{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:55:53Z","timestamp":1783180553780,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ygeno.2023.110766","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T13:22:37Z","timestamp":1703164957000},"page":"110766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive genomic profiling of small bowel adenocarcinoma by tissue and plasma biopsy"],"prefix":"10.1016","volume":"116","author":[{"given":"Dan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejian","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2023.110766_bb0005","year":"2016","journal-title":"Cancer Res. UK"},{"key":"10.1016\/j.ygeno.2023.110766_bb0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023, CA","volume":"73","author":"Siegel","year":"2023","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.ygeno.2023.110766_bb0015","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.amjsurg.2009.05.037","article-title":"A single-institution experience with 491 cases of small bowel adenocarcinoma","volume":"199","author":"Halfdanarson","year":"2010","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.ygeno.2023.110766_bb0020","first-page":"107","article-title":"Impact of tumor location on patient outcomes in small bowel cancers","volume":"21","author":"Yu","year":"2022","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.ygeno.2023.110766_bb0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrclinonc.2013.132","article-title":"Small bowel adenocarcinomas\u2014existing evidence and evolving paradigms","volume":"10","author":"Raghav","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0030","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/cncr.29840","article-title":"Efficacy of adjuvant chemotherapy for small bowel adenocarcinoma: a propensity score\u2013matched analysis","volume":"122","author":"Ecker","year":"2016","journal-title":"Cancer."},{"key":"10.1016\/j.ygeno.2023.110766_bb0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1634\/theoncologist.2017-0568","article-title":"Phase II study of panitumumab in RAS wild-type metastatic adenocarcinoma of small bowel or ampulla of Vater","volume":"23","author":"Gulhati","year":"2018","journal-title":"Oncologist"},{"key":"10.1016\/j.ygeno.2023.110766_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007200","article-title":"Exome-wide somatic mutation characterization of small bowel adenocarcinoma","volume":"14","author":"H\u00e4nninen","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ygeno.2023.110766_bb0055","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/ijc.33392","article-title":"Panel gene profiling of small bowel adenocarcinoma: results from the NADEGE prospective cohort","volume":"148","author":"Aparicio","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygeno.2023.110766_bb0060","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1001\/jamaoncol.2017.1051","article-title":"Genomic profiling of small-bowel adenocarcinoma","volume":"3","author":"Schrock","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0065","doi-asserted-by":"crossref","DOI":"10.1111\/cas.15119","article-title":"Molecular profiling and identification of prognostic factors in Chinese patients with small bowel adenocarcinoma","volume":"112","author":"Pan","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ygeno.2023.110766_bb0070","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1200\/jco.2015.33.15_suppl.3619","article-title":"Programmed death-ligand 1 (PD-L1) expression in small bowel adenocarcinomas (SBA)","volume":"33","author":"Pedersen","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0075","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/AJCP\/AQX070","article-title":"Could the PD-1 pathway be a potential target for treating small intestinal adenocarcinoma?","volume":"148","author":"Thota","year":"2017","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0080","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s40883-019-00141-2","article-title":"The translational status of cancer liquid biopsies","volume":"7","author":"Bratulic","year":"2021","journal-title":"Regen. Eng. Transl. Med."},{"key":"10.1016\/j.ygeno.2023.110766_bb0085","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/2643-3230.BCD-21-0029","article-title":"Circulating tumor DNA in lymphoma: principles and future directions","volume":"3","author":"Roschewski","year":"2022","journal-title":"Blood Cancer Discov."},{"key":"10.1016\/j.ygeno.2023.110766_bb0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-981-32-9620-6_17","article-title":"Liquid biopsy in breast cancer: circulating tumor cells and circulating tumor DNA","volume":"1187","author":"Yoo","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0095","doi-asserted-by":"crossref","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ygeno.2023.110766_bb0100","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3519","article-title":"An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage","volume":"20","author":"Newman","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ygeno.2023.110766_bb0105","doi-asserted-by":"crossref","first-page":"346ra92","DOI":"10.1126\/scitranslmed.aaf6219","article-title":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","volume":"8","author":"Tie","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ygeno.2023.110766_bb0110","first-page":"1","article-title":"Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA","volume":"5","author":"Finkle","year":"2021","journal-title":"Npj Precis. Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0115","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/bioinformatics\/btt755","article-title":"MSIsensor: microsatellite instability detection using paired tumor-normal sequence data","volume":"30","author":"Niu","year":"2014","journal-title":"Bioinformatics."},{"key":"10.1016\/j.ygeno.2023.110766_bb0120","first-page":"873","article-title":"Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab","volume":"1","author":"Bratman","year":"2020","journal-title":"Nat. Can."},{"key":"10.1016\/j.ygeno.2023.110766_bb0125","article-title":"Correlation between variant allele frequency and mean tumor molecules with tumor burden in patients with solid tumors","author":"Kalashnikova","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer","volume":"19","author":"Li","year":"2017","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.ygeno.2023.110766_bb0135","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2023.110766_bb0140","first-page":"257","article-title":"Clinical outcomes of small bowel adenocarcinoma","volume":"18","author":"Akce","year":"2019","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.ygeno.2023.110766_bb0145","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/ijms22010130","article-title":"Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements","volume":"22","author":"Malki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ygeno.2023.110766_bb0150","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12885-021-08108-9","article-title":"Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis","volume":"21","author":"Zhuang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ygeno.2023.110766_bb0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1001\/jamaoncol.2016.4227","article-title":"Prognostic survival associated with left-sided vs right-sided colon cancer: a systematic review and meta-analysis","volume":"3","author":"Petrelli","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0160","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1158\/2159-8290.CD-20-0187","article-title":"EGFR blockade reverts resistance to KRASG12C inhibition in colorectal cancer","volume":"10","author":"Amodio","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ygeno.2023.110766_bb0165","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/gutjnl-2014-309026","article-title":"Activating ERBB2\/HER2 mutations indicate susceptibility to pan-HER inhibitors in lynch and lynch-like colorectal cancer","volume":"65","author":"Kloth","year":"2016","journal-title":"Gut."},{"key":"10.1016\/j.ygeno.2023.110766_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102426","article-title":"Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR\/SREBP-1\/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer","volume":"55","author":"Chen","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0175","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1158\/1078-0432.CCR-21-0159","article-title":"ZEBRA: a multicenter phase II study of pembrolizumab in patients with advanced small-bowel adenocarcinoma","volume":"27","author":"Pedersen","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ygeno.2023.110766_bb0180","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12876-020-01531-5","article-title":"HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery","volume":"20","author":"Grenda","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.ygeno.2023.110766_bb0185","first-page":"djad080","article-title":"Copy number aberrations in circulating tumor DNA enables prognosis prediction and molecular characterization of breast cancer","author":"Kim","year":"2023","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754323002100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754323002100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:43:58Z","timestamp":1760165038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754323002100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0888754323002100"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2023.110766","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive genomic profiling of small bowel adenocarcinoma by tissue and plasma biopsy","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2023.110766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110766"}}