{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:59:29Z","timestamp":1790769569793,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genomics"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ygeno.2024.110923","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T21:37:24Z","timestamp":1724621844000},"page":"110923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K\/AKT\/mTOR\/MYC signaling pathway"],"prefix":"10.1016","volume":"116","author":[{"given":"Junfan","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ygeno.2024.110923_bb0005","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygeno.2024.110923_bb0010","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.tranon.2019.06.007","article-title":"m1A regulated genes modulate PI3K\/AKT\/mTOR and ErbB pathways in gastrointestinal cancer","volume":"12","author":"Zhao","year":"2019","journal-title":"Transl. Oncol."},{"issue":"2013","key":"10.1016\/j.ygeno.2024.110923_bb0015","first-page":"645","article-title":"Non\u2013small cell lung cancer, Version 2","volume":"11","author":"Ettinger","year":"2013","journal-title":"NCCN Guidelines\u00ae Insights"},{"key":"10.1016\/j.ygeno.2024.110923_bb0020","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jtho.2017.08.008","article-title":"The role of thoracic surgery in the therapeutic management of metastatic non-small cell Lung cancer","volume":"12","author":"David","year":"2017","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/07357907.2018.1466895","article-title":"Outcomes of surgery as part of the management of metastatic non-small-cell lung cancer: a surveillance, epidemiology and end results database analysis","volume":"36","author":"Abdel-Rahman","year":"2018","journal-title":"Cancer Invest."},{"key":"10.1016\/j.ygeno.2024.110923_bb0030","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/187152009788451879","article-title":"Role of tyrosine kinase inhibitors in lung cancer","volume":"9","author":"Ansari","year":"2009","journal-title":"Anticancer Agents Med Chem."},{"key":"10.1016\/j.ygeno.2024.110923_bb0035","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1200\/EDBK_100006","article-title":"Targeted therapy in brain metastases: ready for primetime?","volume":"35","author":"Venur","year":"2016","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"issue":"2023","key":"10.1016\/j.ygeno.2024.110923_bb0040","first-page":"159","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ygeno.2024.110923_bb0045","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13402-022-00760-y","article-title":"Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis","volume":"46","author":"Zhang","year":"2023","journal-title":"Cell. Oncol. (Dordr.)"},{"issue":"2023","key":"10.1016\/j.ygeno.2024.110923_bb0050","first-page":"143","article-title":"T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis","volume":"56","author":"Briukhovetska","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.ygeno.2024.110923_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK complexes: structure, biological function, and involvement in human diseases","volume":"47","author":"Hwang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1741-7007-9-54","article-title":"Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration","volume":"9","author":"Bai","year":"2011","journal-title":"BMC Biol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0065","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteom.: MCP"},{"key":"10.1016\/j.ygeno.2024.110923_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.273","article-title":"Fam40b is required for lineage commitment of murine embryonic stem cells","volume":"5","author":"Wagh","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ygeno.2024.110923_bb0075","doi-asserted-by":"crossref","first-page":"22463","DOI":"10.1002\/jcp.28810","article-title":"STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway","volume":"234","author":"Dai","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1109637","article-title":"Long non-coding RNA-TMPO-AS1 as ceRNA binding to let-7c-5p upregulates STRIP2 expression and predicts poor prognosis in lung adenocarcinoma","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ncb3083","article-title":"STRIPAK components determine mode of cancer cell migration and metastasis","volume":"17","author":"Madsen","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","article-title":"ONCOMINE: a cancer microarray database and integrated data-mining platform","volume":"6","author":"Rhodes","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.ygeno.2024.110923_bb0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41598-018-36888-x","article-title":"SP1 and RAR\u03b1 regulate AGAP2 expression in cancer","volume":"9","author":"Doush","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ygeno.2024.110923_bb0100","first-page":"8913","article-title":"SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer","volume":"23","author":"Guo","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ygeno.2024.110923_bb0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40659-018-0200-9","article-title":"MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1","volume":"51","author":"Ren","year":"2018","journal-title":"Biol. Res."},{"key":"10.1016\/j.ygeno.2024.110923_bb0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ptr.6555","article-title":"The regulation and interaction of colon cancer-associated transcript-1 and miR7-5p contribute to the inhibition of SP1 expression by solamargine in human nasopharyngeal carcinoma cells","volume":"34","author":"Wu","year":"2020","journal-title":"Phytotherapy Res.: PTR"},{"key":"10.1016\/j.ygeno.2024.110923_bb0115","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/neuonc\/noaa103","article-title":"Increased activation of HDAC1\/2\/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma","volume":"22","author":"Yang","year":"2020","journal-title":"Neuro-oncology"},{"key":"10.1016\/j.ygeno.2024.110923_bb0120","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1101\/gad.1363206","article-title":"Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways","volume":"20","author":"AJ","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ygeno.2024.110923_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ygeno.2024.110923_bb0130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.omtm.2017.04.001","article-title":"STRIP2 is indispensable for the onset of embryonic stem cell differentiation","volume":"5","author":"Sabour","year":"2017","journal-title":"Mol. Therapy Methods Clin. Dev."},{"key":"10.1016\/j.ygeno.2024.110923_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12860-018-0175-y","article-title":"The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs","volume":"19","author":"Suryavanshi","year":"2018","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0140","first-page":"1581","article-title":"SP1\/TGF-\u03b21\/SMAD2 pathway is involved in angiogenesis during osteogenesis","volume":"21","author":"Ding","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ygeno.2024.110923_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031153","article-title":"Understanding the role of the transcription factor Sp1 in ovarian Cancer: from theory to practice","volume":"21","author":"Vellingiri","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ygeno.2024.110923_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/genes10120977","article-title":"Sp1 mediates the constitutive expression and repression of the PDSS2 Gene in lung Cancer cells","volume":"10","author":"Hu","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.ygeno.2024.110923_bb0155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/2211-5463.12785","article-title":"STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration","volume":"10","author":"Qiu","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.ygeno.2024.110923_bb0160","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jtho.2019.02.019","article-title":"The effect of LKB1 activity on the sensitivity to PI3K\/mTOR inhibition in non-small cell lung Cancer","volume":"14","author":"Shukuya","year":"2019","journal-title":"J. Thoracic Oncol."},{"key":"10.1016\/j.ygeno.2024.110923_bb0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.biochi.2019.08.003","article-title":"Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process","volume":"165","author":"Karimi Roshan","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.ygeno.2024.110923_bb0170","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BST20110609","article-title":"Cross-talk between mitogenic Ras\/MAPK and survival PI3K\/Akt pathways: a fine balance","volume":"40","author":"Aksamitiene","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ygeno.2024.110923_bb0175","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ygeno.2024.110923_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28073157","article-title":"Targeting mTOR for anti-aging and anti-cancer therapy","volume":"28","author":"Fu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ygeno.2024.110923_bb0185","doi-asserted-by":"crossref","first-page":"609","DOI":"10.21873\/anticanres.13990","article-title":"C-myc contributes to malignancy of lung Cancer: a potential anticancer drug target","volume":"40","author":"Chanvorachote","year":"2020","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ygeno.2024.110923_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-019-1174-z","article-title":"Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer","volume":"20","author":"Chen","year":"2019","journal-title":"Respir. Res."}],"container-title":["Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0888754324001447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:59:19Z","timestamp":1728370759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0888754324001447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0888754324001447"],"URL":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110923","relation":{},"ISSN":["0888-7543"],"issn-type":[{"value":"0888-7543","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K\/AKT\/mTOR\/MYC signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ygeno.2024.110923","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110923"}}