp":1789496169341,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":549,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ygeno.2021.03.024","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T12:34:49Z","timestamp":1616589289000},"page":"1522-1533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination"],"prefix":"10.1016","volume":"113","author":[{"given":"Diming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Luo","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2021.03.024_bb0005","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1017\/S1751731113000578","article-title":"Diet effects on urine composition of cattle and N2O emissions","volume":"7","author":"Dijkstra","year":"2013","journal-title":"Animal"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1009747109538","article-title":"Ammonia volatilization from dairy farming systems in temperate areas: a review","volume":"51","author":"Bussink","year":"1998","journal-title":"Nutr. Cycl. Agroecosyst."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0015","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jclepro.2013.12.049","article-title":"An integrated environmental impact assessment of corn-based polyols compared with petroleum-based polyols production","volume":"68","author":"Zhao","year":"2014","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0020","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jclepro.2017.06.096","article-title":"Accounting methane and nitrous oxide emissions, and carbon footprints of livestock food products in different states of India","volume":"162","author":"Kumar","year":"2017","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0025","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3168\/jds.2007-0323","article-title":"Effects of silage soluble nitrogen components on metabolizable protein concentration: a meta-analysis of dairy cow production experiments","volume":"91","author":"Huhtanen","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0030","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.3168\/jds.2007-0299","article-title":"Prediction of ammonia emission from dairy cattle manure based on milk urea nitrogen: relation of milk urea nitrogen to urine urea nitrogen excretion","volume":"90","author":"Burgos","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0035","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.3168\/jds.S0022-0302(04)73561-4","article-title":"Feed efficiency of mid-lactation dairy cows fed yeast culture during summer","volume":"87","author":"Schingoethe","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0040","first-page":"154","article-title":"Voluntary intake, digestibility, rumen VFA concentration and milk production of dairy cattle fed on forage or silage of sorghum (Sorghum bicolor Moench)","volume":"36","author":"Goto","year":"1990","journal-title":"J. Jpn. Soc. Grass Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0045","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.2527\/1995.73113464x","article-title":"Absorption of L-carnosine, L-methionine, and L-methionylglycine by isolated sheep ruminal and omasal epithelial tissue","volume":"73","author":"Matthews","year":"1995","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0050","first-page":"67","article-title":"Relationship between mammary gland metabolism and nitrogen efficiency in the lactating dairy cow","author":"Danes","year":"2015","journal-title":"Dissert. Theses Gradworks."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0055","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.3168\/jds.2014-7961","article-title":"Effects of alfalfa and cereal straw as a forage source on nutrient digestibility and lactation performance in lactating dairy cows","volume":"97","author":"Wang","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0060","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/pr501305g","article-title":"Metabolomics of four biofluids from dairy cows: potential biomarkers for milk production and quality","volume":"14","author":"Sun","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0065","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1021\/ef800001n","article-title":"Improving biodegradability and biogas production of corn Stover through sodium hydroxide solid state pretreatment","volume":"22","author":"Pang","year":"2008","journal-title":"Energy Fuel"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0070","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.3168\/jds.2007-0299","article-title":"Prediction of ammonia emission from dairy cattle manure based on milk urea nitrogen: relation of milk urea nitrogen to urine urea nitrogen excretion","volume":"90","author":"Burgos","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0075","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3168\/jds.S0022-0302(99)75525-6","article-title":"Effect of replacing alfalfa silage with high moisture corn on ruminal protein synthesis estimated from excretion of total purine derivatives","volume":"82","author":"Valadares","year":"1999","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0080","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease","volume":"452","author":"Valur","year":"2008","journal-title":"Nature."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0090","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1073374","article-title":"Hierarchical organization of modularity in metabolic networks","volume":"297","author":"Ravasz","year":"2002","journal-title":"Science."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0095","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/bioinformatics\/btm563","article-title":"Defining clusters from a hierarchical cluster tree: the dynamic tree cut package for R","volume":"24","author":"Langfelder","year":"2008","journal-title":"Bioinformatics."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0100","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1074\/jbc.M113.522516","article-title":"Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.healun.2013.01.565","article-title":"Weighted gene coexpression network analysis (WGCNA) modeling of multiorgan dysfunction syndrome after mechanical circulatory support therapy","volume":"32","author":"Wisniewski","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3168\/jds.2010-4097","article-title":"Effects of dietary protein concentration and balance of absorbable amino acids on productive responses of dairy cows fed corn silage-based diets","volume":"94","author":"Cabrita","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0115","doi-asserted-by":"crossref","first-page":"21194","DOI":"10.1038\/srep21194","article-title":"Systematic microRNAome profiling reveals the roles of microRNAs in milk protein metabolism and quality: insights on low-quality forage utilization","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0003356100018328","article-title":"Inter-breed relationship of maintenance efficiency to milk yield in cattle","volume":"43","author":"Taylor","year":"2010","journal-title":"Anim. Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0125","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3168\/jds.S0022-0302(03)73727-8","article-title":"Effects of changes in dietary amino acid balance on milk yield and mammary function in dairy cows","volume":"86","author":"Yeo","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0130","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2527\/1999.7751277x","article-title":"Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens","volume":"77","author":"Chen","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0135","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.3168\/jds.S0022-0302(94)77220-9","article-title":"Absorption and delivery of nutrients for milk protein synthesis by portal-drained viscera","volume":"77","author":"Reynolds","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0140","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.3168\/jds.2007-0124","article-title":"Effect of glutamine supplementation on splanchnic metabolism in lactating dairy cows","volume":"90","author":"Doepel","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0145","first-page":"1","article-title":"Condensed tannin in drinking water of cattle and sheep to reduce their urine urea excretion and subsequent ammonia pollution","author":"Kronberg","year":"2010","journal-title":"Proc. GLOBECOM Workshops"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0150","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.3168\/jds.2012-5688","article-title":"Effect of sodium chloride intake on urine volume, urinary urea excretion, and milk urea concentration in lactating dairy cattle","volume":"95","author":"Spek","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.livprodsci.2003.09.009","article-title":"Relationship between content of crude protein in rations for dairy cows, N in urine and ammonia release","volume":"84","author":"Swensson","year":"2003","journal-title":"Livest. Prod. Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0160","article-title":"Downregulation of RPL6 by siRNA inhibits proliferation and cell cycle progression of human gastric cancer cell lines","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1095\/biolreprod.112.105080","article-title":"Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the mTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway","volume":"88","author":"Kim","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0170","article-title":"Translational control of arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053698","article-title":"Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells","volume":"8","author":"Paredes","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/path.4762","article-title":"Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes","volume":"240","author":"Dai","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0185","first-page":"452","article-title":"Plasma LUNX mRNA, a non-invasive specific biomarker for diagnosis and prognostic prediction of non-small cell lung cancer","volume":"6","author":"Zhou","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0190","article-title":"Plasma serpinB1 is related to insulin sensitivity but not pancreatic \u03b2-Cell function in non-diabetic adults","volume":"5","author":"Glicksman","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0195","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00125-015-3829-8","article-title":"Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance","volume":"59","author":"Rieusset","year":"2016","journal-title":"Diabetologia."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0200","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.3168\/jds.2009-2743","article-title":"Regulation of protein synthesis in mammary glands of lactating dairy cows by starch and amino acids","volume":"93","author":"Rius","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0205","doi-asserted-by":"crossref","first-page":"5895628","DOI":"10.1155\/2018\/5895628","article-title":"Global, survival, and apoptotic transcriptome during mouse and human early embryonic development","volume":"2018","author":"Haouzi","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0210","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1158\/0008-5472.CAN-18-0688","article-title":"Oncogenic properties of NEAT1 in prostate cancer cells depend on the CDC5L-AGRN transcriptional regulation circuit","volume":"78","author":"Li","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0215","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/039139880903200305","article-title":"The thickness of electrospun poly (epsilon-caprolactone) nanofibrous scaffolds influences cell proliferation","volume":"32","author":"Ghasemi-Mobarakeh","year":"2009","journal-title":"Int. J. Artif. Organs"},{"key":"10.1016\/j.ygeno.2021.03.024_bb0220","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.biopha.2018.02.104","article-title":"miR-615-3p promotes proliferation and migration and inhibits apoptosis through its potential target CELF2 in gastric cancer","volume":"101","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0225","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cellsig.2009.01.006","article-title":"The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis","volume":"21","author":"Paschos","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ygeno.2021.03.024_bb0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2460\/ajvr.72.1.80","article-title":"Adhesion phenotypes of pigs of Chinese and Western breeds and a white Duroc-Erhualian crossbreed with regard to susceptibility to enterotoxigenic Escherichia coli with fimbrial adhesins K99, 987P, and F41","volume":"72","author":"Yan","year":"2011","journal-title":"Am. J. Vet. Res."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754321001166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754321001166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:36:05Z","timestamp":1760164565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754321001166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0888754321001166"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2021.03.024","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2021.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}