{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:14:35Z","timestamp":1778580875113,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ygeno.2024.110809","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T05:13:37Z","timestamp":1710566017000},"page":"110809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mutational profile evaluates metastatic capacity of Chinese colorectal cancer patients, revealed by whole-exome sequencing"],"prefix":"10.1016","volume":"116","author":[{"given":"Yian","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingchuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2024.110809_bb0005","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygeno.2024.110809_bb0010","article-title":"Planning for tomorrow: global cancer incidence and the role of prevention 2020-2070","volume":"18","author":"I, S. & F, B","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0015","article-title":"A review of colorectal Cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","volume":"13","author":"T, S","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ygeno.2024.110809_bb0020","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.36378","article-title":"Comparative effectiveness of biologic agents among black and white Medicare patients in the US with metastatic colorectal Cancer","volume":"4","author":"Goel","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ygeno.2024.110809_bb0025","article-title":"Comparison of breast Cancer molecular features and survival by African and European ancestry in the Cancer genome atlas","volume":"3","author":"D, H","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0030","article-title":"High concordance of genomic profiles between primary and metastatic colorectal cancer","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ygeno.2024.110809_bb0035","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-019-1379-5","article-title":"The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects","volume":"17","author":"Yu","year":"2019","journal-title":"BMC Med."},{"key":"10.1016\/j.ygeno.2024.110809_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.33445","article-title":"Clinical characteristics, medical service utilization, and expenditure for colorectal cancer in China, 2005 to 2014: overall design and results from a multicenter retrospective epidemiologic survey","volume":"127","author":"Shi","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.ygeno.2024.110809_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.08.002","article-title":"Integrated omics of metastatic colorectal Cancer","volume":"38","author":"Li","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ygeno.2024.110809_bb0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13073-021-00962-3","article-title":"Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma","volume":"13","author":"Tang","year":"2021","journal-title":"Genome Med."},{"key":"10.1016\/j.ygeno.2024.110809_bb0055","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2020009530","article-title":"Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options","volume":"138","author":"Malcikova","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ygeno.2024.110809_bb0060","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/s41467-019-10987-3","article-title":"Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases","volume":"10","author":"Sun","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ygeno.2024.110809_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/humu.24059","article-title":"Integrated multi-omics data analyses for exploring the co-occurring and mutually exclusive gene alteration events in colorectal cancer","volume":"41","author":"Zhou","year":"2020","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ygeno.2024.110809_bb0070","article-title":"Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile","author":"B, W","year":"2022","journal-title":"Cancer Med."},{"key":"10.1016\/j.ygeno.2024.110809_bb0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.21037\/jgo-21-9","article-title":"Genome variation in colorectal cancer patient with liver metastasis measured by whole-exome sequencing","volume":"12","author":"Yi","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0080","article-title":"TTN\/OBSCN \u2018double-hit\u2019 predicts favourable prognosis, \u2018immune-hot\u2019 subtype and potentially better immunotherapeutic efficacy in colorectal cancer","volume":"25","author":"Liu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ygeno.2024.110809_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4682589","article-title":"Establishing and validating an aging-related prognostic four-gene signature in Colon adenocarcinoma","volume":"2021","author":"Zheng","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ygeno.2024.110809_bb0090","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.18.01854","article-title":"Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients","volume":"37","author":"Kurian","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0095","doi-asserted-by":"crossref","DOI":"10.2217\/fon-2019-0363","article-title":"Analysis of TGCA data reveals genetic and epigenetic changes and biological function of MUC family genes in colorectal cancer","volume":"15","author":"Jiang","year":"2019","journal-title":"Future Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygyno.2009.08.007","article-title":"CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis","volume":"115","author":"Boivin","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0105","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-18-3259","article-title":"MUC1-C integrates chromatin remodeling and PARP1 activity in the DNA damage response of triple-negative breast cancer cells","volume":"79","author":"Yamamoto","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ygeno.2024.110809_bb0110","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.23966","article-title":"SMAD4-independent activation of TGF-\u03b2 signaling by MUC1 in a human pancreatic cancer cell line","volume":"9","author":"Grover","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ygeno.2024.110809_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030649","article-title":"Mechanistic and functional shades of mucins and associated glycans in colon cancer","volume":"12","author":"Pothuraju","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ygeno.2024.110809_bb0120","article-title":"EGF-containing membrane-bound mucins: a hidden ErbB2 targeting pathway?","volume":"63","author":"M, L., N, J., P, M., I, V. S. & N, L","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ygeno.2024.110809_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.25256","article-title":"MUC12 mRNA expression is an independent marker of prognosis in stage II and stage III colorectal cancer","volume":"127","author":"Matsuyama","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ygeno.2024.110809_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ph14101053","article-title":"Mucin1 and mucin16: Therapeutic targets for cancer therapy","volume":"14","author":"Lee","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ygeno.2024.110809_bb0135","article-title":"Potential of anti-muc1 antibodies as a targeted therapy for gastrointestinal","volume":"8","author":"Bose","year":"2020","journal-title":"Cancers. Vaccin."},{"key":"10.1016\/j.ygeno.2024.110809_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/ng.3441","article-title":"Clock-like mutational processes in human somatic cells","volume":"47","author":"Alexandrov","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygeno.2024.110809_bb0145","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-19-1536","article-title":"Lineage reversion drives wnt independence in intestinal cancer","volume":"10","author":"Han","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ygeno.2024.110809_bb0150","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-15-0224","article-title":"Targeting YAP-dependent MDSC infiltration impairs tumor progression","volume":"6","author":"Wang","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ygeno.2024.110809_bb0155","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1038\/s41388-020-1259-7","article-title":"Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells","volume":"39","author":"Wenzel","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.ygeno.2024.110809_bb0160","article-title":"Fast and accurate short read alignment with burrows-wheeler transform","volume":"25","author":"H, L. & R, D","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2024.110809_bb0165","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2024.110809_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"Depristo","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ygeno.2024.110809_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2024.110809_bb0185","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btab806","article-title":"Make interactive complex Heatmaps in R","volume":"38","author":"Gu","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ygeno.2024.110809_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2024.110809_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/nrg3729","article-title":"Mechanisms underlying mutational signatures in human cancers","volume":"15","author":"Helleday","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ygeno.2024.110809_bb0200","doi-asserted-by":"crossref","DOI":"10.1109\/TPAMI.2012.240","article-title":"Automatic relevance determination in nonnegative matrix factorization with the (\u03b2)-divergence","volume":"35","author":"Tan","year":"2013","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"10.1016\/j.ygeno.2024.110809_bb0205","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx1133","article-title":"MSignatureDB: a database for deciphering mutational signatures in human cancers","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ygeno.2024.110809_bb0210","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-016-0893-4","article-title":"deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution","volume":"17","author":"Rosenthal","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.ygeno.2024.110809_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2024.110809_bb0220","doi-asserted-by":"crossref","DOI":"10.1111\/j.1541-0420.2011.01616.x","article-title":"ggplot2: elegant graphics for data analysis by WICKHAM, H","volume":"67","author":"Wilkinson","year":"2011","journal-title":"Biometrics"},{"key":"10.1016\/j.ygeno.2024.110809_bb0225","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324000302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324000302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T10:58:03Z","timestamp":1716461883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754324000302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0888754324000302"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110809","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutational profile evaluates metastatic capacity of Chinese colorectal cancer patients, revealed by whole-exome sequencing","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110809"}}